The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008] See more...

Aliases for IL17C Gene

Aliases for IL17C Gene

  • Interleukin 17C 2 3 5
  • IL-17C 2 3 4
  • Interleukin-17C 3 4
  • Cytokine CX2 3 4
  • CX2 2 3
  • MGC126884 2
  • MGC138401 2
  • IL17C 5
  • IL-21 2

External Ids for IL17C Gene

Previous GeneCards Identifiers for IL17C Gene

  • GC16P080141
  • GC16P089673
  • GC16P088408
  • GC16P088449
  • GC16P087232
  • GC16P088705
  • GC16P074400

Summaries for IL17C Gene

Entrez Gene Summary for IL17C Gene

  • The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17C Gene

IL17C (Interleukin 17C) is a Protein Coding gene. Diseases associated with IL17C include Chlorhexidine Allergy and Hyper Ige Syndrome. Among its related pathways are IL-17 Family Signaling Pathways and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.

UniProtKB/Swiss-Prot Summary for IL17C Gene

  • Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.

Additional gene information for IL17C Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17C Gene

Genomics for IL17C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL17C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J088638 Promoter/Enhancer 1 EPDnew ENCODE dbSUPER 600.7 -0.1 -94 0.3 ZBTB33 TCF12 POLR2A ZEB1 ZEB2 EGR1 IL17C HSALNG0113520 ZC3H18
GH16J088641 Enhancer 0.7 ENCODE dbSUPER 600.7 +1.2 1206 0.4 KLF9 MCM3 MCM7 SMAD4 NRF1 ZBTB33 ZNF48 MLLT1 POLR2A IL17C SNORD68 ENSG00000260121 PIEZO1 RPL13 CYBA lnc-MVD-1
GH16J088640 Enhancer 0.6 ENCODE dbSUPER 600.7 +0.8 846 0.2 KLF9 ZNF48 POLR2A GLIS2 IL17C CYBA lnc-MVD-1
GH16J088639 Enhancer 0.6 ENCODE dbSUPER 600.7 +0.6 616 0.2 KLF9 ZBTB10 GLIS2 IL17C CYBA lnc-MVD-1
GH16J088596 Enhancer 1 Ensembl ENCODE 17.4 -40.4 -40352 4.4 CEBPG HNRNPL GATAD2A ATF7 PRDM1 TCF12 IKZF2 SP1 CEBPA SOX13 HSALNG0113518 ZC3H18 IL17C CYBA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17C

Top Transcription factor binding sites by QIAGEN in the IL17C gene promoter:
  • AhR
  • AREB6
  • Arnt
  • CUTL1
  • Gfi-1
  • HTF
  • MAZR
  • p53
  • RSRFC4

Genomic Locations for IL17C Gene

Genomic Locations for IL17C Gene
chr16:88,638,572-88,640,468
(GRCh38/hg38)
Size:
1,897 bases
Orientation:
Plus strand
chr16:88,704,999-88,706,882
(GRCh37/hg19)
Size:
1,884 bases
Orientation:
Plus strand

Genomic View for IL17C Gene

Genes around IL17C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17C Gene

Proteins for IL17C Gene

  • Protein details for IL17C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0M4-IL17C_HUMAN
    Recommended name:
    Interleukin-17C
    Protein Accession:
    Q9P0M4
    Secondary Accessions:
    • Q3MIG8
    • Q9HC75

    Protein attributes for IL17C Gene

    Size:
    197 amino acids
    Molecular mass:
    21765 Da
    Quaternary structure:
    • Binds to a heterodimer formed by IL17RA and IL17RE.

neXtProt entry for IL17C Gene

Post-translational modifications for IL17C Gene

No Post-translational modifications

Other Protein References for IL17C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IL17C Gene

Domains & Families for IL17C Gene

Gene Families for IL17C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IL17C Gene

InterPro:
Blocks:
  • Interleukin-17
ProtoNet:

Suggested Antigen Peptide Sequences for IL17C Gene

GenScript: Design optimal peptide antigens:
  • Cytokine CX2 (IL17C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9P0M4

UniProtKB/Swiss-Prot:

IL17C_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17C: view

Function for IL17C Gene

Molecular function for IL17C Gene

UniProtKB/Swiss-Prot Function:
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial stimuli, including by lipopolysaccharides (LPS) in gut epithelial cell lines. This up-regulation may be mediated by Toll-like receptors TLR2 and TLR5. Up-regulated by various proinflammatory cytokines, including TNF, IL1B and IL17F. Up-regulation by IL17A in colon epithelial cells has been observed in some cases (PubMed:21993849), but not in others (PubMed:21993848).
GENATLAS Biochemistry:
interleukin 17C,not detected in several adult tissues,not in activated T cells,not binding to the IL17 receptor

Phenotypes From GWAS Catalog for IL17C Gene

Gene Ontology (GO) - Molecular Function for IL17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS,IEA --
genes like me logo Genes that share ontologies with IL17C: view
genes like me logo Genes that share phenotypes with IL17C: view

Animal Models for IL17C Gene

MGI Knock Outs for IL17C:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17C

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IL17C Gene

Localization for IL17C Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17C Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17C gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
genes like me logo Genes that share ontologies with IL17C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17C Gene

Pathways & Interactions for IL17C Gene

genes like me logo Genes that share pathways with IL17C: view

Pathways by source for IL17C Gene

1 R&D Systems pathway for IL17C Gene

Gene Ontology (GO) - Biological Process for IL17C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS,IEA --
GO:0007166 cell surface receptor signaling pathway TAS 10639155
GO:0007267 cell-cell signaling TAS 10639155
GO:0097400 interleukin-17-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with IL17C: view

No data available for SIGNOR curated interactions for IL17C Gene

Drugs & Compounds for IL17C Gene

No Compound Related Data Available

Transcripts for IL17C Gene

mRNA/cDNA for IL17C Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17C

Alternative Splicing Database (ASD) splice patterns (SP) for IL17C Gene

No ASD Table

Relevant External Links for IL17C Gene

GeneLoc Exon Structure for
IL17C

Expression for IL17C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17C Gene

mRNA differential expression in normal tissues according to GTEx for IL17C Gene

This gene is overexpressed in Testis (x5.6), Stomach (x5.3), and Whole Blood (x4.3).

Protein differential expression in normal tissues from HIPED for IL17C Gene

This gene is overexpressed in Islet of Langerhans (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17C Gene



Protein tissue co-expression partners for IL17C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17C

SOURCE GeneReport for Unigene cluster for IL17C Gene:

Hs.278911

Evidence on tissue expression from TISSUES for IL17C Gene

  • Lung(4.4)
  • Intestine(2.5)
  • Blood(2.3)
  • Lymph node(2.3)
  • Skin(2.2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with IL17C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17C Gene

Orthologs for IL17C Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL17C 30 31
  • 98.98 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL17C 31
  • 78 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia IL17C 31
  • 77 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Il17c 30 17 31
  • 76.79 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il17c 30
  • 74.87 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL17C 31
  • 49 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL17C 31
  • 48 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL17C 31
  • 48 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IL17C 31
  • 41 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia il17c 30
  • 50.6 (n)
Zebrafish
(Danio rerio)
Actinopterygii il17c 31
  • 28 (a)
OneToOne
Species where no ortholog for IL17C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL17C Gene

ENSEMBL:
Gene Tree for IL17C (if available)
TreeFam:
Gene Tree for IL17C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17C: view image

Paralogs for IL17C Gene

Paralogs for IL17C Gene

(1) SIMAP similar genes for IL17C Gene using alignment to 1 proteins:

  • IL17C_HUMAN
genes like me logo Genes that share paralogs with IL17C: view

Variants for IL17C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17C Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
764104 Likely Benign: not provided 88,639,809(+) C/T INTRON_VARIANT
782896 Likely Benign: not provided 88,639,977(+) G/A MISSENSE_VARIANT
786947 Benign: not provided 88,640,066(+) A/G SYNONYMOUS_VARIANT
790169 Benign: not provided 88,639,068(+) G/A MISSENSE_VARIANT
rs11465492 - p.Arg25Gly

Additional dbSNP identifiers (rs#s) for IL17C Gene

Structural Variations from Database of Genomic Variants (DGV) for IL17C Gene

Variant ID Type Subtype PubMed ID
nsv1926 CNV insertion 18451855
nsv482951 CNV loss 15286789
nsv833325 CNV loss 17160897
nsv952070 CNV deletion 24416366

Variation tolerance for IL17C Gene

Residual Variation Intolerance Score: 50.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17C

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17C Gene

Disorders for IL17C Gene

MalaCards: The human disease database

(4) MalaCards diseases for IL17C Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IL17C in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL17C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL17C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17C Gene

Publications for IL17C Gene

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PMID: 10639155) Li H … Wood WI (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 23
  2. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. (PMID: 21993848) Ramirez-Carrozzi V … Pappu R (Nature immunology 2011) 3 4
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 41
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 41

Products for IL17C Gene

Sources for IL17C Gene