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The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
IL17C (Interleukin 17C) is a Protein Coding gene. Diseases associated with IL17C include Chlorhexidine Allergy and Hyper Ige Syndrome. Among its related pathways are IL-17 Family Signaling Pathways and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J088638 | Promoter/Enhancer | 1 | EPDnew ENCODE dbSUPER | 600.7 | -0.1 | -94 | 0.3 | ZBTB33 TCF12 POLR2A ZEB1 ZEB2 EGR1 | IL17C HSALNG0113520 ZC3H18 | |
GH16J088641 | Enhancer | 0.7 | ENCODE dbSUPER | 600.7 | +1.2 | 1206 | 0.4 | KLF9 MCM3 MCM7 SMAD4 NRF1 ZBTB33 ZNF48 MLLT1 POLR2A | IL17C SNORD68 ENSG00000260121 PIEZO1 RPL13 CYBA lnc-MVD-1 | |
GH16J088640 | Enhancer | 0.6 | ENCODE dbSUPER | 600.7 | +0.8 | 846 | 0.2 | KLF9 ZNF48 POLR2A GLIS2 | IL17C CYBA lnc-MVD-1 | |
GH16J088639 | Enhancer | 0.6 | ENCODE dbSUPER | 600.7 | +0.6 | 616 | 0.2 | KLF9 ZBTB10 GLIS2 | IL17C CYBA lnc-MVD-1 | |
GH16J088596 | Enhancer | 1 | Ensembl ENCODE | 17.4 | -40.4 | -40352 | 4.4 | CEBPG HNRNPL GATAD2A ATF7 PRDM1 TCF12 IKZF2 SP1 CEBPA SOX13 | HSALNG0113518 ZC3H18 IL17C CYBA |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS,IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-17 Family Signaling Pathways | ||
2 | Cytokine Signaling in Immune system | ||
3 | PEDF Induced Signaling | ||
4 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006954 | inflammatory response | TAS,IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 10639155 |
GO:0007267 | cell-cell signaling | TAS | 10639155 |
GO:0097400 | interleukin-17-mediated signaling pathway | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL17C 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL17C 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL17C 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il17c 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il17c 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IL17C 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL17C 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL17C 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IL17C 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il17c 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | il17c 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
764104 | Likely Benign: not provided | 88,639,809(+) | C/T | INTRON_VARIANT | |
782896 | Likely Benign: not provided | 88,639,977(+) | G/A | MISSENSE_VARIANT | |
786947 | Benign: not provided | 88,640,066(+) | A/G | SYNONYMOUS_VARIANT | |
790169 | Benign: not provided | 88,639,068(+) | G/A | MISSENSE_VARIANT | |
rs11465492 | - | p.Arg25Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
chlorhexidine allergy |
|
|
hyper ige syndrome |
|
|
systemic lupus erythematosus |
|
|
amyotrophic lateral sclerosis 1 |
|
|