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The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]
IL17C (Interleukin 17C) is a Protein Coding gene. Diseases associated with IL17C include Chlorhexidine Allergy and Hyper Ige Syndrome. Among its related pathways are IL-17 Family Signaling Pathways and Innate Immune System. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH16J088638 | Promoter/Enhancer | 1 | EPDnew ENCODE dbSUPER | 250.7 | -0.1 | -94 | 0.3 | ZEB1 ZEB2 TCF12 EGR1 ZBTB33 POLR2A | HSALNG0113522 IL17C MK280607-007 ZC3H18 | |
GH16J088641 | Enhancer | 0.7 | ENCODE dbSUPER | 250.7 | +1.2 | 1206 | 0.4 | MCM7 MCM3 SMAD4 KLF9 NRF1 ZBTB33 ZNF48 POLR2A MLLT1 | HSALNG0113522 IL17C SNORD68 ENSG00000260121 PIEZO1 RPL13 HSALNG0113523 CYBA | |
GH16J088640 | Enhancer | 0.6 | ENCODE dbSUPER | 250.7 | +0.8 | 846 | 0.2 | KLF9 ZNF48 GLIS2 POLR2A | HSALNG0113522 IL17C HSALNG0113523 CYBA | |
GH16J088639 | Enhancer | 0.6 | ENCODE dbSUPER | 250.7 | +0.6 | 616 | 0.2 | ZBTB10 KLF9 GLIS2 | HSALNG0113522 IL17C HSALNG0113523 CYBA | |
GH16J088615 | Enhancer | 1.3 | FANTOM5 ENCODE dbSUPER | 18.6 | -20.1 | -20080 | 5.5 | MXD4 FEZF1 KDM6A THAP11 ZNF395 FOXA2 SMAD4 SAP130 RXRA MIER3 | CYBA IL17C ZC3H18 SNAI3 MVD RNF166 ZFPM1 HSALNG0113519 HSALNG0113518 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | TAS,IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS,IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-17 Family Signaling Pathways | ||
2 | Cytokine Signaling in Immune system | ||
3 | PEDF Induced Signaling | ||
4 | Innate Immune System |
.61
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006954 | inflammatory response | TAS,IEA | -- |
GO:0007166 | cell surface receptor signaling pathway | TAS | 10639155 |
GO:0007267 | cell-cell signaling | TAS | 10639155 |
GO:0097400 | interleukin-17-mediated signaling pathway | TAS | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL17C 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL17C 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL17C 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il17c 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il17c 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IL17C 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL17C 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL17C 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IL17C 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il17c 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | il17c 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs189998965 | Benign: not provided | 88,639,068(+) |
G/A NM_013278.4(IL17C):c.94G>A (p.Gly32Ser) |
MISSENSE | |
rs199990283 | Likely Benign: not provided | 88,639,977(+) |
G/A NM_013278.4(IL17C):c.499G>A (p.Gly167Ser) |
MISSENSE | |
rs34804164 | Benign: not provided | 88,640,066(+) |
A/G NM_013278.4(IL17C):c.588A>G (p.Ser196=) |
SYNONYMOUS | |
rs763144818 | Likely Benign: not provided | 88,639,809(+) |
C/T NM_013278.4(IL17C):c.336-5C>T |
INTRON | |
rs11465492 | - |
p.Arg25Gly |
Disorder | Aliases | PubMed IDs |
---|---|---|
chlorhexidine allergy |
|
|
hyper ige syndrome |
|
|
septal myocardial infarction |
|
|
pustulosis of palm and sole |
|
|
amyotrophic lateral sclerosis 1 |
|
|