The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing resu... See more...

Aliases for IL17B Gene

Aliases for IL17B Gene

  • Interleukin 17B 2 3 5
  • Neuronal Interleukin-17-Related Factor 2 4
  • Interleukin-17B 3 4
  • IL-17B 3 4
  • ZCYTO7 3 4
  • IL-20 3 4
  • NIRF 3 4
  • Neuronal Interleukin-17 Related Factor 3
  • Cytokine-Like Protein ZCYTO7 3
  • Interleukin-17 Beta 3
  • Cytokine Zcyto7 4
  • Interleukin 20 3
  • Interleukin-20 4
  • IL20 4

External Ids for IL17B Gene

Previous GeneCards Identifiers for IL17B Gene

  • GC05M148797
  • GC05M149348
  • GC05M148782
  • GC05M148734
  • GC05M143900

Summaries for IL17B Gene

Entrez Gene Summary for IL17B Gene

  • The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for IL17B Gene

IL17B (Interleukin 17B) is a Protein Coding gene. Diseases associated with IL17B include Leiomyoma and Keratoconus 1. Among its related pathways are IL-17 Family Signaling Pathways and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17D.

UniProtKB/Swiss-Prot Summary for IL17B Gene

  • Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

Additional gene information for IL17B Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17B Gene

Genomics for IL17B Gene

GeneHancer (GH) Regulatory Elements for IL17B Gene

Promoters and enhancers for IL17B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17B on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17B

Top Transcription factor binding sites by QIAGEN in the IL17B gene promoter:
  • AREB6
  • c-Myb
  • GR
  • GR-alpha
  • GR-beta
  • HEN1
  • Ik-2

Genomic Locations for IL17B Gene

Genomic Locations for IL17B Gene
chr5:149,371,324-149,404,244
(GRCh38/hg38)
Size:
32,921 bases
Orientation:
Minus strand
chr5:148,750,887-148,783,765
(GRCh37/hg19)
Size:
32,879 bases
Orientation:
Minus strand

Genomic View for IL17B Gene

Genes around IL17B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17B Gene

Proteins for IL17B Gene

  • Protein details for IL17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHF5-IL17B_HUMAN
    Recommended name:
    Interleukin-17B
    Protein Accession:
    Q9UHF5
    Secondary Accessions:
    • Q14CE5

    Protein attributes for IL17B Gene

    Size:
    180 amino acids
    Molecular mass:
    20437 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IL17B Gene

Post-translational modifications for IL17B Gene

  • Glycosylation at Asn75

Other Protein References for IL17B Gene

No data available for DME Specific Peptides for IL17B Gene

Domains & Families for IL17B Gene

Gene Families for IL17B Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for IL17B Gene

Blocks:
  • Interleukin-17
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17B Gene

GenScript: Design optimal peptide antigens:
  • Neuronal interleukin-17-related factor (IL17B_HUMAN)
  • IL17B protein (Q6IAG3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHF5

UniProtKB/Swiss-Prot:

IL17B_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17B: view

Function for IL17B Gene

Molecular function for IL17B Gene

UniProtKB/Swiss-Prot Function:
Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
GENATLAS Biochemistry:
interleukin 17B,expressed in adult pancreas,small intestine stomach,not expressed in activated T cells,not binding to the IL17 receptor

Phenotypes From GWAS Catalog for IL17B Gene

Gene Ontology (GO) - Molecular Function for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
genes like me logo Genes that share ontologies with IL17B: view
genes like me logo Genes that share phenotypes with IL17B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IL17B

CRISPR Products

miRNA for IL17B Gene

miRTarBase miRNAs that target IL17B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL17B Gene

Localization for IL17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17B gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with IL17B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17B Gene

Pathways & Interactions for IL17B Gene

genes like me logo Genes that share pathways with IL17B: view

Pathways by source for IL17B Gene

1 R&D Systems pathway for IL17B Gene

SIGNOR curated interactions for IL17B Gene

Activates:

Gene Ontology (GO) - Biological Process for IL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 10639155
GO:0007165 signal transduction IEA --
GO:0007267 cell-cell signaling TAS 10639155
GO:1900017 positive regulation of cytokine production involved in inflammatory response IEA --
genes like me logo Genes that share ontologies with IL17B: view

Drugs & Compounds for IL17B Gene

(1) Drugs for IL17B Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vidofludimus Investigational Pharma inhibitor DHODH inhibitor 0
genes like me logo Genes that share compounds with IL17B: view

Transcripts for IL17B Gene

mRNA/cDNA for IL17B Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL17B Gene

No ASD Table

Relevant External Links for IL17B Gene

GeneLoc Exon Structure for
IL17B

Expression for IL17B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL17B Gene

This gene is overexpressed in Nerve - Tibial (x14.8), Artery - Tibial (x4.8), and Artery - Aorta (x4.7).

Protein differential expression in normal tissues from HIPED for IL17B Gene

This gene is overexpressed in CD8 Tcells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL17B Gene



Protein tissue co-expression partners for IL17B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17B

SOURCE GeneReport for Unigene cluster for IL17B Gene:

Hs.156979

mRNA Expression by UniProt/SwissProt for IL17B Gene:

Q9UHF5-IL17B_HUMAN
Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
genes like me logo Genes that share expression patterns with IL17B: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17B Gene

Orthologs for IL17B Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL17B 31 30
  • 99.44 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL17B 31 30
  • 89.63 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL17B 31 30
  • 89.44 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il17b 30
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Il17b 17 31 30
  • 84.63 (n)
oppossum
(Monodelphis domestica)
Mammalia IL17B 31
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL17B 31
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL17B 31 30
  • 67.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL17B 31
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia il17b 30
  • 60.71 (n)
Species where no ortholog for IL17B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL17B Gene

ENSEMBL:
Gene Tree for IL17B (if available)
TreeFam:
Gene Tree for IL17B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17B: view image

Paralogs for IL17B Gene

Paralogs for IL17B Gene

genes like me logo Genes that share paralogs with IL17B: view

Variants for IL17B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17B Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
755793 Likely Benign: not provided 149,374,579(-) A/C SYNONYMOUS_VARIANT
769665 Benign: not provided 149,379,195(-) C/T INTRON_VARIANT
789182 Benign: not provided 149,374,486(-) C/T SYNONYMOUS_VARIANT
rs201298520 Uncertain Significance: Keratoconus 1 149,374,385(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for IL17B Gene

Structural Variations from Database of Genomic Variants (DGV) for IL17B Gene

Variant ID Type Subtype PubMed ID
nsv599948 CNV loss 21841781

Variation tolerance for IL17B Gene

Residual Variation Intolerance Score: 67.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17B

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17B Gene

Disorders for IL17B Gene

MalaCards: The human disease database

(6) MalaCards diseases for IL17B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leiomyoma
  • leiomyomatous neoplasm
keratoconus 1
  • ktcn1
keratoconus
  • conical cornea
psoriasis
klebsiella pneumonia
  • pneumonia due to klebsiella pneumoniae
- elite association - COSMIC cancer census association via MalaCards
Search IL17B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL17B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17B Gene

Publications for IL17B Gene

  1. Cloning and characterization of IL-17B and IL-17C, two new members of the IL-17 cytokine family. (PMID: 10639155) Li H … Wood WI (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 4 23 54
  2. Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. (PMID: 19845895) Koskinen LL … Saavalainen P (Tissue antigens 2009) 3 41 54
  3. Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. (PMID: 15713213) Ryan AW … McManus R (Tissue antigens 2005) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 54

Products for IL17B Gene

  • Biorbyt antibodies for IL17B

Sources for IL17B Gene