This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defens... See more...

Aliases for IL17A Gene

Aliases for IL17A Gene

  • Interleukin 17A 2 3 5
  • IL-17A 2 3 4
  • IL-17 2 3 4
  • Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) 2 3
  • Cytotoxic T-Lymphocyte-Associated Protein 8 2 3
  • Cytotoxic T-Lymphocyte-Associated Antigen 8 3 4
  • Interleukin-17A 3 4
  • CTLA-8 3 4
  • CTLA8 3 4
  • IL17 3 4
  • IL17A 5

External Ids for IL17A Gene

Previous HGNC Symbols for IL17A Gene

  • CTLA8
  • IL17

Previous GeneCards Identifiers for IL17A Gene

  • GC06P052160
  • GC06P052051
  • GC06P051882

Summaries for IL17A Gene

Entrez Gene Summary for IL17A Gene

  • This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]

GeneCards Summary for IL17A Gene

IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Bronchiolitis Obliterans. Among its related pathways are IL-17 Family Signaling Pathways and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.

UniProtKB/Swiss-Prot Summary for IL17A Gene

  • Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122). Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity).

Gene Wiki entry for IL17A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17A Gene

Genomics for IL17A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL17A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J052186 Promoter/Enhancer 0.6 EPDnew dbSUPER 250.7 0.0 -19 0.1 MTA3 IL17A HSALNG0050599 LINCMD1 PKHD1
GH06J052184 Enhancer 0.3 Ensembl dbSUPER 250.7 -1.7 -1674 0.2 IL17A HSALNG0050599 LINCMD1 PKHD1
GH06J052154 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -30.1 -30098 4.2 BCLAF1 SP1 BCL11A IRF4 EBF1 CBFB BHLHE40 BATF ELF1 STAT5A LINCMD1 IL17F SLC25A20P1 IL17A PKHD1 MCM3 PAQR8 HSALNG0050599
GH06J052263 Enhancer 0.9 Ensembl ENCODE 10.2 +77.7 77667 0.7 BCLAF1 ZNF654 SSRP1 REST CTCF TRIM22 THAP11 ZNF511 RAD21 RFX5 LINCMD1 MIR133B PKHD1 IL17A MIR206 lnc-MCM3-1 IL17F piR-43046 MCM3
GH06J052234 Enhancer 0.7 Ensembl 11.2 +48.0 48025 0.8 ZNF654 IKZF1 ZNF600 ZNF10 REST TRIM22 FEZF1 CTCF RAD21 IRF4 IL17A LINCMD1 MIR133B MIR206 PKHD1 IL17F HSALNG0050602 lnc-IL17A-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17A

Top Transcription factor binding sites by QIAGEN in the IL17A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CUTL1
  • STAT1
  • STAT3
  • STAT5A
  • STAT5B

Genomic Locations for IL17A Gene

Latest Assembly
chr6:52,186,375-52,190,638
(GRCh38/hg38)
Size:
4,264 bases
Orientation:
Plus strand

Previous Assembly
chr6:52,051,173-52,055,436
(GRCh37/hg19 by Entrez Gene)
Size:
4,264 bases
Orientation:
Plus strand

chr6:52,051,185-52,055,436
(GRCh37/hg19 by Ensembl)
Size:
4,252 bases
Orientation:
Plus strand

Genomic View for IL17A Gene

Genes around IL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL17A Gene

Proteins for IL17A Gene

  • Protein details for IL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16552-IL17_HUMAN
    Recommended name:
    Interleukin-17A
    Protein Accession:
    Q16552
    Secondary Accessions:
    • Q5T2P0

    Protein attributes for IL17A Gene

    Size:
    155 amino acids
    Molecular mass:
    17504 Da
    Quaternary structure:
    • Homodimer (PubMed:19835883). Forms complexes with IL17RA and IL17RC receptors with 2:1 binding stoichiometry: two receptor chains for one interleukin molecule (PubMed:32187518). IL17A homodimer preferentially drives the formation of IL17RA-IL17RC heterodimeric receptor complex (PubMed:32187518). IL17A homodimer adopts an asymmetrical ternary structure with one IL17RA molecule, allowing for high affinity interactions of one IL17A monomer with one IL17RA molecule (via D1 and D2 domains), while disfavoring binding of a second IL17RA molecule on the other IL17A monomer (PubMed:23695682). Heterodimer with IL17F (PubMed:17355969). IL17A-IL17F forms complexes with IL17RA-IL17RC, but with lower affinity when compared to IL17A homodimer (PubMed:32187518). IL17RA and IL17RC chains can not distinguish between IL17A and IL17F molecules, potentially enabling the formation of topologically distinct complexes (PubMed:17355969, PubMed:28827714).

    Three dimensional structures from OCA and Proteopedia for IL17A Gene

neXtProt entry for IL17A Gene

Post-translational modifications for IL17A Gene

  • N-glycosylated. Found both in glycosylated and nonglycosylated forms.
  • Glycosylation at Asn68
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Assay products for research

  • Abcam assays for IL17A

No data available for DME Specific Peptides for IL17A Gene

Domains & Families for IL17A Gene

Gene Families for IL17A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL17A Gene

InterPro:
Blocks:
  • Interleukin-17

Suggested Antigen Peptide Sequences for IL17A Gene

GenScript: Design optimal peptide antigens:
  • Cytotoxic T-lymphocyte-associated antigen 8 (IL17_HUMAN)
  • Interleukin-17 (Q5QEX9_HUMAN)
  • Interleukin 17A (Q6NZ94_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16552

UniProtKB/Swiss-Prot:

IL17_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17A: view

Function for IL17A Gene

Molecular function for IL17A Gene

UniProtKB/Swiss-Prot Function:
Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:19825828, PubMed:21350122, PubMed:17911633, PubMed:18684971, PubMed:8676080, PubMed:24120361). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122). Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced upon differentiation of CD4-positive T cells. Up-regulated by IL23A-IL12B (PubMed:17763419). Up-regulated in peripheral blood mononuclear cells upon West Nile virus infection (PubMed:27795421).

Phenotypes From GWAS Catalog for IL17A Gene

Gene Ontology (GO) - Molecular Function for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS,IEA --
GO:0005515 protein binding IPI 23695682
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with IL17A: view
genes like me logo Genes that share phenotypes with IL17A: view

Animal Models for IL17A Gene

MGI Knock Outs for IL17A:

miRNA for IL17A Gene

miRTarBase miRNAs that target IL17A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17A Gene

Localization for IL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17A gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
mitochondrion 3
nucleus 3
cytosol 3
lysosome 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL17A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17A Gene

Pathways & Interactions for IL17A Gene

PathCards logo

SuperPathways for IL17A Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 IL-17 Family Signaling Pathways
.48
3 TGF-Beta Pathway
.60
.60
.57
.43
.40
4 Akt Signaling
.60
.60
.55
5 ERK Signaling
.61
.61
.51
genes like me logo Genes that share pathways with IL17A: view

Pathways by source for IL17A Gene

4 GeneGo (Thomson Reuters) pathways for IL17A Gene
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
  • Immune response IL-23 signaling pathway
  • Mucin expression in CF via IL-6, IL-17 signaling pathways
25 Qiagen pathways for IL17A Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Cytokine Network
  • Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for IL17A Gene

Interacting Proteins for IL17A Gene

SIGNOR curated interactions for IL17A Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002225 positive regulation of antimicrobial peptide production IEA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process TAS 7499828
GO:0006954 inflammatory response IEA --
genes like me logo Genes that share ontologies with IL17A: view

Drugs & Compounds for IL17A Gene

(32) Drugs for IL17A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ixekizumab Approved, Investigational Pharma Target, antibody 48
Secukinumab Approved Pharma Target, antagonist 0
Vidofludimus Investigational Pharma inhibitor DHODH inhibitor 0
opioids Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(19) Additional Compounds for IL17A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for IL17A Gene

Compound Action Cas Number
Y-320 288250-47-5
genes like me logo Genes that share compounds with IL17A: view

Transcripts for IL17A Gene

mRNA/cDNA for IL17A Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17A

Alternative Splicing Database (ASD) splice patterns (SP) for IL17A Gene

No ASD Table

Relevant External Links for IL17A Gene

GeneLoc Exon Structure for
IL17A

Expression for IL17A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17A Gene

mRNA differential expression in normal tissues according to GTEx for IL17A Gene

This gene is overexpressed in Minor Salivary Gland (x8.8), Esophagus - Mucosa (x8.2), Small Intestine - Terminal Ileum (x5.7), Vagina (x4.5), and Fallopian Tube (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17A

SOURCE GeneReport for Unigene cluster for IL17A Gene:

Hs.41724

mRNA Expression by UniProt/SwissProt for IL17A Gene:

Q16552-IL17_HUMAN
Tissue specificity: Expressed in memory Th17 cells (at protein level).

Evidence on tissue expression from TISSUES for IL17A Gene

  • Blood(4.7)
  • Spleen(3.3)
  • Lymph node(3.3)
  • Intestine(3.2)
  • Heart(2.9)
  • Skin(2.9)
  • Nervous system(2.8)
  • Bone marrow(2.8)
  • Pancreas(2.8)
  • Liver(2.8)
  • Muscle(2.8)
  • Lung(2.8)
  • Kidney(2.6)
  • Bone(2.6)
  • Eye(2.2)
  • Stomach(2.2)
  • Adrenal gland(2.1)
  • Urine(2.1)
  • Saliva(2)
genes like me logo Genes that share expression patterns with IL17A: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17A Gene

Orthologs for IL17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL17A 29 30
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL17A 29
  • 86.67 (n)
IL-17A 30
  • 79 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia IL17A 29
  • 84.69 (n)
IL17 30
  • 75 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il17a 29
  • 77.05 (n)
Mouse
(Mus musculus)
Mammalia Il17a 29 16 30
  • 74.62 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IL17A 30
  • 54 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL17A 30
  • 49 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL17F 30
  • 40 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 35 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101734167 29
  • 58.7 (n)
Zebrafish
(Danio rerio)
Actinopterygii il17a/f3 30
  • 29 (a)
ManyToMany
il17a/f1 30
  • 27 (a)
ManyToMany
Species where no ortholog for IL17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL17A Gene

ENSEMBL:
Gene Tree for IL17A (if available)
TreeFam:
Gene Tree for IL17A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17A: view image
Alliance of Genome Resources:
Additional Orthologs for IL17A

Paralogs for IL17A Gene

Paralogs for IL17A Gene

(1) SIMAP similar genes for IL17A Gene using alignment to 2 proteins:

  • IL17_HUMAN
  • Q6NZ94_HUMAN
genes like me logo Genes that share paralogs with IL17A: view

Variants for IL17A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17A Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17880588 Benign: not provided 52,189,226(+) G/A
NM_002190.3(IL17A):c.402G>A (p.Arg134=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL17A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL17A Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Variation tolerance for IL17A Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17A Gene

Human Gene Mutation Database (HGMD)
IL17A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17A
Leiden Open Variation Database (LOVD)
IL17A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17A Gene

Disorders for IL17A Gene

MalaCards: The human disease database

(279) MalaCards diseases for IL17A Gene - From: COP and GCD

Disorder Aliases PubMed IDs
arthritis
  • inflammatory disorder of joint
bronchiolitis obliterans
  • bronchiolitis exudativa
allergic contact dermatitis
  • contact dermatitis, allergic
amebiasis
  • amoebiasis
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards
Search IL17A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL17A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17A Gene

Publications for IL17A Gene

  1. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PMID: 19414056) Shibata T … Arisawa T (Human immunology 2009) 3 22 40
  2. Structure of IL-17A in complex with a potent, fully human neutralizing antibody. (PMID: 19835883) Gerhardt S … Russell C (Journal of molecular biology 2009) 3 4 22
  3. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. (PMID: 17876645) Furuya T … Kotake S (Clinical rheumatology 2007) 3 22 40
  4. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. (PMID: 27795421) Acharya D … Bai F (Journal of virology 2017) 3 4
  5. The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. (PMID: 28827714) Goepfert A … Rondeau JM (Scientific reports 2017) 3 4

Products for IL17A Gene

Sources for IL17A Gene