IL17A Gene (Protein Coding)

Interleukin 17A

GC06P052186
GIFtS:
42
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with seve... See more...

Aliases for IL17A Gene

Aliases for IL17A Gene

  • Interleukin 17A 2 3 5
  • IL-17A 2 3 4
  • IL-17 2 3 4
  • Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) 2 3
  • Cytotoxic T-Lymphocyte-Associated Protein 8 2 3
  • Cytotoxic T-Lymphocyte-Associated Antigen 8 3 4
  • Interleukin-17A 3 4
  • CTLA-8 3 4
  • CTLA8 3 4
  • IL17 3 4
  • IL17A 5

External Ids for IL17A Gene

Previous HGNC Symbols for IL17A Gene

  • CTLA8
  • IL17

Previous GeneCards Identifiers for IL17A Gene

  • GC06P052160
  • GC06P052051
  • GC06P051882

Summaries for IL17A Gene

Entrez Gene Summary for IL17A Gene

  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17A Gene

IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Bronchiolitis Obliterans. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.

UniProtKB/Swiss-Prot Summary for IL17A Gene

  • Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Gene Wiki entry for IL17A Gene

Additional gene information for IL17A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17A Gene

Genomics for IL17A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IL17A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J052186 Promoter/Enhancer 0.6 EPDnew dbSUPER 600.7 0.0 -19 0.1 MTA3 IL17A LINCMD1 PKHD1
GH06J052150 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -31.0 -30998 6 SP1 CREB1 ZNF512 JUND PKNOX1 IKZF2 RCOR1 EP300 SCRT2 RELA LINCMD1 IL17F SLC25A20P1 IL17A PKHD1 MCM3 PAQR8
GH06J052263 Enhancer 0.9 Ensembl ENCODE 10.2 +77.7 77667 0.7 CTCF ZNF143 RXRB REST RAD21 TRIM22 ZNF561 POLR2A BCLAF1 SMC3 LINCMD1 MIR133B PKHD1 IL17A MIR206 lnc-MCM3-1 IL17F piR-43046 MCM3
GH06J052261 Enhancer 0.9 Ensembl ENCODE 10.3 +75.2 75226 1.2 PRDM10 ZNF629 PRDM1 SMAD5 POLR2A ZNF600 ZNF639 ZNF10 TSHZ1 ZSCAN5C EFHC1 MCM3 PKHD1 IL17A LINCMD1 MIR133B lnc-MCM3-1 IL17F piR-43046
GH06J052234 Enhancer 0.7 Ensembl 11.2 +48.0 48025 0.8 CTCF IKZF1 REST RAD21 TRIM22 ZNF600 ZNF10 ZXDB RUNX3 OSR2 HSALNG0050600 IL17A LINCMD1 MIR133B MIR206 PKHD1 IL17F lnc-IL17A-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL17A

Top Transcription factor binding sites by QIAGEN in the IL17A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CUTL1
  • STAT1
  • STAT3
  • STAT5A
  • STAT5B

Genomic Locations for IL17A Gene

Genomic Locations for IL17A Gene
chr6:52,186,375-52,190,638
(GRCh38/hg38)
Size:
4,264 bases
Orientation:
Plus strand
chr6:52,051,185-52,055,436
(GRCh37/hg19)
Size:
4,252 bases
Orientation:
Plus strand

Genomic View for IL17A Gene

Genes around IL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL17A Gene

Proteins for IL17A Gene

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  • Protein details for IL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16552-IL17_HUMAN
    Recommended name:
    Interleukin-17A
    Protein Accession:
    Q16552
    Secondary Accessions:
    • Q5T2P0

    Protein attributes for IL17A Gene

    Size:
    155 amino acids
    Molecular mass:
    17504 Da
    Quaternary structure:
    • Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).

    Three dimensional structures from OCA and Proteopedia for IL17A Gene

neXtProt entry for IL17A Gene

Post-translational modifications for IL17A Gene

  • Found both in glycosylated and nonglycosylated forms.
  • Glycosylation at Asn68
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

Assay Products

  • Abcam assays for IL17A

No data available for DME Specific Peptides for IL17A Gene

Domains & Families for IL17A Gene

Gene Families for IL17A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL17A Gene

InterPro:
Blocks:
  • Interleukin-17
ProtoNet:

Suggested Antigen Peptide Sequences for IL17A Gene

GenScript: Design optimal peptide antigens:
  • Cytotoxic T-lymphocyte-associated antigen 8 (IL17_HUMAN)
  • Interleukin-17 (Q5QEX9_HUMAN)
  • Interleukin 17A (Q6NZ94_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16552

UniProtKB/Swiss-Prot:

IL17_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17A: view

Function for IL17A Gene

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Molecular function for IL17A Gene

UniProtKB/Swiss-Prot Function:
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Phenotypes From GWAS Catalog for IL17A Gene

Gene Ontology (GO) - Molecular Function for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity TAS,IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IL17A: view
genes like me logo Genes that share phenotypes with IL17A: view

Animal Models for IL17A Gene

MGI Knock Outs for IL17A:

CRISPR Products

miRNA for IL17A Gene

miRTarBase miRNAs that target IL17A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17A Gene

Localization for IL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17A gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytoskeleton 3
mitochondrion 3
nucleus 3
cytosol 3
lysosome 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL17A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17A Gene

Pathways & Interactions for IL17A Gene

PathCards logo

SuperPathways for IL17A Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 IL-17 Family Signaling Pathways
IL-17 Family Signaling Pathways
.51
IL17 signaling pathway
.51
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
IL-17 signaling pathway
.33
Interleukin-17 signaling
.01
3 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
4 IL27-mediated signaling events
IL12 Signaling Pathway
.45
IL12 Signaling Pathway
.45
IL27-mediated signaling events
.45
5 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
genes like me logo Genes that share pathways with IL17A: view

Pathways by source for IL17A Gene

2 Sino Biological pathways for IL17A Gene
4 GeneGo (Thomson Reuters) pathways for IL17A Gene
  • Cytokine production by Th17 cells in CF
  • Cytokine production by Th17 cells in CF (Mouse model)
  • Immune response IL-23 signaling pathway
  • Mucin expression in CF via IL-6, IL-17 signaling pathways
25 Qiagen pathways for IL17A Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Cytokine Network
  • Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for IL17A Gene

Interacting Proteins for IL17A Gene

Selected Interacting proteins: Q16552-IL17_HUMAN for IL17A Gene via UniProtKB IID

GPS-Prot Interaction Network for IL17A

SIGNOR curated interactions for IL17A Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7499828
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 7499828
GO:0007267 cell-cell signaling TAS 7499828
GO:0008219 cell death TAS 8390535
genes like me logo Genes that share ontologies with IL17A: view

Drugs & Compounds for IL17A Gene

Products:

  1. Drug

(32) Drugs for IL17A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ixekizumab Approved, Investigational Pharma Target, antibody 42
Secukinumab Approved Pharma Target, antagonist 0
Vidofludimus Investigational Pharma inhibitor DHODH inhibitor 0
opioids Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(19) Additional Compounds for IL17A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for IL17A Gene

Compound Action Cas Number
Y-320 288250-47-5
genes like me logo Genes that share compounds with IL17A: view

Transcripts for IL17A Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL17A Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17A

Alternative Splicing Database (ASD) splice patterns (SP) for IL17A Gene

No ASD Table

Relevant External Links for IL17A Gene

GeneLoc Exon Structure for
IL17A

Expression for IL17A Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL17A Gene

mRNA expression in normal human tissues for IL17A Gene
mRNA expression by GTEx for IL17A GenemRNA expression by BioGPS for IL17A Gene

mRNA differential expression in normal tissues according to GTEx for IL17A Gene

This gene is overexpressed in Minor Salivary Gland (x8.8), Esophagus - Mucosa (x8.2), Small Intestine - Terminal Ileum (x5.7), Vagina (x4.5), and Fallopian Tube (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL17A

SOURCE GeneReport for Unigene cluster for IL17A Gene:

Hs.41724

mRNA Expression by UniProt/SwissProt for IL17A Gene:

Q16552-IL17_HUMAN
Tissue specificity: Restricted to activated memory T-cells.

Evidence on tissue expression from TISSUES for IL17A Gene

  • Blood(4.8)
  • Spleen(3.7)
  • Lymph node(3.7)
  • Intestine(3.5)
  • Heart(3.2)
  • Bone marrow(3.2)
  • Skin(3.2)
  • Nervous system(3.2)
  • Lung(3.1)
  • Liver(3.1)
  • Muscle(3)
  • Pancreas(3)
  • Kidney(2.9)
  • Bone(2.9)
  • Eye(2.5)
  • Stomach(2.5)
  • Urine(2.3)
  • Adrenal gland(2.3)
  • Saliva(2.2)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with IL17A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17A Gene

Orthologs for IL17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IL17A 30 31
  • 99.78 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia IL17A 30
  • 86.67 (n)
IL-17A 31
  • 79 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia IL17A 30
  • 84.69 (n)
IL17 31
  • 75 (a)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Il17a 30
  • 77.05 (n)
Mouse
(Mus musculus)
 Mammalia Il17a 30 17 31
  • 74.62 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia IL17A 31
  • 54 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia IL17A 31
  • 49 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves IL17F 31
  • 40 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 35 (a)
 OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia LOC101734167 30
  • 58.7 (n)
Zebrafish
(Danio rerio)
 Actinopterygii il17a/f3 31
  • 29 (a)
 ManyToMany
il17a/f1 31
  • 27 (a)
 ManyToMany
Species where no ortholog for IL17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL17A Gene

ENSEMBL:
Gene Tree for IL17A (if available)
TreeFam:
Gene Tree for IL17A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17A: view image

Paralogs for IL17A Gene

Paralogs for IL17A Gene

(1) SIMAP similar genes for IL17A Gene using alignment to 2 proteins:

  • IL17_HUMAN
  • Q6NZ94_HUMAN
genes like me logo Genes that share paralogs with IL17A: view

Variants for IL17A Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL17A Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
771398 Benign: not provided 52,189,226(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for IL17A Gene

Structural Variations from Database of Genomic Variants (DGV) for IL17A Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Variation tolerance for IL17A Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17A Gene

Human Gene Mutation Database (HGMD)
IL17A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17A Gene

Disorders for IL17A Gene

MalaCards: The human disease database

(263) MalaCards diseases for IL17A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthritis
  • inflammatory disorder of joint
bronchiolitis obliterans
  • bronchiolitis exudativa
amebiasis
  • amoebiasis
allergic contact dermatitis
  • contact dermatitis, allergic
colitis
- elite association - COSMIC cancer census association via MalaCards
Search IL17A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL17A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17A Gene

Publications for IL17A Gene

  1. Structure of IL-17A in complex with a potent, fully human neutralizing antibody. (PMID: 19835883) Gerhardt S … Russell C (Journal of molecular biology 2009) 3 4 23
  2. Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis. (PMID: 19414056) Shibata T … Arisawa T (Human immunology 2009) 3 23 41
  3. Associations between HLA-DRB1, RANK, RANKL, OPG, and IL-17 genotypes and disease severity phenotypes in Japanese patients with early rheumatoid arthritis. (PMID: 17876645) Furuya T … Kotake S (Clinical rheumatology 2007) 3 23 41
  4. Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study. (PMID: 21062626) Zhang X … Han Y (Clinica chimica acta; international journal of clinical chemistry 2011) 3 41
  5. IL-17 in cutaneous lupus erythematosus. (PMID: 20493423) Tanasescu C … Georgescu A (European journal of internal medicine 2010) 3 23

ExternalLinks

View latest publications for IL17A gene in Mastermind

Products for IL17A Gene

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Sources for IL17A Gene