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The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Bronchiolitis Obliterans. Among its related pathways are PEDF Induced Signaling and Immune response IL-23 signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS,IEA | -- |
GO:0009897 | external side of plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | IL-17 Family Signaling Pathways |
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
|
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | IL27-mediated signaling events | ||
5 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006915 | apoptotic process | TAS | 7499828 |
GO:0006954 | inflammatory response | IEA | -- |
GO:0006955 | immune response | TAS | 7499828 |
GO:0007267 | cell-cell signaling | TAS | 7499828 |
GO:0008219 | cell death | TAS | 8390535 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Ixekizumab | Approved, Investigational | Pharma | Target, antibody | 42 | ||
Secukinumab | Approved | Pharma | Target, antagonist | 0 | ||
Vidofludimus | Investigational | Pharma | inhibitor | DHODH inhibitor | 0 | |
opioids | Pharma | 0 | ||||
Tumor necrosis factor alpha (TNF-alpha) inhibitors | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
Y-320 | 288250-47-5 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL17A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL17A 30 |
|
||
IL-17A 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | IL17A 30 |
|
||
IL17 31 |
|
OneToOne | |||
Rat (Rattus norvegicus) |
Mammalia | Il17a 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Il17a 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IL17A 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL17A 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL17F 31 |
|
ManyToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC101734167 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | il17a/f3 31 |
|
ManyToMany | |
il17a/f1 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
771398 | Benign: not provided | 52,189,226(+) | G/A | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
arthritis |
|
|
bronchiolitis obliterans |
|
|
amebiasis |
|
|
allergic contact dermatitis |
|
|
colitis |
|