Aliases for IL17A Gene
External Ids for IL17A Gene
Previous HGNC Symbols for IL17A Gene
Previous GeneCards Identifiers for IL17A Gene
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL17A Gene
IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Amebiasis. Among its related pathways are Cytokine Signaling in Immune system and Immune response IFN alpha/beta signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.
UniProtKB/Swiss-Prot Summary for IL17A Gene
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).