IL17A Gene (Protein Coding)

Interleukin 17A

GC06P052186
GIFtS:
44
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with seve... See more...

Aliases for IL17A Gene

Aliases for IL17A Gene

  • Interleukin 17A 2 3 5
  • Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) 2 3
  • Cytotoxic T-Lymphocyte-Associated Antigen 8 3 4
  • Cytotoxic T-Lymphocyte-Associated Protein 8 2 3
  • Interleukin-17A 3 4
  • CTLA-8 3 4
  • IL-17A 3 4
  • CTLA8 3 4
  • IL-17 3 4
  • IL17 3 4

External Ids for IL17A Gene

Previous HGNC Symbols for IL17A Gene

  • CTLA8
  • IL17

Previous GeneCards Identifiers for IL17A Gene

  • GC06P052160
  • GC06P052051
  • GC06P051882

Summaries for IL17A Gene

Entrez Gene Summary for IL17A Gene

  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL17A Gene

IL17A (Interleukin 17A) is a Protein Coding gene. Diseases associated with IL17A include Arthritis and Amebiasis. Among its related pathways are Cytokine Signaling in Immune system and Immune response IFN alpha/beta signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is IL17F.

UniProtKB/Swiss-Prot Summary for IL17A Gene

  • Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Gene Wiki entry for IL17A Gene

Additional gene information for IL17A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL17A Gene

Genomics for IL17A Gene

GeneHancer (GH) Regulatory Elements for IL17A Gene

Promoters and enhancers for IL17A Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J052186 Promoter/Enhancer 0.5 EPDnew dbSUPER 750.6 0.0 -19 0.1 IL17A LINCMD1
GH06J052150 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -31.0 -30998 6 SP1 JUND ETV6 IKZF1 MLLT1 CREM RELA ZBED1 CREB1 ZNF512 LINCMD1 MCM3 IL17F SLC25A20P1 LOC646517 IL17A PKHD1 PAQR8
GH06J052263 Enhancer 0.9 Ensembl ENCODE 10.2 +77.7 77667 0.7 CTCF NR2F6 RAD21 ELF3 PPARG KAT8 REST TRIM22 ZNF143 RXRB LINCMD1 MIR133B PKHD1 IL17A MIR206 lnc-MCM3-1 piR-43046 MCM3
GH06J052261 Enhancer 0.9 Ensembl ENCODE 10.3 +75.2 75226 1.2 POLR2A SP7 PRDM1 PRDM10 ZNF639 ZEB2 SMAD5 ZNF629 ZSCAN5C ZNF10 EFHC1 MCM3 PKHD1 IL17A LINCMD1 MIR133B lnc-MCM3-1 piR-43046
GH06J052234 Enhancer 0.7 Ensembl 11.2 +48.0 48025 0.8 CTCF RAD21 CEBPG IKZF1 PKNOX1 RXRA REST TRIM22 ZXDB ZNF10 HSALNG0050600 IL17A LINCMD1 MIR133B MIR206 PKHD1 IL17F lnc-IL17A-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL17A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL17A gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CUTL1
  • STAT1
  • STAT3
  • STAT5A
  • STAT5B

Genomic Locations for IL17A Gene

Genomic Locations for IL17A Gene
chr6:52,186,375-52,190,638
(GRCh38/hg38)
Size:
4,264 bases
Orientation:
Plus strand
chr6:52,051,185-52,055,436
(GRCh37/hg19)
Size:
4,252 bases
Orientation:
Plus strand

Genomic View for IL17A Gene

Genes around IL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL17A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL17A Gene

Proteins for IL17A Gene

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  • Protein details for IL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16552-IL17_HUMAN
    Recommended name:
    Interleukin-17A
    Protein Accession:
    Q16552
    Secondary Accessions:
    • Q5T2P0

    Protein attributes for IL17A Gene

    Size:
    155 amino acids
    Molecular mass:
    17504 Da
    Quaternary structure:
    • Homodimer (PubMed:19835883). Heterodimer with IL17F (PubMed:17355969).

    Three dimensional structures from OCA and Proteopedia for IL17A Gene

neXtProt entry for IL17A Gene

Post-translational modifications for IL17A Gene

  • Found both in glycosylated and nonglycosylated forms.
  • Glycosylation at Asn68
  • Modification sites at PhosphoSitePlus

Other Protein References for IL17A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Protein Products

Assay Products

  • Abcam assays for IL17A

No data available for DME Specific Peptides for IL17A Gene

Domains & Families for IL17A Gene

Gene Families for IL17A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL17A Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL17A Gene

GenScript: Design optimal peptide antigens:
  • Cytotoxic T-lymphocyte-associated antigen 8 (IL17_HUMAN)
  • Interleukin-17 (Q5QEX9_HUMAN)
  • Interleukin 17A (Q6NZ94_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16552

UniProtKB/Swiss-Prot:

IL17_HUMAN :
  • Belongs to the IL-17 family.
Family:
  • Belongs to the IL-17 family.
genes like me logo Genes that share domains with IL17A: view

Function for IL17A Gene

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Molecular function for IL17A Gene

UniProtKB/Swiss-Prot Function:
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080).

Phenotypes From GWAS Catalog for IL17A Gene

Gene Ontology (GO) - Molecular Function for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IL17A: view
genes like me logo Genes that share phenotypes with IL17A: view

Animal Models for IL17A Gene

MGI Knock Outs for IL17A:

Animal Model Products

CRISPR Products

miRNA for IL17A Gene

miRTarBase miRNAs that target IL17A

Inhibitory RNA Products

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  • Addgene plasmids for IL17A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL17A Gene

Localization for IL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL17A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL17A gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS,IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL17A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL17A Gene

Pathways & Interactions for IL17A Gene

PathCards logo

SuperPathways for IL17A Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 IL-17 Family Signaling Pathways
IL-17 Family Signaling Pathways
.51
IL17 signaling pathway
.51
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
IL-17 signaling pathway
.33
Interleukin-17 signaling
.01
3 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
4 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
5 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
genes like me logo Genes that share pathways with IL17A: view

Interacting Proteins for IL17A Gene

Selected Interacting proteins: Q16552-IL17_HUMAN for IL17A Gene via UniProtKB IID

GPS-Prot Interaction Network for IL17A

SIGNOR curated interactions for IL17A Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7499828
GO:0006954 inflammatory response IEA --
GO:0006955 immune response TAS 7499828
GO:0007267 cell-cell signaling TAS 7499828
GO:0008219 cell death TAS 8390535
genes like me logo Genes that share ontologies with IL17A: view

Drugs & Compounds for IL17A Gene

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(32) Drugs for IL17A Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ixekizumab Approved, Investigational Pharma Target, antibody 36
Secukinumab Approved Pharma Target, antagonist 0
Vidofludimus Investigational Pharma inhibitor DHODH inhibitor 0
opioids Pharma 0
Tumor necrosis factor alpha (TNF-alpha) inhibitors Pharma 0

(19) Additional Compounds for IL17A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for IL17A Gene

Compound Action Cas Number
Y-320 288250-47-5
genes like me logo Genes that share compounds with IL17A: view

Transcripts for IL17A Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL17A Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(20) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL17A

Clone Products

  • Addgene plasmids for IL17A

Alternative Splicing Database (ASD) splice patterns (SP) for IL17A Gene

No ASD Table

Relevant External Links for IL17A Gene

GeneLoc Exon Structure for
IL17A
ECgene alternative splicing isoforms for
IL17A

Expression for IL17A Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL17A Gene

mRNA expression in normal human tissues for IL17A Gene
mRNA expression by GTEx for IL17A GenemRNA expression by BioGPS for IL17A Gene

mRNA differential expression in normal tissues according to GTEx for IL17A Gene

This gene is overexpressed in Minor Salivary Gland (x8.8), Esophagus - Mucosa (x8.2), Small Intestine - Terminal Ileum (x5.7), Vagina (x4.5), and Fallopian Tube (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of IL17A Gene:

IL17A

SOURCE GeneReport for Unigene cluster for IL17A Gene:

Hs.41724

mRNA Expression by UniProt/SwissProt for IL17A Gene:

Q16552-IL17_HUMAN
Tissue specificity: Restricted to activated memory T-cells.

Evidence on tissue expression from TISSUES for IL17A Gene

  • Blood(4.7)
  • Spleen(3.1)
  • Lymph node(3)
  • Intestine(2.9)
  • Lung(2.8)
  • Skin(2.8)
  • Nervous system(2.3)
  • Bone marrow(2.2)
  • Heart(2.2)
  • Liver(2.1)
  • Kidney(2)
  • Muscle(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with IL17A: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL17A Gene

Orthologs for IL17A Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL17A 33 32
  • 99.78 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia IL17A 32
  • 86.67 (n)
IL-17A 33
  • 79 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia IL17A 32
  • 84.69 (n)
IL17 33
  • 75 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Il17a 32
  • 77.05 (n)
mouse
(Mus musculus)
 Mammalia Il17a 17 33 32
  • 74.62 (n)
oppossum
(Monodelphis domestica)
 Mammalia IL17A 33
  • 54 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IL17A 33
  • 49 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves IL17F 33
  • 40 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia -- 33
  • 35 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC101734167 32
  • 58.7 (n)
zebrafish
(Danio rerio)
 Actinopterygii il17a/f3 33
  • 29 (a)
 ManyToMany
il17a/f1 33
  • 27 (a)
 ManyToMany
Species where no ortholog for IL17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL17A Gene

ENSEMBL:
Gene Tree for IL17A (if available)
TreeFam:
Gene Tree for IL17A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL17A: view image

Paralogs for IL17A Gene

Paralogs for IL17A Gene

(1) SIMAP similar genes for IL17A Gene using alignment to 2 proteins:

  • IL17_HUMAN
  • Q6NZ94_HUMAN
genes like me logo Genes that share paralogs with IL17A: view

Variants for IL17A Gene

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Sequence variations from dbSNP and Humsavar for IL17A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000402748 -- 52,187,484(+) C/T intron_variant
rs1000879143 -- 52,190,780(+) C/T downstream_transcript_variant
rs1001348709 -- 52,184,951(+) C/G upstream_transcript_variant
rs1001565921 -- 52,187,337(+) C/T intron_variant
rs1001598373 -- 52,187,138(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IL17A Gene

Variant ID Type Subtype PubMed ID
nsv522645 CNV gain 19592680
nsv830662 CNV gain 17160897

Variation tolerance for IL17A Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL17A Gene

Human Gene Mutation Database (HGMD)
IL17A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL17A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL17A Gene

Disorders for IL17A Gene

MalaCards: The human disease database

(111) MalaCards diseases for IL17A Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
arthritis
  • inflammatory disorder of joint
amebiasis
  • amoebiasis
bronchiolitis obliterans
  • bronchiolitis exudativa
aspiration pneumonia
  • aspiration pneumonitis
allergic contact dermatitis
  • contact dermatitis, allergic
- elite association - COSMIC cancer census association via MalaCards
Search IL17A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL17A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL17A Gene

Publications for IL17A Gene

  1. Structure of IL-17A in complex with a potent, fully human neutralizing antibody. (PMID: 19835883) Gerhardt S … Russell C (Journal of molecular biology 2009) 3 4 23 56
  2. Interleukin-17A gene variants and risk of coronary artery disease: a large angiography-based study. (PMID: 21062626) Zhang X … Han Y (Clinica chimica acta; international journal of clinical chemistry 2011) 3 43 56
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 43 56
  4. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. (PMID: 20503287) Schuurhof A … Janssen R (Pediatric pulmonology 2010) 3 43 56
  5. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells. (PMID: 19968632) Xu G … Li HB (Allergy 2010) 3 23 56

ExternalLinks

View latest publications for IL17A gene in Mastermind

Products for IL17A Gene

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