This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessa... See more...

Aliases for IL15RA Gene

Aliases for IL15RA Gene

  • Interleukin 15 Receptor Subunit Alpha 2 3 5
  • Interleukin-15 Receptor Subunit Alpha 3 4
  • Interleukin 15 Receptor, Alpha 2 3
  • Interleukin 15 Receptor Alpha Isoform EM2 3
  • Interleukin 15 Receptor Alpha Isoform IC2 3
  • Interleukin 15 Receptor Alpha Isoform IC3 3
  • Interleukin 15 Receptor Alpha Isoform IC4 3
  • Interleukin 15 Receptor Alpha Isoform IC5 3
  • Interleukin 15 Receptor Alpha Isoform IC6 3
  • Interleukin 15 Receptor Alpha Isoform IC7 3
  • Interleukin 15 Receptor Alpha Isoform IC8 3
  • IL-15 Receptor Subunit Alpha 4
  • CD215 Antigen 4
  • IL-15R-Alpha 4
  • IL-15RA 4
  • CD215 3

External Ids for IL15RA Gene

Previous GeneCards Identifiers for IL15RA Gene

  • GC10M005938
  • GC10M006141
  • GC10M005998
  • GC10M006034
  • GC10M005921
  • GC10M005991

Summaries for IL15RA Gene

Entrez Gene Summary for IL15RA Gene

  • This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]

GeneCards Summary for IL15RA Gene

IL15RA (Interleukin 15 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL15RA include T-Cell Large Granular Lymphocyte Leukemia and Ossification Of The Posterior Longitudinal Ligament Of Spine. Among its related pathways are ERK Signaling and JAK-STAT signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and cytokine receptor activity.

UniProtKB/Swiss-Prot Summary for IL15RA Gene

  • High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).
  • [Isoform 5]: Does not bind IL15.
  • [Isoform 6]: Does not bind IL15.
  • [Isoform 7]: Does not bind IL15.
  • [Isoform 8]: Does not bind IL15.

Gene Wiki entry for IL15RA Gene

Additional gene information for IL15RA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL15RA Gene

Genomics for IL15RA Gene

GeneHancer (GH) Regulatory Elements for IL15RA Gene

Promoters and enhancers for IL15RA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL15RA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL15RA

Top Transcription factor binding sites by QIAGEN in the IL15RA gene promoter:
  • IRF-1
  • ISGF-3
  • MAZR
  • Nkx2-5

Genomic Locations for IL15RA Gene

Genomic Locations for IL15RA Gene
chr10:5,943,639-5,978,634
(GRCh38/hg38)
Size:
34,996 bases
Orientation:
Minus strand
chr10:5,990,855-6,020,150
(GRCh37/hg19)
Size:
29,296 bases
Orientation:
Minus strand

Genomic View for IL15RA Gene

Genes around IL15RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL15RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL15RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL15RA Gene

Proteins for IL15RA Gene

  • Protein details for IL15RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13261-I15RA_HUMAN
    Recommended name:
    Interleukin-15 receptor subunit alpha
    Protein Accession:
    Q13261
    Secondary Accessions:
    • B4E2C2
    • Q3B769
    • Q5JVA1
    • Q5JVA2
    • Q5JVA4
    • Q6B0J2
    • Q7LDR4
    • Q7Z609

    Protein attributes for IL15RA Gene

    Size:
    267 amino acids
    Molecular mass:
    28233 Da
    Quaternary structure:
    • The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (PubMed:17643103). Interacts with SYK (PubMed:15123770).
    SequenceCaution:
    • Sequence=AAB88175.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW86419.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL15RA Gene

    Alternative splice isoforms for IL15RA Gene

neXtProt entry for IL15RA Gene

Post-translational modifications for IL15RA Gene

  • N-glycosylated and O-glycosylated.
  • A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor (PubMed:15265897). It also binds IL-15 and thus interferes with IL-15 binding to the membrane receptor (PubMed:15265897).
  • Glycosylation at Asn137

No data available for DME Specific Peptides for IL15RA Gene

Domains & Families for IL15RA Gene

Gene Families for IL15RA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for IL15RA Gene

Blocks:
  • Sushi domain/SCR domain/CCP module
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL15RA Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-15 receptor subunit alpha (I15RA_HUMAN)
  • Interleukin 15 receptor, alpha (Q3B769_HUMAN)
  • Interleukin 15 receptor, alpha (Q5JVA0_HUMAN)
  • Interleukin 15 receptor, alpha, isoform CRA_c (Q5JVA1_HUMAN)
  • Interleukin 15 receptor, alpha (Q5JVA5_HUMAN)
genes like me logo Genes that share domains with IL15RA: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IL15RA Gene

Function for IL15RA Gene

Molecular function for IL15RA Gene

UniProtKB/Swiss-Prot Function:
High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).
UniProtKB/Swiss-Prot Function:
[Isoform 5]: Does not bind IL15.
UniProtKB/Swiss-Prot Function:
[Isoform 6]: Does not bind IL15.
UniProtKB/Swiss-Prot Function:
[Isoform 7]: Does not bind IL15.
UniProtKB/Swiss-Prot Function:
[Isoform 8]: Does not bind IL15.
GENATLAS Biochemistry:
interleukin 15,receptor,alpha chain,ubiquitously expressed

Phenotypes From GWAS Catalog for IL15RA Gene

Gene Ontology (GO) - Molecular Function for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity TAS 7641685
GO:0005515 protein binding IPI 16284400
GO:0019901 protein kinase binding IPI 15123770
GO:0042010 interleukin-15 receptor activity IEA,IDA 15123770
genes like me logo Genes that share ontologies with IL15RA: view
genes like me logo Genes that share phenotypes with IL15RA: view

Animal Models for IL15RA Gene

MGI Knock Outs for IL15RA:

Animal Model Products

CRISPR Products

miRNA for IL15RA Gene

miRTarBase miRNAs that target IL15RA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL15RA Gene

Localization for IL15RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL15RA Gene

Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Cell surface. Note=Mainly found associated with the nuclear membrane.
[Isoform 5]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
[Isoform 6]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
[Isoform 7]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
[Isoform 8]: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane.
[Soluble interleukin-15 receptor subunit alpha]: Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL15RA gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
plasma membrane 4
extracellular 4
nucleus 4
endosome 4
mitochondrion 2
cytosol 2
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
GO:0005634 nucleus IEA --
GO:0005768 endosome TAS --
genes like me logo Genes that share ontologies with IL15RA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL15RA Gene

Pathways & Interactions for IL15RA Gene

genes like me logo Genes that share pathways with IL15RA: view

Pathways by source for IL15RA Gene

2 Sino Biological pathways for IL15RA Gene
1 BioSystems pathway for IL15RA Gene
7 Qiagen pathways for IL15RA Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • MAPK Family Pathway
  • Molecular Mechanisms of Cancer
  • p38 Signaling

SIGNOR curated interactions for IL15RA Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL15RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035723 interleukin-15-mediated signaling pathway TAS,IEA --
GO:0050766 positive regulation of phagocytosis IMP 15123770
genes like me logo Genes that share ontologies with IL15RA: view

Drugs & Compounds for IL15RA Gene

No Compound Related Data Available

Transcripts for IL15RA Gene

mRNA/cDNA for IL15RA Gene

7 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
22 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL15RA Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - -
SP8: - - - -
SP9: - -

Relevant External Links for IL15RA Gene

GeneLoc Exon Structure for
IL15RA

Expression for IL15RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL15RA Gene

Protein differential expression in normal tissues from HIPED for IL15RA Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL15RA Gene



Protein tissue co-expression partners for IL15RA Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL15RA

SOURCE GeneReport for Unigene cluster for IL15RA Gene:

Hs.445124

mRNA Expression by UniProt/SwissProt for IL15RA Gene:

Q13261-I15RA_HUMAN
Tissue specificity: Expressed in neutrophils (at protein level) (PubMed:15123770). Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus (PubMed:12114302). Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures (PubMed:12114302). Isoforms 1, 3, 4, 5, 6, 7, 8 and 9: Widely expressed (PubMed:10480910, PubMed:8530383).

Evidence on tissue expression from TISSUES for IL15RA Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with IL15RA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL15RA Gene

Orthologs for IL15RA Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL15RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL15RA 31 30
  • 98.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL15RA 31 30
  • 72.32 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Il15ra 30
  • 71.28 (n)
mouse
(Mus musculus)
Mammalia Il15ra 17 31 30
  • 70.85 (n)
cow
(Bos Taurus)
Mammalia IL15RA 31 30
  • 69.41 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IL15RA 31
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL15RA 31
  • 28 (a)
OneToOne
Species where no ortholog for IL15RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL15RA Gene

ENSEMBL:
Gene Tree for IL15RA (if available)
TreeFam:
Gene Tree for IL15RA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL15RA: view image

Paralogs for IL15RA Gene

(1) SIMAP similar genes for IL15RA Gene using alignment to 10 proteins:

  • I15RA_HUMAN
  • E7ETI1_HUMAN
  • E9PQ64_HUMAN
  • G8CVM3_HUMAN
  • H0Y4R3_HUMAN
  • H0Y6E8_HUMAN
  • H0YD11_HUMAN
  • Q3B769_HUMAN
  • Q5JVA3_HUMAN
  • Q6P0Q3_HUMAN
genes like me logo Genes that share paralogs with IL15RA: view

No data available for Paralogs for IL15RA Gene

Variants for IL15RA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL15RA Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
709069 Benign: not provided 5,953,184(-) C/T MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,THREE_PRIME_UTR_VARIANT
770960 Benign: not provided 5,963,793(-) G/A MISSENSE_VARIANT,INTRON_VARIANT
773514 Likely Benign: not provided 5,977,583(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
781672 Benign: not provided 5,960,437(-) G/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
rs2228059 - p.Asn182Thr

Additional dbSNP identifiers (rs#s) for IL15RA Gene

Structural Variations from Database of Genomic Variants (DGV) for IL15RA Gene

Variant ID Type Subtype PubMed ID
dgv1e49 CNV loss 18971310
dgv666n100 CNV gain 25217958
nsv519436 CNV loss 19592680
nsv549907 CNV loss 21841781
nsv549908 CNV loss 21841781
nsv549909 CNV loss 21841781
nsv831775 CNV loss 17160897
nsv975792 CNV duplication 23825009

Variation tolerance for IL15RA Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL15RA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL15RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL15RA Gene

Disorders for IL15RA Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL15RA Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL15RA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL15RA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL15RA Gene

Publications for IL15RA Gene

  1. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. (PMID: 8530383) Anderson DM … Jenkins NA (The Journal of biological chemistry 1995) 2 3 4 23 54
  2. Role of interleukin-15 receptor alpha polymorphisms in normal weight obese syndrome. (PMID: 19309557) Di Renzo L … De Lorenzo A (International journal of immunopathology and pharmacology 2009) 3 23 41 54
  3. Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome. (PMID: 18514540) Pistilli EE … Hoffman EP (Cytokine 2008) 3 23 41 54
  4. Normal Weight Obese syndrome: role of single nucleotide polymorphism of IL-1 5Ralpha and MTHFR 677C-->T genes in the relationship between body composition and resting metabolic rate. (PMID: 17121316) Di Renzo L … De Lorenzo A (European review for medical and pharmacological sciences 2006) 3 23 41 54
  5. The structure of the interleukin-15 alpha receptor and its implications for ligand binding. (PMID: 16377614) Lorenzen I … Grötzinger J (The Journal of biological chemistry 2006) 3 4 23 54

Products for IL15RA Gene

Sources for IL15RA Gene