Aliases for IL15RA Gene
External Ids for IL15RA Gene
Previous GeneCards Identifiers for IL15RA Gene
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]
GeneCards Summary for IL15RA Gene
IL15RA (Interleukin 15 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL15RA include T-Cell Large Granular Lymphocyte Leukemia and Ossification Of The Posterior Longitudinal Ligament Of Spine. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Allograft rejection. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and cytokine receptor activity.
UniProtKB/Swiss-Prot Summary for IL15RA Gene
High-affinity receptor for interleukin-15 (PubMed:8530383). Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (PubMed:15123770). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (PubMed:15123770). Expression of different isoforms may alter or interfere with signal transduction (PubMed:10480910).
[Isoform 5]: Does not bind IL15.
[Isoform 6]: Does not bind IL15.
[Isoform 7]: Does not bind IL15.
[Isoform 8]: Does not bind IL15.