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The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown ... See more...
Aliases for IL15 Gene
External Ids for IL15 Gene
- HGNC: 5977
- NCBI Entrez Gene: 3600
- Ensembl: ENSG00000164136
- OMIM®: 600554
- UniProtKB/Swiss-Prot: P40933
Previous GeneCards Identifiers for IL15 Gene
- GC04P143420
- GC04P142875
- GC04P143023
- GC04P143135
- GC04P142915
- GC04P142557
- GC04P138287
Summaries for IL15 Gene
-
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
GeneCards Summary for IL15 Gene
IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include Nk Cell Deficiency and T Cell Deficiency. Among its related pathways are Rheumatoid arthritis and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.
UniProtKB/Swiss-Prot Summary for IL15 Gene
-
Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).
Additional gene information for IL15 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL15 Gene
Genomics for IL15 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IL15 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL15 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL15
- Top Transcription factor binding sites by QIAGEN in the IL15 gene promoter:
-
- AP-2gamma
- GR
- GR-alpha
- ISGF-3
- STAT3
- STAT5A
Genomic Locations for IL15 Gene
Latest Assembly
- chr4:141,636,583-141,733,987
- (GRCh38/hg38)
- Size:
- 97,405 bases
- Orientation:
- Plus strand
Previous Assembly
- chr4:142,557,736-142,655,140
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 97,405 bases
- Orientation:
- Plus strand
Genomic View for IL15 Gene
Genes around IL15 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4q31.21 by HGNC
- 4q31.21 by Entrez Gene
- 4q31.21 by Ensembl
IL15 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL15 Gene
Proteins for IL15 Gene
-
Protein details for IL15 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P40933-IL15_HUMAN
- Recommended name:
- Interleukin-15
- Protein Accession:
- P40933
- D3DNZ2
- O00440
- O43512
- Q495Z8
- Q6FGX7
- Q93058
- Q9UBA3
Protein attributes for IL15 Gene
- Size:
- 162 amino acids
- Molecular mass:
- 18086 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=CAA71044.1; Type=Miscellaneous discrepancy; Note=Man-made cDNA with a signal peptide sequence to increase protein secretion (substitution with a signal peptide derived from the mouse IgV kappa chain).; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for IL15 Gene
Post-translational modifications for IL15 Gene
Other Protein References for IL15 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences IL15 Antibody
- GeneTex Anti-IL15 antibody [34593.11]
- Novus Biologicals Antibodies for IL15
-
Abcam antibodies for IL15
- Invitrogen Antibodies for IL15 (AFLGC-IL15)
- antibodies-online: Show 78 available IL15 Antibodies ranked by validation data
- Compare Top IL15 Antibodies
-
Recommended
- 63 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 138 WB Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 28 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
-
Biorbyt antibodies for IL15
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL15
- Sino Biological Antibodies for IL15
Protein products for research
- G Biosciences Human IL-15, Lyophilized
- Search Origene for MassSpec and Protein Over-expression Lysates for IL15
- Origene Custom Protein Services for IL15
- Sino Biological Recombinant Proteins for IL15
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for IL15
-
Abcam proteins for IL15
Assay products for research
- RayBiotech Human IL-15 ELISA
- Novus Biologicals ELISA Kits for IL15
- antibodies-online: Show 131 available IL15 Elisa Kits ranked by validation data
- Compare Top IL15 Elisa Kits
-
Quality Products:
- ABIN625012
- ABIN414877
- ABIN2684586
- ABIN411313
- ABIN2472074
- ABIN365226
- ABIN3032941
- ABIN924854
- ABIN1028965
- ABIN1115618
- ABIN1115617
- ABIN365238
- ABIN415505
- ABIN625405
- ABIN5563469
- ABIN1570628
- ABIN1379998
- ABIN5521001
- ABIN5526808
- ABIN2684587
- ABIN1115619
- ABIN365261
- ABIN416368
- ABIN1570630
- ABIN5521004
- ABIN5670499
- ABIN627226
- ABIN5592274
- ABIN5655793
- ABIN4970360
- ABIN413988
- ABIN1570623
- ABIN841945
- ABIN993207
- ABIN4881452
- ABIN6384720
- ABIN5655789
- ABIN2535393
- ABIN6205356
- ABIN1138613
-
Abcam assays for IL15
- Sino Biological Assays for IL15
No data available for DME Specific Peptides for IL15 Gene
Domains & Families for IL15 Gene
Gene Families for IL15 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for IL15 Gene
- InterPro:
- Blocks:
-
- Interleukin 15
Suggested Antigen Peptide Sequences for IL15 Gene
- GenScript: Design optimal peptide antigens:
-
- Interleukin-15 (IL15_HUMAN)
- Interleukin (Q6FGX7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P40933- Family:
-
- Belongs to the IL-15/IL-21 family.
Function for IL15 Gene
Molecular function for IL15 Gene
- UniProtKB/Swiss-Prot Function:
- Cytokine that stimulates the proliferation of T-lymphocytes (PubMed:8178155). Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (PubMed:8178155). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (PubMed:15123770).
- GENATLAS Biochemistry:
- interleukin 15,structurally and functionally related to IL2,involved in the differentiation of natural killer cells
LifeMap Function Summary for IL15 Gene
IL15 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
- Blood
Phenotypes From GWAS Catalog for IL15 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005125 | cytokine activity | IBA | 21873635 |
| GO:0005126 | cytokine receptor binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 16284400 |
Phenotypes for IL15 Gene
- MGI mutant phenotypes for IL15:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for IL15:
Animal Models for IL15 Gene
Animal Models for research
-
Taconic Biosciences Mouse Models for IL15
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL15 - Starting at $85 >
- * IL15 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL15
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL15
miRNA for IL15 Gene
- miRTarBase miRNAs that target IL15
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL15
- Browse OriGene Inhibitory RNA Products For IL15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL15
Clone products for research
- Applied Biological Materials (abm): Clones for IL15 - Starting at $45 >
- * IL15 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201274
- MR201274
- MR201274L1
- MR201274L2
- MR201274L3
- MR201274L4
- MR228225
- RC202282
- RC202282L3
- RC202282L4
- RC219294
- RC219294L1
- RC219294L2
- RC219294L3
- RC219294L4
- RC233293
- RG202282
- RG219294
- RG233293
- RR213678
- RR213678L3
- RR213678L4
- MR201274L1V
- MR201274L2V
- MR201274L3V
- MR201274L4V
- RC202282L3V
- RC202282L4V
- RC219294L1V
- RC219294L2V
- RC219294L3V
- RC219294L4V
- RR213678L3V
- RR213678L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL15
Cell Lines for research
-
Horizon Cell Lines for IL15
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL15 Gene
Localization for IL15 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL15 Gene
- [Isoform IL15-S48AA]: Secreted.
- [Isoform IL15-S21AA]: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| nucleus | 5 |
| cytosol | 5 |
| endosome | 4 |
| golgi apparatus | 4 |
| plasma membrane | 3 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
- Nuclear speckles (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | TAS,IBA | 21873635 |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | TAS | 10851076 |
Pathways & Interactions for IL15 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
| 2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.40
|
| 3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
| 4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
| 5 | PAK Pathway |
Antioxidant Action of Vitamin-C
.56
|
PAK Pathway
.56
|
Pathways by source for IL15 Gene
3 Sino Biological pathways for IL15 Gene
2 BioSystems pathways for IL15 Gene
3 Reactome pathways for IL15 Gene
7 KEGG pathways for IL15 Gene
4 R&D Systems pathways for IL15 Gene
25 Qiagen pathways for IL15 Gene
- Akt Signaling
- all-trans-Retinoic Acid Signaling in Brain
- Antioxidant Action of Vitamin-C
- Cytokine Network
- Endothelin-1 Signaling Pathway
Interacting Proteins for IL15 Gene
Selected Interacting proteins:
P40933-IL15_HUMAN
ENSP00000296545
for IL15 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL15
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001819 | positive regulation of cytokine production | IBA | 21873635 |
| GO:0001866 | NK T cell proliferation | IEA | -- |
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0006955 | immune response | TAS,IEA | -- |
| GO:0007165 | signal transduction | TAS | 8178155 |
Drugs & Compounds for IL15 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fludarabine | Approved | Pharma | DNA synthsis inhibitor | 1633,1633 | ||
| Cyclophosphamide | Approved, Investigational | Pharma | Nitrogen mustard alkylating agent and prodrug. | 3864 | ||
| Cefazolin | Approved | Pharma | Target, inhibitor | 175 | ||
| Alkylating Agents | Pharma | 5597 | ||||
| Antirheumatic Agents | Pharma | 12815 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for IL15 Gene
mRNA/cDNA for IL15 Gene
- 3 REFSEQ mRNAs :
- 20 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296545 2472 nts (view in UCSC)
- ENST00000320650 2015 nts (view in UCSC)
- ENST00000394159 1545 nts (view in UCSC)
- ENST00000477265 6026 nts (view in UCSC)
- ENST00000505351 645 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IL15 - Starting at $85 >
- * IL15 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IL15
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL15
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL15
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL15
- Browse OriGene Inhibitory RNA Products For IL15
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL15
Clone products for research
- Applied Biological Materials (abm): Clones for IL15 - Starting at $45 >
- * IL15 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG201274
- MR201274
- MR201274L1
- MR201274L2
- MR201274L3
- MR201274L4
- MR228225
- RC202282
- RC202282L3
- RC202282L4
- RC219294
- RC219294L1
- RC219294L2
- RC219294L3
- RC219294L4
- RC233293
- RG202282
- RG219294
- RG233293
- RR213678
- RR213678L3
- RR213678L4
- MR201274L1V
- MR201274L2V
- MR201274L3V
- MR201274L4V
- RC202282L3V
- RC202282L4V
- RC219294L1V
- RC219294L2V
- RC219294L3V
- RC219294L4V
- RR213678L3V
- RR213678L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IL15
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL15
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: |
Relevant External Links for IL15 Gene
- GeneLoc Exon Structure for
- IL15
Expression for IL15 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Gonad (Reproductive System)
- Testis Somatic Cells Primitive Gonad
-
Testis (Reproductive System)
- Testis Somatic Cells Primitive Gonad
- Adipose (Muscoskeletal System)
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL15
SOURCE GeneReport for Unigene cluster for IL15 Gene:
Hs.168132mRNA Expression by UniProt/SwissProt for IL15 Gene:
P40933-IL15_HUMAN
Tissue specificity:
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Evidence on tissue expression from TISSUES for IL15 Gene
- Bone marrow(4.6)
- Nervous system(4.6)
- Intestine(4.6)
- Heart(4.5)
- Skin(4.5)
- Lymph node(3.4)
- Spleen(3.3)
- Blood(3.2)
- Muscle(2.6)
- Liver(2.5)
- Lung(2.5)
- Kidney(2.4)
- Thyroid gland(2.2)
Primer products for research
-
OriGene qPCR primer pairs for IL15
-
OriGene qPCR primer pairs and template standards for IL15
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL15 Gene
Orthologs for IL15 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IL15 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IL15 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IL15 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Il15 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Il15 29 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IL15 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IL15 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IL15 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IL15 30 |
|
OneToOne |
- Species where no ortholog for IL15 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IL15 Gene
- ENSEMBL:
- Gene Tree for IL15 (if available)
- TreeFam:
- Gene Tree for IL15 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL15: view image
- Alliance of Genome Resources:
- Additional Orthologs for IL15
Paralogs for IL15 Gene
No data available for Paralogs for IL15 Gene
Variants for IL15 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL15 Gene
| SNP ID | Clinical significance and condition | Chr 04 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs116501276 | Benign: not provided | 141,729,955(+) |
C/T NM_000585.5(IL15):c.349C>T (p.Leu117=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs145684493 | Likely Benign: not provided | 141,732,767(+) |
T/C NM_000585.5(IL15):c.408T>C (p.Cys136=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3564735 | CNV | deletion | 23714750 |
| nsv1018949 | CNV | gain | 25217958 |
| nsv830094 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL15 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL15 Gene
Disorders for IL15 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| nk cell deficiency |
|
|
| t cell deficiency |
|
|
| severe combined immunodeficiency, x-linked |
|
|
| rheumatoid arthritis |
|
|
| microscopic colitis |
|
|
Search IL15 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL15
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IL15 Gene
Publications for IL15 Gene
- Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. (PMID: 8178155) Grabstein KH … Ahdieh M (Science (New York, N.Y.) 1994) 2 3 4 22
- Influences of genetic variants in interleukin-15 gene and serum interleukin-15 levels on coronary heart disease. (PMID: 19796965) Gokkusu C … Umman B (Cytokine 2010) 3 22 40
- Cytokine and cytokine receptor single-nucleotide polymorphisms predict risk for non-small cell lung cancer among women. (PMID: 19505916) Van Dyke AL … Schwartz AG (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009) 3 22 40
- Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. (PMID: 15123770) Ratthé C … Girard D (Journal of leukocyte biology 2004) 3 4 22
- Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth. (PMID: 20140262) Ryckman KK … Jacobsson B (PloS one 2010) 3 40
ExternalLinks
Products for IL15 Gene
- View all 38 R&D Systems IL15 (IL-15) Products
- View all 3 R&D Systems IL15 (IL-15) Proteins and Enzymes
- View all 21 R&D Systems IL15 (IL-15) Primary Antibodies
- View all 3 R&D Systems IL15 (IL-15) ELISAs
- View all R&D Systems IL15 (IL-15) Simple Plex Assays
- View all 8 R&D Systems IL15 (IL-15) Luminex Assays
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- View all R&D Systems IL15 (IL-15) cDNA Clones
- Learn more about R&D Systems custom IL15 antibody, protein, and immunoassay development services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for IL15 (AFLGC-IL15)
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- VectorBuilder Viral vectors for IL15 (ie. lentivirus, AAV, adenovirus)
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- antibodies-online: Show 78 available IL15 Antibodies ranked by validation data
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- Recommended
- 63 WB Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 2 RIA Antibodies (anti-mouse)
- 1 FACS Antibody (anti-mouse)
- 1 Func Antibody (anti-mouse)
- 138 WB Antibodies (anti-human)
- 14 FACS Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 2 IP Antibodies (anti-human)
- 1 Func Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 28 WB Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- antibodies-online: Show 131 available IL15 Elisa Kits ranked by validation data
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- antibodies-online: Show 143 available IL15 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for IL15
- Search Santa Cruz Biotechnology (SCBT) for IL15 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL15
- Horizon Cell Lines for IL15
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL15
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- Biorbyt antibodies for IL15
Sources for IL15 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
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- (24) DrugBank
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- (29) HomoloGene
- (30) PanEnsembl
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- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
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- (37) dbSNP
- (38) GenAtlas
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- (43) Atlas
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- (48) Leiden
- (49) miRBase
- (50) DME
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- (52) PubMed
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- (55) Abcam
- (56) Novus Biologicals
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- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
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- (81) Illumina
- (82) COMPARTMENTS
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- (92) GeneReviews
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- (94) Taconic Biosciences
- (95) GTEx
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