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The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
IL15 (Interleukin 15) is a Protein Coding gene. Diseases associated with IL15 include Severe Combined Immunodeficiency, X-Linked and T Cell Deficiency. Among its related pathways are PEDF Induced Signaling and AKT Siganaling Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J141635 | Promoter/Enhancer | 1.8 | EPDnew FANTOM5 Ensembl ENCODE | 612.1 | +0.7 | 718 | 3.8 | PRDM10 REST BACH1 LARP7 STAT3 RELA ZIC2 PATZ1 IKZF2 EZH2 | IL15 ZNF330 HSALNG0037541 | |
GH04J141642 | Enhancer | 1 | FANTOM5 Ensembl ENCODE | 23.1 | +8.9 | 8918 | 7.4 | PKNOX1 SP1 RELB CEBPB NR3C1 FOS FOSL2 STAT1 JUND PRDM6 | IL15 ZNF330 HSALNG0037541 | |
GH04J141686 | Enhancer | 1 | Ensembl ENCODE | 21.5 | +50.3 | 50318 | 1.4 | ZNF629 PRDM1 ZNF501 RBAK CEBPB ZNF140 ZBTB20 SP1 ZNF639 KLF7 | IL15 HSALNG0037541 piR-34093-018 | |
GH04J141349 | Enhancer | 1 | FANTOM5 ENCODE dbSUPER | 13.9 | -286.0 | -285980 | 1.9 | REST SP1 CEBPB ESR1 FOXA2 ATF3 NR3C1 YY1 ZBTB33 JUND | LINC02432 IL15 ZNF330 lnc-RNF150-7 lnc-ZNF330-3 | |
GH04J141328 | Enhancer | 1.1 | FANTOM5 ENCODE dbSUPER | 11.6 | -307.4 | -307405 | 2.1 | CEBPG HDAC1 CEBPB SP1 POLR2A HDAC2 CHD2 JUN RCOR1 JUND | LINC02432 IL15 ZNF330 RF00951-121 SNODB763 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA | -- |
GO:0005126 | cytokine receptor binding | IEA | -- |
GO:0005515 | protein binding | IPI | 16284400 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005615 | extracellular space | TAS,IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | TAS | 10851076 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
3 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
4 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
5 | Jak Stat Signaling Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001819 | positive regulation of cytokine production | IBA | 21873635 |
GO:0001866 | NK T cell proliferation | IEA | -- |
GO:0006954 | inflammatory response | IEA | -- |
GO:0006955 | immune response | TAS,IEA | -- |
GO:0007165 | signal transduction | TAS | 8178155 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||
SP6: |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL15 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL15 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL15 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Il15 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il15 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | IL15 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL15 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL15 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IL15 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3564735 | CNV | deletion | 23714750 |
nsv1018949 | CNV | gain | 25217958 |
nsv830094 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
severe combined immunodeficiency, x-linked |
|
|
t cell deficiency |
|
|
rheumatoid arthritis |
|
|
cutaneous t cell lymphoma |
|
|
severe combined immunodeficiency |
|