The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008] See more...

Aliases for IL13RA2 Gene

Aliases for IL13RA2 Gene

  • Interleukin 13 Receptor Subunit Alpha 2 2 3 5
  • Interleukin-13 Receptor Subunit Alpha-2 3 4
  • Interleukin 13 Receptor, Alpha 2 2 3
  • IL-13 Receptor Subunit Alpha-2 3 4
  • Cancer/Testis Antigen 19 2 3
  • IL-13R Subunit Alpha-2 3 4
  • IL-13R-Alpha-2 3 4
  • IL-13RA2 3 4
  • IL-13R 2 3
  • IL13BP 2 3
  • CT19 2 3
  • Interleukin 13 Receptor Alpha 2 Chain 3
  • Interleukin 13 Binding Protein 3
  • Interleukin-13-Binding Protein 4
  • CD213a2 Antigen 4
  • CD213A2 3
  • IL13RA2 5
  • CD213a2 2
  • IL13R 4

External Ids for IL13RA2 Gene

Previous GeneCards Identifiers for IL13RA2 Gene

  • GC0XM109214
  • GC0XM111363
  • GC0XM112274
  • GC0XM113005
  • GC0XM113006
  • GC0XM114061
  • GC0XM114238
  • GC0XM103824

Summaries for IL13RA2 Gene

Entrez Gene Summary for IL13RA2 Gene

  • The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13RA2 Gene

IL13RA2 (Interleukin 13 Receptor Subunit Alpha 2) is a Protein Coding gene. Diseases associated with IL13RA2 include Glioblastoma and Idiopathic Interstitial Pneumonia. Among its related pathways are IL4-mediated signaling events and Akt Signaling. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and cytokine receptor activity. An important paralog of this gene is PRLR.

UniProtKB/Swiss-Prot Summary for IL13RA2 Gene

  • Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Gene Wiki entry for IL13RA2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL13RA2 Gene

Genomics for IL13RA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL13RA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ115017 Promoter 0.6 EPDnew 250.7 +2.4 2381 0.1 BMI1 RFX1 RFX5 IL13RA2 lnc-IL13RA2-1 HSALNG0139621 HTR2C
GH0XJ115018 Enhancer 0.4 Ensembl ENCODE 255.5 +0.9 937 1.3 CTCF IL13RA2 lnc-IL13RA2-1 HSALNG0139621 HTR2C
GH0XJ115042 Promoter 0.3 EPDnew 263 -22.6 -22567 0.1 IL13RA2 RF00026-1148 RNU6-648P RF00994-1203 RBMXL3
GH0XJ115233 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 5.5 -213.1 -213123 3.4 ZNF600 ZNF10 SIN3A SP2 YY1 PRDM6 ZNF664 ATF2 ZNF366 POLR2A LRCH2 API5P1 IL13RA2 HSALNG0139628 RBMXL3
GH0XJ115021 Enhancer 0.9 Ensembl ENCODE 9.9 -3.2 -3223 2.8 NCOR1 IKZF1 JUND TAL1 ZNF316 NFE2 STAT5A MAFK MAFG TCF12 HSALNG0139623 IL13RA2 HSALNG0139624 RBMXL3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL13RA2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL13RA2

Top Transcription factor binding sites by QIAGEN in the IL13RA2 gene promoter:
  • aMEF-2
  • ATF-2
  • CUTL1
  • GATA-1
  • MEF-2A
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • STAT1

Genomic Locations for IL13RA2 Gene

Latest Assembly
chrX:115,003,975-115,019,977
(GRCh38/hg38)
Size:
16,003 bases
Orientation:
Minus strand

Previous Assembly
chrX:114,238,545-114,252,179
(GRCh37/hg19 by Entrez Gene)
Size:
13,635 bases
Orientation:
Minus strand

chrX:114,238,538-114,254,540
(GRCh37/hg19 by Ensembl)
Size:
16,003 bases
Orientation:
Minus strand

Genomic View for IL13RA2 Gene

Genes around IL13RA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13RA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13RA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13RA2 Gene

Proteins for IL13RA2 Gene

  • Protein details for IL13RA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14627-I13R2_HUMAN
    Recommended name:
    Interleukin-13 receptor subunit alpha-2
    Protein Accession:
    Q14627
    Secondary Accessions:
    • A8K7E2
    • O00667

    Protein attributes for IL13RA2 Gene

    Size:
    380 amino acids
    Molecular mass:
    44176 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IL13RA2 Gene

neXtProt entry for IL13RA2 Gene

Post-translational modifications for IL13RA2 Gene

  • Glycosylation at Asn115, Asn215, Asn290, and Asn299

Other Protein References for IL13RA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for IL13RA2 Gene

Domains & Families for IL13RA2 Gene

Gene Families for IL13RA2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • CD markers
  • Predicted membrane proteins

Protein Domains for IL13RA2 Gene

Suggested Antigen Peptide Sequences for IL13RA2 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-13 receptor alpha 2 variant (D0EFR8_HUMAN)
  • Interleukin-13-binding protein (I13R2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14627

UniProtKB/Swiss-Prot:

I13R2_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL13RA2: view

Function for IL13RA2 Gene

Molecular function for IL13RA2 Gene

UniProtKB/Swiss-Prot Function:
Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
GENATLAS Biochemistry:
interleukin 13 receptor,alpha

Gene Ontology (GO) - Molecular Function for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity TAS 9725226
GO:0005515 protein binding IPI 20223216
GO:0019955 cytokine binding IBA 21873635
genes like me logo Genes that share ontologies with IL13RA2: view
genes like me logo Genes that share phenotypes with IL13RA2: view

Animal Models for IL13RA2 Gene

MGI Knock Outs for IL13RA2:

miRNA for IL13RA2 Gene

miRTarBase miRNAs that target IL13RA2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL13RA2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13RA2 Gene

Localization for IL13RA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13RA2 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL13RA2 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Plasma membrane (2)
  • Vesicles (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 9083087
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL13RA2: view

Pathways & Interactions for IL13RA2 Gene

PathCards logo

SuperPathways for IL13RA2 Gene

SuperPathway Contained pathways
1 Akt Signaling
.60
.60
.55
2 PEDF Induced Signaling
.47
3 Cytokine Signaling in Immune system
4 JAK-STAT signaling pathway
5 PAK Pathway
.56
genes like me logo Genes that share pathways with IL13RA2: view

Pathways by source for IL13RA2 Gene

7 Qiagen pathways for IL13RA2 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • MAPK Family Pathway
  • Molecular Mechanisms of Cancer
  • p38 Signaling

Gene Ontology (GO) - Biological Process for IL13RA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002638 negative regulation of immunoglobulin production IEA --
GO:0016064 immunoglobulin mediated immune response IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0043305 negative regulation of mast cell degranulation IEA --
genes like me logo Genes that share ontologies with IL13RA2: view

No data available for SIGNOR curated interactions for IL13RA2 Gene

Drugs & Compounds for IL13RA2 Gene

(4) Drugs for IL13RA2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
AER001 Investigational Pharma Target 0
Cintredekin besudotox Investigational Pharma 0
AER001,AEROVANT Pharma 0

(1) Additional Compounds for IL13RA2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL13RA2: view

Transcripts for IL13RA2 Gene

mRNA/cDNA for IL13RA2 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL13RA2

Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA2 Gene

No ASD Table

Relevant External Links for IL13RA2 Gene

GeneLoc Exon Structure for
IL13RA2

Expression for IL13RA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL13RA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13RA2 Gene

This gene is overexpressed in Artery - Aorta (x9.3), Testis (x8.9), and Brain - Hypothalamus (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL13RA2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL13RA2

SOURCE GeneReport for Unigene cluster for IL13RA2 Gene:

Hs.336046

Evidence on tissue expression from TISSUES for IL13RA2 Gene

  • Nervous system(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with IL13RA2: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL13RA2 Gene

Orthologs for IL13RA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL13RA2 29 30
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL13RA2 29 30
  • 82.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia LOC616008 29
  • 82.21 (n)
IL13RA2 30
  • 70 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Il13ra2 29 16 30
  • 73.24 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il13ra2 29
  • 72.3 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL13RA2 30
  • 47 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL13RA2 30
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL13RA2 29 30
  • 52.19 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia il13ra2 29
  • 51.86 (n)
Zebrafish
(Danio rerio)
Actinopterygii il13ra2 29 30
  • 50 (n)
OneToOne
Species where no ortholog for IL13RA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL13RA2 Gene

ENSEMBL:
Gene Tree for IL13RA2 (if available)
TreeFam:
Gene Tree for IL13RA2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL13RA2: view image
Alliance of Genome Resources:
Additional Orthologs for IL13RA2

Paralogs for IL13RA2 Gene

genes like me logo Genes that share paralogs with IL13RA2: view

Variants for IL13RA2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL13RA2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs17095919 -- p.Trp111Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL13RA2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL13RA2 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV gain+loss 17666407
esv3577049 CNV gain 25503493
nsv511667 CNV gain 21212237
nsv513764 CNV insertion 21212237
nsv516624 CNV gain 19592680

Variation tolerance for IL13RA2 Gene

Residual Variation Intolerance Score: 23.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.42; 9.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL13RA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL13RA2
Leiden Open Variation Database (LOVD)
IL13RA2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13RA2 Gene

Disorders for IL13RA2 Gene

MalaCards: The human disease database

(10) MalaCards diseases for IL13RA2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
glioblastoma
  • adult glioblastoma multiforme
idiopathic interstitial pneumonia
  • diffuse idiopathic pulmonary fibrosis
low-grade astrocytoma
brain cancer
  • adult brain tumor
high grade glioma
  • glial cell tumor
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL13RA2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL13RA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL13RA2 Gene

Publications for IL13RA2 Gene

  1. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. (PMID: 8663118) Caput D … Ferrara P (The Journal of biological chemistry 1996) 2 3 4 22
  2. IL13RA2 gene polymorphisms are associated with systemic sclerosis. (PMID: 16981293) Granel B … Dessein A (The Journal of rheumatology 2006) 3 22 40
  3. Chromosome mapping and expression of the human interleukin-13 receptor. (PMID: 9177784) Guo J … Minvielle S (Genomics 1997) 3 4 22
  4. Interleukin 13 mediates signal transduction through interleukin 13 receptor alpha2 in pancreatic ductal adenocarcinoma: role of IL-13 Pseudomonas exotoxin in pancreatic cancer therapy. (PMID: 20068108) Shimamura T … Puri RK (Clinical cancer research : an official journal of the American Association for Cancer Research 2010) 3 22
  5. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. (PMID: 20223216) Lupardus PJ … Garcia KC (Structure (London, England : 1993) 2010) 3 4

Products for IL13RA2 Gene

Sources for IL13RA2 Gene