Aliases for IL13RA1 Gene
External Ids for IL13RA1 Gene
Previous GeneCards Identifiers for IL13RA1 Gene
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL13RA1 Gene
IL13RA1 (Interleukin 13 Receptor Subunit Alpha 1) is a Protein Coding gene. Diseases associated with IL13RA1 include Low-Grade Astrocytoma and Syndromic X-Linked Intellectual Disability Cabezas Type. Among its related pathways are IL4-mediated signaling events and Akt Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-13 receptor activity. An important paralog of this gene is IL6ST.
UniProtKB/Swiss-Prot Summary for IL13RA1 Gene
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.