The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may me... See more...

Aliases for IL13RA1 Gene

Aliases for IL13RA1 Gene

  • Interleukin 13 Receptor Subunit Alpha 1 2 3 5
  • CD213a1 Antigen 2 3 4
  • Interleukin-13 Receptor Subunit Alpha-1 3 4
  • Interleukin 13 Receptor, Alpha 1 2 3
  • IL-13 Receptor Subunit Alpha-1 3 4
  • IL13 Receptor Alpha-1 Chain 2 3
  • Cancer/Testis Antigen 19 3 4
  • IL-13R Subunit Alpha-1 3 4
  • IL-13Ra 2 3
  • CT19 3 4
  • NR4 2 3
  • IL-13R-Alpha-1 4
  • IL-13RA1 4
  • CD213A1 3
  • IL13RA1 5
  • CD213a1 2
  • IL13RA 4
  • IL13R 4

External Ids for IL13RA1 Gene

Previous GeneCards Identifiers for IL13RA1 Gene

  • GC0XP112851
  • GC0XP114847
  • GC0XP115836
  • GC0XP116615
  • GC0XP117643
  • GC0XP117745
  • GC0XP117861
  • GC0XP107355

Summaries for IL13RA1 Gene

Entrez Gene Summary for IL13RA1 Gene

  • The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13RA1 Gene

IL13RA1 (Interleukin 13 Receptor Subunit Alpha 1) is a Protein Coding gene. Diseases associated with IL13RA1 include Low-Grade Astrocytoma and Syndromic X-Linked Intellectual Disability Cabezas Type. Among its related pathways are IL4-mediated signaling events and Akt Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-13 receptor activity. An important paralog of this gene is IL6ST.

UniProtKB/Swiss-Prot Summary for IL13RA1 Gene

  • Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Gene Wiki entry for IL13RA1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL13RA1 Gene

Genomics for IL13RA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL13RA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL13RA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL13RA1

Top Transcription factor binding sites by QIAGEN in the IL13RA1 gene promoter:
  • AML1a
  • c-Fos
  • HNF-4alpha1
  • JunD
  • NF-1
  • NF-1/L
  • STAT1
  • STAT3
  • YY1

Genomic Locations for IL13RA1 Gene

Latest Assembly
chrX:118,726,954-118,794,535
(GRCh38/hg38)
Size:
67,582 bases
Orientation:
Plus strand

Previous Assembly
chrX:117,861,569-117,928,496
(GRCh37/hg19 by Entrez Gene)
Size:
66,928 bases
Orientation:
Plus strand

chrX:117,861,535-117,928,502
(GRCh37/hg19 by Ensembl)
Size:
66,968 bases
Orientation:
Plus strand

Genomic View for IL13RA1 Gene

Genes around IL13RA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13RA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13RA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13RA1 Gene

Proteins for IL13RA1 Gene

  • Protein details for IL13RA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78552-I13R1_HUMAN
    Recommended name:
    Interleukin-13 receptor subunit alpha-1
    Protein Accession:
    P78552
    Secondary Accessions:
    • O95646
    • Q5JSL4
    • Q99656
    • Q9UDY5

    Protein attributes for IL13RA1 Gene

    Size:
    427 amino acids
    Molecular mass:
    48760 Da
    Quaternary structure:
    • Interleukin-13 receptor is a complex of IL4R, IL13RA1, and possibly other components. Interacts with TRAF3IP1.

    Three dimensional structures from OCA and Proteopedia for IL13RA1 Gene

    Alternative splice isoforms for IL13RA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL13RA1 Gene

Post-translational modifications for IL13RA1 Gene

  • Glycosylation at Asn37, Asn61, Asn105, Asn138, Asn151, Asn157, Asn235, Asn265, Asn293, Asn329, and Asn341
  • Ubiquitination at Lys386
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • I13R1_HUMAN (2052)

Other Protein References for IL13RA1 Gene

Antibodies for research

No data available for DME Specific Peptides for IL13RA1 Gene

Domains & Families for IL13RA1 Gene

Gene Families for IL13RA1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IL13RA1 Gene

InterPro:
Blocks:
  • Short hematopoietin receptor, family 2

Suggested Antigen Peptide Sequences for IL13RA1 Gene

GenScript: Design optimal peptide antigens:
  • Cancer/testis antigen 19 (I13R1_HUMAN)
  • cDNA, FLJ94013, Homo sapiens interleukin 13 receptor, alpha 1 (IL13RA1), mRNA (Q5JSL4_HUMAN)
  • Interleukin 13 receptor, alpha 1 (Q96BB4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P78552

UniProtKB/Swiss-Prot:

I13R1_HUMAN :
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
  • The box 1 motif is required for JAK interaction and/or activation.
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.
genes like me logo Genes that share domains with IL13RA1: view

Function for IL13RA1 Gene

Molecular function for IL13RA1 Gene

UniProtKB/Swiss-Prot Function:
Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.

Phenotypes From GWAS Catalog for IL13RA1 Gene

Gene Ontology (GO) - Molecular Function for IL13RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0004923 leukemia inhibitory factor receptor activity IBA 21873635
GO:0004924 contributes_to oncostatin-M receptor activity IBA 21873635
GO:0005127 ciliary neurotrophic factor receptor binding IBA 21873635
GO:0005515 protein binding IPI 12935900
genes like me logo Genes that share ontologies with IL13RA1: view
genes like me logo Genes that share phenotypes with IL13RA1: view

Animal Models for IL13RA1 Gene

MGI Knock Outs for IL13RA1:

Animal Models for research

miRNA for IL13RA1 Gene

miRTarBase miRNAs that target IL13RA1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL13RA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL13RA1 Gene

Localization for IL13RA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13RA1 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL13RA1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
extracellular 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL13RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005898 interleukin-13 receptor complex TAS 9013879
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL13RA1: view

Pathways & Interactions for IL13RA1 Gene

PathCards logo

SuperPathways for IL13RA1 Gene

genes like me logo Genes that share pathways with IL13RA1: view

Pathways by source for IL13RA1 Gene

1 R&D Systems pathway for IL13RA1 Gene
7 Qiagen pathways for IL13RA1 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • MAPK Family Pathway
  • Molecular Mechanisms of Cancer
  • p38 Signaling

SIGNOR curated interactions for IL13RA1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL13RA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 9013879
GO:0008284 positive regulation of cell proliferation IBA 21873635
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0038165 oncostatin-M-mediated signaling pathway IEA --
GO:0048861 leukemia inhibitory factor signaling pathway IEA --
genes like me logo Genes that share ontologies with IL13RA1: view

Drugs & Compounds for IL13RA1 Gene

(5) Drugs for IL13RA1 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cintredekin besudotox Investigational Pharma 0
AER001,AEROVANT Pharma 0

(2) Additional Compounds for IL13RA1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL13RA1: view

Transcripts for IL13RA1 Gene

mRNA/cDNA for IL13RA1 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL13RA1

Alternative Splicing Database (ASD) splice patterns (SP) for IL13RA1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: -
SP3: -
SP4:

Relevant External Links for IL13RA1 Gene

GeneLoc Exon Structure for
IL13RA1

Expression for IL13RA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL13RA1 Gene

Protein differential expression in normal tissues from HIPED for IL13RA1 Gene

This gene is overexpressed in Cervix (35.7) and Serum (33.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IL13RA1 Gene



Protein tissue co-expression partners for IL13RA1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL13RA1

SOURCE GeneReport for Unigene cluster for IL13RA1 Gene:

Hs.496646

mRNA Expression by UniProt/SwissProt for IL13RA1 Gene:

P78552-I13R1_HUMAN
Tissue specificity: Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.

Evidence on tissue expression from TISSUES for IL13RA1 Gene

  • Nervous system(4.7)
  • Blood(4.4)
  • Pancreas(4.4)
  • Lung(2.9)
  • Spleen(2.7)
  • Liver(2.7)
  • Heart(2.5)
  • Lymph node(2.3)
  • Intestine(2.3)
  • Muscle(2.3)
  • Kidney(2.1)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with IL13RA1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL13RA1 Gene

Orthologs for IL13RA1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL13RA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL13RA1 29 30
  • 99.53 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL13RA1 29 30
  • 88.91 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL13RA1 29 30
  • 88.6 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il13ra1 29 16 30
  • 81.95 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il13ra1 29
  • 81.8 (n)
Oppossum
(Monodelphis domestica)
Mammalia IL13RA1 30
  • 56 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia IL13RA1 30
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves IL13RA1 29 30
  • 51.35 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia il13ra1 29
  • 46.61 (n)
Species where no ortholog for IL13RA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL13RA1 Gene

ENSEMBL:
Gene Tree for IL13RA1 (if available)
TreeFam:
Gene Tree for IL13RA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL13RA1: view image
Alliance of Genome Resources:
Additional Orthologs for IL13RA1

Paralogs for IL13RA1 Gene

genes like me logo Genes that share paralogs with IL13RA1: view

Variants for IL13RA1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL13RA1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs111349573 Benign: not provided 118,776,517(+) A/G
NM_001560.3(IL13RA1):c.1191+6A>G
INTRON
rs12853794 Benign: not provided 118,773,934(+) C/T
NM_001560.3(IL13RA1):c.1065C>T (p.Ile355=)
SYNONYMOUS
rs760024863 Likely Benign: not provided 118,758,117(+) G/A
NM_001560.3(IL13RA1):c.551G>A (p.Gly184Asp)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL13RA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL13RA1 Gene

Variant ID Type Subtype PubMed ID
dgv527n21 CNV gain 19592680
esv1709061 CNV insertion 17803354
esv3559240 CNV deletion 23714750
esv3574403 CNV loss 25503493

Variation tolerance for IL13RA1 Gene

Residual Variation Intolerance Score: 69.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL13RA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL13RA1
Leiden Open Variation Database (LOVD)
IL13RA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13RA1 Gene

Disorders for IL13RA1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for IL13RA1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
low-grade astrocytoma
syndromic x-linked intellectual disability cabezas type
  • cabezas syndrome; syndromic x-linked mental retardation 15
asthma
  • asthma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IL13RA1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL13RA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL13RA1 Gene

Publications for IL13RA1 Gene

  1. Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. (PMID: 17392323) Konstantinidis AK … Holloway JW (The European respiratory journal 2007) 3 22 40
  2. Gene-gene interaction between IL-13 and IL-13Ralpha1 is associated with total IgE in Korean children with atopic asthma. (PMID: 17006604) Kim HB … Hong SJ (Journal of human genetics 2006) 3 22 40
  3. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. (PMID: 9013879) Miloux B … Ferrara P (FEBS letters 1997) 2 3 4
  4. cDNA cloning and characterization of the human interleukin 13 receptor alpha chain. (PMID: 8910586) Aman MJ … Leonard WJ (The Journal of biological chemistry 1996) 2 3 4
  5. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. (PMID: 20223216) Lupardus PJ … Garcia KC (Structure (London, England : 1993) 2010) 3 22

Products for IL13RA1 Gene

Sources for IL13RA1 Gene