This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytok... See more...

Aliases for IL13 Gene

Aliases for IL13 Gene

  • Interleukin 13 2 3 5
  • IL-13 2 3 4
  • Interleukin-13 3 4
  • P600 2 3
  • Bronchial Hyperresponsiveness-1 (Bronchial Asthma) 2
  • Allergic Rhinitis 2
  • MGC116786 2
  • MGC116788 2
  • MGC116789 2
  • IL13 5
  • ALRH 2
  • BHR1 2
  • NC30 4

External Ids for IL13 Gene

Previous GeneCards Identifiers for IL13 Gene

  • GC05P131516
  • GC05P132441
  • GC05P132023
  • GC05P132070
  • GC05P132021
  • GC05P131991
  • GC05P127186

Summaries for IL13 Gene

Entrez Gene Summary for IL13 Gene

  • This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL13 Gene

IL13 (Interleukin 13) is a Protein Coding gene. Diseases associated with IL13 include Asthma and Allergic Rhinitis. Among its related pathways are PEDF Induced Signaling and Innate Lymphoid Cell Differentiation Pathways. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-13 receptor binding.

UniProtKB/Swiss-Prot Summary for IL13 Gene

  • Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).

Tocris Summary for IL13 Gene

  • Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes.

Gene Wiki entry for IL13 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL13 Gene

Genomics for IL13 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J132655 Promoter 1.2 EPDnew Ensembl 250.7 +0.0 38 1 CTCF RAD21 BHLHE40 IKZF1 HDGF NR2F1 BACH1 EGR1 GATA2 ZNF687 TH2LCRR HSALNG0044865-001 IL13 IL4
GH05J132658 Promoter 0.4 EPDnew 250.7 +1.9 1891 0.1 ZBTB33 IL13 TH2LCRR IL4
GH05J132770 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.8 +118.2 118240 7.9 NCOR1 MYC IKZF1 ZNF600 SIX5 ZNF592 ZNF10 NFIC ZIC2 ZBTB10 SEPTIN8 IL4 ENSG00000202533 AFF4 CCNI2 KIF3A RAD50 SOWAHA SHROOM1 TH2LCRR
GH05J132736 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 11.1 +81.3 81274 3.1 ZNF207 ZNF600 KLF9 POLR2A BRCA1 NFIC ZIC2 YY1 MXD4 CTCF KIF3A SEPTIN8 ENSG00000230612 IL4 TH2LCRR IL13 SHROOM1 IL5 RAD50 RNU7-15P
GH05J132806 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 9.8 +151.1 151138 2 MYC ZMYM3 KLF9 CEBPA YY1 MXD4 REST TRIM22 CHD2 HOMEZ SEPTIN8 GDF9 TH2LCRR RNU7-15P RNA5SP192 IL13 SOWAHA HSALNG0044877
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL13 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL13

Top Transcription factor binding sites by QIAGEN in the IL13 gene promoter:
  • AML1a

Genomic Locations for IL13 Gene

Latest Assembly
chr5:132,656,263-132,661,110
(GRCh38/hg38)
Size:
4,848 bases
Orientation:
Plus strand

Previous Assembly
chr5:131,992,214-131,996,802
(GRCh37/hg19 by Entrez Gene)
Size:
4,589 bases
Orientation:
Plus strand

chr5:131,991,955-131,996,802
(GRCh37/hg19 by Ensembl)
Size:
4,848 bases
Orientation:
Plus strand

Genomic View for IL13 Gene

Genes around IL13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL13 Gene

Proteins for IL13 Gene

  • Protein details for IL13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35225-IL13_HUMAN
    Recommended name:
    Interleukin-13
    Protein Accession:
    P35225
    Secondary Accessions:
    • O43644
    • Q4VB52
    • Q9UDC7

    Protein attributes for IL13 Gene

    Size:
    146 amino acids
    Molecular mass:
    15816 Da
    Quaternary structure:
    • Interacts with IL13RA2.
    SequenceCaution:
    • Sequence=AAA36107.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAA83738.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAB01681.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC03535.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAK53823.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA48824.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IL13 Gene

neXtProt entry for IL13 Gene

Post-translational modifications for IL13 Gene

  • Glycosylation at Asn52, Asn63, Asn71, and Asn86

Other Protein References for IL13 Gene

Antibodies for research

  • Abcam antibodies for IL13

Assay products for research

  • Abcam assays for IL13

No data available for DME Specific Peptides for IL13 Gene

Domains & Families for IL13 Gene

Gene Families for IL13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL13 Gene

InterPro:
Blocks:
  • Interleukin-4/interleukin-13

Suggested Antigen Peptide Sequences for IL13 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 13, isoform CRA_b (D3DQ88_HUMAN)
  • Interleukin-13 (IL13_HUMAN)
  • Interleukin 13 (Q4VB50_HUMAN)
  • IL13 protein (Q4VB51_HUMAN)
  • IL13 protein (Q4VB53_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P35225

UniProtKB/Swiss-Prot:

IL13_HUMAN :
  • Belongs to the IL-4/IL-13 family.
Family:
  • Belongs to the IL-4/IL-13 family.
genes like me logo Genes that share domains with IL13: view

Function for IL13 Gene

Molecular function for IL13 Gene

UniProtKB/Swiss-Prot Function:
Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).
GENATLAS Biochemistry:
interleukin 13,expressed in activated T cell,important switch factor directing Ig-E synthesis

Phenotypes From GWAS Catalog for IL13 Gene

Gene Ontology (GO) - Molecular Function for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005126 cytokine receptor binding IEA --
GO:0005144 interleukin-13 receptor binding IEA --
GO:0005515 protein binding IPI 18243101
genes like me logo Genes that share ontologies with IL13: view
genes like me logo Genes that share phenotypes with IL13: view

Human Phenotype Ontology for IL13 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL13 Gene

MGI Knock Outs for IL13:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL13 Gene

Localization for IL13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL13 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL13 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 4
nucleus 3
lysosome 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space ISS 16275384
GO:0005737 cytoplasm IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with IL13: view

Pathways & Interactions for IL13 Gene

PathCards logo

SuperPathways for IL13 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.40
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 Allograft rejection
.44
genes like me logo Genes that share pathways with IL13: view

SIGNOR curated interactions for IL13 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEA --
GO:0002639 positive regulation of immunoglobulin production IEA --
GO:0006954 inflammatory response IEA --
GO:0006955 immune response IEA --
GO:0009612 response to mechanical stimulus IEA --
genes like me logo Genes that share ontologies with IL13: view

Drugs & Compounds for IL13 Gene

(96) Drugs for IL13 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Histamine Approved, Investigational Pharma 1228
Montelukast Approved Pharma 321
Omalizumab Approved, Investigational Pharma 186
Sunitinib Approved, Investigational Pharma VEGFR/PDGFRβ/ KIT/ FLT3/RET/CSF-1R inhibitor, RTK inhibitor, Potent VEGFR, PDGFRbeta and KIT inhibitor, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 556
Coal tar Approved Pharma 369

(47) Additional Compounds for IL13 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AS 101
106566-58-9
GIT 27
6501-72-0

(4) Tocris Compounds for IL13 Gene

Compound Action Cas Number
AS 101 Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1alpha, IL-2 and TNF-alpha release 106566-58-9
GIT 27 Immunomodulator; reduces production of pro-inflammatory cytokines 6501-72-0
Pirfenidone Antifibrotic agent; regulates cytokine levels in vivo 53179-13-8
Thalidomide TNF-alpha synthesis inhibitor 50-35-1
genes like me logo Genes that share compounds with IL13: view

Transcripts for IL13 Gene

mRNA/cDNA for IL13 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL13

Alternative Splicing Database (ASD) splice patterns (SP) for IL13 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: -
SP2: - -
SP3: - -
SP4:
SP5:

Relevant External Links for IL13 Gene

GeneLoc Exon Structure for
IL13

Expression for IL13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL13 Gene

This gene is overexpressed in Testis (x46.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL13

SOURCE GeneReport for Unigene cluster for IL13 Gene:

Hs.845

Evidence on tissue expression from TISSUES for IL13 Gene

  • Blood(4.7)
  • Lung(3.5)
  • Spleen(3.3)
  • Lymph node(3.2)
  • Intestine(3.1)
  • Bone marrow(3)
  • Skin(3)
  • Muscle(2.9)
  • Heart(2.8)
  • Nervous system(2.8)
  • Liver(2.6)
  • Stomach(2.6)
  • Kidney(2.6)
  • Pancreas(2.3)
  • Bone(2.2)
  • Adrenal gland(2.1)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with IL13: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL13 Gene

Orthologs for IL13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IL13 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL13 29 30
  • 99.24 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IL13 29 30
  • 80.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL13 29 30
  • 79.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il13 29
  • 74.32 (n)
Mouse
(Mus musculus)
Mammalia Il13 29 16 30
  • 71.04 (n)
OneToOne
Species where no ortholog for IL13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL13 Gene

ENSEMBL:
Gene Tree for IL13 (if available)
TreeFam:
Gene Tree for IL13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL13: view image
Alliance of Genome Resources:
Additional Orthologs for IL13

Paralogs for IL13 Gene

No data available for Paralogs for IL13 Gene

Variants for IL13 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL13 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs20541 Risk Factor: Allergic rhinitis, susceptibility to; Asthma, susceptibility to 132,660,272(+) A/Gp.Arg144Gln
NM_002188.3(IL13):c.431A>G (p.Gln144Arg)
MISSENSE
rs34255686 Benign: not provided 132,658,339(+) C/A
NM_002188.3(IL13):c.153C>A (p.Val51=)
SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IL13 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IL13 Gene

Variant ID Type Subtype PubMed ID
nsv528281 CNV gain 19592680
nsv950392 CNV deletion 24416366

Variation tolerance for IL13 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL13 Gene

Human Gene Mutation Database (HGMD)
IL13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL13
Leiden Open Variation Database (LOVD)
IL13

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL13 Gene

Disorders for IL13 Gene

MalaCards: The human disease database

(193) MalaCards diseases for IL13 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
asthma
  • asthma, susceptibility to
allergic rhinitis
  • alrh
rhinitis
  • runny nose
allergic asthma
  • atopic asthma
penicillin allergy
  • allergy to penicillin
- elite association - COSMIC cancer census association via MalaCards
Search IL13 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IL13_HUMAN
  • Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for IL13

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IL13: view

No data available for Genatlas for IL13 Gene

Publications for IL13 Gene

  1. A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. (PMID: 12928861) Wang M … Yu LS (Human genetics 2003) 3 4 22 40 72
  2. Genetic variants of IL-13 signalling and human asthma and atopy. (PMID: 10699178) Heinzmann A … Deichmann KA (Human molecular genetics 2000) 3 4 22 40 72
  3. Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease. (PMID: 15483090) Hiromatsu Y … Bednarczuk T (The Journal of clinical endocrinology and metabolism 2005) 3 22 40 72
  4. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. (PMID: 11588017) Howard TD … Bleecker ER (American journal of respiratory cell and molecular biology 2001) 3 4 40 72
  5. Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2. (PMID: 20223216) Lupardus PJ … Garcia KC (Structure (London, England : 1993) 2010) 3 4 22

Products for IL13 Gene

  • Addgene plasmids for IL13

Sources for IL13 Gene