Aliases for IL12RB2 Gene
Aliases for IL12RB2 Gene
External Ids for IL12RB2 Gene
- HGNC: 5972
- Entrez Gene: 3595
- Ensembl: ENSG00000081985
- OMIM: 601642
- UniProtKB: Q99665
Previous GeneCards Identifiers for IL12RB2 Gene
- GC01P067733
- GC01P066704
- GC01P067130
- GC01P067142
- GC01P067485
- GC01P067545
- GC01P067773
- GC01P065882
Summaries for IL12RB2 Gene
-
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for IL12RB2 Gene
IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) is a Protein Coding gene. Diseases associated with IL12RB2 include Sinusitis and Lepromatous Leprosy. Among its related pathways are Cytokine Signaling in Immune system and Th2 Differentiation Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot for IL12RB2 Gene
-
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Additional gene information for IL12RB2 Gene
- Monarch Initiative
- Search for IL12RB2 at DataMed
- Search for IL12RB2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL12RB2 Gene
Genomics for IL12RB2 Gene
GeneHancer (GH) Regulatory Elements for IL12RB2 Gene
Promoters and enhancers for IL12RB2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I067306 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 555.7 | +0.4 | 392 | 1.8 | MXI1 SP3 L3MBTL2 SUZ12 ZNF335 ZFHX2 GLIS1 SCRT2 ZBTB33 ZBTB17 | IL12RB2 SERBP1 LOC105378779 | |
| GH01I067332 | Enhancer | 0.8 | ENCODE | 23.9 | +25.8 | 25829 | 1.9 | PKNOX1 SMAD1 BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 | IL12RB2 RNU4ATAC4P LOC105378779 | |
| GH01I067339 | Enhancer | 1 | Ensembl ENCODE | 18.2 | +33.0 | 32985 | 1.8 | PKNOX1 BMI1 BATF IRF4 RELA FOSL1 ZNF766 ZNF366 ATF7 FOS | IL12RB2 SERBP1 RNU6-387P LOC105378779 | |
| GH01I067347 | Enhancer | 0.9 | Ensembl ENCODE | 17.3 | +40.8 | 40840 | 1.4 | CTCF ZNF654 TRIM22 ZFP37 REST RAD21 CC2D1A ARID2 ZNF143 SMC3 | IL12RB2 LOC105378779 | |
| GH01I067500 | Enhancer | 1.1 | Ensembl ENCODE | 10.8 | +193.3 | 193348 | 0.6 | FOXA2 ATF1 ARNT ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 ARID2 | RNU6-387P IL12RB2 RNU4ATAC4P GC01P067513 PIR38616 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IL12RB2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL12RB2 gene promoter:
Regulatory Element Products
Genomic Locations for IL12RB2 Gene
Genomic Locations for IL12RB2 Gene
- chr1:67,307,351-67,396,900
- (GRCh38/hg38)
- Size:
- 89,550 bases
- Orientation:
- Plus strand
- chr1:67,773,047-67,862,583
- (GRCh37/hg19)
Genomic View for IL12RB2 Gene
Genes around IL12RB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by Ensembl
- 1p31.3 by Entrez Gene
- 1p31.3 by HGNC
IL12RB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL12RB2 Gene
Proteins for IL12RB2 Gene
-
Protein details for IL12RB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99665-I12R2_HUMAN
- Recommended name:
- Interleukin-12 receptor subunit beta-2
- Protein Accession:
- Q99665
- B1AN98
- B7ZKL9
- F5H7L6
- Q2M3V3
Protein attributes for IL12RB2 Gene
- Size:
- 862 amino acids
- Molecular mass:
- 97135 Da
- Quaternary structure:
-
- Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.
Protein Expression for IL12RB2 Gene
Post-translational modifications for IL12RB2 Gene
- On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
- Glycosylation at posLast=4848, posLast=129129, posLast=166166, isoforms=2, 3195, isoforms=2, 3271, posLast=347347, posLast=376376, and isoforms=2, 3480
Other Protein References for IL12RB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IL12RB2 (IL-12 R beta 2)
-
Custom Antibody ServicesOriGene Antibodies for IL12RB2
- Novus Biologicals Antibodies for IL12RB2
-
Abcam antibodies for IL12RB2
-
Cloud-Clone Corp. Antibodies for IL12RB2
- Invitrogen Antibodies for IL12RB2
- antibodies-online: Search results for 87 available IL12RB2 Antibodies ranked by validation data
- Compare Top IL12RB2 Antibodies
-
Recommended
- 1 IHC (p) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 46 WB Antibodies (anti-human)
- 6 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 16 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 46 WB Antibodies (anti-human)
- 6 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 16 WB Antibodies (anti-mouse)
- GeneTex IL12RB2 antibody for IL12RB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL12RB2
- Sino Biological Antibodies for IL12RB2
Protein Products
- R&D Systems Proteins and Enzymes for IL12RB2 (IL-12 R beta 2)
-
OriGene Purified Proteins for IL12RB2
- Search Origene for MassSpec and Protein Over-expression Lysates for IL12RB2
- Origene Custom Protein Services for IL12RB2
- Sino Biological Recombinant Proteins for IL12RB2
- Sino Biological Cell Lysates for IL12RB2
-
Cloud-Clone Corp. Proteins for IL12RB2
- Search GeneTex for Proteins for IL12RB2
-
ProSci Proteins for IL12RB2
-
Abcam proteins for IL12RB2
Assay Products
-
Cloud-Clone Corp. Assay Kits for IL12RB2
No data available for DME Specific Peptides for IL12RB2 Gene
Domains & Families for IL12RB2 Gene
Gene Families for IL12RB2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL12RB2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL12RB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99665UniProtKB/Swiss-Prot:
I12R2_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL12RB2 Gene
Molecular function for IL12RB2 Gene
- GENATLAS Biochemistry:
- interleukin 12 receptor,subunit B2,low affinity,132kDa,heterodimerizing with IL12RB1,expressed on Th1 cells
- UniProtKB/Swiss-Prot Function:
- Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
- UniProtKB/Swiss-Prot Induction:
- In vitro, up-regulated by IFN-alpha.
Phenotypes From GWAS Catalog for IL12RB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | TAS | 8943050 |
| GO:0019901 | protein kinase binding | IEA | -- |
Phenotypes for IL12RB2 Gene
- MGI mutant phenotypes for IL12RB2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for IL12RB2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL12RB2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IL12RB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL12RB2 gene
- Search ViGene Biosciences for IL12RB2
CRISPR Products
-
OriGene CRISPR knockouts for IL12RB2
- genomics-online: gRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- Applied Biological Materials CRISPR for IL12RB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL12RB2
- GenScript: Design CRISPR guide RNA sequences for IL12RB2
miRNA for IL12RB2 Gene
- miRTarBase miRNAs that target IL12RB2
-
- hsa-mir-7-5p (MIRT025732)
- hsa-mir-625-5p (MIRT039597)
- hsa-mir-3180-5p (MIRT531927)
- hsa-mir-493-5p (MIRT531928)
- hsa-mir-525-5p (MIRT531929)
- hsa-mir-520a-5p (MIRT531930)
- hsa-mir-200b-5p (MIRT531931)
- hsa-mir-200a-5p (MIRT531932)
- hsa-mir-129-5p (MIRT621064)
- hsa-mir-6513-5p (MIRT621065)
- hsa-mir-887-5p (MIRT621066)
- hsa-mir-3913-5p (MIRT621067)
- hsa-mir-3122 (MIRT621068)
- hsa-mir-450a-1-3p (MIRT621069)
- hsa-mir-151a-3p (MIRT735530)
miRNA Products
- Search ViGene Biosciences for IL12RB2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IL12RB2
- Browse OriGene Inhibitory RNA Products For IL12RB2
- genomics-online: shRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
-
ViGene Biosciences ready-to-package AAV shRNAs for IL12RB2 gene
Clone Products
- Sino Biological Human cDNA Clone for IL12RB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IL12RB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL12RB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- orf clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- Applied Biological Materials Clones for IL12RB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL12RB2 (IL-12 R beta 2)
Cell Line Products
-
Horizon Cell Lines for IL12RB2
-
ViGene Biosciences adenoviral particle packaged cDNA for IL12RB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IL12RB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IL12RB2 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL12RB2 Gene
Localization for IL12RB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL12RB2 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (1)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8943050 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for IL12RB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | Akt Signaling |
.60
.60
|
|
| 3 | PEDF Induced Signaling |
.47
|
|
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | Th1 Differentiation Pathway | ||
Pathways by source for IL12RB2 Gene
2 Sino Biological pathways for IL12RB2 Gene
2 BioSystems pathways for IL12RB2 Gene
6 Reactome pathways for IL12RB2 Gene
5 KEGG pathways for IL12RB2 Gene
3 GeneGo (Thomson Reuters) pathways for IL12RB2 Gene
4 R&D Systems pathways for IL12RB2 Gene
8 Qiagen pathways for IL12RB2 Gene
Interacting Proteins for IL12RB2 Gene
Selected Interacting proteins:
ENSP00000262345
Q99665-I12R2_HUMAN
for IL12RB2 Gene via
STRING
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | TAS | 8943050 |
| GO:0008284 | positive regulation of cell proliferation | TAS | 8943050 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | -- |
| GO:0032496 | response to lipopolysaccharide | IEA | -- |
Transcripts for IL12RB2 Gene
mRNA/cDNA for IL12RB2 Gene
- (14) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (13) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IL12RB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL12RB2
- genomics-online: gRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- Applied Biological Materials CRISPR for IL12RB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL12RB2
- GenScript: Design CRISPR guide RNA sequences for IL12RB2
miRNA Products
- Search ViGene Biosciences for IL12RB2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IL12RB2
- Browse OriGene Inhibitory RNA Products For IL12RB2
- genomics-online: shRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
-
ViGene Biosciences ready-to-package AAV shRNAs for IL12RB2 gene
Clone Products
- Sino Biological Human cDNA Clone for IL12RB2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for IL12RB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL12RB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- orf clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- Applied Biological Materials Clones for IL12RB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL12RB2 (IL-12 R beta 2)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for IL12RB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for IL12RB2 Gene
This gene is overexpressed in Muscle - Skeletal (x6.2) and Whole Blood (x4.2).
This gene is overexpressed in Pancreas (48.6), Placenta (6.2), and Bone marrow mesenchymal stem cell (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IL12RB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of IL12RB2 Gene:
IL12RB2SOURCE GeneReport for Unigene cluster for IL12RB2 Gene:
Hs.479347mRNA Expression by UniProt/SwissProt for IL12RB2 Gene:
Q99665-I12R2_HUMAN
Tissue specificity:
Isoform 2 is expressed at similar levels in both naive and activated T-cells.
Evidence on tissue expression from TISSUES for IL12RB2 Gene
- Blood(4.3)
- Nervous system(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL12RB2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- face
- head
- meninges
- mouth
- neck
Thorax:
- esophagus
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- penis
- testicle
- vagina
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for IL12RB2
-
OriGene qPCR primer pairs and template standards for IL12RB2
- genomics-online: primer clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
- pPB-C-His
- pPB-N-His
- pPB-His-GST
- pGFP-V-RS
- pRFP-C-RS
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-C-mGFP
- pLenti-C-Myc-DDK
- pCMV6-Entry
- pCMV6-XL4
Orthologs for IL12RB2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL12RB2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | IL12RB2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | IL12RB2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Il12rb2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Il12rb2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL12RB2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IL12RB2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL12RB2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il12rb2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | il12rb2 33 34 |
|
||
| IL12RB2 (2 of 2) 34 |
|
OneToMany |
- Species where no ortholog for IL12RB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IL12RB2 Gene
Variants for IL12RB2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IL12RB2 Gene
- I12R2_HUMAN-Q99665
- Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000094339 | -- | 67,376,175(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000120405 | -- | 67,341,263(+) | AAAAAAA/AAAAAAAA | intron_variant | |
| rs1000153803 | -- | 67,362,868(+) | G/A | intron_variant | |
| rs1000166408 | -- | 67,377,885(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000229472 | -- | 67,355,151(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.05;
60.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL12RB2 Gene
Disorders for IL12RB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sinusitis |
|
|
| lepromatous leprosy |
|
|
| crohn's disease |
|
|
| mumps |
|
|
| smallpox |
|
|
Search IL12RB2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL12RB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IL12RB2 Gene
Publications for IL12RB2 Gene
- Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya. (PMID: 20350312) Zhang L … Shi YP (Malaria journal 2010) 3 22 44 58
- Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PMID: 19458352) Hirschfield GM … Siminovitch KA (The New England journal of medicine 2009) 3 22 44 58
- Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population. (PMID: 18353079) Takeuchi-Hatanaka K … Takashiba S (Journal of clinical periodontology 2008) 3 22 44 58
- A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. (PMID: 17236132) Cargill M … Begovich AB (American journal of human genetics 2007) 3 22 44 58
- A novel polymorphic GATA site in the human IL-12Rbeta2 promoter region affects transcriptional activity. (PMID: 15140029) van Rietschoten JG … Wierenga EA (Tissue antigens 2004) 3 22 44 58
Products for IL12RB2 Gene
- R&D Systems Antibodies for IL12RB2 (IL-12 R beta 2)
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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- VectorBuilder custom plasmid, inducible vectors for IL12RB2
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 87 available IL12RB2 Antibodies ranked by validation data
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- 12 IF (p) Antibodies (anti-mouse)
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- 12 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- antibodies-online: Search results for 9 available IL12RB2 Elisa Kits ranked by validation data
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- GeneTex IL12RB2 antibody for IL12RB2
- Search GeneTex for Proteins for IL12RB2
- ViGene Biosciences adenoviral particle packaged cDNA for IL12RB2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for IL12RB2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for IL12RB2 gene
- Search ViGene Biosciences for IL12RB2
- Santa Cruz Biotechnology (SCBT) Antibodies for IL12RB2
- Search Santa Cruz Biotechnology (SCBT) for IL12RB2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL12RB2
- Search for IL12RB2 Antibodies at ProSci
- Custom Antibody Services
- ProSci Proteins for IL12RB2
- Horizon Cell Lines for IL12RB2
- genomics-online: cdna clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
- Recommended
- pCMV6-XL4
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- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
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- pPB-C-His
- orf clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
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- pCMV6-XL4
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- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- genomics-online: gRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
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- pCMV6-XL4
- pCMV6-Entry
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- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- genomics-online: primer clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- genomics-online: shRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
- Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
Sources for IL12RB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (14) ProtoNet
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- (32) SOURCE
- (33) HomoloGene
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- (37) FlyBase
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- (47) Atlas
- (48) Cell Signaling Technology
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- (54) Leiden
- (55) miRBase
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- (57) OriGene
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- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
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