Aliases for IL12RB2 Gene
Aliases for IL12RB2 Gene
External Ids for IL12RB2 Gene
- HGNC: 5972
- Entrez Gene: 3595
- Ensembl: ENSG00000081985
- OMIM: 601642
- UniProtKB: Q99665
Previous GeneCards Identifiers for IL12RB2 Gene
- GC01P067733
- GC01P066704
- GC01P067130
- GC01P067142
- GC01P067485
- GC01P067545
- GC01P067773
- GC01P065882
Summaries for IL12RB2 Gene
-
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
GeneCards Summary for IL12RB2 Gene
IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) is a Protein Coding gene. Diseases associated with IL12RB2 include Sinusitis and Lepromatous Leprosy. Among its related pathways are Akt Signaling and Immune response_IL-12 signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cytokine receptor activity. An important paralog of this gene is CSF3R.
UniProtKB/Swiss-Prot for IL12RB2 Gene
-
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Additional gene information for IL12RB2 Gene
- Monarch Initiative
- Search for IL12RB2 at DataMed
- Search for IL12RB2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL12RB2 Gene
Genomics for IL12RB2 Gene
GeneHancer (GH) Regulatory Elements for IL12RB2 Gene
Promoters and enhancers for IL12RB2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01J067306 | Promoter/Enhancer | 1.6 | EPDnew Ensembl ENCODE | 655.7 | +0.4 | 392 | 1.8 | MXI1 SP3 L3MBTL2 SUZ12 ZNF335 ZFHX2 GLIS1 SCRT2 ZBTB33 ZBTB17 | IL12RB2 SERBP1 LOC105378779 | |
| GH01J067332 | Enhancer | 0.8 | ENCODE | 23.9 | +25.8 | 25829 | 1.9 | PKNOX1 SMAD1 STAT5A BMI1 BATF IRF4 ATF7 ETV6 BCLAF1 IKZF2 | IL12RB2 RNU4ATAC4P LOC105378779 | |
| GH01J067339 | Enhancer | 1 | Ensembl ENCODE | 18.2 | +33.0 | 32985 | 1.8 | PKNOX1 BMI1 BATF IRF4 RELA FOSL1 ZNF766 ZNF366 EED ATF7 | IL12RB2 SERBP1 RNU6-387P LOC105378779 | |
| GH01J067347 | Enhancer | 0.8 | Ensembl ENCODE | 17.3 | +40.8 | 40840 | 1.4 | CTCF ZNF654 ZFP37 TRIM22 REST RAD21 CC2D1A ARID2 ZNF143 SMC3 | IL12RB2 LOC105378779 | |
| GH01J067500 | Enhancer | 1.1 | Ensembl ENCODE | 10.8 | +193.3 | 193348 | 0.6 | FOXA2 ATF1 ARNT ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 ARID2 | RNU6-387P IL12RB2 RNU4ATAC4P GC01P067513 PIR38616 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL12RB2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL12RB2 gene promoter:
-
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- STAT4
- STAT5A
- STAT5B
- STAT6
Regulatory Element Products
Genomic Locations for IL12RB2 Gene
Genomic Locations for IL12RB2 Gene
- chr1:67,307,351-67,396,900
- (GRCh38/hg38)
- Size:
- 89,550 bases
- Orientation:
- Plus strand
- chr1:67,773,047-67,862,583
- (GRCh37/hg19)
- Size:
- 89,537 bases
- Orientation:
- Plus strand
Genomic View for IL12RB2 Gene
Genes around IL12RB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by Entrez Gene
- 1p31.3 by HGNC
- 1p31.3 by Ensembl
IL12RB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL12RB2 Gene
Proteins for IL12RB2 Gene
-
Protein details for IL12RB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99665-I12R2_HUMAN
- Recommended name:
- Interleukin-12 receptor subunit beta-2
- Protein Accession:
- Q99665
- B1AN98
- B7ZKL9
- F5H7L6
- Q2M3V3
Protein attributes for IL12RB2 Gene
- Size:
- 862 amino acids
- Molecular mass:
- 97135 Da
- Quaternary structure:
-
- Heterodimer/heterooligomer; disulfide-linked. The functional high affinity IL12 receptor is composed of I12RB1 and IL12RB2. Il12RB2 binds JAK2 (via its N-terminal) through a membrane-proximal region of the cytoplasmic domain. Interaction, in vitro and in vivo, with SOCS3 (via its SH2 domain) inhibits the STAT4-mediated activation. Binds STAT4 through a membrane-distal C-terminal region.
Protein Expression for IL12RB2 Gene
Post-translational modifications for IL12RB2 Gene
- On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding.
- Glycosylation at isoforms=2, 3480, Asn376, Asn347, Asn271, isoforms=2, 3195, Asn166, isoforms=2, 3129, and isoforms=2, 348
- Modification sites at PhosphoSitePlus
Other Protein References for IL12RB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IL12RB2 (IL-12 R beta 2)
-
Custom Antibody ServicesOriGene Antibodies for IL12RB2
- Novus Biologicals Antibodies for IL12RB2
-
Abcam antibodies for IL12RB2
- Invitrogen Antibodies for IL12RB2
- antibodies-online: Search results for 87 available IL12RB2 Antibodies ranked by validation data
- Compare Top IL12RB2 Antibodies
-
Recommended
- 16 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 46 WB Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 16 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 9 FACS Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-rat)
- 6 WB Antibodies (anti-rat)
- 46 WB Antibodies (anti-human)
- 12 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- GeneTex IL12RB2 Antibody for IL12RB2
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL12RB2
- Sino Biological Antibodies for IL12RB2
Protein Products
- R&D Systems Proteins and Enzymes for IL12RB2 (IL-12 R beta 2)
-
OriGene Purified Proteins for IL12RB2
- Search Origene for MassSpec and Protein Over-expression Lysates for IL12RB2
- Origene Custom Protein Services for IL12RB2
- Sino Biological Cell Lysates for IL12RB2
- Sino Biological Recombinant Proteins for IL12RB2
- Search GeneTex for Proteins for IL12RB2
-
ProSci Proteins for IL12RB2
-
Abcam proteins for IL12RB2
Assay Products
No data available for DME Specific Peptides for IL12RB2 Gene
Domains & Families for IL12RB2 Gene
Gene Families for IL12RB2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
- Predicted secreted proteins
Protein Domains for IL12RB2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL12RB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q99665UniProtKB/Swiss-Prot:
I12R2_HUMAN :- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Domain:
-
- The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
- The box 1 motif is required for JAK interaction and/or activation.
- Family:
-
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
Function for IL12RB2 Gene
Molecular function for IL12RB2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
- UniProtKB/Swiss-Prot Induction:
- In vitro, up-regulated by IFN-alpha.
- GENATLAS Biochemistry:
- interleukin 12 receptor,subunit B2,low affinity,132kDa,heterodimerizing with IL12RB1,expressed on Th1 cells
Phenotypes From GWAS Catalog for IL12RB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | TAS | 8943050 |
| GO:0005515 | protein binding | IEA | -- |
| GO:0019901 | protein kinase binding | IEA | -- |
Phenotypes for IL12RB2 Gene
- MGI mutant phenotypes for IL12RB2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for IL12RB2:
Animal Models for IL12RB2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL12RB2
-
CRISPR Products
-
OriGene CRISPR knockouts for IL12RB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL12RB2
- genomics-online: gRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- Applied Biological Materials CRISPR for IL12RB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL12RB2
- GenScript: Design CRISPR guide RNA sequences for IL12RB2
miRNA for IL12RB2 Gene
- miRTarBase miRNAs that target IL12RB2
-
- hsa-mir-7-5p (MIRT025732)
- hsa-mir-625-5p (MIRT039597)
- hsa-mir-3180-5p (MIRT531927)
- hsa-mir-493-5p (MIRT531928)
- hsa-mir-525-5p (MIRT531929)
- hsa-mir-520a-5p (MIRT531930)
- hsa-mir-200b-5p (MIRT531931)
- hsa-mir-200a-5p (MIRT531932)
- hsa-mir-129-5p (MIRT621064)
- hsa-mir-6513-5p (MIRT621065)
- hsa-mir-887-5p (MIRT621066)
- hsa-mir-3913-5p (MIRT621067)
- hsa-mir-3122 (MIRT621068)
- hsa-mir-450a-1-3p (MIRT621069)
- hsa-mir-151a-3p (MIRT735530)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IL12RB2
- Browse OriGene Inhibitory RNA Products For IL12RB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL12RB2
- genomics-online: shRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
Clone Products
- Sino Biological Human cDNA Clone for IL12RB2
- VectorBuilder custom plasmid, inducible vectors for IL12RB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL12RB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL12RB2
- genomics-online: cdna clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- Applied Biological Materials Clones for IL12RB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL12RB2 (IL-12 R beta 2)
Cell Line Products
-
Horizon Cell Lines for IL12RB2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IL12RB2 Gene
Localization for IL12RB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL12RB2 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 3 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Cytosol (1)
- Plasma membrane (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 8943050 |
| GO:0009897 | external side of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for IL12RB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Th17 cell differentiation | ||
| 2 | Akt Signaling |
.60
.60
|
|
| 3 | PEDF Induced Signaling |
.47
|
|
| 4 | Jak-STAT signaling pathway (KEGG) | ||
| 5 | Th1 Differentiation Pathway | ||
Pathways by source for IL12RB2 Gene
2 Sino Biological pathways for IL12RB2 Gene
2 BioSystems pathways for IL12RB2 Gene
6 Reactome pathways for IL12RB2 Gene
5 KEGG pathways for IL12RB2 Gene
3 GeneGo (Thomson Reuters) pathways for IL12RB2 Gene
4 R&D Systems pathways for IL12RB2 Gene
8 Qiagen pathways for IL12RB2 Gene
Interacting Proteins for IL12RB2 Gene
Selected Interacting proteins:
Q99665-I12R2_HUMAN
ENSP00000262345
for IL12RB2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for IL12RB2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007166 | cell surface receptor signaling pathway | TAS | 8943050 |
| GO:0008284 | positive regulation of cell proliferation | TAS | 8943050 |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IEA | -- |
| GO:0019221 | cytokine-mediated signaling pathway | IEA | -- |
| GO:0032496 | response to lipopolysaccharide | IEA | -- |
Transcripts for IL12RB2 Gene
mRNA/cDNA for IL12RB2 Gene
- (13) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (13) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000262345 4040 bps (uc001ddu.3)
- ENST00000371000 2454 bps (uc057hjp.2)
- ENST00000441640 687 bps (uc057hjq.1)
- ENST00000465396 604 bps (uc057hjr.1)
- ENST00000544434 3782 bps (uc010oql.3)
Unigene Clusters for IL12RB2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL12RB2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL12RB2
- genomics-online: gRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- Applied Biological Materials CRISPR for IL12RB2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL12RB2
- GenScript: Design CRISPR guide RNA sequences for IL12RB2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for IL12RB2
- Browse OriGene Inhibitory RNA Products For IL12RB2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL12RB2
- genomics-online: shRNA clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
Clone Products
- Sino Biological Human cDNA Clone for IL12RB2
- VectorBuilder custom plasmid, inducible vectors for IL12RB2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL12RB2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL12RB2
- genomics-online: cdna clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- orf clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- Applied Biological Materials Clones for IL12RB2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL12RB2 (IL-12 R beta 2)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: |
Expression for IL12RB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Blood (Hematopoietic System)
- Natural Killer Cells Peripheral Blood
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for IL12RB2 Gene
This gene is overexpressed in Muscle - Skeletal (x6.2) and Whole Blood (x4.2).
This gene is overexpressed in Pancreas (48.6), Placenta (6.2), and Bone marrow mesenchymal stem cell (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL12RB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of IL12RB2 Gene:
IL12RB2SOURCE GeneReport for Unigene cluster for IL12RB2 Gene:
Hs.479347mRNA Expression by UniProt/SwissProt for IL12RB2 Gene:
Q99665-I12R2_HUMAN
Tissue specificity:
Isoform 2 is expressed at similar levels in both naive and activated T-cells.
Evidence on tissue expression from TISSUES for IL12RB2 Gene
- Blood(4.3)
- Nervous system(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL12RB2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- reproductive
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cranial nerve
- eye
- face
- head
- meninges
- mouth
- neck
Thorax:
- esophagus
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- penis
- testicle
- vagina
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for IL12RB2
-
OriGene qPCR primer pairs for IL12RB2
- genomics-online: primer clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
-
Recommended
- pCMV6-XL4
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- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
- pCMV6-XL4
- pCMV6-Entry
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
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- pRFP-C-RS
- pGFP-V-RS
- pPB-His-GST
- pPB-N-His
- pPB-C-His
Gene Expression Assay Products
Orthologs for IL12RB2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL12RB2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IL12RB2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IL12RB2 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Il12rb2 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Il12rb2 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | IL12RB2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | IL12RB2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | IL12RB2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il12rb2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | il12rb2 34 33 |
|
OneToMany | |
| IL12RB2 (2 of 2) 34 |
|
OneToMany |
- Species where no ortholog for IL12RB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IL12RB2 Gene
- ENSEMBL:
- Gene Tree for IL12RB2 (if available)
- TreeFam:
- Gene Tree for IL12RB2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL12RB2: view image
Paralogs for IL12RB2 Gene
Variants for IL12RB2 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IL12RB2 Gene
- I12R2_HUMAN-Q99665
- Heterozygotic variants Gly-313 and Arg-720 are associated with atopy, an immunological condition that can lead to clinical symptoms such as allergic rhinitis, sinusitis, asthma and eczema.
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000094339 | -- | 67,376,175(+) | A/G | genic_downstream_transcript_variant, intron_variant | |
| rs1000120405 | -- | 67,341,263(+) | AAAAAAA/AAAAAAAA | intron_variant | |
| rs1000153803 | -- | 67,362,868(+) | G/A | intron_variant | |
| rs1000166408 | -- | 67,377,885(+) | G/A | genic_downstream_transcript_variant, intron_variant | |
| rs1000229472 | -- | 67,355,151(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.05;
60.61% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL12RB2 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for IL12RB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sinusitis |
|
|
| lepromatous leprosy |
|
|
| crohn's disease |
|
|
| mumps |
|
|
| smallpox |
|
|
Search IL12RB2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IL12RB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IL12RB2 Gene
Publications for IL12RB2 Gene
- Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya. (PMID: 20350312) Zhang L … Shi YP (Malaria journal 2010) 3 22 44 58
- Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PMID: 19458352) Hirschfield GM … Siminovitch KA (The New England journal of medicine 2009) 3 22 44 58
- Polymorphisms in the 5' flanking region of IL12RB2 are associated with susceptibility to periodontal diseases in the Japanese population. (PMID: 18353079) Takeuchi-Hatanaka K … Takashiba S (Journal of clinical periodontology 2008) 3 22 44 58
- A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. (PMID: 17236132) Cargill M … Begovich AB (American journal of human genetics 2007) 3 22 44 58
- Association between IFNA genotype and the risk of sarcoidosis. (PMID: 15004750) Akahoshi M … Shirakawa T (Human genetics 2004) 3 22 44 58
Products for IL12RB2 Gene
- R&D Systems Antibodies for IL12RB2 (IL-12 R beta 2)
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- VectorBuilder custom plasmid, inducible vectors for IL12RB2
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 87 available IL12RB2 Antibodies ranked by validation data
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- GeneTex IL12RB2 Antibody for IL12RB2
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- genomics-online: cdna clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
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- Overview of 140 available IL12RB2 gene related products
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- genomics-online: primer clones - Search results for 140 available IL12RB2 gene related products
- Overview of 140 available IL12RB2 gene related products
- Recommended
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- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
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- pGFP-V-RS
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- pGFP-V-RS
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Sources for IL12RB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
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- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (133) ENCODE
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- (135) Horizon
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- (139) VectorBuilder
- (140) SNPedia
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- (143) CIViC
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- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
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- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt