The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to suppor... See more...

Aliases for IL11 Gene

Aliases for IL11 Gene

  • Interleukin 11 2 3 5
  • Adipogenesis Inhibitory Factor 2 3 4
  • Oprelvekin 2 3 4
  • IL-11 2 3 4
  • AGIF 2 3 4
  • Interleukin-11 3 4
  • IL11 5

External Ids for IL11 Gene

Previous GeneCards Identifiers for IL11 Gene

  • GC19M056740
  • GC19M056300
  • GC19M060551
  • GC19M060567
  • GC19M055875
  • GC19M052197

Summaries for IL11 Gene

Entrez Gene Summary for IL11 Gene

  • The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for IL11 Gene

IL11 (Interleukin 11) is a Protein Coding gene. Diseases associated with IL11 include Hemorrhagic Cystitis and Plasmacytoma. Among its related pathways are Interleukin-11 Signaling Pathway and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-11 receptor binding.

UniProtKB/Swiss-Prot Summary for IL11 Gene

  • Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.

Gene Wiki entry for IL11 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL11 Gene

Genomics for IL11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IL11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL11

Top Transcription factor binding sites by QIAGEN in the IL11 gene promoter:
  • AML1a
  • HEN1
  • NF-1
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT3
  • STAT5A

Genomic Locations for IL11 Gene

Genomic Locations for IL11 Gene
chr19:55,364,382-55,370,463
(GRCh38/hg38)
Size:
6,082 bases
Orientation:
Minus strand
chr19:55,875,757-55,881,831
(GRCh37/hg19)
Size:
6,075 bases
Orientation:
Minus strand

Genomic View for IL11 Gene

Genes around IL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL11 Gene

Proteins for IL11 Gene

  • Protein details for IL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20809-IL11_HUMAN
    Recommended name:
    Interleukin-11
    Protein Accession:
    P20809
    Secondary Accessions:
    • B4DQV5
    • Q96EB4

    Protein attributes for IL11 Gene

    Size:
    199 amino acids
    Molecular mass:
    21429 Da
    Quaternary structure:
    • Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.

    Three dimensional structures from OCA and Proteopedia for IL11 Gene

    Alternative splice isoforms for IL11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IL11 Gene

Post-translational modifications for IL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IL11 Gene

Antibody Products

  • Abcam antibodies for IL11

No data available for DME Specific Peptides for IL11 Gene

Domains & Families for IL11 Gene

Gene Families for IL11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL11 Gene

Suggested Antigen Peptide Sequences for IL11 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ96313, Homo sapiens interleukin 11 (IL11), mRNA (A8K3F7_HUMAN)
  • Adipogenesis inhibitory factor (IL11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P20809

UniProtKB/Swiss-Prot:

IL11_HUMAN :
  • Belongs to the IL-6 superfamily.
Family:
  • Belongs to the IL-6 superfamily.
genes like me logo Genes that share domains with IL11: view

Function for IL11 Gene

Molecular function for IL11 Gene

UniProtKB/Swiss-Prot Function:
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
GENATLAS Biochemistry:
interleukin 11,40kDa,interleukin-6 cytokine family member,stimulating the proliferation of B cells,T cell dependent

Phenotypes From GWAS Catalog for IL11 Gene

Gene Ontology (GO) - Molecular Function for IL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IBA 21873635
GO:0005142 interleukin-11 receptor binding NAS 2145578
GO:0005515 protein binding IPI 16189514
GO:0008083 growth factor activity IBA,IDA 2145578
genes like me logo Genes that share ontologies with IL11: view
genes like me logo Genes that share phenotypes with IL11: view

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IL11 Gene

Localization for IL11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL11 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL11 gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with IL11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL11 Gene

Pathways & Interactions for IL11 Gene

PathCards logo

SuperPathways for IL11 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.94
.94
.73
.71
.62
.61
.57
.51
.47
.46
.43
2 TGF-Beta Pathway
.60
.60
.57
.43
.41
3 Akt Signaling
.60
.60
.55
4 ERK Signaling
.61
.61
.51
5 PAK Pathway
.56
.56
genes like me logo Genes that share pathways with IL11: view

Pathways by source for IL11 Gene

1 GeneGo (Thomson Reuters) pathway for IL11 Gene
  • Immune response TLR signaling pathways
26 Qiagen pathways for IL11 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Endothelin-1 Signaling Pathway
  • ERK Signaling

SIGNOR curated interactions for IL11 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0008284 positive regulation of cell proliferation IBA,IDA 2145578
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0030183 B cell differentiation NAS 2145578
GO:0030219 megakaryocyte differentiation NAS 2145578
genes like me logo Genes that share ontologies with IL11: view

Drugs & Compounds for IL11 Gene

(60) Drugs for IL11 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Escitalopram Approved Pharma 0

(32) Additional Compounds for IL11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL11: view

Transcripts for IL11 Gene

mRNA/cDNA for IL11 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL11

Alternative Splicing Database (ASD) splice patterns (SP) for IL11 Gene

No ASD Table

Relevant External Links for IL11 Gene

GeneLoc Exon Structure for
IL11

Expression for IL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL11 Gene

mRNA differential expression in normal tissues according to GTEx for IL11 Gene

This gene is overexpressed in Prostate (x7.1), Pituitary (x5.9), Brain - Cerebellum (x5.7), Brain - Cerebellar Hemisphere (x5.0), and Kidney - Cortex (x5.0).

Protein differential expression in normal tissues from HIPED for IL11 Gene

This gene is overexpressed in Skin (53.3) and Islet of Langerhans (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL11 Gene



Protein tissue co-expression partners for IL11 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL11

SOURCE GeneReport for Unigene cluster for IL11 Gene:

Hs.467304

Evidence on tissue expression from TISSUES for IL11 Gene

  • Bone marrow(4.6)
  • Blood(2.9)
  • Bone(2.7)
  • Intestine(2.6)
  • Heart(2.4)
  • Spleen(2.4)
  • Liver(2.4)
  • Lymph node(2.3)
  • Nervous system(2.2)
  • Muscle(2.2)
  • Skin(2.2)
  • Lung(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with IL11: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IL11 Gene

Orthologs for IL11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IL11 30 31
  • 99.5 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IL11 30 31
  • 87.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Il11 30 17 31
  • 82.91 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Il11 30
  • 82.08 (n)
Cow
(Bos Taurus)
Mammalia IL11 31
  • 78 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia IL11 31
  • 43 (a)
OneToOne
Species where no ortholog for IL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IL11 Gene

ENSEMBL:
Gene Tree for IL11 (if available)
TreeFam:
Gene Tree for IL11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL11: view image

Paralogs for IL11 Gene

No data available for Paralogs for IL11 Gene

Variants for IL11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL11 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
774358 Benign: not provided 55,366,073(-) C/A SYNONYMOUS_VARIANT
rs4252548 - p.Arg112His
rs4252576 - p.Val108Met

Additional dbSNP identifiers (rs#s) for IL11 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL11 Gene

Variant ID Type Subtype PubMed ID
nsv470162 CNV loss 18288195
nsv516199 CNV loss 19592680
nsv953624 CNV deletion 24416366

Variation tolerance for IL11 Gene

Gene Damage Index Score: 2.49; 43.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL11 Gene

Human Gene Mutation Database (HGMD)
IL11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IL11 Gene

Disorders for IL11 Gene

MalaCards: The human disease database

(42) MalaCards diseases for IL11 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hemorrhagic cystitis
plasmacytoma
  • myeloma - solitary
mucositis
  • inflammatory disease of mucous membrane
thrombocytosis
  • thrombocythaemia
acquired thrombocytopenia
  • secondary thrombocytopenia
- elite association - COSMIC cancer census association via MalaCards
Search IL11 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL11 Gene

Publications for IL11 Gene

  1. Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). (PMID: 1386338) McKinley D … Yang YC (Genomics 1992) 2 3 4 23
  2. Genome-wide pharmacogenetics of antidepressant response in the GENDEP project. (PMID: 20360315) Uher R … McGuffin P (The American journal of psychiatry 2010) 3 23 41
  3. A polymorphism in the IL11 gene is associated with ulcerative colitis. (PMID: 12486609) Klein W … Epplen JT (Genes and immunity 2002) 3 23 41
  4. The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6. (PMID: 25195742) Putoczki TL … Griffin MD (Acta crystallographica. Section D, Biological crystallography 2014) 3 4
  5. IL-11 expression in retinal and corneal cells is regulated by interferon-gamma. (PMID: 19913506) Nagineni CN … Detrick B (Biochemical and biophysical research communications 2010) 3 23

Products for IL11 Gene

Sources for IL11 Gene