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The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
IL10RB (Interleukin 10 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL10RB include Inflammatory Bowel Disease 25, Autosomal Recessive and Inflammatory Bowel Disease 25. Among its related pathways are Tuberculosis and AKT Siganaling Pathway. Gene Ontology (GO) annotations related to this gene include interleukin-10 receptor activity. An important paralog of this gene is IL20RA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004896 | cytokine receptor activity | IBA | 21873635 |
GO:0004920 | contributes_to interleukin-10 receptor activity | TAS | 10954742 |
GO:0005515 | protein binding | IPI | 12483210 |
GO:0038023 | signaling receptor activity | TAS | 8314576 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA,IBA | 21873635 |
GO:0032002 | interleukin-28 receptor complex | NAS | 12483210 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
|
Glucocorticoid Receptor Signaling
.43
|
2 | JAK-STAT signaling pathway | ||
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
|
JAK-STAT Pathway
.57
JNK Pathway
.51
|
4 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
5 | Th17 cell differentiation |
Immune response IL-22 signaling pathway
.36
|
IL-22 Pathway
.01
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006954 | inflammatory response | TAS | 10954742 |
GO:0006955 | immune response | TAS | 9463407 |
GO:0007165 | signal transduction | TAS | 10954742 |
GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
GO:0046427 | positive regulation of JAK-STAT cascade | IDA | 16982608 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL10RB 30 |
|
||
-- 31 |
|
OneToMany | |||
Cow (Bos Taurus) |
Mammalia | IL10RB 30 31 |
|
OneToMany | |
Dog (Canis familiaris) |
Mammalia | LOC100856489 30 |
|
||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Il10rb 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Il10rb 30 17 31 |
|
ManyToMany | |
Gm21970 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | IL10RB 30 |
|
||
IL10R2 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il10rb 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | crfb4 30 31 |
|
ManyToMany | |
crfb15 31 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 21 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
636551 | Likely Pathogenic: not provided | 33,268,395(+) | AT/A | FRAMESHIFT_VARIANT | |
639329 | Uncertain Significance: Inflammatory bowel disease 25, autosomal recessive | 33,296,328(+) | A/T | MISSENSE_VARIANT | |
641708 | Uncertain Significance: Inflammatory bowel disease 25, autosomal recessive | 33,288,172(+) | C/A | MISSENSE_VARIANT | |
644924 | Uncertain Significance: Inflammatory bowel disease 25, autosomal recessive | 33,296,268(+) | G/A | MISSENSE_VARIANT | |
651724 | Uncertain Significance: Inflammatory bowel disease 25, autosomal recessive | 33,288,252(+) | C/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
inflammatory bowel disease 25, autosomal recessive |
|
|
inflammatory bowel disease 25 |
|
|
colitis |
|
|
crohn's disease |
|
|
inflammatory bowel disease |
|
|