Aliases for IL10RB Gene
Aliases for IL10RB Gene
External Ids for IL10RB Gene
- HGNC: 5965
- Entrez Gene: 3588
- Ensembl: ENSG00000243646
- OMIM: 123889
- UniProtKB: Q08334
Previous HGNC Symbols for IL10RB Gene
- CRFB4
- D21S58
- D21S66
Previous GeneCards Identifiers for IL10RB Gene
- GC21P031216
- GC21P033556
- GC21P033559
- GC21P033560
- GC21P034638
- GC21P020104
Summaries for IL10RB Gene
-
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
GeneCards Summary for IL10RB Gene
IL10RB (Interleukin 10 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL10RB include Inflammatory Bowel Disease 25, Autosomal Recessive and Inflammatory Bowel Disease 25. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-10 receptor activity. An important paralog of this gene is IFNGR2.
UniProtKB/Swiss-Prot for IL10RB Gene
-
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
Additional gene information for IL10RB Gene
- Monarch Initiative
- Search for IL10RB at DataMed
- Search for IL10RB at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10RB Gene
Genomics for IL10RB Gene
GeneHancer (GH) Regulatory Elements for IL10RB Gene
Promoters and enhancers for IL10RB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IL10RB on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IL10RB gene promoter:
-
- STAT3
- NF-YB
- NF-YA
- NF-Y
- CP1A
- CBF-B
- CBF-A
- CBF(2)
- HSF2
Regulatory Element Products
Genomic Locations for IL10RB Gene
Genomic Locations for IL10RB Gene
- chr21:33,266,358-33,310,187
- (GRCh38/hg38)
- Size:
- 43,830 bases
- Orientation:
- Plus strand
- chr21:34,638,663-34,669,539
- (GRCh37/hg19)
- Size:
- 30,877 bases
- Orientation:
- Plus strand
Genomic View for IL10RB Gene
Genes around IL10RB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 21q22.11 by Entrez Gene
- 21q22.11 by HGNC
- 21q22.11 by Ensembl
IL10RB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IL10RB Gene
Proteins for IL10RB Gene
-
Protein details for IL10RB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08334-I10R2_HUMAN
- Recommended name:
- Interleukin-10 receptor subunit beta
- Protein Accession:
- Q08334
- Q9BUU4
Protein attributes for IL10RB Gene
- Size:
- 325 amino acids
- Molecular mass:
- 36995 Da
- Quaternary structure:
-
- Heterodimer with IFNLR1.
Protein Expression for IL10RB Gene
Post-translational modifications for IL10RB Gene
Other Protein References for IL10RB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IL10RB (IL-10 R beta)
- Novus Biologicals Antibodies for IL10RB
-
Abcam antibodies for IL10RB
- Invitrogen Antibodies for IL10RB
- GeneTex IL10RB Antibody for IL10RB
-
Santa Cruz Biotechnology (SCBT) Antibodies for IL10RB
- Sino Biological Antibodies for IL10RB
Protein Products
- R&D Systems Proteins and Enzymes for IL10RB (IL-10 R beta)
-
OriGene Purified Proteins for IL10RB
- Search Origene for MassSpec and Protein Over-expression Lysates for IL10RB
- Origene Custom Protein Services for IL10RB
- Sino Biological Recombinant Proteins for IL10RB
- Sino Biological Cell Lysates for IL10RB
- ProSpec Recombinant Proteins for IL10RB
- Search GeneTex for Proteins for IL10RB
-
ProSci Proteins for IL10RB
-
Abcam proteins for IL10RB
Assay Products
- Novus Biologicals ELISA Kits for IL10RB
- antibodies-online: Search results for 13 available IL10RB Elisa Kits ranked by validation data
- Compare Top IL10RB Elisa Kits
-
Quality Products:
- Sino Biological Assays for IL10RB
No data available for DME Specific Peptides for IL10RB Gene
Domains & Families for IL10RB Gene
Gene Families for IL10RB Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- CD markers
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IL10RB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IL10RB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q08334- Family:
-
- Belongs to the type II cytokine receptor family.
Function for IL10RB Gene
Molecular function for IL10RB Gene
- UniProtKB/Swiss-Prot Function:
- Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
- GENATLAS Biochemistry:
- interleukin 10,receptor beta,cytokine receptor family II,member 4 (CRF2-4)
Phenotypes From GWAS Catalog for IL10RB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004896 | cytokine receptor activity | IBA | -- |
| GO:0004920 | contributes_to interleukin-10 receptor activity | TAS | 10954742 |
| GO:0005515 | protein binding | IPI | 12483210 |
| GO:0038023 | signaling receptor activity | TAS | 8314576 |
Phenotypes for IL10RB Gene
- MGI mutant phenotypes for IL10RB:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IL10RB:
-
- Moderately decreased NFAT1-GFP nuclear translocation
- Increased shRNA abundance (Z-score > 2)
- Synthetic lethal with c-Myc after tamoxifen stimulation
- Reduced mammosphere formation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased shRNA abundance (Z-score < -2)
- Mildly decreased CFP-tsO45G cell surface transport
- Increased transferrin (TF) endocytosis
Animal Models for IL10RB Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IL10RB
-
CRISPR Products
-
OriGene CRISPR knockouts for IL10RB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL10RB
- genomics-online: gRNA clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- Applied Biological Materials CRISPR for IL10RB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL10RB
- GenScript: Design CRISPR guide RNA sequences for IL10RB
miRNA for IL10RB Gene
- miRTarBase miRNAs that target IL10RB
-
- bta-mir-15b (MIRT053810)
- bta-mir-16a (MIRT053835)
- bta-mir-146a (MIRT053925)
- bta-mir-146b (MIRT053941)
- hsa-mir-6749-3p (MIRT620781)
- hsa-mir-4772-3p (MIRT620782)
- hsa-mir-1304-3p (MIRT620783)
- hsa-mir-660-3p (MIRT620784)
- hsa-mir-5193 (MIRT620785)
- hsa-mir-6890-3p (MIRT620786)
- hsa-mir-4284 (MIRT648712)
- hsa-mir-4638-5p (MIRT648713)
- hsa-mir-1307-3p (MIRT648714)
- hsa-mir-6741-3p (MIRT648715)
- hsa-mir-4532 (MIRT648716)
- hsa-mir-1247-3p (MIRT648717)
- hsa-mir-129-5p (MIRT679391)
- hsa-mir-8055 (MIRT679392)
- hsa-mir-4309 (MIRT679393)
- hsa-mir-3198 (MIRT679394)
- hsa-mir-6879-3p (MIRT679395)
- hsa-mir-4294 (MIRT679396)
- hsa-mir-1289 (MIRT679397)
- hsa-mir-8082 (MIRT679398)
- hsa-mir-4534 (MIRT679399)
- hsa-mir-1273f (MIRT679400)
- hsa-mir-4708-5p (MIRT679401)
- hsa-mir-6088 (MIRT679402)
- hsa-mir-4770 (MIRT679403)
- hsa-mir-143-3p (MIRT679404)
- hsa-mir-6514-5p (MIRT679405)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL10RB
- Browse OriGene Inhibitory RNA Products For IL10RB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL10RB
- genomics-online: shRNA clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for IL10RB
- Sino Biological Human cDNA Clone for IL10RB
- VectorBuilder custom plasmid, inducible vectors for IL10RB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL10RB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL10RB
- Applied Biological Materials Clones for IL10RB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL10RB (IL-10 R beta)
Cell Line Products
-
Horizon Cell Lines for IL10RB
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL10RB Gene
Localization for IL10RB Gene
Subcellular locations from UniProtKB/Swiss-Prot for IL10RB Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS,IBA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,TAS | 9312047 |
| GO:0032002 | interleukin-28 receptor complex | NAS | 12483210 |
| GO:0070062 | extracellular exosome | HDA | -- |
Pathways & Interactions for IL10RB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PEDF Induced Signaling |
.47
|
|
| 2 | TGF-Beta Pathway |
.60
|
.57
.51
|
| 3 | Jak-STAT signaling pathway (KEGG) | ||
| 4 | Akt Signaling |
.60
.60
|
|
| 5 | Type III Interferon Signaling Pathways | ||
Pathways by source for IL10RB Gene
2 Sino Biological pathways for IL10RB Gene
1 BioSystems pathway for IL10RB Gene
5 Reactome pathways for IL10RB Gene
1 PharmGKB pathway for IL10RB Gene
5 KEGG pathways for IL10RB Gene
2 GeneGo (Thomson Reuters) pathways for IL10RB Gene
3 R&D Systems pathways for IL10RB Gene
15 Qiagen pathways for IL10RB Gene
Interacting Proteins for IL10RB Gene
Selected Interacting proteins:
Q08334-I10R2_HUMAN
ENSP00000290200
for IL10RB Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IL10RB
SIGNOR curated interactions for IL10RB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | TAS | 10954742 |
| GO:0006955 | immune response | TAS | 9463407 |
| GO:0007165 | signal transduction | TAS | 10954742 |
| GO:0019221 | cytokine-mediated signaling pathway | TAS | -- |
| GO:0051607 | defense response to virus | IEA | -- |
Transcripts for IL10RB Gene
mRNA/cDNA for IL10RB Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (163) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000290200 1963 bps (uc002yrk.3)
- ENST00000422891 786 bps (uc061zpq.1)
- ENST00000493295 1991 bps (uc061zpr.1)
- ENST00000498371 568 bps (uc061zps.1)
- ENST00000451065 898 bps (uc061zpt.1)
Unigene Clusters for IL10RB Gene
CRISPR Products
-
OriGene CRISPR knockouts for IL10RB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL10RB
- genomics-online: gRNA clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- Applied Biological Materials CRISPR for IL10RB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IL10RB
- GenScript: Design CRISPR guide RNA sequences for IL10RB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL10RB
- Browse OriGene Inhibitory RNA Products For IL10RB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL10RB
- genomics-online: shRNA clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
Clone Products
- GenScript: Custom all cDNA clones Services for IL10RB
- Sino Biological Human cDNA Clone for IL10RB
- VectorBuilder custom plasmid, inducible vectors for IL10RB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL10RB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL10RB
- Applied Biological Materials Clones for IL10RB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for IL10RB (IL-10 R beta)
Expression for IL10RB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Lung (Respiratory System)
- Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for IL10RB Gene
This gene is overexpressed in Whole Blood (x11.5).
This gene is overexpressed in Neutrophil (60.0) and Urine (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL10RB Gene
NURSA nuclear receptor signaling pathways regulating expression of IL10RB Gene:
IL10RBSOURCE GeneReport for Unigene cluster for IL10RB Gene:
Hs.654593Evidence on tissue expression from TISSUES for IL10RB Gene
- Kidney(4.3)
- Nervous system(4.3)
- Blood(2.4)
- Intestine(2.3)
- Spleen(2.2)
- Liver(2)
- Lymph node(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10RB Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- reproductive
- respiratory
Regions:
Abdomen:
- intestine
- large intestine
- small intestine
- stomach
Pelvis:
- anus
- rectum
- vagina
General:
- blood
- bone marrow
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for IL10RB
-
OriGene qPCR primer pairs for IL10RB
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for IL10RB Gene
Orthologs for IL10RB Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IL10RB 33 |
|
||
| -- 34 |
|
OneToMany | |||
| cow (Bos Taurus) |
Mammalia | IL10RB 34 33 |
|
OneToMany | |
| dog (Canis familiaris) |
Mammalia | IL10RB 33 |
|
||
| -- 34 |
|
ManyToMany | |||
| -- 34 |
|
ManyToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Il10rb 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Il10rb 16 34 33 |
|
||
| Gm21970 34 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | IL10RB 33 |
|
||
| IL10R2 34 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | il10rb 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crfb4 34 33 |
|
ManyToMany | |
| crfb15 34 34 |
|
ManyToMany |
- Species where no ortholog for IL10RB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IL10RB Gene
- ENSEMBL:
- Gene Tree for IL10RB (if available)
- TreeFam:
- Gene Tree for IL10RB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IL10RB: view image
Paralogs for IL10RB Gene
Variants for IL10RB Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for IL10RB Gene
- I10R2_HUMAN-Q08334
- Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].
| SNP ID | Clin | Chr 21 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1054452549 | uncertain-significance, Inflammatory bowel disease | 33,296,973(+) | A/G | 3_prime_UTR_variant | |
| rs1058861 | uncertain-significance, Inflammatory bowel disease | 33,288,184(+) | G/A/T | coding_sequence_variant, missense_variant | |
| rs1058867 | benign, Inflammatory bowel disease | 33,297,076(+) | G/A | 3_prime_UTR_variant | |
| rs118117891 | uncertain-significance, Inflammatory bowel disease | 33,297,173(+) | T/C | 3_prime_UTR_variant | |
| rs121909601 | pathogenic, Inflammatory bowel disease 25, autosomal recessive | 33,279,897(+) | G/A | coding_sequence_variant, stop_gained |
Residual Variation Intolerance Score:
74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.34;
90.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IL10RB Gene
SNP Genotyping and Copy Number Assay Products
Disorders for IL10RB Gene
(11) MalaCards diseases for IL10RB Gene - From: HGMD, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| inflammatory bowel disease 25, autosomal recessive |
|
|
| inflammatory bowel disease 25 |
|
|
| colitis |
|
|
| crohn's disease |
|
|
| hepatitis b |
|
|
Search IL10RB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
I10R2_HUMAN- Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IL10RB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for IL10RB Gene
Publications for IL10RB Gene
- A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. (PMID: 8314576) Lutfalla G … Uzé G (Genomics 1993) 2 3 4 22 58
- Structure and mechanism of receptor sharing by the IL-10R2 common chain. (PMID: 20462497) Yoon SI … Walter MR (Structure (London, England : 1993) 2010) 3 4 22 58
- Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PMID: 19890111) Glocker EO … Klein C (The New England journal of medicine 2009) 3 4 22 58
- Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. (PMID: 18588853) Hikami K … Tsuchiya N (Biochemical and biophysical research communications 2008) 3 22 44 58
- Identification and functional characterization of a second chain of the interleukin-10 receptor complex. (PMID: 9312047) Kotenko SV … Pestka S (The EMBO journal 1997) 2 3 4 58
Products for IL10RB Gene
- R&D Systems Antibodies for IL10RB (IL-10 R beta)
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- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for IL10RB (IL-10 R beta)
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- Search Origene for MassSpec and Protein Over-expression Lysates for IL10RB
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for IL10RB
- Browse OriGene Inhibitory RNA Products For IL10RB
- OriGene qPCR primer pairs and template standards for IL10RB
- OriGene qPCR primer pairs for IL10RB
- OriGene CRISPR knockouts for IL10RB
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for IL10RB
- Sino Biological Human cDNA Clone for IL10RB
- Sino Biological Recombinant Proteins for IL10RB
- Sino Biological Cell Lysates for IL10RB
- Sino Biological Antibodies for IL10RB
- Sino Biological Assays for IL10RB
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for IL10RB
- Novus Biologicals lysates and proteins for IL10RB
- Novus Biologicals ELISA Kits for IL10RB
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for IL10RB
- Abcam proteins for IL10RB
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for IL10RB
- VectorBuilder custom plasmid, inducible vectors for IL10RB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IL10RB
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 96 available IL10RB Antibodies ranked by validation data
- Compare Top IL10RB Antibodies
- antibodies-online: Search results for 13 available IL10RB Elisa Kits ranked by validation data
- Compare Top IL10RB Elisa Kits
- Quality Products:
- antibodies-online: Search results for 23 available IL10RB Proteins ranked by validation data
- Compare Top IL10RB Proteins
- GeneTex IL10RB Antibody for IL10RB
- Search GeneTex for Proteins for IL10RB
- Santa Cruz Biotechnology (SCBT) Antibodies for IL10RB
- Search Santa Cruz Biotechnology (SCBT) for IL10RB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IL10RB
- Horizon Cell Lines for IL10RB
- genomics-online: cdna clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- orf clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- genomics-online: gRNA clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- genomics-online: primer clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- genomics-online: shRNA clones - Search results for 138 available IL10RB gene related products
- Overview of 138 available IL10RB gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IL10RB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IL10RB
- GeneCopoeia miRNA 3'UTR Target clone products for IL10RB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL10RB
Sources for IL10RB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt