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Aliases for IL10RB Gene

Aliases for IL10RB Gene

  • Interleukin 10 Receptor Subunit Beta 2 3 5
  • Cytokine Receptor Class-II Member 4 3 4
  • Cytokine Receptor Family 2 Member 4 3 4
  • Interleukin-10 Receptor Subunit 2 3 4
  • Interleukin 10 Receptor, Beta 2 3
  • IL-10 Receptor Subunit Beta 3 4
  • IL-10R Subunit Beta 3 4
  • IL-10R Subunit 2 3 4
  • IL-10R2 3 4
  • IL-10RB 3 4
  • D21S58 3 4
  • D21S66 3 4
  • CRF2-4 3 4
  • CRFB4 3 4
  • Cytokine Receptor Family II, Member 4 3
  • Interleukin-10 Receptor Subunit Beta 3
  • Cytokine Receptor Class-II CRF2-4 3
  • CDw210b Antigen 4
  • CDW210B 3

External Ids for IL10RB Gene

Previous HGNC Symbols for IL10RB Gene

  • CRFB4
  • D21S58
  • D21S66

Previous GeneCards Identifiers for IL10RB Gene

  • GC21P031216
  • GC21P033556
  • GC21P033559
  • GC21P033560
  • GC21P034638
  • GC21P020104

Summaries for IL10RB Gene

Entrez Gene Summary for IL10RB Gene

  • The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]

GeneCards Summary for IL10RB Gene

IL10RB (Interleukin 10 Receptor Subunit Beta) is a Protein Coding gene. Diseases associated with IL10RB include Inflammatory Bowel Disease 25, Autosomal Recessive and Inflammatory Bowel Disease 25. Among its related pathways are Akt Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include interleukin-10 receptor activity. An important paralog of this gene is IFNGR2.

UniProtKB/Swiss-Prot for IL10RB Gene

  • Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.

Gene Wiki entry for IL10RB Gene

Additional gene information for IL10RB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10RB Gene

Genomics for IL10RB Gene

GeneHancer (GH) Regulatory Elements for IL10RB Gene

Promoters and enhancers for IL10RB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J033264 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 663.9 +1.6 1635 6.6 PKNOX1 SMAD1 ZFP64 SIN3A IRF4 POLR2B ZNF207 ZNF143 FOS SP3 IL10RB IL10RB-DT PAXBP1 MIS18A IFNAR2 CFAP298 DONSON SON ENSG00000249624 IFNAR1
GH21J033265 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 -1.7 -1682 0.1 IFNAR2 IL10RB IL10RB-DT ENSG00000249624
GH21J033276 Promoter 0.5 EPDnew 650.4 +10.4 10378 0.1 IL10RB IFNAR2 ENSG00000249624 IFNAR1
GH21J033298 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.4 +34.6 34609 4.7 PKNOX1 ATF1 TCF12 ZNF766 CAVIN1 ZNF592 MEF2D SMARCA4 HMBOX1 KDM1A IFNAR1 IFNAR2 PAXBP1 SON TMEM50B IL10RB IFNGR2 GART URB1 EVA1C
GH21J033228 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13.1 -35.1 -35091 5.1 HDGF PKNOX1 SMAD1 SIN3A ZNF2 IRF4 ZNF143 ZNF207 KLF13 ZNF263 IFNAR2 ENSG00000249624 PAXBP1 TMEM50B DONSON IL10RB SON MIS18A C21orf62-AS1 IL10RB-DT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL10RB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL10RB gene promoter:
  • STAT3
  • NF-YB
  • NF-YA
  • NF-Y
  • CP1A
  • CBF-B
  • CBF-A
  • CBF(2)
  • HSF2

Genomic Locations for IL10RB Gene

Genomic Locations for IL10RB Gene
chr21:33,266,358-33,310,187
(GRCh38/hg38)
Size:
43,830 bases
Orientation:
Plus strand
chr21:34,638,663-34,669,539
(GRCh37/hg19)
Size:
30,877 bases
Orientation:
Plus strand

Genomic View for IL10RB Gene

Genes around IL10RB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10RB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10RB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10RB Gene

Proteins for IL10RB Gene

  • Protein details for IL10RB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08334-I10R2_HUMAN
    Recommended name:
    Interleukin-10 receptor subunit beta
    Protein Accession:
    Q08334
    Secondary Accessions:
    • Q9BUU4

    Protein attributes for IL10RB Gene

    Size:
    325 amino acids
    Molecular mass:
    36995 Da
    Quaternary structure:
    • Heterodimer with IFNLR1.

    Three dimensional structures from OCA and Proteopedia for IL10RB Gene

neXtProt entry for IL10RB Gene

Post-translational modifications for IL10RB Gene

  • Glycosylation at isoforms=161, Asn102, Asn68, and Asn49
  • Modification sites at PhosphoSitePlus

Other Protein References for IL10RB Gene

No data available for DME Specific Peptides for IL10RB Gene

Domains & Families for IL10RB Gene

Gene Families for IL10RB Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IL10RB Gene

Suggested Antigen Peptide Sequences for IL10RB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q08334

UniProtKB/Swiss-Prot:

I10R2_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL10RB: view

Function for IL10RB Gene

Molecular function for IL10RB Gene

UniProtKB/Swiss-Prot Function:
Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
GENATLAS Biochemistry:
interleukin 10,receptor beta,cytokine receptor family II,member 4 (CRF2-4)

Phenotypes From GWAS Catalog for IL10RB Gene

Gene Ontology (GO) - Molecular Function for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA --
GO:0004920 contributes_to interleukin-10 receptor activity TAS 10954742
GO:0005515 protein binding IPI 12483210
GO:0038023 signaling receptor activity TAS 8314576
genes like me logo Genes that share ontologies with IL10RB: view
genes like me logo Genes that share phenotypes with IL10RB: view

Human Phenotype Ontology for IL10RB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10RB Gene

MGI Knock Outs for IL10RB:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL10RB Gene

Localization for IL10RB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10RB Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL10RB gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS 9312047
GO:0032002 interleukin-28 receptor complex NAS 12483210
GO:0070062 extracellular exosome HDA --
genes like me logo Genes that share ontologies with IL10RB: view

Pathways & Interactions for IL10RB Gene

genes like me logo Genes that share pathways with IL10RB: view

SIGNOR curated interactions for IL10RB Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL10RB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response TAS 10954742
GO:0006955 immune response TAS 9463407
GO:0007165 signal transduction TAS 10954742
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0051607 defense response to virus IEA --
genes like me logo Genes that share ontologies with IL10RB: view

Drugs & Compounds for IL10RB Gene

(4) Drugs for IL10RB Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
IFN-Λ1 Pharma 0
IFN-Λ2 Pharma 0
IFN-Λ3 Pharma 0
PEG-INTERFERON LAMBA Pharma 0
genes like me logo Genes that share compounds with IL10RB: view

Transcripts for IL10RB Gene

mRNA/cDNA for IL10RB Gene

Unigene Clusters for IL10RB Gene

Interleukin 10 receptor, beta:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10RB Gene

No ASD Table

Relevant External Links for IL10RB Gene

GeneLoc Exon Structure for
IL10RB
ECgene alternative splicing isoforms for
IL10RB

Expression for IL10RB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL10RB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IL10RB Gene

This gene is overexpressed in Whole Blood (x11.5).

Protein differential expression in normal tissues from HIPED for IL10RB Gene

This gene is overexpressed in Neutrophil (60.0) and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL10RB Gene



Protein tissue co-expression partners for IL10RB Gene

NURSA nuclear receptor signaling pathways regulating expression of IL10RB Gene:

IL10RB

SOURCE GeneReport for Unigene cluster for IL10RB Gene:

Hs.654593

Evidence on tissue expression from TISSUES for IL10RB Gene

  • Kidney(4.3)
  • Nervous system(4.3)
  • Blood(2.4)
  • Intestine(2.3)
  • Spleen(2.2)
  • Liver(2)
  • Lymph node(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10RB Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
Regions:
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • anus
  • rectum
  • vagina
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL10RB: view

No data available for mRNA Expression by UniProt/SwissProt for IL10RB Gene

Orthologs for IL10RB Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10RB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL10RB 33
  • 99.59 (n)
-- 34
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia IL10RB 34 33
  • 84.23 (n)
OneToMany
dog
(Canis familiaris)
Mammalia IL10RB 33
  • 83.28 (n)
-- 34
  • 68 (a)
ManyToMany
-- 34
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Il10rb 33
  • 76.95 (n)
mouse
(Mus musculus)
Mammalia Il10rb 16 34 33
  • 76.65 (n)
Gm21970 34
  • 50 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves IL10RB 33
  • 55.01 (n)
IL10R2 34
  • 38 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia il10rb 33
  • 48.83 (n)
zebrafish
(Danio rerio)
Actinopterygii crfb4 34 33
  • 45.26 (n)
ManyToMany
crfb15 34 34
  • 25 (a)
ManyToMany
Species where no ortholog for IL10RB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10RB Gene

ENSEMBL:
Gene Tree for IL10RB (if available)
TreeFam:
Gene Tree for IL10RB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL10RB: view image

Paralogs for IL10RB Gene

Paralogs for IL10RB Gene

genes like me logo Genes that share paralogs with IL10RB: view

Variants for IL10RB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10RB Gene

I10R2_HUMAN-Q08334
Genetic variations in IL10RB influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424].

Sequence variations from dbSNP and Humsavar for IL10RB Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs1054452549 uncertain-significance, Inflammatory bowel disease 33,296,973(+) A/G 3_prime_UTR_variant
rs1058861 uncertain-significance, Inflammatory bowel disease 33,288,184(+) G/A/T coding_sequence_variant, missense_variant
rs1058867 benign, Inflammatory bowel disease 33,297,076(+) G/A 3_prime_UTR_variant
rs118117891 uncertain-significance, Inflammatory bowel disease 33,297,173(+) T/C 3_prime_UTR_variant
rs121909601 pathogenic, Inflammatory bowel disease 25, autosomal recessive 33,279,897(+) G/A coding_sequence_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for IL10RB Gene

Variant ID Type Subtype PubMed ID
nsv587376 CNV gain 21841781
nsv587377 CNV loss 21841781
nsv587378 CNV gain 21841781

Variation tolerance for IL10RB Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.34; 90.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL10RB Gene

Human Gene Mutation Database (HGMD)
IL10RB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL10RB

Disorders for IL10RB Gene

MalaCards: The human disease database

(11) MalaCards diseases for IL10RB Gene - From: HGMD, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 25, autosomal recessive
  • ibd25
inflammatory bowel disease 25
  • inflammatory bowel disease 25, autosomal recessive
colitis
crohn's disease
  • ileitis
hepatitis b
  • chronic hepatitis b
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I10R2_HUMAN
  • Inflammatory bowel disease 25 (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IL10RB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL10RB: view

No data available for Genatlas for IL10RB Gene

Publications for IL10RB Gene

  1. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. (PMID: 8314576) Lutfalla G … Uzé G (Genomics 1993) 2 3 4 22 58
  2. Structure and mechanism of receptor sharing by the IL-10R2 common chain. (PMID: 20462497) Yoon SI … Walter MR (Structure (London, England : 1993) 2010) 3 4 22 58
  3. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PMID: 19890111) Glocker EO … Klein C (The New England journal of medicine 2009) 3 4 22 58
  4. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. (PMID: 18588853) Hikami K … Tsuchiya N (Biochemical and biophysical research communications 2008) 3 22 44 58
  5. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. (PMID: 9312047) Kotenko SV … Pestka S (The EMBO journal 1997) 2 3 4 58

Products for IL10RB Gene

Sources for IL10RB Gene

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