The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate... See more...

Aliases for IL10RA Gene

Aliases for IL10RA Gene

  • Interleukin 10 Receptor Subunit Alpha 2 3 5
  • Interleukin-10 Receptor Subunit Alpha 3 4
  • Interleukin-10 Receptor Subunit 1 3 4
  • Interleukin 10 Receptor, Alpha 2 3
  • IL-10 Receptor Subunit Alpha 3 4
  • IL-10R Subunit Alpha 3 4
  • IL-10R Subunit 1 3 4
  • IL-10R1 3 4
  • IL-10RA 3 4
  • IL10R 3 4
  • Interleukin-10 Receptor Alpha Chain 3
  • CD210 Antigen 4
  • CDW210A 3
  • HIL-10R 3
  • CDw210a 4
  • CD210a 3
  • CD210 3

External Ids for IL10RA Gene

Previous HGNC Symbols for IL10RA Gene

  • IL10R

Previous GeneCards Identifiers for IL10RA Gene

  • GC11P120213
  • GC11P119368
  • GC11P117891
  • GC11P117394
  • GC11P117362
  • GC11P113790
  • GC11P117857

Summaries for IL10RA Gene

Entrez Gene Summary for IL10RA Gene

  • The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for IL10RA Gene

IL10RA (Interleukin 10 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL10RA include Inflammatory Bowel Disease 28, Autosomal Recessive and Inflammatory Bowel Disease 28. Among its related pathways are Allograft rejection and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and interleukin-10 receptor activity. An important paralog of this gene is IFNLR1.

UniProtKB/Swiss-Prot Summary for IL10RA Gene

  • Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).

Gene Wiki entry for IL10RA Gene

Additional gene information for IL10RA Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL10RA Gene

Genomics for IL10RA Gene

GeneHancer (GH) Regulatory Elements for IL10RA Gene

Promoters and enhancers for IL10RA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL10RA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL10RA gene promoter:
  • Brachyury
  • E47
  • MRF-2
  • NF-AT
  • NF-AT1
  • NF-AT2
  • STAT1
  • STAT3
  • STAT5A

Genomic Locations for IL10RA Gene

Genomic Locations for IL10RA Gene
chr11:117,986,348-118,003,037
(GRCh38/hg38)
Size:
16,690 bases
Orientation:
Plus strand
chr11:117,857,063-117,872,198
(GRCh37/hg19)
Size:
15,136 bases
Orientation:
Plus strand

Genomic View for IL10RA Gene

Genes around IL10RA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10RA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10RA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IL10RA Gene

Proteins for IL10RA Gene

  • Protein details for IL10RA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13651-I10R1_HUMAN
    Recommended name:
    Interleukin-10 receptor subunit alpha
    Protein Accession:
    Q13651
    Secondary Accessions:
    • A8K6I0
    • B0YJ27

    Protein attributes for IL10RA Gene

    Size:
    578 amino acids
    Molecular mass:
    63003 Da
    Quaternary structure:
    • Interacts with IL10 (PubMed:16982608, PubMed:15837194). Interacts with IL10RB (PubMed:16982608). Interacts (via its cytoplasmic domain) with JAK1 (via N-terminus) (PubMed:12133952). Interacts with BTRC; this interaction leads to IL10RA ubiquitination and subsequent degradation (PubMed:22087322). Interacts with STAT3 (By similarity).
    • (Microbial infection) Interacts with human cytomegalovirus protein IL10.
    • (Microbial infection) Interacts with Epstein-Barr virus protein IL10.

    Three dimensional structures from OCA and Proteopedia for IL10RA Gene

neXtProt entry for IL10RA Gene

Post-translational modifications for IL10RA Gene

  • Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation.
  • Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
  • Glycosylation at Asn50, Asn74, Asn110, Asn154, Asn177, and Asn189
  • Modification sites at PhosphoSitePlus

Other Protein References for IL10RA Gene

Antibody Products

  • Abcam antibodies for IL10RA

No data available for DME Specific Peptides for IL10RA Gene

Domains & Families for IL10RA Gene

Gene Families for IL10RA Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for IL10RA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IL10RA Gene

GenScript: Design optimal peptide antigens:
  • Interleukin-10 receptor subunit 1 (I10R1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13651

UniProtKB/Swiss-Prot:

I10R1_HUMAN :
  • Belongs to the type II cytokine receptor family.
Family:
  • Belongs to the type II cytokine receptor family.
genes like me logo Genes that share domains with IL10RA: view

Function for IL10RA Gene

Molecular function for IL10RA Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).
GENATLAS Biochemistry:
interleukin 10,receptor alpha,90-110kDa,expressed in hemopoietic cells and cell lines

Phenotypes From GWAS Catalog for IL10RA Gene

Gene Ontology (GO) - Molecular Function for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004896 cytokine receptor activity IBA 21873635
GO:0004920 interleukin-10 receptor activity TAS,IBA 21873635
GO:0005515 protein binding IPI 11485736
GO:0019969 interleukin-10 binding IEA --
GO:0038023 signaling receptor activity TAS 8407942
genes like me logo Genes that share ontologies with IL10RA: view
genes like me logo Genes that share phenotypes with IL10RA: view

Human Phenotype Ontology for IL10RA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10RA Gene

MGI Knock Outs for IL10RA:

Animal Model Products

  • Taconic Biosciences Mouse Models for IL10RA

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IL10RA Gene

Localization for IL10RA Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10RA Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL10RA gene
Compartment Confidence
plasma membrane 5
extracellular 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS,IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IL10RA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL10RA Gene

Pathways & Interactions for IL10RA Gene

PathCards logo

SuperPathways for IL10RA Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
.51
.47
.43
2 TGF-Beta Pathway
.60
.60
.57
.51
3 Akt Signaling
.60
.60
.55
4 JAK-STAT signaling pathway (KEGG)
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with IL10RA: view

Pathways by source for IL10RA Gene

1 GeneGo (Thomson Reuters) pathway for IL10RA Gene
14 Qiagen pathways for IL10RA Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Glucocorticoid Receptor Signaling
  • IL-10 Pathway
  • JAK-STAT Pathway

SIGNOR curated interactions for IL10RA Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for IL10RA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010507 negative regulation of autophagy IDA 26962683
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032496 response to lipopolysaccharide IEA --
GO:0046427 positive regulation of JAK-STAT cascade IDA 16982608
GO:0050807 regulation of synapse organization IEA --
genes like me logo Genes that share ontologies with IL10RA: view

Drugs & Compounds for IL10RA Gene

(2) Drugs for IL10RA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IL10RA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL10RA: view

Transcripts for IL10RA Gene

mRNA/cDNA for IL10RA Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10RA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP2: -
SP3: - -

Relevant External Links for IL10RA Gene

GeneLoc Exon Structure for
IL10RA
ECgene alternative splicing isoforms for
IL10RA

Expression for IL10RA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL10RA Gene

mRNA differential expression in normal tissues according to GTEx for IL10RA Gene

This gene is overexpressed in Whole Blood (x13.0) and Spleen (x8.2).

Protein differential expression in normal tissues from HIPED for IL10RA Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL10RA Gene



Protein tissue co-expression partners for IL10RA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IL10RA Gene:

IL10RA

SOURCE GeneReport for Unigene cluster for IL10RA Gene:

Hs.504035

mRNA Expression by UniProt/SwissProt for IL10RA Gene:

Q13651-I10R1_HUMAN
Tissue specificity: Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expresssed in non-hematopoetic cells such as fibroblasts or endothelial cells.

Evidence on tissue expression from TISSUES for IL10RA Gene

  • Blood(4.6)
  • Spleen(2.9)
  • Lymph node(2.7)
  • Intestine(2.5)
  • Bone marrow(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10RA Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • reproductive
  • respiratory
Regions:
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • anus
  • rectum
  • vagina
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with IL10RA: view

Orthologs for IL10RA Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10RA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IL10RA 33 32
  • 98.96 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IL10RA 33 32
  • 79.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IL10RA 33 32
  • 78.68 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Il10ra 17 33 32
  • 68.97 (n)
rat
(Rattus norvegicus)
Mammalia Il10ra 32
  • 68.49 (n)
oppossum
(Monodelphis domestica)
Mammalia IL10RA 33
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IL10RA 33
  • 35 (a)
OneToOne
chicken
(Gallus gallus)
Aves IL10RA 32
  • 49.59 (n)
IL10R1 33
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IL10RA 33
  • 30 (a)
OneToOne
Species where no ortholog for IL10RA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IL10RA Gene

ENSEMBL:
Gene Tree for IL10RA (if available)
TreeFam:
Gene Tree for IL10RA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL10RA: view image

Paralogs for IL10RA Gene

genes like me logo Genes that share paralogs with IL10RA: view

Variants for IL10RA Gene

Sequence variations from dbSNP and Humsavar for IL10RA Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs112317511 benign, Inflammatory bowel disease 28, autosomal recessive 117,988,450(+) A/G 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs117423374 uncertain-significance, Inflammatory bowel disease 28, autosomal recessive 117,999,139(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs12290349 uncertain-significance, Inflammatory bowel disease 117,995,720(+) G/A intron_variant
rs1343534194 Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,989,458(+) T/C coding_sequence_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs137853579 pathogenic, Inflammatory bowel disease 28, Inflammatory bowel disease 28 (IBD28) [MIM:613148] 117,993,294(+) G/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant

Variation tolerance for IL10RA Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL10RA Gene

Human Gene Mutation Database (HGMD)
IL10RA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL10RA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for IL10RA Gene

Disorders for IL10RA Gene

MalaCards: The human disease database

(14) MalaCards diseases for IL10RA Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
inflammatory bowel disease 28, autosomal recessive
  • inflammatory bowel disease, early-onset, autosomal recessive
inflammatory bowel disease 28
  • inflammatory bowel disease 28, autosomal recessive
inflammatory bowel disease 25, autosomal recessive
  • ibd25
cytomegalovirus retinitis
  • cmv retinitis
crohn's disease
  • ileitis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

I10R1_HUMAN
  • Inflammatory bowel disease 28 (IBD28) [MIM:613148]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269 PubMed:19890111, ECO:0000269 PubMed:23839161, ECO:0000269 PubMed:24785691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IL10RA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL10RA: view

No data available for Genatlas for IL10RA Gene

Publications for IL10RA Gene

  1. Expression cloning and characterization of a human IL-10 receptor. (PMID: 8120391) Liu Y … Moore KW (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 4 23 56
  2. Interleukin 10 receptor alpha subunit (IL-10RA) gene polymorphism and IL-10 serum levels in Egyptian atopic patients. (PMID: 20232770) Hussein PY … Bakr N (Journal of investigational allergology & clinical immunology 2010) 3 23 43 56
  3. Environmental and genetic factors influence the relationship between circulating IL-10 and obesity phenotypes. (PMID: 19798061) Bassols J … Fernandez-Real JM (Obesity (Silver Spring, Md.) 2010) 3 23 43 56
  4. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. (PMID: 19890111) Glocker EO … Klein C (The New England journal of medicine 2009) 3 4 23 56
  5. IL10R1 loss-of-function alleles in rheumatoid arthritis and systemic lupus erythematosus. (PMID: 19772791) Hermann J … Gasche C (Clinical and experimental rheumatology 2009) 3 23 43 56

Products for IL10RA Gene

Sources for IL10RA Gene