Aliases for IL10RA Gene
External Ids for IL10RA Gene
Previous HGNC Symbols for IL10RA Gene
Previous GeneCards Identifiers for IL10RA Gene
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
GeneCards Summary for IL10RA Gene
IL10RA (Interleukin 10 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL10RA include Inflammatory Bowel Disease 28, Autosomal Recessive and Inflammatory Bowel Disease 28. Among its related pathways are Allograft rejection and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and interleukin-10 receptor activity. An important paralog of this gene is IFNLR1.
UniProtKB/Swiss-Prot Summary for IL10RA Gene
Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608). In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952). These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (PubMed:26962683).