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IL10 Gene(Protein Coding)

Interleukin 10

GCID:
GC01M206767
GIFtS:
54
Genes Participants
UDN Logo

Aliases for IL10 Gene

Aliases for IL10 Gene

  • Interleukin 10 2 3 5
  • Cytokine Synthesis Inhibitory Factor 2 3 4
  • T-Cell Growth Inhibitory Factor 2 3
  • IL-10 3 4
  • CSIF 3 4
  • Interleukin-10 3
  • GVHDS 3
  • IL10A 3
  • TGIF 3

External Ids for IL10 Gene

Previous GeneCards Identifiers for IL10 Gene

  • GC01M205600
  • GC01M202651
  • GC01M203584
  • GC01M204024
  • GC01M203329
  • GC01M205007
  • GC01M206940
  • GC01M177639

Summaries for IL10 Gene

Entrez Gene Summary for IL10 Gene

  • The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]

GeneCards Summary for IL10 Gene

IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Akt Signaling and T cell receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-10 receptor binding.

UniProtKB/Swiss-Prot for IL10 Gene

  • Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.

Gene Wiki entry for IL10 Gene

Additional gene information for IL10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IL10 Gene

Genomics for IL10 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IL10 Gene

Promoters and enhancers for IL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J206768 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 656.8 +3.7 3683 4.6 HDGF HDAC1 PKNOX1 SMAD1 STAT5A ZBTB40 BATF KLF5 IRF4 ZNF143 IL10 ENSG00000284486 IL19 MAPKAPK2 IL24 IL20 C4BPB RASSF5
GH01J206782 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 43.1 -7.9 -7922 0.7 PKNOX1 SMAD1 RB1 BATF KLF5 IRF4 ZNF207 ZNF143 ATF7 ETV6 IL10 IL19
GH01J206722 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +50.9 50919 2.2 SIN3A MZF1 BRCA1 RAD21 RFX5 YY1 EGR1 RCOR1 FOS DEK MAPKAPK2 IL19 IL10 FCMR PIGR IL24 IL20 DYRK3 RASSF5 GC01M206749
GH01J206864 Promoter/Enhancer 1.4 EPDnew ENCODE 10.2 -90.6 -90559 1.1 PKNOX1 RB1 ARNT NFIB SIN3A RAD21 RFX5 ARID2 ZNF143 RCOR1 IL20 IL19 IL24 FCMR PIGR FCAMR IL10 LOC105372878
GH01J206802 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.7 -29.1 -29130 2.1 HDGF PKNOX1 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ZNF207 ZNF143 IL10 IL19 LOC105372878
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IL10 gene promoter:
  • STAT3
  • Sp1
  • deltaCREB
  • CREB
  • GR-beta
  • GR-alpha
  • GR
  • Pbx1a

Genomic Locations for IL10 Gene

Genomic Locations for IL10 Gene
chr1:206,767,602-206,774,607
(GRCh38/hg38)
Size:
7,006 bases
Orientation:
Minus strand
chr1:206,940,947-206,945,839
(GRCh37/hg19)
Size:
4,893 bases
Orientation:
Minus strand

Genomic View for IL10 Gene

Genes around IL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL10 Gene

Proteins for IL10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22301-IL10_HUMAN
    Recommended name:
    Interleukin-10
    Protein Accession:
    P22301

    Protein attributes for IL10 Gene

    Size:
    178 amino acids
    Molecular mass:
    20517 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for IL10 Gene

neXtProt entry for IL10 Gene

Protein Expression for IL10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL10 Gene

Other Protein References for IL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL10

No data available for DME Specific Peptides for IL10 Gene

Domains & Families for IL10 Gene

Gene Families for IL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for IL10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IL10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22301

UniProtKB/Swiss-Prot:

IL10_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL10: view

Function for IL10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IL10 Gene

UniProtKB/Swiss-Prot Function:
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
GENATLAS Biochemistry:
interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of B,T,mast cell

Phenotypes From GWAS Catalog for IL10 Gene

Gene Ontology (GO) - Molecular Function for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,NAS 10443688
GO:0005141 interleukin-10 receptor binding NAS 1847510
GO:0005515 protein binding IPI 11485736
GO:0008083 growth factor activity NAS 1371884
genes like me logo Genes that share ontologies with IL10: view
genes like me logo Genes that share phenotypes with IL10: view

Human Phenotype Ontology for IL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10 Gene

MGI Knock Outs for IL10:

Animal Model Products

Transcription Factor Targets for IL10 Gene

Selected GeneGlobe predicted Target genes for IL10

Clone Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for IL10 Gene

Localization for IL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL10 gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IDA 10443688
genes like me logo Genes that share ontologies with IL10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL10 Gene

Pathways & Interactions for IL10 Gene

genes like me logo Genes that share pathways with IL10: view

SIGNOR curated interactions for IL10 Gene

Activates:

Gene Ontology (GO) - Biological Process for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002237 response to molecule of bacterial origin IDA 17449476
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA 10443688
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus IEA --
GO:0002904 positive regulation of B cell apoptotic process IDA 9184696
genes like me logo Genes that share ontologies with IL10: view

Drugs & Compounds for IL10 Gene

Products:

  1. Drug

(116) Drugs for IL10 Gene - From: DrugBank, PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Niacin Approved, Investigational Nutra Unknown, Agonist, Full agonist 946,946
Nicotinamide Approved, Investigational Nutra 942,946
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1603
Mycophenolate mofetil Approved, Investigational Pharma IMPDH inhibitor 987

(53) Additional Compounds for IL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL10: view

Transcripts for IL10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL10 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IL10 Gene

Interleukin 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IL10 Gene

No ASD Table

Relevant External Links for IL10 Gene

GeneLoc Exon Structure for
IL10
ECgene alternative splicing isoforms for
IL10

Expression for IL10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IL10 Gene

mRNA expression in normal human tissues for IL10 Gene
mRNA expression by BioGPS for IL10 GenemRNA expression by GTEx for IL10 Gene

mRNA differential expression in normal tissues according to GTEx for IL10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.3), Whole Blood (x6.1), and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for IL10 Gene

This gene is overexpressed in Tlymphocyte (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL10 Gene



Protein tissue co-expression partners for IL10 Gene

NURSA nuclear receptor signaling pathways regulating expression of IL10 Gene:

IL10

SOURCE GeneReport for Unigene cluster for IL10 Gene:

Hs.193717

mRNA Expression by UniProt/SwissProt for IL10 Gene:

P22301-IL10_HUMAN
Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Evidence on tissue expression from TISSUES for IL10 Gene

  • Blood(4.8)
  • Lymph node(3.7)
  • Spleen(3.7)
  • Intestine(3.3)
  • Lung(3.1)
  • Nervous system(3)
  • Bone marrow(2.8)
  • Liver(2.8)
  • Skin(2.8)
  • Kidney(2.7)
  • Heart(2.6)
  • Pancreas(2.6)
  • Muscle(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
Thorax:
  • esophagus
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • anus
  • penis
  • rectum
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with IL10: view

Orthologs for IL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IL10 34 33
  • 99.63 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia IL10 34 33
  • 84.56 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia IL10 34 33
  • 83.43 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Il10 33
  • 82.21 (n)
mouse
(Mus musculus)
 Mammalia Il10 16 34 33
  • 81.09 (n)
oppossum
(Monodelphis domestica)
 Mammalia IL10 34
  • 59 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IL10 34
  • 52 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves IL10 34 33
  • 57.89 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia IL10 34
  • 51 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia il10 33
  • 59.1 (n)
zebrafish
(Danio rerio)
 Actinopterygii il10 34 33
  • 47.78 (n)
 OneToOne
Species where no ortholog for IL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IL10 Gene

ENSEMBL:
Gene Tree for IL10 (if available)
TreeFam:
Gene Tree for IL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL10: view image

Paralogs for IL10 Gene

No data available for Paralogs for IL10 Gene

Variants for IL10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10 Gene

IL10_HUMAN-P22301
A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.

Sequence variations from dbSNP and Humsavar for IL10 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs145922845 benign, Inflammatory bowel disease 206,772,393(-) C/T coding_sequence_variant, missense_variant
rs1800872 risk-factor, protective, Human immunodeficiency virus type 1, susceptibility to, Graft-versus-host disease, resistance to 206,773,062(-) T/G upstream_transcript_variant
rs1000660306 -- 206,771,802(-) T/C intron_variant
rs1000968106 -- 206,773,654(-) G/C upstream_transcript_variant
rs1001055509 -- 206,767,177(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IL10 Gene

Variant ID Type Subtype PubMed ID
esv3578391 CNV loss 25503493

Variation tolerance for IL10 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL10 Gene

Human Gene Mutation Database (HGMD)
IL10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL10

SNP Genotyping and Copy Number Assay Products

Disorders for IL10 Gene

MalaCards: The human disease database

(235) MalaCards diseases for IL10 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
graft-versus-host disease
  • graft-versus-host disease, susceptibility to
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
inflammatory bowel disease 25, autosomal recessive
  • ibd25
rheumatoid arthritis
  • ra
chagas disease
  • american trypanosomiasis
- elite association - COSMIC cancer census association via MalaCards
Search IL10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL10 Gene

Publications for IL10 Gene

  1. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study. (PMID: 19700159) Heiskanen M … Hulkkonen J (Atherosclerosis 2010) 3 22 44 58
  2. Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk. (PMID: 19908237) VanCleave TT … Kidd LC (The Prostate 2010) 3 22 44 58
  3. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F … Ferrari R (Current pharmaceutical design 2010) 3 22 44 58
  4. IL-10 promoter gene polymorphisms and sustained response to combination therapy in Taiwanese chronic hepatitis C patients. (PMID: 19004675) Chuang JY … Kao JH (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2009) 3 22 44 58
  5. Interleukin 10 gene promoter polymorphisms in women with pregnancy loss: preferential association with embryonic wastage. (PMID: 19208551) Cochery-Nouvellon E … Gris JC (Biology of reproduction 2009) 3 22 44 58

Products for IL10 Gene

Sources for IL10 Gene