Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Tuberculosis and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-10 receptor binding. An important paralog of this gene is IL20.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005125 | cytokine activity | IEA,NAS | 10443688 |
GO:0005141 | interleukin-10 receptor binding | NAS | 1847510 |
GO:0005515 | protein binding | IPI | 11485736 |
GO:0008083 | growth factor activity | NAS | 1371884 |
GO:0046983 | protein dimerization activity | IDA | 16982608 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | IEA,TAS | -- |
GO:0005615 | extracellular space | IEA,IDA | 10443688 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PEDF Induced Signaling |
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
|
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
|
2 | Allograft rejection |
.44
THC Differentiation Pathway
.39
|
|
3 | TGF-Beta Pathway |
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
|
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
|
4 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
5 | ERK Signaling |
ERK Signaling
.61
Rho Family GTPases
.61
|
Molecular Mechanisms of Cancer
.51
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001818 | negative regulation of cytokine production | IEA,IDA | 1940799 |
GO:0001938 | positive regulation of endothelial cell proliferation | IEA | -- |
GO:0002237 | response to molecule of bacterial origin | IDA | 17449476 |
GO:0002719 | negative regulation of cytokine production involved in immune response | IDA | 10443688 |
GO:0002740 | negative regulation of cytokine secretion involved in immune response | IDA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Nicotinamide | Approved, Investigational | Pharma | 427,427 | |||
Niacin | Approved, Investigational | Nutra | Agonist, Unknown, Full agonist | 432,432 | ||
Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist, Inhibitor, Inhibition | Immunosuppressive agent, Calcineurin inhibitor | 0 | |
Methotrexate | Approved | Pharma | Folate antagonist,inhibits DFHR | 1825 | ||
Mycophenolate mofetil | Approved, Investigational | Pharma | IMPDH inhibitor | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IL10 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IL10 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IL10 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Il10 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Il10 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IL10 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | IL10 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | IL10 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | IL10 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | il10 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | il10 30 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
662170 | Uncertain Significance: Inflammatory bowel disease | 206,768,659(-) | T/C | MISSENSE_VARIANT | |
726782 | Likely Benign: not provided | 206,772,388(-) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
729261 | Likely Benign: Inflammatory bowel disease | 206,772,380(-) | C/T | MISSENSE_VARIANT,INTRON_VARIANT | |
729486 | Benign: Inflammatory bowel disease | 206,772,263(-) | A/G | INTRON_VARIANT | |
745482 | Likely Benign: Inflammatory bowel disease | 206,770,940(-) | G/A | SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3578391 | CNV | loss | 25503493 |
Disorder | Aliases | PubMed IDs |
---|---|---|
graft-versus-host disease |
|
|
human immunodeficiency virus type 1 |
|
|
inflammatory bowel disease 25, autosomal recessive |
|
|
rheumatoid arthritis |
|
|
chagas disease |
|
|