IL10 Gene (Protein Coding)

Interleukin 10

GC01M206767
GIFtS:
47
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production.... See more...

Aliases for IL10 Gene

Aliases for IL10 Gene

  • Interleukin 10 2 3 5
  • Cytokine Synthesis Inhibitory Factor 2 3 4
  • IL-10 2 3 4
  • CSIF 2 3 4
  • T-Cell Growth Inhibitory Factor 2 3
  • Interleukin-10 3 4
  • IL10A 2 3
  • TGIF 2 3
  • GVHDS 3
  • IL10 5

External Ids for IL10 Gene

Previous GeneCards Identifiers for IL10 Gene

  • GC01M205600
  • GC01M202651
  • GC01M203584
  • GC01M204024
  • GC01M203329
  • GC01M205007
  • GC01M206940
  • GC01M177639

Summaries for IL10 Gene

Entrez Gene Summary for IL10 Gene

  • The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]

GeneCards Summary for IL10 Gene

IL10 (Interleukin 10) is a Protein Coding gene. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Tuberculosis and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-10 receptor binding. An important paralog of this gene is IL20.

UniProtKB/Swiss-Prot Summary for IL10 Gene

  • Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).

Gene Wiki entry for IL10 Gene

Additional gene information for IL10 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IL10 Gene

Genomics for IL10 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IL10 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH01J206768 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 606.7 +3.6 3621 4.5 SP1 IKZF1 POLR2A BACH1 ZNF143 RELA TCF12 IKZF2 TRIM22 HDAC1 IL10 IL19 lnc-IL10-5 MAPKAPK2 IL24 IL20 C4BPB RASSF5
GH01J206773 Promoter/Enhancer 0.8 Ensembl dbSUPER 600.7 +0.8 840 0.6 DPF2 RELB IKZF1 MTA2 IL10 lnc-IL10-5 MAPKAPK2 PIGR IL20 FCAMR EIF2D RASSF5 C4BPB IL19
GH01J206782 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 43.1 -8.0 -7988 0.7 SP1 ZNF143 RELA TCF12 IKZF2 TRIM22 PKNOX1 EED ARID3A RELB IL10 IL19 lnc-IL19-1 IL20
GH01J206734 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +36.6 36640 7.4 SP1 CTCF PRDM10 LEF1 IKZF1 POLR2A BACH1 JUND LARP7 ZNF143 MAPKAPK2 FCMR IL19 IL10 PIGR IL20 IL24 C1orf116 DYRK3 CD55
GH01J206752 Enhancer 0.9 FANTOM5 Ensembl 16.7 +21.0 21040 3.8 RNF2 ZNF512 JUND PRDM1 MTA2 ZSCAN4 MTA1 ZNF24 ZNF512B YBX3 LOC105372877 MAPKAPK2 IL10 IL24 IL20 PIGR FCAMR EIF2D RASSF5 IL19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IL10 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IL10

Top Transcription factor binding sites by QIAGEN in the IL10 gene promoter:
  • CREB
  • deltaCREB
  • GR
  • GR-alpha
  • GR-beta
  • Pbx1a
  • Sp1
  • STAT3

Genomic Locations for IL10 Gene

Genomic Locations for IL10 Gene
chr1:206,767,602-206,774,541
(GRCh38/hg38)
Size:
6,940 bases
Orientation:
Minus strand
chr1:206,940,947-206,945,839
(GRCh37/hg19)
Size:
4,893 bases
Orientation:
Minus strand

Genomic View for IL10 Gene

Genes around IL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IL10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IL10 Gene

Proteins for IL10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22301-IL10_HUMAN
    Recommended name:
    Interleukin-10
    Protein Accession:
    P22301

    Protein attributes for IL10 Gene

    Size:
    178 amino acids
    Molecular mass:
    20517 Da
    Quaternary structure:
    • Homodimer (PubMed:11485736, PubMed:15837194). Interacts with IL10RA and IL10RB (PubMed:16982608).

    Three dimensional structures from OCA and Proteopedia for IL10 Gene

neXtProt entry for IL10 Gene

Protein Expression for IL10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IL10 Gene

  • Glycosylation at Asn134

Other Protein References for IL10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for IL10

Protein Products

  • Abcam proteins for IL10

Assay Products

No data available for DME Specific Peptides for IL10 Gene

Domains & Families for IL10 Gene

Gene Families for IL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IL10 Gene

InterPro:
Blocks:
  • Interleukin-10
ProtoNet:

Suggested Antigen Peptide Sequences for IL10 Gene

GenScript: Design optimal peptide antigens:
  • Interleukin 10 (B3VI66_HUMAN)
  • Cytokine synthesis inhibitory factor (IL10_HUMAN)
  • Interleukin 10 (Q5VUT4_HUMAN)
  • IL10 protein (Q6FGS9_HUMAN)
  • Interleukin 10 (Q6FGW4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P22301

UniProtKB/Swiss-Prot:

IL10_HUMAN :
  • Belongs to the IL-10 family.
Family:
  • Belongs to the IL-10 family.
genes like me logo Genes that share domains with IL10: view

Function for IL10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IL10 Gene

UniProtKB/Swiss-Prot Function:
Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3 (PubMed:16982608). In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators (PubMed:18025162). Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF-alpha (PubMed:1940799, PubMed:7512027, PubMed:11564774). Interferes also with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (PubMed:8144879). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity).
GENATLAS Biochemistry:
interleukin 10,20.5kDa,cytokine synthesis inhibitory factor,costimulator of proliferation and differentiation of B,T,mast cell

Phenotypes From GWAS Catalog for IL10 Gene

Gene Ontology (GO) - Molecular Function for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA,NAS 10443688
GO:0005141 interleukin-10 receptor binding NAS 1847510
GO:0005515 protein binding IPI 11485736
GO:0008083 growth factor activity NAS 1371884
GO:0046983 protein dimerization activity IDA 16982608
genes like me logo Genes that share ontologies with IL10: view
genes like me logo Genes that share phenotypes with IL10: view

Human Phenotype Ontology for IL10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IL10 Gene

MGI Knock Outs for IL10:

Animal Model Products

CRISPR Products

Transcription Factor Targets for IL10 Gene

Selected GeneGlobe predicted Target genes for IL10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL10

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for IL10 Gene

Localization for IL10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IL10 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IL10 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 3
endosome 3
cytosol 3
lysosome 3
peroxisome 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA,IDA 10443688
genes like me logo Genes that share ontologies with IL10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IL10 Gene

Pathways & Interactions for IL10 Gene

PathCards logo

SuperPathways for IL10 Gene

SuperPathway Contained pathways
1 PEDF Induced Signaling
MIF Mediated Glucocorticoid Regulation
.94
MIF Regulation of Innate Immune Cells
.94
PEDF Induced Signaling
.73
all-trans-Retinoic Acid Signaling in Brain
.71
RAR-Gamma-RXR-Alpha Degradation
.62
IL-6 Pathway
.61
NFAT Signaling and Lymphocyte Interactions
.57
PGC1Alpha Pathway
.51
STAT3 Pathway
.47
Endothelin-1 Signaling Pathway
.46
Glucocorticoid Receptor Signaling
.43
Cytokine-cytokine receptor interaction
.43
2 Allograft rejection
Allograft rejection
.65
Autoimmune thyroid disease
.60
Allograft Rejection
.46
Asthma
.44
THC Differentiation Pathway
.39
Intestinal immune network for IgA production
.38
3 TGF-Beta Pathway
MAPK Family Pathway
.60
TGF-Beta Pathway
.60
JAK-STAT Pathway
.57
Regulation of eIF4 and p70S6K
.43
SOCS Pathway
.41
4 Akt Signaling
Akt Signaling
.60
p38 Signaling
.60
Tec Kinases Signaling
.55
5 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
Molecular Mechanisms of Cancer
.51
genes like me logo Genes that share pathways with IL10: view

Pathways by source for IL10 Gene

2 GeneGo (Thomson Reuters) pathways for IL10 Gene
  • Apoptosis and survival APRIL and BAFF signaling
  • Immune response IL-10 signaling pathway
28 Qiagen pathways for IL10 Gene
  • Akt Signaling
  • all-trans-Retinoic Acid Signaling in Brain
  • Antioxidant Action of Vitamin-C
  • Cytokine Network
  • Endothelin-1 Signaling Pathway
1 Cell Signaling Technology pathway for IL10 Gene
1 GeneTex pathway for IL10 Gene

SIGNOR curated interactions for IL10 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001818 negative regulation of cytokine production IEA,IDA 1940799
GO:0001938 positive regulation of endothelial cell proliferation IEA --
GO:0002237 response to molecule of bacterial origin IDA 17449476
GO:0002719 negative regulation of cytokine production involved in immune response IDA 10443688
GO:0002740 negative regulation of cytokine secretion involved in immune response IDA --
genes like me logo Genes that share ontologies with IL10: view

Drugs & Compounds for IL10 Gene

Products:

  1. Drug

(118) Drugs for IL10 Gene - From: DrugBank, PharmGKB, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved, Investigational Pharma 427,427
Niacin Approved, Investigational Nutra Agonist, Unknown, Full agonist 432,432
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibitor, Inhibition Immunosuppressive agent, Calcineurin inhibitor 0
Methotrexate Approved Pharma Folate antagonist,inhibits DFHR 1825
Mycophenolate mofetil Approved, Investigational Pharma IMPDH inhibitor 0

(50) Additional Compounds for IL10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IL10: view

Transcripts for IL10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IL10 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IL10

Alternative Splicing Database (ASD) splice patterns (SP) for IL10 Gene

No ASD Table

Relevant External Links for IL10 Gene

GeneLoc Exon Structure for
IL10

Expression for IL10 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IL10 Gene

mRNA expression in normal human tissues for IL10 Gene
mRNA expression by BioGPS for IL10 GenemRNA expression by GTEx for IL10 Gene

mRNA differential expression in normal tissues according to GTEx for IL10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.3), Whole Blood (x6.1), and Spleen (x5.0).

Protein differential expression in normal tissues from HIPED for IL10 Gene

This gene is overexpressed in Tlymphocyte (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IL10 Gene



Protein tissue co-expression partners for IL10 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IL10

SOURCE GeneReport for Unigene cluster for IL10 Gene:

Hs.193717

mRNA Expression by UniProt/SwissProt for IL10 Gene:

P22301-IL10_HUMAN
Tissue specificity: Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.

Evidence on tissue expression from TISSUES for IL10 Gene

  • Blood(4.8)
  • Lymph node(4)
  • Spleen(4)
  • Intestine(3.7)
  • Nervous system(3.6)
  • Bone marrow(3.6)
  • Liver(3.5)
  • Heart(3.4)
  • Kidney(3.4)
  • Skin(3.3)
  • Pancreas(3.3)
  • Muscle(3.2)
  • Lung(3.2)
  • Bone(2.9)
  • Stomach(2.7)
  • Adrenal gland(2.7)
  • Urine(2.7)
  • Eye(2.6)
  • Saliva(2.6)
  • Thyroid gland(2.4)
  • Gall bladder(2.4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IL10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
Thorax:
  • esophagus
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • anus
  • penis
  • rectum
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with IL10: view

Orthologs for IL10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IL10 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia IL10 30 31
  • 99.63 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia IL10 30 31
  • 84.56 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia IL10 30 31
  • 83.43 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Il10 30
  • 82.21 (n)
Mouse
(Mus musculus)
 Mammalia Il10 30 17 31
  • 81.09 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia IL10 31
  • 59 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia IL10 31
  • 52 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves IL10 30 31
  • 57.89 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia IL10 31
  • 51 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia il10 30
  • 59.1 (n)
Zebrafish
(Danio rerio)
 Actinopterygii il10 30 31
  • 47.78 (n)
 OneToOne
Species where no ortholog for IL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IL10 Gene

ENSEMBL:
Gene Tree for IL10 (if available)
TreeFam:
Gene Tree for IL10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IL10: view image

Paralogs for IL10 Gene

Paralogs for IL10 Gene

genes like me logo Genes that share paralogs with IL10: view

Variants for IL10 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Polymorphic Variants from UniProtKB/Swiss-Prot for IL10 Gene

IL10_HUMAN-P22301
A polymorphism in IL10 promoter region is associated with resistance to graft-versus-host disease (GVHDS) [MIM:614395]. GVHDS is a major complication of allogeneic bone marrow transplantation, in which mature donor T-cells that contaminate the allogeneic bone marrow recognize the tissues of the recipient as foreign, causing a severe inflammatory disease.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IL10 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
662170 Uncertain Significance: Inflammatory bowel disease 206,768,659(-) T/C MISSENSE_VARIANT
726782 Likely Benign: not provided 206,772,388(-) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
729261 Likely Benign: Inflammatory bowel disease 206,772,380(-) C/T MISSENSE_VARIANT,INTRON_VARIANT
729486 Benign: Inflammatory bowel disease 206,772,263(-) A/G INTRON_VARIANT
745482 Likely Benign: Inflammatory bowel disease 206,770,940(-) G/A SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for IL10 Gene

Structural Variations from Database of Genomic Variants (DGV) for IL10 Gene

Variant ID Type Subtype PubMed ID
esv3578391 CNV loss 25503493

Variation tolerance for IL10 Gene

Residual Variation Intolerance Score: 69% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IL10 Gene

Human Gene Mutation Database (HGMD)
IL10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IL10

SNP Genotyping and Copy Number Assay Products

Disorders for IL10 Gene

MalaCards: The human disease database

(464) MalaCards diseases for IL10 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
graft-versus-host disease
  • graft-versus-host disease, susceptibility to
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
inflammatory bowel disease 25, autosomal recessive
  • ibd25
rheumatoid arthritis
  • ra
chagas disease
  • american trypanosomiasis
- elite association - COSMIC cancer census association via MalaCards
Search IL10 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IL10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IL10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IL10 Gene

Publications for IL10 Gene

  1. Environmental and genetic factors influence the relationship between circulating IL-10 and obesity phenotypes. (PMID: 19798061) Bassols J … Fernandez-Real JM (Obesity (Silver Spring, Md.) 2010) 3 23 41
  2. Interleukin (IL)-1beta, IL-1 receptor antagonist, IL-6, IL-8, IL-10, and tumor necrosis factor alpha gene polymorphisms in patients with febrile seizures. (PMID: 20486195) Chou IC … Tsai FJ (Journal of clinical laboratory analysis 2010) 3 23 41
  3. Gene-gene and gene - clinical factors interaction in acute myocardial infarction: a new detailed risk chart. (PMID: 20388088) Licastro F … Ferrari R (Current pharmaceutical design 2010) 3 23 41
  4. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: the Cardiovascular Risk in Young Finns Study. (PMID: 19700159) Heiskanen M … Hulkkonen J (Atherosclerosis 2010) 3 23 41
  5. Interaction among variant vascular endothelial growth factor (VEGF) and its receptor in relation to prostate cancer risk. (PMID: 19908237) VanCleave TT … Kidd LC (The Prostate 2010) 3 23 41

ExternalLinks

View latest publications for IL10 gene in Mastermind

Products for IL10 Gene