Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] See more...

Aliases for IKZF5 Gene

Aliases for IKZF5 Gene

  • IKAROS Family Zinc Finger 5 2 3 5
  • Zinc Finger Protein, Subfamily 1A, 5 (Pegasus) 2 3
  • Zinc Finger Protein Pegasus 3 4
  • ZNFN1A5 3 4
  • Zinc Finger Transcription Factor Pegasus 3
  • IKAROS Family Zinc Finger 5 (Pegasus) 2
  • Zinc Finger Protein, Subfamily 1A, 5 2
  • Ikaros Family Zinc Finger Protein 5 4
  • PEGASUS 3

External Ids for IKZF5 Gene

Previous HGNC Symbols for IKZF5 Gene

  • ZNFN1A5

Previous GeneCards Identifiers for IKZF5 Gene

  • GC10M124740
  • GC10M118370

Summaries for IKZF5 Gene

Entrez Gene Summary for IKZF5 Gene

  • Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

GeneCards Summary for IKZF5 Gene

IKZF5 (IKAROS Family Zinc Finger 5) is a Protein Coding gene. An important paralog of this gene is ZFAT.

UniProtKB/Swiss-Prot Summary for IKZF5 Gene

  • DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.

Additional gene information for IKZF5 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKZF5 Gene

Genomics for IKZF5 Gene

GeneHancer (GH) Regulatory Elements for IKZF5 Gene

Promoters and enhancers for IKZF5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J123007 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.1 149 3.4 ZNF217 EP300 ZSCAN5C SIN3A NRF1 USF1 POLR2G SP1 PHF8 ZFX ACADSB IKZF5 lnc-IKZF5-1 BTBD16 C10orf88
GH10J122979 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.6 +28.2 28249 2 ZBTB40 ZNF217 EP300 CTCF MYC NRF1 POLR2G SP1 JUND PHF8 PSTK ACADSB IKZF5 BTBD16 C10orf88 lnc-IKZF5-1
GH10J122952 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.6 +55.2 55150 3 ZBTB40 ZNF217 EP300 ZSCAN5C TCF12 SIN3A NRF1 USF1 POLR2G SP1 C10orf88 PSTK lnc-IKZF5-2 BUB3 NSMCE4A IKZF5
GH10J123139 Enhancer 0.9 ENCODE 20.2 -130.5 -130474 1.7 POLR2G TCF7 AFF1 REST MYC TGIF2 CTBP1 ZBTB26 TEAD1 TAF9B IKZF5 C10orf88 ACADSB HMX2 HMX3
GH10J122306 Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.8 +699.4 699446 6.5 EP300 FOXK2 ZSCAN5C TCF12 POLR2G NCOR1 JUND FOS ZNF10 ZIC2 BTBD16 IKZF5 BUB3 NSMCE4A HSALNG0081195 HSALNG0081198
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IKZF5 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKZF5

Top Transcription factor binding sites by QIAGEN in the IKZF5 gene promoter:
  • E47
  • GATA-1
  • GR
  • GR-alpha
  • GR-beta
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • STAT5B
  • Tal-1

Genomic Locations for IKZF5 Gene

Genomic Locations for IKZF5 Gene
chr10:122,990,806-123,008,850
(GRCh38/hg38)
Size:
18,045 bases
Orientation:
Minus strand
chr10:124,750,322-124,768,333
(GRCh37/hg19)
Size:
18,012 bases
Orientation:
Minus strand

Genomic View for IKZF5 Gene

Genes around IKZF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKZF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKZF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF5 Gene

Proteins for IKZF5 Gene

  • Protein details for IKZF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H5V7-IKZF5_HUMAN
    Recommended name:
    Zinc finger protein Pegasus
    Protein Accession:
    Q9H5V7
    Secondary Accessions:
    • B3KVH7
    • D3DRE7
    • Q9H2T0

    Protein attributes for IKZF5 Gene

    Size:
    419 amino acids
    Molecular mass:
    46510 Da
    Quaternary structure:
    • Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 AND IKZF4.
    Miscellaneous:
    • 'Pegasus' was the winged horse in Greek mythology.

neXtProt entry for IKZF5 Gene

Post-translational modifications for IKZF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IKZF5 Gene

Domains & Families for IKZF5 Gene

Gene Families for IKZF5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for IKZF5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IKZF5 Gene

GenScript: Design optimal peptide antigens:
  • Ikaros family zinc finger protein 5 (IKZF5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H5V7

UniProtKB/Swiss-Prot:

IKZF5_HUMAN :
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
Domain:
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • C-terminal zinc fingers mediate homodimerization.
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with IKZF5: view

Function for IKZF5 Gene

Molecular function for IKZF5 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor.

Phenotypes From GWAS Catalog for IKZF5 Gene

Gene Ontology (GO) - Molecular Function for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 10978333
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 10978333
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
genes like me logo Genes that share ontologies with IKZF5: view
genes like me logo Genes that share phenotypes with IKZF5: view

Animal Models for IKZF5 Gene

MGI Knock Outs for IKZF5:
  • Ikzf5 Ikzf5<tm1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKZF5 Gene

Localization for IKZF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKZF5 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
GO:0032991 protein-containing complex IMP 15491138
genes like me logo Genes that share ontologies with IKZF5: view

Pathways & Interactions for IKZF5 Gene

PathCards logo

SuperPathways for IKZF5 Gene

No Data Available

SIGNOR curated interactions for IKZF5 Gene

Activates:

Gene Ontology (GO) - Biological Process for IKZF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 10978333
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
GO:0051291 protein heterooligomerization IMP 15491138
genes like me logo Genes that share ontologies with IKZF5: view

No data available for Pathways by source for IKZF5 Gene

Drugs & Compounds for IKZF5 Gene

No Compound Related Data Available

Transcripts for IKZF5 Gene

mRNA/cDNA for IKZF5 Gene

10 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF5

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6:
SP7: - -
SP8:

Relevant External Links for IKZF5 Gene

GeneLoc Exon Structure for
IKZF5

Expression for IKZF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IKZF5 Gene

Protein differential expression in normal tissues from HIPED for IKZF5 Gene

This gene is overexpressed in Adrenal (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IKZF5 Gene



Protein tissue co-expression partners for IKZF5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IKZF5

SOURCE GeneReport for Unigene cluster for IKZF5 Gene:

Hs.501289

mRNA Expression by UniProt/SwissProt for IKZF5 Gene:

Q9H5V7-IKZF5_HUMAN
Tissue specificity: Expressed in brain, heart, skeletal muscle, kidney, and liver. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.

Evidence on tissue expression from TISSUES for IKZF5 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with IKZF5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF5 Gene

Orthologs for IKZF5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKZF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF5 31 30
  • 99.68 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IKZF5 31
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IKZF5 31
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IKZF5 31 30
  • 93.79 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ikzf5 30
  • 92.28 (n)
cow
(Bos Taurus)
Mammalia IKZF5 31 30
  • 91.81 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf5 17 31 30
  • 91.25 (n)
chicken
(Gallus gallus)
Aves IKZF5 31 30
  • 82.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IKZF5 31
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf5 30
  • 75.66 (n)
zebrafish
(Danio rerio)
Actinopterygii ikzf5 31 30
  • 67.49 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.781 31
  • 18 (a)
OneToOne
Species where no ortholog for IKZF5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKZF5 Gene

ENSEMBL:
Gene Tree for IKZF5 (if available)
TreeFam:
Gene Tree for IKZF5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IKZF5: view image

Paralogs for IKZF5 Gene

Variants for IKZF5 Gene

Additional dbSNP identifiers (rs#s) for IKZF5 Gene

Structural Variations from Database of Genomic Variants (DGV) for IKZF5 Gene

Variant ID Type Subtype PubMed ID
nsv7586 CNV insertion 18451855
nsv832010 CNV gain 17160897

Variation tolerance for IKZF5 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IKZF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKZF5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IKZF5 Gene

Disorders for IKZF5 Gene

Additional Disease Information for IKZF5

No disorders were found for IKZF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKZF5 Gene

Publications for IKZF5 Gene

  1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 2 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions. (PMID: 30217970) Yang JS … Maurer SP (Nature communications 2018) 3 54
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 54

Products for IKZF5 Gene

Sources for IKZF5 Gene