Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] See more...

Aliases for IKZF4 Gene

Aliases for IKZF4 Gene

  • IKAROS Family Zinc Finger 4 2 3 5
  • Zinc Finger Protein, Subfamily 1A, 4 (Eos) 2 3
  • Ikaros Family Zinc Finger Protein 4 3 4
  • Zinc Finger Protein Eos 3 4
  • ZNFN1A4 3 4
  • Zinc Finger Transcription Factor Eos 3
  • IKAROS Family Zinc Finger 4 (Eos) 2
  • KIAA1782 4
  • IKZF4 5
  • EOS 3
  • Eos 2

External Ids for IKZF4 Gene

Previous HGNC Symbols for IKZF4 Gene

  • ZNFN1A4

Previous GeneCards Identifiers for IKZF4 Gene

  • GC12P054705
  • GC12P056414
  • GC12P053453

Summaries for IKZF4 Gene

Entrez Gene Summary for IKZF4 Gene

  • Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

GeneCards Summary for IKZF4 Gene

IKZF4 (IKAROS Family Zinc Finger 4) is a Protein Coding gene. Diseases associated with IKZF4 include Alopecia Areata and Sulfite Oxidase Deficiency, Isolated. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is IKZF2.

UniProtKB/Swiss-Prot Summary for IKZF4 Gene

  • DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

Gene Wiki entry for IKZF4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKZF4 Gene

Genomics for IKZF4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IKZF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IKZF4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKZF4

Top Transcription factor binding sites by QIAGEN in the IKZF4 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • FAC1
  • GATA-1
  • GATA-2
  • GATA-3
  • Nkx6-1
  • STAT5A

Genomic Locations for IKZF4 Gene

Genomic Locations for IKZF4 Gene
chr12:56,007,504-56,038,435
(GRCh38/hg38)
Size:
30,932 bases
Orientation:
Plus strand
chr12:56,401,443-56,432,219
(GRCh37/hg19)
Size:
30,777 bases
Orientation:
Plus strand

Genomic View for IKZF4 Gene

Genes around IKZF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKZF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKZF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF4 Gene

Proteins for IKZF4 Gene

  • Protein details for IKZF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2S9-IKZF4_HUMAN
    Recommended name:
    Zinc finger protein Eos
    Protein Accession:
    Q9H2S9
    Secondary Accessions:
    • Q96JP3

    Protein attributes for IKZF4 Gene

    Size:
    585 amino acids
    Molecular mass:
    64106 Da
    Quaternary structure:
    • Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 and IKZF5. Interacts with CTBP2. Interacts with SPI1, MITF, FOXP3 and CTBP1 (By similarity).
    SequenceCaution:
    • Sequence=AAG39221.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB47411.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • 'Eos' means 'rising sun' in Greek.

    Three dimensional structures from OCA and Proteopedia for IKZF4 Gene

    Alternative splice isoforms for IKZF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKZF4 Gene

Post-translational modifications for IKZF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for IKZF4 Gene

Domains & Families for IKZF4 Gene

Gene Families for IKZF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for IKZF4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IKZF4 Gene

GenScript: Design optimal peptide antigens:
  • Ikaros family zinc finger protein 4 (IKZF4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H2S9

UniProtKB/Swiss-Prot:

IKZF4_HUMAN :
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
Domain:
  • The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
  • C-terminal zinc fingers mediate homodimerization.
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with IKZF4: view

Function for IKZF4 Gene

Molecular function for IKZF4 Gene

UniProtKB/Swiss-Prot Function:
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).

Phenotypes From GWAS Catalog for IKZF4 Gene

Gene Ontology (GO) - Molecular Function for IKZF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA,TAS 10978333
GO:0005515 protein binding IPI 15491138
genes like me logo Genes that share ontologies with IKZF4: view
genes like me logo Genes that share phenotypes with IKZF4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IKZF4 Gene

Localization for IKZF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKZF4 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 2
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IKZF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10978333
GO:0005654 nucleoplasm IBA,IDA --
GO:0016604 nuclear body IDA --
GO:0032991 protein-containing complex IMP 15491138
genes like me logo Genes that share ontologies with IKZF4: view

Pathways & Interactions for IKZF4 Gene

PathCards logo

SuperPathways for IKZF4 Gene

No Data Available

SIGNOR curated interactions for IKZF4 Gene

Activates:

Gene Ontology (GO) - Biological Process for IKZF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated TAS 10978333
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
GO:0051260 protein homooligomerization IMP 15491138
genes like me logo Genes that share ontologies with IKZF4: view

No data available for Pathways by source for IKZF4 Gene

Drugs & Compounds for IKZF4 Gene

No Compound Related Data Available

Transcripts for IKZF4 Gene

mRNA/cDNA for IKZF4 Gene

5 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF4

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF4 Gene

No ASD Table

Relevant External Links for IKZF4 Gene

GeneLoc Exon Structure for
IKZF4

Expression for IKZF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IKZF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IKZF4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IKZF4 Gene



Protein tissue co-expression partners for IKZF4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IKZF4

SOURCE GeneReport for Unigene cluster for IKZF4 Gene:

Hs.553221

mRNA Expression by UniProt/SwissProt for IKZF4 Gene:

Q9H2S9-IKZF4_HUMAN
Tissue specificity: Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.

Evidence on tissue expression from TISSUES for IKZF4 Gene

  • Nervous system(4.6)
  • Blood(2.8)
genes like me logo Genes that share expression patterns with IKZF4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF4 Gene

Orthologs for IKZF4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for IKZF4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia IKZF4 30 31
  • 99.62 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia IKZF4 30 31
  • 94.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia IKZF4 30 31
  • 93.56 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ikzf4 30 17 31
  • 92.42 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia IKZF4 31
  • 91 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 74 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves IKZF4 30
  • 80.75 (n)
Lizard
(Anolis carolinensis)
Reptilia IKZF4 31
  • 80 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ikzf4 30
  • 74.15 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:dkey-166n8.9 30
  • 65.26 (n)
IKZF4 31
  • 57 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes STP1 33
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10790 31
  • 26 (a)
OneToMany
Species where no ortholog for IKZF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IKZF4 Gene

ENSEMBL:
Gene Tree for IKZF4 (if available)
TreeFam:
Gene Tree for IKZF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IKZF4: view image

Paralogs for IKZF4 Gene

(35) SIMAP similar genes for IKZF4 Gene using alignment to 4 proteins:

  • IKZF4_HUMAN
  • F8VPL6_HUMAN
  • F8VW19_HUMAN
  • G5E9S4_HUMAN
genes like me logo Genes that share paralogs with IKZF4: view

Variants for IKZF4 Gene

Additional dbSNP identifiers (rs#s) for IKZF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for IKZF4 Gene

Variant ID Type Subtype PubMed ID
nsv1051961 CNV gain 25217958
nsv1119959 CNV deletion 24896259
nsv1138138 CNV deletion 24896259
nsv832424 CNV loss 17160897
nsv832427 CNV loss 17160897

Variation tolerance for IKZF4 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.60; 30.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IKZF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKZF4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IKZF4 Gene

Disorders for IKZF4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for IKZF4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alopecia areata
  • aa
sulfite oxidase deficiency, isolated
  • isod
- elite association - COSMIC cancer census association via MalaCards
Search IKZF4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IKZF4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with IKZF4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IKZF4 Gene

Publications for IKZF4 Gene

  1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 2 3 4 23
  2. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PMID: 20596022) Petukhova L … Christiano AM (Nature 2010) 3 41
  3. A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PMID: 18198356) Hakonarson H … Polychronakos C (Diabetes 2008) 3 41
  4. The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. (PMID: 12444977) Perdomo J … Crossley M (European journal of biochemistry 2002) 3 4
  5. A molecular dissection of the repression circuitry of Ikaros. (PMID: 12015313) Koipally J … Georgopoulos K (The Journal of biological chemistry 2002) 3 4

Products for IKZF4 Gene

Sources for IKZF4 Gene