Aliases for IKZF4 Gene
Aliases for IKZF4 Gene
External Ids for IKZF4 Gene
- HGNC: 13179
- Entrez Gene: 64375
- Ensembl: ENSG00000123411
- OMIM: 606239
- UniProtKB: Q9H2S9
Previous HGNC Symbols for IKZF4 Gene
- ZNFN1A4
Previous GeneCards Identifiers for IKZF4 Gene
- GC12P054705
- GC12P056414
- GC12P053453
Summaries for IKZF4 Gene
-
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
GeneCards Summary for IKZF4 Gene
IKZF4 (IKAROS Family Zinc Finger 4) is a Protein Coding gene. Diseases associated with IKZF4 include Alopecia Areata. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is IKZF2.
UniProtKB/Swiss-Prot for IKZF4 Gene
-
DNA-binding protein that binds to the 5GGGAATRCC-3 Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).
Additional gene information for IKZF4 Gene
- Monarch Initiative
- Search for IKZF4 at DataMed
- Search for IKZF4 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF4 Gene
Genomics for IKZF4 Gene
GeneHancer (GH) Regulatory Elements for IKZF4 Gene
Promoters and enhancers for IKZF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around IKZF4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the IKZF4 gene promoter:
-
- AP-2gamma
- AP-2beta
- AP-2alphaA
- AP-2alpha
- STAT5A
- GATA-3
- GATA-1
- GATA-2
- Nkx6-1
- FAC1
Regulatory Element Products
Genomic Locations for IKZF4 Gene
Genomic Locations for IKZF4 Gene
- chr12:56,007,647-56,038,435
- (GRCh38/hg38)
- Size:
- 30,789 bases
- Orientation:
- Plus strand
- chr12:56,401,443-56,432,219
- (GRCh37/hg19)
- Size:
- 30,777 bases
- Orientation:
- Plus strand
Genomic View for IKZF4 Gene
Genes around IKZF4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by Entrez Gene
- 12q13.2 by HGNC
- 12q13.2 by Ensembl
IKZF4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IKZF4 Gene
Proteins for IKZF4 Gene
-
Protein details for IKZF4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H2S9-IKZF4_HUMAN
- Recommended name:
- Zinc finger protein Eos
- Protein Accession:
- Q9H2S9
- Q96JP3
Protein attributes for IKZF4 Gene
- Size:
- 585 amino acids
- Molecular mass:
- 64106 Da
- Quaternary structure:
-
- Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 and IKZF5. Interacts with CTBP2. Interacts with SPI1, MITF, FOXP3 and CTBP1 (By similarity).
- Miscellaneous:
-
- Eos means rising sun in Greek.
- SequenceCaution:
-
- Sequence=AAG39221.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB47411.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for IKZF4 Gene
Post-translational modifications for IKZF4 Gene
Other Protein References for IKZF4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005269143.1
- XP_016875304.1
- NP_071910.3
- NP_001338018.1
- XP_016875303.1
- XP_016875294.1
- XP_011536966.1
- XP_016875305.1
- XP_024304897.1
- XP_016875298.1
- NP_001338020.1
- XP_016875295.1
- NP_001338019.1
- XP_016875300.1
- XP_024304899.1
- XP_016875296.1
- XP_011536971.1
- XP_024304896.1
- XP_016875299.1
- XP_016875302.1
- NP_001338021.1
- XP_024304898.1
- XP_016875297.1
- XP_016875301.1
- XP_005269146.1
Antibody Products
- Novus Biologicals Antibodies for IKZF4
-
Abcam antibodies for IKZF4
- Invitrogen Antibodies for IKZF4 (AFLGC-IKZF4)
- GeneTex IKZF4 Antibody for IKZF4
-
Boster Bio Antibodies for IKZF4
Protein Products
-
OriGene Purified Proteins for IKZF4
- Search Origene for MassSpec and Protein Over-expression Lysates for IKZF4
- Origene Custom Protein Services for IKZF4
- antibodies-online: Search results for 4 available IKZF4 Proteins ranked by validation data
- Compare Top IKZF4 Proteins
-
Quality Products:
- Search GeneTex for Proteins for IKZF4
-
Abcam proteins for IKZF4
Assay Products
- antibodies-online: Search results for 1 available IKZF4 Elisa Kits ranked by validation data
- Compare Top IKZF4 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for IKZF4 Gene
Domains & Families for IKZF4 Gene
Gene Families for IKZF4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for IKZF4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IKZF4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H2S9UniProtKB/Swiss-Prot:
IKZF4_HUMAN :- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
- Domain:
-
- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- C-terminal zinc fingers mediate homodimerization.
- Family:
-
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
Function for IKZF4 Gene
Molecular function for IKZF4 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-binding protein that binds to the 5GGGAATRCC-3 Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).
Phenotypes From GWAS Catalog for IKZF4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | TAS | 10978333 |
| GO:0008270 | zinc ion binding | IMP | 15491138 |
| GO:0019904 | protein domain specific binding | IPI | 15491138 |
Phenotypes for IKZF4 Gene
- GenomeRNAi human phenotypes for IKZF4:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased homologous recombination repair frequency
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Downregulation of Wnt pathway after Wnt3A stimulation
- Decreased shRNA abundance
- Increased Nanog expression
- Decreased viability
- no effect
- Decreased Aire reporter expression
- Increased vaccinia virus (VACV) infection
- Decreased viability after Maraba virus infection
- Decreased NF-kappaB reporter expression
- Increased viability
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for IKZF4
-
CRISPR Products
-
OriGene CRISPR knockouts for IKZF4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IKZF4
- genomics-online: gRNA clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials CRISPR for IKZF4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF4
- GenScript: Design CRISPR guide RNA sequences for IKZF4
miRNA for IKZF4 Gene
- miRTarBase miRNAs that target IKZF4
-
- hsa-mir-130b-3p (MIRT020311)
- hsa-mir-93-5p (MIRT028174)
- hsa-mir-30b-5p (MIRT046120)
- hsa-mir-30c-5p (MIRT047855)
- hsa-mir-32-5p (MIRT049855)
- hsa-mir-16-5p (MIRT051190)
- hsa-mir-125b-5p (MIRT054202)
- hsa-mir-190a-3p (MIRT338331)
- hsa-mir-656-3p (MIRT338333)
- hsa-mir-3924 (MIRT338334)
- hsa-mir-5011-5p (MIRT338335)
- hsa-mir-1277-5p (MIRT511369)
- hsa-mir-548c-3p (MIRT511370)
- hsa-mir-3920 (MIRT523021)
- hsa-mir-4801 (MIRT523022)
- hsa-mir-4731-3p (MIRT523023)
- hsa-mir-4762-3p (MIRT567154)
- hsa-mir-3192-3p (MIRT567155)
- hsa-mir-29a-5p (MIRT567156)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IKZF4
- Browse OriGene Inhibitory RNA Products For IKZF4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF4
- genomics-online: shRNA clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
Clone Products
- Sino Biological Human cDNA Clone for IKZF4
- Addgene plasmids for IKZF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF4
- genomics-online: cdna clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- orf clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials Clones for IKZF4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IKZF4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IKZF4 Gene
Localization for IKZF4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IKZF4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10978333 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
| GO:0032991 | protein-containing complex | IMP | 15491138 |
Pathways & Interactions for IKZF4 Gene
No Data Available
Interacting Proteins for IKZF4 Gene
GPS-Prot Interaction Network for IKZF4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | TAS | 10978333 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | -- |
| GO:0051260 | protein homooligomerization | IMP | 15491138 |
No data available for Pathways by source and SIGNOR curated interactions for IKZF4 Gene
Transcripts for IKZF4 Gene
mRNA/cDNA for IKZF4 Gene
- (25) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (100) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000262032 5229 bps (uc058pgc.1)
- ENST00000548601 696 bps (uc058pgd.1)
- ENST00000550860 543 bps (uc058pgf.1)
- ENST00000552689 420 bps (uc058pgg.1)
- ENST00000549519 492 bps (uc058pgh.1)
Unigene Clusters for IKZF4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for IKZF4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IKZF4
- genomics-online: gRNA clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials CRISPR for IKZF4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF4
- GenScript: Design CRISPR guide RNA sequences for IKZF4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IKZF4
- Browse OriGene Inhibitory RNA Products For IKZF4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF4
- genomics-online: shRNA clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
Clone Products
- Sino Biological Human cDNA Clone for IKZF4
- Addgene plasmids for IKZF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF4
- genomics-online: cdna clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- orf clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- Applied Biological Materials Clones for IKZF4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for IKZF4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thyroid (Endocrine System)
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IKZF4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IKZF4 Gene:
IKZF4SOURCE GeneReport for Unigene cluster for IKZF4 Gene:
Hs.553221mRNA Expression by UniProt/SwissProt for IKZF4 Gene:
Q9H2S9-IKZF4_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
Evidence on tissue expression from TISSUES for IKZF4 Gene
- Nervous system(4.5)
- Blood(2)
Primer Products
-
OriGene qPCR primer pairs for IKZF4
-
OriGene qPCR primer pairs and template standards for IKZF4
- genomics-online: primer clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
-
Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF4 Gene
Orthologs for IKZF4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IKZF4 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | IKZF4 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | IKZF4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ikzf4 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IKZF4 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| -- 34 |
|
ManyToMany | |||
| chicken (Gallus gallus) |
Aves | IKZF4 33 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | IKZF4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ikzf4 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-166n8.9 33 |
|
||
| IKZF4 34 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STP1 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.10790 34 |
|
OneToMany |
- Species where no ortholog for IKZF4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for IKZF4 Gene
- ENSEMBL:
- Gene Tree for IKZF4 (if available)
- TreeFam:
- Gene Tree for IKZF4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IKZF4: view image
Paralogs for IKZF4 Gene
(35) SIMAP similar genes for IKZF4 Gene using alignment to 4 proteins:
- IKZF4_HUMAN
- F8VPL6_HUMAN
- F8VW19_HUMAN
- G5E9S4_HUMAN
Variants for IKZF4 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000101620 | -- | 56,026,080(+) | C/G/T | intron_variant | |
| rs1000200670 | -- | 56,027,699(+) | G/A | intron_variant | |
| rs1000219368 | -- | 56,019,782(+) | A/C | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs1000382000 | -- | 56,012,713(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000416922 | -- | 56,017,617(+) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1051961 | CNV | gain | 25217958 |
| nsv1119959 | CNV | deletion | 24896259 |
| nsv1138138 | CNV | deletion | 24896259 |
| nsv832424 | CNV | loss | 17160897 |
| nsv832427 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.60;
30.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IKZF4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IKZF4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKZF4 Gene
Disorders for IKZF4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alopecia areata |
|
|
Search IKZF4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IKZF4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for IKZF4 Gene
Publications for IKZF4 Gene
- Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 2 3 4 22 58
- Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PMID: 20596022) Petukhova L … Christiano AM (Nature 2010) 3 44 58
- A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PMID: 18198356) Hakonarson H … Polychronakos C (Diabetes 2008) 3 44 58
- A molecular dissection of the repression circuitry of Ikaros. (PMID: 12015313) Koipally J … Georgopoulos K (The Journal of biological chemistry 2002) 3 4 58
- The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. (PMID: 12444977) Perdomo J … Crossley M (European journal of biochemistry 2002) 3 4 58
Products for IKZF4 Gene
- Browse R&D Systems for Antibodies
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- antibodies-online: Search results for 41 available IKZF4 Antibodies ranked by validation data
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- antibodies-online: Search results for 1 available IKZF4 Elisa Kits ranked by validation data
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- GeneTex IKZF4 Antibody for IKZF4
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- genomics-online: cdna clones - Search results for 44 available IKZF4 gene related products
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- Overview of 44 available IKZF4 gene related products
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- pPB-His-GST
- pPB-N-His
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- genomics-online: gRNA clones - Search results for 44 available IKZF4 gene related products
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- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- genomics-online: primer clones - Search results for 44 available IKZF4 gene related products
- Overview of 44 available IKZF4 gene related products
- Recommended
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
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- pCMV6-XL4
- pLenti-C-Myc-DDK
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- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
- pCMV6-Entry
- pCMV6-XL4
- pLenti-C-Myc-DDK
- pLenti-C-mGFP
- pLenti-U6-sgRNA-PGK-Neo
- pLenti-U6-sgRNA-SFFV-Cas9-2A-Puro
- pPB-His-GST
- pPB-N-His
- pPB-His-MBP
- pPB-C-His
- pRFP-C-RS
- pGFP-V-RS
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Sources for IKZF4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt