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Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002] See more...
Aliases for IKZF4 Gene
Aliases for IKZF4 Gene
External Ids for IKZF4 Gene
- HGNC: 13179
- Entrez Gene: 64375
- Ensembl: ENSG00000123411
- OMIM: 606239
- UniProtKB: Q9H2S9
Previous HGNC Symbols for IKZF4 Gene
- ZNFN1A4
Previous GeneCards Identifiers for IKZF4 Gene
- GC12P054705
- GC12P056414
- GC12P053453
Summaries for IKZF4 Gene
-
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
GeneCards Summary for IKZF4 Gene
IKZF4 (IKAROS Family Zinc Finger 4) is a Protein Coding gene. Diseases associated with IKZF4 include Alopecia Areata and Sulfite Oxidase Deficiency, Isolated. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is IKZF2.
UniProtKB/Swiss-Prot Summary for IKZF4 Gene
-
DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).
Additional gene information for IKZF4 Gene
- HGNC(13179)
- Entrez Gene(64375)
- Ensembl(ENSG00000123411)
- OMIM(606239)
- UniProtKB(Q9H2S9)
- Open Targets Platform(ENSG00000123411)
- Monarch Initiative
- Search for IKZF4 at DataMed
- Search for IKZF4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKZF4 Gene
Genomics for IKZF4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IKZF4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IKZF4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKZF4
- Top Transcription factor binding sites by QIAGEN in the IKZF4 gene promoter:
-
- AP-2alpha
- AP-2alphaA
- AP-2beta
- AP-2gamma
- FAC1
- GATA-1
- GATA-2
- GATA-3
- Nkx6-1
- STAT5A
Genomic Locations for IKZF4 Gene
Genomic Locations for IKZF4 Gene
- chr12:56,007,504-56,038,435
- (GRCh38/hg38)
- Size:
- 30,932 bases
- Orientation:
- Plus strand
- chr12:56,401,443-56,432,219
- (GRCh37/hg19)
- Size:
- 30,777 bases
- Orientation:
- Plus strand
Genomic View for IKZF4 Gene
Genes around IKZF4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by HGNC
- 12q13.2 by Entrez Gene
- 12q13.2 by Ensembl
IKZF4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IKZF4 Gene
Proteins for IKZF4 Gene
-
Protein details for IKZF4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H2S9-IKZF4_HUMAN
- Recommended name:
- Zinc finger protein Eos
- Protein Accession:
- Q9H2S9
- Q96JP3
Protein attributes for IKZF4 Gene
- Size:
- 585 amino acids
- Molecular mass:
- 64106 Da
- Quaternary structure:
-
- Self-associates. Interacts with other family members; IKZF1, IKZF2, IKZF3 and IKZF5. Interacts with CTBP2. Interacts with SPI1, MITF, FOXP3 and CTBP1 (By similarity).
- SequenceCaution:
-
- Sequence=AAG39221.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB47411.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- 'Eos' means 'rising sun' in Greek.
Protein Expression for IKZF4 Gene
Post-translational modifications for IKZF4 Gene
Other Protein References for IKZF4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005269143.1
- XP_005269146.1
- XP_011536966.1
- XP_011536971.1
- XP_016875295.1
- XP_016875296.1
- XP_016875297.1
- XP_016875298.1
- XP_016875299.1
- XP_016875300.1
- XP_016875301.1
- XP_016875302.1
- XP_016875303.1
- XP_016875304.1
- XP_016875305.1
- XP_024304896.1
- XP_024304897.1
- XP_024304898.1
- XP_024304899.1
- NP_001338018.1
- NP_001338019.1
- NP_001338020.1
- NP_001338021.1
- NP_071910.3
Antibody Products
- G Biosciences Immunotag™ IKZF4 Antibody
- GeneTex Anti-IKZF4 antibody and Anti-IKZF4 antibody [GT976]
- BioLegend EOS Antibody
- Novus Biologicals Antibodies for IKZF4
-
Abcam antibodies for IKZF4
- Invitrogen Antibodies for IKZF4 (AFLGC-IKZF4)
-
Biorbyt antibodies for IKZF4
-
Boster Bio Antibodies for IKZF4
- Sino Biological Antibodies for IKZF4
Protein Products
-
OriGene Purified Proteins for IKZF4
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- antibodies-online: Show 4 available IKZF4 Proteins ranked by validation data
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Abcam proteins for IKZF4
Assay Products
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-
Quality Products:
No data available for DME Specific Peptides for IKZF4 Gene
Domains & Families for IKZF4 Gene
Gene Families for IKZF4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for IKZF4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IKZF4 Gene
- GenScript: Design optimal peptide antigens:
-
- Ikaros family zinc finger protein 4 (IKZF4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H2S9UniProtKB/Swiss-Prot:
IKZF4_HUMAN :- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
- Domain:
-
- The N-terminal zinc fingers are involved in sequence-specific DNA binding and heterotypic associations with other family members.
- C-terminal zinc fingers mediate homodimerization.
- Family:
-
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
Function for IKZF4 Gene
Molecular function for IKZF4 Gene
- UniProtKB/Swiss-Prot Function:
- DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity).
Phenotypes From GWAS Catalog for IKZF4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IBA,TAS | 10978333 |
| GO:0005515 | protein binding | IPI | 15491138 |
Phenotypes for IKZF4 Gene
- MGI mutant phenotypes for IKZF4:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for IKZF4:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Moderately decreased NFAT1-GFP nuclear translocation
- Decreased shRNA abundance (Z-score < -2)
- Decreased shRNA abundance
- Downregulation of Wnt pathway after Wnt3A stimulation
- Inconclusive
- Decreased viability after Maraba virus infection
- Increased Nanog expression
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased Aire reporter expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IKZF4 - Select products 50% OFF >
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-
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-
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miRNA for IKZF4 Gene
- miRTarBase miRNAs that target IKZF4
-
- hsa-miR-130b-3p (MIRT020311)
- hsa-miR-93-5p (MIRT028174)
- hsa-miR-30b-5p (MIRT046120)
- hsa-miR-30c-5p (MIRT047855)
- hsa-miR-32-5p (MIRT049855)
- hsa-miR-16-5p (MIRT051190)
- hsa-miR-125b-5p (MIRT054202)
- hsa-miR-190a-3p (MIRT338331)
- hsa-miR-656-3p (MIRT338333)
- hsa-miR-3924 (MIRT338334)
- hsa-miR-5011-5p (MIRT338335)
- hsa-miR-1277-5p (MIRT511369)
- hsa-miR-548c-3p (MIRT511370)
- hsa-miR-3920 (MIRT523021)
- hsa-miR-4801 (MIRT523022)
- hsa-miR-4731-3p (MIRT523023)
- hsa-miR-4762-3p (MIRT567154)
- hsa-miR-3192-3p (MIRT567155)
- hsa-miR-29a-5p (MIRT567156)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IKZF4
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Clone Products
- Applied Biological Materials (abm): Clones for IKZF4 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for IKZF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF4
Cell Line Products
-
Horizon Cell Lines for IKZF4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IKZF4 Gene
Localization for IKZF4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IKZF4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| golgi apparatus | 1 |
- Nuclear bodies (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS | 10978333 |
| GO:0005654 | nucleoplasm | IBA,IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
| GO:0032991 | protein-containing complex | IMP | 15491138 |
Pathways & Interactions for IKZF4 Gene
Interacting Proteins for IKZF4 Gene
Selected Interacting proteins:
Q9H2S9-IKZF4_HUMAN
ENSP00000262032
for IKZF4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for IKZF4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045892 | negative regulation of transcription, DNA-templated | TAS | 10978333 |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0051260 | protein homooligomerization | IMP | 15491138 |
No data available for Pathways by source for IKZF4 Gene
Transcripts for IKZF4 Gene
mRNA/cDNA for IKZF4 Gene
- 5 REFSEQ mRNAs :
- 7 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262032 5229 nts (view in UCSC)
- ENST00000431367 5021 nts (view in UCSC)
- ENST00000547167 5313 nts (view in UCSC)
- ENST00000547556 593 nts (view in UCSC)
- ENST00000547668 552 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IKZF4 - Select products 50% OFF >
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-
OriGene CRISPR knockouts for IKZF4
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-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IKZF4
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Clone Products
- Applied Biological Materials (abm): Clones for IKZF4 - Select products 50% OFF >
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- Sino Biological Human cDNA Clone for IKZF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF4
Relevant External Links for IKZF4 Gene
- GeneLoc Exon Structure for
- IKZF4
Expression for IKZF4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
-
Thyroid (Endocrine System)
This gene is overexpressed in Peripheral blood mononuclear cells (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IKZF4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IKZF4
SOURCE GeneReport for Unigene cluster for IKZF4 Gene:
Hs.553221mRNA Expression by UniProt/SwissProt for IKZF4 Gene:
Q9H2S9-IKZF4_HUMAN
Tissue specificity:
Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
Evidence on tissue expression from TISSUES for IKZF4 Gene
- Nervous system(4.6)
- Blood(2.8)
Primer Products
-
OriGene qPCR primer pairs for IKZF4
-
OriGene qPCR primer pairs and template standards for IKZF4
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF4 Gene
Orthologs for IKZF4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IKZF4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IKZF4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IKZF4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ikzf4 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | IKZF4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Chicken (Gallus gallus) |
Aves | IKZF4 30 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | IKZF4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ikzf4 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-166n8.9 30 |
|
||
| IKZF4 31 |
|
OneToOne | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STP1 33 |
|
|
|
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10790 31 |
|
OneToMany |
- Species where no ortholog for IKZF4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IKZF4 Gene
- ENSEMBL:
- Gene Tree for IKZF4 (if available)
- TreeFam:
- Gene Tree for IKZF4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IKZF4: view image
Paralogs for IKZF4 Gene
Paralogs for IKZF4 Gene
(35) SIMAP similar genes for IKZF4 Gene using alignment to 4 proteins:
- IKZF4_HUMAN
- F8VPL6_HUMAN
- F8VW19_HUMAN
- G5E9S4_HUMAN
Variants for IKZF4 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1051961 | CNV | gain | 25217958 |
| nsv1119959 | CNV | deletion | 24896259 |
| nsv1138138 | CNV | deletion | 24896259 |
| nsv832424 | CNV | loss | 17160897 |
| nsv832427 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.60;
30.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IKZF4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- IKZF4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IKZF4 Gene
Disorders for IKZF4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alopecia areata |
|
|
| sulfite oxidase deficiency, isolated |
|
|
Search IKZF4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IKZF4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IKZF4 Gene
Publications for IKZF4 Gene
- Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 2 3 4 23
- Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. (PMID: 20596022) Petukhova L … Christiano AM (Nature 2010) 3 41
- A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PMID: 18198356) Hakonarson H … Polychronakos C (Diabetes 2008) 3 41
- The Ikaros family protein Eos associates with C-terminal-binding protein corepressors. (PMID: 12444977) Perdomo J … Crossley M (European journal of biochemistry 2002) 3 4
- A molecular dissection of the repression circuitry of Ikaros. (PMID: 12015313) Koipally J … Georgopoulos K (The Journal of biological chemistry 2002) 3 4
ExternalLinks
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- Search Santa Cruz Biotechnology (SCBT) for IKZF4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for IKZF4
- Horizon Cell Lines for IKZF4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IKZF4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for IKZF4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF4
- Boster Bio Antibodies for IKZF4
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for IKZF4
Sources for IKZF4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (17) MGI
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- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
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- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
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- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB