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Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
IKZF4 (IKAROS Family Zinc Finger 4) is a Protein Coding gene. Diseases associated with IKZF4 include Alopecia Areata and Sulfite Oxidase Deficiency, Isolated. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein homodimerization activity. An important paralog of this gene is IKZF2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA,TAS | 10978333 |
GO:0005515 | protein binding | IPI | 15491138 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 10978333 |
GO:0005654 | nucleoplasm | IBA,IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
GO:0032991 | protein-containing complex | IMP | 15491138 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0045892 | negative regulation of transcription, DNA-templated | TAS | 10978333 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0051260 | protein homooligomerization | IMP | 15491138 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | IKZF4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | IKZF4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | IKZF4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ikzf4 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | IKZF4 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Chicken (Gallus gallus) |
Aves | IKZF4 30 |
|
||
Lizard (Anolis carolinensis) |
Reptilia | IKZF4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ikzf4 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-166n8.9 30 |
|
||
IKZF4 31 |
|
OneToOne | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | STP1 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10790 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1051961 | CNV | gain | 25217958 |
nsv1119959 | CNV | deletion | 24896259 |
nsv1138138 | CNV | deletion | 24896259 |
nsv832424 | CNV | loss | 17160897 |
nsv832427 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
alopecia areata |
|
|
sulfite oxidase deficiency, isolated |
|
|