Aliases for IKZF3 Gene
External Ids for IKZF3 Gene
Previous HGNC Symbols for IKZF3 Gene
Previous GeneCards Identifiers for IKZF3 Gene
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
GeneCards Summary for IKZF3 Gene
IKZF3 (IKAROS Family Zinc Finger 3) is a Protein Coding gene. Diseases associated with IKZF3 include Leukemia, Chronic Lymphocytic and B-Cell Adult Acute Lymphocytic Leukemia. Among its related pathways are NF-kappaB Signaling and IL-2 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IKZF1.
UniProtKB/Swiss-Prot Summary for IKZF3 Gene
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.