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This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ika... See more...
Aliases for IKZF3 Gene
Aliases for IKZF3 Gene
External Ids for IKZF3 Gene
- HGNC: 13178
- Entrez Gene: 22806
- Ensembl: ENSG00000161405
- OMIM: 606221
- UniProtKB: Q9UKT9
Previous HGNC Symbols for IKZF3 Gene
- ZNFN1A3
Previous GeneCards Identifiers for IKZF3 Gene
- GC17M035175
- GC17M037913
- GC17M033714
- GC17M037921
Summaries for IKZF3 Gene
-
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
GeneCards Summary for IKZF3 Gene
IKZF3 (IKAROS Family Zinc Finger 3) is a Protein Coding gene. Diseases associated with IKZF3 include Leukemia, Chronic Lymphocytic and Primary Biliary Cirrhosis. Among its related pathways are IL-2 Signaling Pathway and NF-kappaB Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is IKZF1.
UniProtKB/Swiss-Prot Summary for IKZF3 Gene
-
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Additional gene information for IKZF3 Gene
- HGNC(13178)
- Entrez Gene(22806)
- Ensembl(ENSG00000161405)
- OMIM(606221)
- UniProtKB(Q9UKT9)
- Open Targets Platform(ENSG00000161405)
- Monarch Initiative
- Search for IKZF3 at DataMed
- Search for IKZF3 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKZF3 Gene
Genomics for IKZF3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IKZF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IKZF3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKZF3
- Top Transcription factor binding sites by QIAGEN in the IKZF3 gene promoter:
-
- AML1a
- ATF-2
- E2F
- FAC1
- MAZR
- Pax-5
- RORalpha2
- SRF
- SRF (504 AA)
Genomic Locations for IKZF3 Gene
Genomic Locations for IKZF3 Gene
- chr17:39,757,715-39,864,312
- (GRCh38/hg38)
- Size:
- 106,598 bases
- Orientation:
- Minus strand
- chr17:37,921,198-38,020,441
- (GRCh37/hg19)
- Size:
- 99,244 bases
- Orientation:
- Minus strand
Genomic View for IKZF3 Gene
Genes around IKZF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q12-q21.1 by HGNC
- 17q12-q21.1 by Entrez Gene
- 17q21.1 by Ensembl
IKZF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IKZF3 Gene
Proteins for IKZF3 Gene
-
Protein details for IKZF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UKT9-IKZF3_HUMAN
- Recommended name:
- Zinc finger protein Aiolos
- Protein Accession:
- Q9UKT9
- B4DVV5
- Q69BL6
- Q69BL7
- Q69BL8
- Q69BL9
- Q69BM0
- Q69BM1
- Q69BM2
- Q69BM3
- Q69BM5
- Q8N574
- Q8WWQ9
- Q8WWR0
- Q8WWR1
- Q8WWR2
- Q8WWR3
Protein attributes for IKZF3 Gene
- Size:
- 509 amino acids
- Molecular mass:
- 58023 Da
- Quaternary structure:
-
- Homodimer, and heterodimer with other IKAROS family members. Interacts with IKZF4 AND IKZF5. Interacts with IKZF1. Interacts with HRAS. Interacts with FOXP3; this interaction may be required for silencing target genes and regulating the suppressive activity of FOXP3-positive regulatory T-cells (Treg). Interacts with BCL21L isoform Bcl-X(L); this interaction blocks the anti-apoptotic role of BCL21L. Associates with histone deacetylase complexes containing HDAC1, MTA2 and SIN3A.
Protein Expression for IKZF3 Gene
Post-translational modifications for IKZF3 Gene
- Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for IKZF3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences IKZF3 / AIOLOS Antibody (LS-B7231) and IKZF3 / AIOLOS Antibody (LS-B8074)
- G Biosciences Immunotag™ IKZF3 Antibody
- GeneTex Anti-IKZF3 antibody [N1C2] and Anti-IKZF3 antibody
- Creative Diagnostics Rabbit anti-Human IKZF3 polyclonal antibody
-
BioLegend
- Aiolos Antibody (371007)
- Aiolos Antibody (371004)
- Aiolos Antibody (371104)
- Aiolos Antibody (371105)
- Aiolos Antibody (371103)
- Aiolos Antibody (371102)
- Aiolos Antibody (371002)
- Aiolos Antibody (371003)
- Aiolos Antibody (371106)
- Aiolos Antibody (371006)
- Aiolos Antibody (371008)
- Aiolos Antibody (371005)
- Aiolos Antibody (371107)
- Aiolos Antibody (371009)
- Aiolos Antibody (371108)
- Aiolos Antibody (371010)
-
Custom Antibody ServicesOriGene Antibodies for IKZF3
- Novus Biologicals Antibodies for IKZF3
-
Abcam antibodies for IKZF3
- Invitrogen Antibodies for IKZF3 (AFLGC-Ikzf3)
-
Biorbyt antibodies for IKZF3
-
Boster Bio Antibodies for IKZF3
-
Santa Cruz Biotechnology (SCBT) Antibodies for IKZF3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for IKZF3
- Origene Custom Protein Services for IKZF3
- antibodies-online: Show 4 available IKZF3 Proteins ranked by validation data
- Compare Top IKZF3 Proteins
-
Quality Products:
-
Signalway Proteins for IKZF3
-
Abcam proteins for IKZF3
Assay Products
- antibodies-online: Show 2 available IKZF3 Elisa Kits ranked by validation data
- Compare Top IKZF3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for IKZF3 Gene
Domains & Families for IKZF3 Gene
Gene Families for IKZF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for IKZF3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for IKZF3 Gene
- GenScript: Design optimal peptide antigens:
-
- Ikaros family zinc finger protein 3 (IKZF3_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UKT9- Family:
-
- Belongs to the Ikaros C2H2-type zinc-finger protein family.
Function for IKZF3 Gene
Molecular function for IKZF3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated by TGFB1 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in activated AHR T-cells.
Phenotypes From GWAS Catalog for IKZF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA | -- |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for IKZF3 Gene
- MGI mutant phenotypes for IKZF3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for IKZF3:
Animal Models for IKZF3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IKZF3 - Select products 50% OFF >
- * IKZF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for IKZF3
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-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF3
miRNA for IKZF3 Gene
- miRTarBase miRNAs that target IKZF3
-
- hsa-miR-125b-5p (MIRT054201)
- hsa-miR-661 (MIRT475222)
- hsa-miR-196a-3p (MIRT475223)
- hsa-miR-1233-3p (MIRT475224)
- hsa-miR-1225-3p (MIRT475225)
- hsa-miR-6860 (MIRT475226)
- hsa-miR-612 (MIRT475227)
- hsa-miR-5189-5p (MIRT475228)
- hsa-miR-3187-5p (MIRT475229)
- hsa-miR-1285-3p (MIRT475230)
- hsa-miR-939-3p (MIRT475231)
- hsa-miR-6840-3p (MIRT475232)
- hsa-miR-6849-3p (MIRT475233)
- hsa-miR-4433a-3p (MIRT475234)
- hsa-miR-5000-3p (MIRT475235)
- hsa-miR-4436a (MIRT475236)
- hsa-miR-5000-5p (MIRT475237)
- hsa-miR-665 (MIRT511371)
- hsa-miR-8055 (MIRT511372)
- hsa-miR-6807-5p (MIRT511373)
- hsa-miR-4266 (MIRT511374)
- hsa-miR-6894-5p (MIRT511375)
- hsa-miR-7160-5p (MIRT511376)
- hsa-miR-3135a (MIRT511377)
- hsa-miR-4445-5p (MIRT511378)
- hsa-miR-202-3p (MIRT511379)
- hsa-miR-98-5p (MIRT511380)
- hsa-miR-4500 (MIRT511381)
- hsa-miR-4458 (MIRT511382)
- hsa-let-7i-5p (MIRT511383)
- hsa-let-7g-5p (MIRT511384)
- hsa-let-7f-5p (MIRT511385)
- hsa-let-7e-5p (MIRT511386)
- hsa-let-7d-5p (MIRT511387)
- hsa-let-7c-5p (MIRT511388)
- hsa-let-7b-5p (MIRT511389)
- hsa-let-7a-5p (MIRT511390)
- hsa-miR-6884-5p (MIRT511391)
- hsa-miR-485-5p (MIRT511392)
- hsa-miR-6823-3p (MIRT511393)
- hsa-miR-2114-3p (MIRT511394)
- hsa-miR-7162-3p (MIRT511395)
- hsa-miR-4478 (MIRT511396)
- hsa-miR-4419b (MIRT511397)
- hsa-miR-3929 (MIRT511398)
- hsa-miR-4779 (MIRT511399)
- hsa-miR-4695-5p (MIRT511400)
- hsa-miR-6720-5p (MIRT542077)
- hsa-miR-6512-3p (MIRT542078)
- hsa-miR-766-3p (MIRT542079)
- hsa-miR-372-5p (MIRT542080)
- hsa-miR-371a-5p (MIRT542081)
- hsa-miR-616-5p (MIRT542082)
- hsa-miR-373-5p (MIRT542083)
- hsa-miR-371b-5p (MIRT542084)
- hsa-miR-5699-3p (MIRT542085)
- hsa-miR-4421 (MIRT542086)
- hsa-miR-6748-3p (MIRT542087)
- hsa-miR-759 (MIRT542088)
- hsa-miR-5586-3p (MIRT542089)
- hsa-miR-508-5p (MIRT542090)
- hsa-miR-4797-5p (MIRT542091)
- hsa-miR-651-5p (MIRT628726)
- hsa-miR-7977 (MIRT628727)
- hsa-miR-342-3p (MIRT628728)
- hsa-miR-383-3p (MIRT628729)
- hsa-miR-1228-3p (MIRT628730)
- hsa-miR-24-3p (MIRT634612)
- hsa-miR-4284 (MIRT638563)
- hsa-miR-498 (MIRT657190)
- hsa-miR-6783-3p (MIRT657191)
- hsa-miR-1343-3p (MIRT657192)
- hsa-miR-23b-5p (MIRT657193)
- hsa-miR-23a-5p (MIRT657194)
- hsa-miR-6829-3p (MIRT657195)
- hsa-miR-6791-3p (MIRT657196)
- hsa-miR-1976 (MIRT657197)
- hsa-miR-3653-5p (MIRT657198)
- hsa-miR-6742-3p (MIRT657199)
- hsa-miR-6852-5p (MIRT657200)
- hsa-miR-6747-3p (MIRT657201)
- hsa-miR-6727-3p (MIRT657202)
- hsa-miR-4722-3p (MIRT657203)
- hsa-miR-562 (MIRT657204)
- hsa-miR-129-5p (MIRT671962)
- hsa-miR-3912-5p (MIRT671963)
- hsa-miR-4309 (MIRT671964)
- hsa-miR-3198 (MIRT671965)
- hsa-miR-6794-3p (MIRT671966)
- hsa-miR-6755-3p (MIRT671967)
- hsa-miR-198 (MIRT671968)
- hsa-miR-4294 (MIRT671969)
- hsa-miR-1289 (MIRT671970)
- hsa-miR-8082 (MIRT671971)
- hsa-miR-4534 (MIRT671972)
- hsa-miR-1273f (MIRT671973)
- hsa-miR-4708-5p (MIRT671974)
- hsa-miR-6088 (MIRT671975)
- hsa-miR-4770 (MIRT671976)
- hsa-miR-143-3p (MIRT671977)
- hsa-miR-367-5p (MIRT671978)
- hsa-miR-1267 (MIRT671979)
- hsa-miR-1304-3p (MIRT671980)
- hsa-miR-4639-3p (MIRT671981)
- hsa-miR-6514-5p (MIRT671982)
- hsa-miR-3664-5p (MIRT671983)
- hsa-miR-4279 (MIRT677018)
- hsa-miR-887-5p (MIRT681297)
- hsa-miR-6780a-5p (MIRT681298)
- hsa-miR-6779-5p (MIRT681299)
- hsa-miR-3689c (MIRT681300)
- hsa-miR-3689b-3p (MIRT681301)
- hsa-miR-3689a-3p (MIRT681302)
- hsa-miR-30b-3p (MIRT681303)
- hsa-miR-1273h-5p (MIRT681304)
- hsa-miR-6788-5p (MIRT681305)
- hsa-miR-30c-2-3p (MIRT681306)
- hsa-miR-30c-1-3p (MIRT681307)
- hsa-miR-6799-5p (MIRT681308)
- hsa-miR-6883-5p (MIRT681309)
- hsa-miR-6785-5p (MIRT681310)
- hsa-miR-4728-5p (MIRT681311)
- hsa-miR-149-3p (MIRT681312)
- hsa-miR-7106-5p (MIRT681313)
- hsa-miR-890 (MIRT681314)
- hsa-miR-1200 (MIRT761227)
- hsa-miR-4324 (MIRT768616)
- hsa-miR-544b (MIRT774003)
- hsa-miR-6869-5p (MIRT780678)
- hsa-miR-1273g-3p (MIRT783333)
- hsa-miR-1292-3p (MIRT783428)
- hsa-miR-4252 (MIRT785532)
- hsa-miR-4793-3p (MIRT786794)
- hsa-miR-7703 (MIRT789544)
miRNA Products
Inhibitory RNA Products
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- Browse OriGene Inhibitory RNA Products For IKZF3
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Clone Products
- Applied Biological Materials (abm): Clones for IKZF3 - Select products 50% OFF >
- * IKZF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227380
- MR227380
- MR227380L3
- MR227380L4
- RC207547
- RC207547L1
- RC207547L2
- RC207547L3
- RC207547L4
- RC217779
- RC217779L3
- RC217779L4
- RC219642
- RC219642L3
- RC219642L4
- RC219693
- RC219693L3
- RC219693L4
- RC219750
- RC219750L3
- RC219750L4
- RC223824
- RC223824L3
- RC223824L4
- RC232381
- RC232491
- RC232590
- RC232692
- RC233911
- RC234090
- RC234209
- RC237008
- RC237009
- RC237010
- RG207547
- RG217779
- RG219642
- RG219693
- RG219750
- RG223824
- RG232381
- RG232491
- RG232590
- RG232692
- RG233911
- RG234090
- RG234209
- RR201604
- RR201604L3
- RR201604L4
- MR227380L3V
- MR227380L4V
- RC207547L1V
- RC207547L2V
- RC207547L3V
- RC207547L4V
- RC217779L3V
- RC217779L4V
- RC219642L3V
- RC219642L4V
- RC219693L3V
- RC219693L4V
- RC219750L3V
- RC219750L4V
- RC223824L3V
- RC223824L4V
- RR201604L3V
- RR201604L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IKZF3
- Addgene plasmids for IKZF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF3
Cell Line Products
-
Horizon Cell Lines for IKZF3
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKZF3 Gene
Localization for IKZF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IKZF3 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 2 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 10369681 |
| GO:0005654 | nucleoplasm | IBA,IDA | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 10369681 |
| GO:0005829 | cytosol | IDA | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for IKZF3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NF-kappaB Signaling | ||
| 2 | IL-2 Signaling Pathway | ||
Pathways by source for IKZF3 Gene
1 BioSystems pathway for IKZF3 Gene
1 Cell Signaling Technology pathway for IKZF3 Gene
Interacting Proteins for IKZF3 Gene
Selected Interacting proteins:
Q9UKT9-IKZF3_HUMAN
ENSP00000344544
for IKZF3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for IKZF3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006357 | regulation of transcription by RNA polymerase II | TAS | 10552935 |
| GO:0007498 | mesoderm development | TAS | 10552935 |
| GO:0009617 | response to bacterium | IEA | -- |
| GO:0030888 | regulation of B cell proliferation | ISS | -- |
| GO:0042113 | B cell activation | IEA | -- |
Transcripts for IKZF3 Gene
mRNA/cDNA for IKZF3 Gene
- 16 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000293068 2224 nts (view in UCSC)
- ENST00000346243 1296 nts (view in UCSC)
- ENST00000346872 9788 nts (view in UCSC)
- ENST00000348427 2056 nts (view in UCSC)
- ENST00000350532 1413 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for IKZF3 - Select products 50% OFF >
- * IKZF3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for IKZF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IKZF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKZF3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IKZF3
- Browse OriGene Inhibitory RNA Products For IKZF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKZF3
Clone Products
- Applied Biological Materials (abm): Clones for IKZF3 - Select products 50% OFF >
- * IKZF3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227380
- MR227380
- MR227380L3
- MR227380L4
- RC207547
- RC207547L1
- RC207547L2
- RC207547L3
- RC207547L4
- RC217779
- RC217779L3
- RC217779L4
- RC219642
- RC219642L3
- RC219642L4
- RC219693
- RC219693L3
- RC219693L4
- RC219750
- RC219750L3
- RC219750L4
- RC223824
- RC223824L3
- RC223824L4
- RC232381
- RC232491
- RC232590
- RC232692
- RC233911
- RC234090
- RC234209
- RC237008
- RC237009
- RC237010
- RG207547
- RG217779
- RG219642
- RG219693
- RG219750
- RG223824
- RG232381
- RG232491
- RG232590
- RG232692
- RG233911
- RG234090
- RG234209
- RR201604
- RR201604L3
- RR201604L4
- MR227380L3V
- MR227380L4V
- RC207547L1V
- RC207547L2V
- RC207547L3V
- RC207547L4V
- RC217779L3V
- RC217779L4V
- RC219642L3V
- RC219642L4V
- RC219693L3V
- RC219693L4V
- RC219750L3V
- RC219750L4V
- RC223824L3V
- RC223824L4V
- RR201604L3V
- RR201604L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for IKZF3
- Addgene plasmids for IKZF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKZF3
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
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Relevant External Links for IKZF3 Gene
- GeneLoc Exon Structure for
- IKZF3
Expression for IKZF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for IKZF3 Gene
This gene is overexpressed in Whole Blood (x4.2).
This gene is overexpressed in Blymphocyte (23.4), CD8 Tcells (20.0), Peripheral blood mononuclear cells (13.8), and NK cells (8.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IKZF3 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IKZF3
SOURCE GeneReport for Unigene cluster for IKZF3 Gene:
Hs.371680mRNA Expression by UniProt/SwissProt for IKZF3 Gene:
Q9UKT9-IKZF3_HUMAN
Tissue specificity:
Expressed most strongly in peripheral blood leukocytes, the spleen, and the thymus.
Evidence on tissue expression from TISSUES for IKZF3 Gene
- Spleen(4.7)
- Liver(4.4)
- Blood(3)
- Lymph node(2.7)
- Bone marrow(2.4)
- Intestine(2.4)
- Lung(2.2)
Primer Products
-
OriGene qPCR primer pairs for IKZF3
-
OriGene qPCR primer pairs and template standards for IKZF3
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF3 Gene
Orthologs for IKZF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IKZF3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IKZF3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IKZF3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ikzf3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ikzf3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IKZF3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IKZF3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | AIOLOS 31 |
|
OneToOne | |
| IKZF3 30 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | IKZF3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ikzf3 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10790 31 |
|
OneToMany |
- Species where no ortholog for IKZF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for IKZF3 Gene
- ENSEMBL:
- Gene Tree for IKZF3 (if available)
- TreeFam:
- Gene Tree for IKZF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IKZF3: view image
Paralogs for IKZF3 Gene
Paralogs for IKZF3 Gene
(14) SIMAP similar genes for IKZF3 Gene using alignment to 2 proteins:
- IKZF3_HUMAN
- B4DVV5_HUMAN
Variants for IKZF3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IKZF3 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 718369 | Benign: not provided | 39,766,369(-) | G/A | SYNONYMOUS_VARIANT | |
| VAR_064724 | - | p.Glu277Gln |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1009212 | CNV | deletion | 20482838 |
| esv1483215 | CNV | deletion | 17803354 |
| esv2659729 | CNV | deletion | 23128226 |
| esv2715904 | CNV | deletion | 23290073 |
| esv3640548 | CNV | loss | 21293372 |
| nsv1070404 | CNV | deletion | 25765185 |
| nsv1116523 | OTHER | inversion | 24896259 |
| nsv1121720 | CNV | deletion | 24896259 |
| nsv1146669 | OTHER | inversion | 26484159 |
| nsv978421 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.33;
26.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IKZF3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKZF3 Gene
Disorders for IKZF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukemia, chronic lymphocytic |
|
|
| primary biliary cirrhosis |
|
|
| leukemia, acute lymphoblastic |
|
|
| autosomal recessive non-syndromic intellectual disability |
|
|
| myeloma, multiple |
|
|
Search IKZF3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for IKZF3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for IKZF3 Gene
Publications for IKZF3 Gene
- Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. (PMID: 10552935) Hosokawa Y … Seto M (Genomics 1999) 2 3 4 23
- Combinatorial effects of splice variants modulate function of Aiolos. (PMID: 17646674) Caballero R … Ballestar E (Journal of cell science 2007) 3 4 23
- Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene. (PMID: 11745366) Liippo J … Lassila O (European journal of immunology 2001) 3 4 23
- Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 3 4 23
- Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. (PMID: 10369681) Romero F … Rebollo A (The EMBO journal 1999) 3 4 23
ExternalLinks
Products for IKZF3 Gene
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Sources for IKZF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31)