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Aliases for IKZF2 Gene

Aliases for IKZF2 Gene

  • IKAROS Family Zinc Finger 2 2 3 5
  • Zinc Finger Protein, Subfamily 1A, 2 (Helios) 2 3
  • Ikaros Family Zinc Finger Protein 2 3 4
  • ZNFN1A2 3 4
  • HELIOS 3 4
  • Zinc Finger DNA Binding Protein Helios 3
  • IKAROS Family Zinc Finger 2 (Helios) 2
  • Zinc Finger Protein Helios 3
  • ANF1A2 3
  • ZNF1A2 3

External Ids for IKZF2 Gene

Previous HGNC Symbols for IKZF2 Gene

  • ZNFN1A2

Previous GeneCards Identifiers for IKZF2 Gene

  • GC02M213579
  • GC02M213864
  • GC02M205713

Summaries for IKZF2 Gene

Entrez Gene Summary for IKZF2 Gene

  • This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for IKZF2 Gene

IKZF2 (IKAROS Family Zinc Finger 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein heterodimerization activity. An important paralog of this gene is IKZF4.

UniProtKB/Swiss-Prot for IKZF2 Gene

  • Associates with Ikaros at centromeric heterochromatin.

Gene Wiki entry for IKZF2 Gene

Additional gene information for IKZF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKZF2 Gene

Genomics for IKZF2 Gene

GeneHancer (GH) Regulatory Elements for IKZF2 Gene

Promoters and enhancers for IKZF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J213141 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 671.7 +6.3 6337 13.7 HDGF ATF1 SMAD1 ARNT SIN3A DMAP1 IRF4 YY1 ZNF766 GLIS2 IKZF2 ENSG00000270659 GC02P213151 GC02P213140
GH02J213155 Enhancer 0.2 dbSUPER 650.7 -1.6 -1642 0.6 IKZF2 LINC01953
GH02J213156 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 18.5 -3.1 -3140 1.5 STAT5A EBF1 YY1 RELA NFATC1 ZNF207 ATF7 IKZF2 RUNX3 CREM IKZF2 LINC01953
GH02J213164 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 15.2 -12.0 -11987 2.7 ZNF687 RFX1 TRIM22 JUNB MEF2B DPF2 ATF2 JUND NFATC1 NBN LINC01953 LOC105373864 IKZF2
GH02J213230 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 7.2 -81.7 -81652 10.7 HDGF PKNOX1 FOXA2 SMAD1 ARID4B DMAP1 YBX1 IRF4 ETS1 YY1 SPAG16 LOC100130451 IKZF2 ENSG00000272519 LOC105373864
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IKZF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IKZF2 gene promoter:
  • Nkx2-5
  • Pbx1a
  • E47
  • Tal-1beta
  • ATF

Genomic Locations for IKZF2 Gene

Genomic Locations for IKZF2 Gene
chr2:212,999,684-213,154,266
(GRCh38/hg38)
Size:
154,583 bases
Orientation:
Minus strand
chr2:213,864,408-214,017,151
(GRCh37/hg19)
Size:
152,744 bases
Orientation:
Minus strand

Genomic View for IKZF2 Gene

Genes around IKZF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKZF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKZF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKZF2 Gene

Proteins for IKZF2 Gene

  • Protein details for IKZF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKS7-IKZF2_HUMAN
    Recommended name:
    Zinc finger protein Helios
    Protein Accession:
    Q9UKS7
    Secondary Accessions:
    • Q53YJ5
    • Q6PQC5
    • Q6PQC6
    • Q6PQC7
    • Q6PQC8
    • Q6PQD0
    • Q6PQD1
    • Q8N6S1

    Protein attributes for IKZF2 Gene

    Size:
    526 amino acids
    Molecular mass:
    59574 Da
    Quaternary structure:
    • Interacts with IKZF4 AND IKZF5.

    Alternative splice isoforms for IKZF2 Gene

neXtProt entry for IKZF2 Gene

Post-translational modifications for IKZF2 Gene

  • Ubiquitination at isoforms=2, 7288 and Lys283
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IKZF2 Gene

Domains & Families for IKZF2 Gene

Gene Families for IKZF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for IKZF2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9UKS7

UniProtKB/Swiss-Prot:

IKZF2_HUMAN :
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
Family:
  • Belongs to the Ikaros C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with IKZF2: view

Function for IKZF2 Gene

Molecular function for IKZF2 Gene

UniProtKB/Swiss-Prot Function:
Associates with Ikaros at centromeric heterochromatin.

Phenotypes From GWAS Catalog for IKZF2 Gene

Gene Ontology (GO) - Molecular Function for IKZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003674 molecular_function ND --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
genes like me logo Genes that share ontologies with IKZF2: view
genes like me logo Genes that share phenotypes with IKZF2: view

Animal Models for IKZF2 Gene

MGI Knock Outs for IKZF2:

Animal Model Products

miRNA for IKZF2 Gene

miRTarBase miRNAs that target IKZF2

Clone Products

  • Addgene plasmids for IKZF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKZF2 Gene

Localization for IKZF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKZF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKZF2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IKZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with IKZF2: view

Pathways & Interactions for IKZF2 Gene

SuperPathways for IKZF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IKZF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with IKZF2: view

No data available for Pathways by source and SIGNOR curated interactions for IKZF2 Gene

Drugs & Compounds for IKZF2 Gene

(1) Drugs for IKZF2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for IKZF2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with IKZF2: view

Transcripts for IKZF2 Gene

Unigene Clusters for IKZF2 Gene

IKAROS family zinc finger 2 (Helios):
Representative Sequences:

Clone Products

  • Addgene plasmids for IKZF2

Alternative Splicing Database (ASD) splice patterns (SP) for IKZF2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b · 16c ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: - - -
SP14: - - - - - -
SP15:

ExUns: 16d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for IKZF2 Gene

GeneLoc Exon Structure for
IKZF2
ECgene alternative splicing isoforms for
IKZF2

Expression for IKZF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IKZF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IKZF2 Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2).

Protein differential expression in normal tissues from HIPED for IKZF2 Gene

This gene is overexpressed in NK cells (23.6), CD8 Tcells (15.4), Platelet (13.7), Placenta (8.8), and Colon (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IKZF2 Gene



Protein tissue co-expression partners for IKZF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of IKZF2 Gene:

IKZF2

SOURCE GeneReport for Unigene cluster for IKZF2 Gene:

Hs.604950

Evidence on tissue expression from TISSUES for IKZF2 Gene

  • Blood(2.2)
genes like me logo Genes that share expression patterns with IKZF2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKZF2 Gene

Orthologs for IKZF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKZF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IKZF2 34 33
  • 99.94 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IKZF2 34 33
  • 97.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IKZF2 34 33
  • 97.59 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IKZF2 34
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ikzf2 16 34 33
  • 95.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia IKZF2 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ikzf2 33
  • 92.69 (n)
chicken
(Gallus gallus)
Aves HELIOS 34
  • 89 (a)
OneToOne
IKZF2 33
  • 87.9 (n)
lizard
(Anolis carolinensis)
Reptilia IKZF2 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ikzf2 33
  • 76.25 (n)
African clawed frog
(Xenopus laevis)
Amphibia znfn1a1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii si:zfos-1425h8.1 33
  • 62.04 (n)
IKZF2 34
  • 55 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10790 34
  • 27 (a)
OneToMany
Species where no ortholog for IKZF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKZF2 Gene

ENSEMBL:
Gene Tree for IKZF2 (if available)
TreeFam:
Gene Tree for IKZF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IKZF2: view image

Paralogs for IKZF2 Gene

Paralogs for IKZF2 Gene

genes like me logo Genes that share paralogs with IKZF2: view

Variants for IKZF2 Gene

Sequence variations from dbSNP and Humsavar for IKZF2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000035391 -- 213,018,048(-) C/G intron_variant
rs1000040563 -- 213,079,093(-) A/T intron_variant
rs1000068776 -- 213,064,169(-) G/T intron_variant
rs1000109957 -- 213,017,817(-) T/C intron_variant
rs1000125179 -- 213,101,431(-) T/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IKZF2 Gene

Variant ID Type Subtype PubMed ID
nsv954831 CNV duplication 24416366
nsv834530 CNV gain 17160897
nsv834529 CNV gain 17160897
nsv834528 CNV loss 17160897
nsv584429 CNV loss 21841781
nsv584428 CNV loss 21841781
nsv517070 CNV loss 19592680
nsv470514 CNV loss 18288195
nsv3151 CNV insertion 18451855
nsv213831 CNV deletion 16902084
nsv1136468 CNV deletion 24896259
nsv1072491 CNV deletion 25765185
nsv1072490 CNV deletion 25765185
esv3594222 CNV loss 21293372
esv3407699 CNV insertion 20981092
esv3306725 CNV mobile element insertion 20981092
esv27259 CNV gain 19812545

Variation tolerance for IKZF2 Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IKZF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKZF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKZF2 Gene

Disorders for IKZF2 Gene

Additional Disease Information for IKZF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IKZF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IKZF2 Gene

Publications for IKZF2 Gene

  1. Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities. (PMID: 10978333) Perdomo J … Crossley M (The Journal of biological chemistry 2000) 3 4 22 58
  2. Human Helios, an Ikaros-related zinc finger DNA binding protein: cDNA cloning and tissue expression pattern. (PMID: 10541817) Hosokawa Y … Seto M (Immunogenetics 1999) 3 4 22 58
  3. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin. (PMID: 9512513) Hahm K … Smale ST (Genes & development 1998) 2 3 22 58
  4. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. (PMID: 20226531) Getnet D … Drake CG (Molecular immunology 2010) 3 22 58
  5. Analysis of Ikaros family splicing variants in human hematopoietic lineages. (PMID: 20432734) Matulić M … Antica M (Collegium antropologicum 2010) 3 22 58

Products for IKZF2 Gene

Sources for IKZF2 Gene

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