This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly s... See more...

Aliases for IKBKG Gene

Aliases for IKBKG Gene

  • Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma 2 3 5
  • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Gamma 2 3
  • Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Gamma 2 3
  • IkB Kinase-Associated Protein 1 3 4
  • NF-Kappa-B Essential Modulator 3 4
  • I-Kappa-B Kinase Subunit Gamma 3 4
  • NF-Kappa-B Essential Modifier 3 4
  • IkB Kinase Subunit Gamma 3 4
  • Incontinentia Pigmenti 2 3
  • IKK-Gamma 3 4
  • IKKAP1 3 4
  • FIP-3 3 4
  • FIP3 3 4
  • IKKG 3 4
  • NEMO 3 4
  • Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Gamma 4
  • AMCBX1 3
  • EDAID1 3
  • ZC2HC9 3
  • Fip3p 3
  • IMD33 3
  • IPD2 3
  • IP1 3
  • IP2 3
  • IP 3

External Ids for IKBKG Gene

Previous HGNC Symbols for IKBKG Gene

  • IP2
  • IP1

Previous GeneCards Identifiers for IKBKG Gene

  • GC0XM147930
  • GC0XP150151
  • GC0XP151354
  • GC0XP152238
  • GC0XP152243
  • GC0XP153334
  • GC0XP153423
  • GC0XP153769
  • GC0XP142347

Summaries for IKBKG Gene

Entrez Gene Summary for IKBKG Gene

  • This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]

GeneCards Summary for IKBKG Gene

IKBKG (Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma) is a Protein Coding gene. Diseases associated with IKBKG include Incontinentia Pigmenti and Immunodeficiency 33. Among its related pathways are Metabolism of proteins and MicroRNAs in cardiomyocyte hypertrophy. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and obsolete signal transducer activity. An important paralog of this gene is OPTN.

UniProtKB/Swiss-Prot Summary for IKBKG Gene

  • Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

Gene Wiki entry for IKBKG Gene

Additional gene information for IKBKG Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKBKG Gene

Genomics for IKBKG Gene

GeneHancer (GH) Regulatory Elements for IKBKG Gene

Promoters and enhancers for IKBKG Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ154540 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 524 +4.3 4347 10.1 ZBTB40 ZNF217 NRF1 TCF12 POLR2G PHF8 JUND FOS ZFX ZNF639 IKBKG G6PD lnc-FAM3A-2 FAM3A DKC1 F8A1 F8A2 SNORA70 PLXNA3 SNORA56
GH0XJ154796 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.3 +260.1 260101 10.6 HNRNPK ZSCAN5C NRF1 TCF12 NCOR1 RBAK PHB2 FOS ZNF10 ZIC2 MPP1 F8A1 DKC1 SNORA56 F8A2 SNORA70 SNORA36A IKBKG TMLHE GDI1
GH0XJ154726 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.3 +191.9 191912 12.7 FOS ZIC2 REST NR2F2 FOXA2 NFIC POLR2A MAX NR3C1 PBX2 F8A1 F8A2 DKC1 IKBKG GAB3 EMD F8 DNASE1L1 TKTL1 MPP1
GH0XJ154038 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 10 -499.6 -499551 5.9 FOS TEAD1 SAP130 NR2F2 ZNF664 POLR2A BHLHE40 NFIL3 TEAD3 NR3C1 TMEM187 HCFC1 HCFC1-AS1 IKBKG ABCD1 DNASE1L1 MECP2 FAM50A ATP6AP1 EMD
GH0XJ154364 Promoter/Enhancer 2.7 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.3 -167.8 -167798 17.2 HNRNPK ZNF217 EP300 CTCF SIN3A NRF1 TCF12 POLR2G SP1 PHF8 EMD FLNA ENSG00000285018 PLXNA3 DKC1 SNORA70 SLC10A3 FAM50A RPL10 TMEM187
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IKBKG on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKBKG

Top Transcription factor binding sites by QIAGEN in the IKBKG gene promoter:
  • HNF-4alpha1
  • p53

Genomic Locations for IKBKG Gene

Genomic Locations for IKBKG Gene
chrX:154,541,199-154,568,573
(GRCh38/hg38)
Size:
27,375 bases
Orientation:
Plus strand
chrX:153,769,414-153,796,782
(GRCh37/hg19)
Size:
27,369 bases
Orientation:
Plus strand

Genomic View for IKBKG Gene

Genes around IKBKG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKBKG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKBKG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKBKG Gene

Proteins for IKBKG Gene

  • Protein details for IKBKG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6K9-NEMO_HUMAN
    Recommended name:
    NF-kappa-B essential modulator
    Protein Accession:
    Q9Y6K9
    Secondary Accessions:
    • Q7LBY6
    • Q7Z7F1

    Protein attributes for IKBKG Gene

    Size:
    419 amino acids
    Molecular mass:
    48198 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and PIDD1. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with IKBKE. Interacts with TANK; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5. Interacts with RIPK2. Interacts with TNIP1 and TNFAIP3; TNIP1 facilitates the TNFAIP3-mediated de-ubiquitination of IKBKG. Interacts with TNFAIP3; the interaction is induced by TNF stimulation and by polyubiquitin. Binds polyubiquitin; the interaction is mediated by two domains; reports about the binding to 'Lys-63'-linked and/or linear polyubiquitin, respective binding affinities and stoichiometry are conflicting. Interacts with NLRP10. Interacts with TANK; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375). Interacts with TRIM29; this interaction induces IKBKG/NEMO ubiquitination and proteolytic degradation (PubMed:27695001). Interacts with TRIM13; this interaction leads to IKBKG/NEMO ubiquitination (PubMed:25152375). Interacts with ARFIP2 (PubMed:26296658). Interacts with RIPK1 (By similarity).
    • (Microbial infection) Interacts with Molluscum contagiosum virus protein MC005; this interaction inhibits NF-kappa-B activation.
    • (Microbial infection) Interacts with HTLV-1 Tax oncoprotein; the interaction activates IKBKG.
    • (Microbial infection) Interacts with Shigella flexneri ipah9.8; the interaction promotes TNIP1-dependent 'Lys-27'-linked polyubiquitination of IKBKG which perturbs NF-kappa-B activation during bacterial infection.

    Three dimensional structures from OCA and Proteopedia for IKBKG Gene

    Alternative splice isoforms for IKBKG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKBKG Gene

Post-translational modifications for IKBKG Gene

  • Phosphorylation at Ser-68 attenuates aminoterminal homodimerization.
  • Polyubiquitinated on Lys-285 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Polyubiquitinated on Lys-399 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-277 and Lys-309; promotes nuclear export. Polyubiquitinated through 'Lys-27' by TRIM23; involved in antiviral innate and inflammatory responses. Linear polyubiquitinated on Lys-111, Lys-143, Lys-226, Lys-246, Lys-264, Lys-277, Lys-285, Lys-292, Lys-302, Lys-309 and Lys-326; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation. Deubiquitinated by USP10 in a TANK-dependent and -independent manner, leading to the negative regulation of NF-kappa-B signaling upon DNA damage (PubMed:25861989).
  • Sumoylated on Lys-277 and Lys-309 with SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues.
  • Neddylated by TRIM40, resulting in stabilization of NFKBIA and down-regulation of NF-kappa-B activity.
  • (Microbial infection) Cleaved by hepatitis A virus (HAV) protease 3C allowing the virus to disrupt the host innate immune signaling.
  • (Microbial infection) Polyubiquitinated on Lys-309 and Lys-321 via 'Lys-27'-linked ubiquitin by Shigella flexneri E3 ubiquitin-protein ligase ipah9.8, leading to its degradation by the proteasome.
  • Ubiquitination at Lys111, Lys139, Lys143, Lys226, Lys246, Lys321, Lys325, Lys326, Lys264, Lys283, Lys285, Lys292, Lys399, and Lys302
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for IKBKG Gene

Domains & Families for IKBKG Gene

Gene Families for IKBKG Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for IKBKG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IKBKG Gene

GenScript: Design optimal peptide antigens:
  • Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b (D3DWY0_HUMAN)
  • Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_a (D3DWY2_HUMAN)
  • NF-kappa-B essential modifier (NEMO_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y6K9

UniProtKB/Swiss-Prot:

NEMO_HUMAN :
  • The leucine-zipper domain and the CCHC NOA-type zinc-finger are essential for polyubiquitin binding and for the activation of IRF3.
Domain:
  • The leucine-zipper domain and the CCHC NOA-type zinc-finger are essential for polyubiquitin binding and for the activation of IRF3.
genes like me logo Genes that share domains with IKBKG: view

Function for IKBKG Gene

Molecular function for IKBKG Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.
GENATLAS Biochemistry:
inhibitor of kappa light polypeptide enhancer in B cells,kinase gamma,complexing with IKBKA and IKBKB,associating preferentially with IKBKB,required for the activation of the complex

Phenotypes From GWAS Catalog for IKBKG Gene

Gene Ontology (GO) - Molecular Function for IKBKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9751060
GO:0019904 protein domain specific binding IPI 15341735
GO:0031625 ubiquitin protein ligase binding IPI 23453807
GO:0042802 identical protein binding IPI 18462684
GO:0042803 protein homodimerization activity IDA 23091055
genes like me logo Genes that share ontologies with IKBKG: view
genes like me logo Genes that share phenotypes with IKBKG: view

Human Phenotype Ontology for IKBKG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IKBKG Gene

MGI Knock Outs for IKBKG:

Animal Model Products

CRISPR Products

miRNA for IKBKG Gene

miRTarBase miRNAs that target IKBKG

Clone Products

  • Addgene plasmids for IKBKG

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for IKBKG Gene

Localization for IKBKG Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBKG Gene

Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKBKG gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 3
plasma membrane 2
extracellular 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IKBKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IPI 17314283
GO:0000922 spindle pole IDA 24561039
GO:0005622 intracellular IDA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IBA 14651848
genes like me logo Genes that share ontologies with IKBKG: view

Pathways & Interactions for IKBKG Gene

PathCards logo

SuperPathways for IKBKG Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 TNFR1 Pathway
.87
.87
.56
.55
.52
.46
.42
.42
.40
.35
3 4-1BB Pathway
.54
.54
.48
.46
.42
.42
.37
.36
.30
4 Cytosolic sensors of pathogen-associated DNA
5 Toll-like Receptor Signaling Pathway
genes like me logo Genes that share pathways with IKBKG: view

Pathways by source for IKBKG Gene

22 GeneGo (Thomson Reuters) pathways for IKBKG Gene
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
  • Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
  • Apoptosis and survival APRIL and BAFF signaling
  • Apoptosis and survival Lymphotoxin-beta receptor signaling
  • Apoptosis and survival TNFR1 signaling pathway
62 Qiagen pathways for IKBKG Gene
  • 14-3-3 Induced Apoptosis
  • 4-1BB Pathway
  • Activation of NF-KappaB by PKR
  • Akt Signaling
  • Angiopoietin-TIE2 Signaling
1 Cell Signaling Technology pathway for IKBKG Gene
2 GeneTex pathways for IKBKG Gene

SIGNOR curated interactions for IKBKG Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for IKBKG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006915 apoptotic process TAS 9927690
genes like me logo Genes that share ontologies with IKBKG: view

Drugs & Compounds for IKBKG Gene

(25) Drugs for IKBKG Gene - From: DrugBank, PharmGKB, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Artesunate Approved, Investigational Pharma 205
Primaquine Approved Pharma 91
Pyrimethamine Approved, Investigational, Vet_approved Pharma Inhibition, Inhibitor DHFR inhibitor, Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor 171
Sulfadoxine Approved, Investigational Pharma 142
Luteolin Experimental Pharma Antioxidant and free radical scavenger 5

(2) Additional Compounds for IKBKG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(11) ApexBio Compounds for IKBKG Gene

Compound Action Cas Number
Andrographolide NF-κB signaling Inhibitor 5508-58-7
Bay 11-7085 NK-κB activation inhibitor 196309-76-9
Bay 11-7821(BAY 11-7082) IKK/NF-κB/TNFα inhibitor 19542-67-7
BMS-345541 IKK inhibitor,highly selective 547757-23-3
Honokiol Antioxidant/antitumor/antiangiogenic agent 35354-74-6
IKK-16 (IKK Inhibitor VII) Selective IκB kinase inhibitor 873225-46-8
IMD 0354 978-62-1
Luteolin Antioxidant and free radical scavenger 491-70-3
Tanshinone IIA Antioxidant and anti-inflammatory reagent 568-72-9
TPCA-1 IKK-2 inhibitor,potent and selective 507475-17-4
WS6 1421227-53-3
genes like me logo Genes that share compounds with IKBKG: view

Drug Products

Transcripts for IKBKG Gene

mRNA/cDNA for IKBKG Gene

6 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for IKBKG

Alternative Splicing Database (ASD) splice patterns (SP) for IKBKG Gene

No ASD Table

Relevant External Links for IKBKG Gene

GeneLoc Exon Structure for
IKBKG

Expression for IKBKG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IKBKG Gene

mRNA differential expression in normal tissues according to GTEx for IKBKG Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for IKBKG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.3) and Bone marrow stromal cell (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IKBKG Gene



Protein tissue co-expression partners for IKBKG Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IKBKG

SOURCE GeneReport for Unigene cluster for IKBKG Gene:

Hs.43505

mRNA Expression by UniProt/SwissProt for IKBKG Gene:

Q9Y6K9-NEMO_HUMAN
Tissue specificity: Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for IKBKG Gene

  • Skin(4.6)
  • Liver(4.4)
  • Lung(4.4)
  • Nervous system(3.4)
  • Blood(2.6)
  • Intestine(2.3)
  • Kidney(2.1)
  • Lymph node(2)
  • Muscle(2)
  • Spleen(2)
  • Stomach(2)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IKBKG Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • scalp
  • skull
  • tooth
Thorax:
  • breast
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • nail
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • hair
  • lymph node
  • lymph vessel
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • sweat gland
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with IKBKG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for IKBKG Gene

Orthologs for IKBKG Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKBKG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100610002 30
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia IKBKG 30
  • 89.05 (n)
rat
(Rattus norvegicus)
Mammalia Ikbkg 30
  • 84.47 (n)
mouse
(Mus musculus)
Mammalia Ikbkg 17 30
  • 84.25 (n)
cow
(Bos Taurus)
Mammalia IKBKG 30
  • 83.77 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ikbkg 30
  • 60.55 (n)
zebrafish
(Danio rerio)
Actinopterygii ikbkg 30
  • 54.93 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5570 30
Species where no ortholog for IKBKG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKBKG Gene

ENSEMBL:
Gene Tree for IKBKG (if available)
TreeFam:
Gene Tree for IKBKG (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IKBKG: view image

Paralogs for IKBKG Gene

Paralogs for IKBKG Gene

Pseudogenes.org Pseudogenes for IKBKG Gene

genes like me logo Genes that share paralogs with IKBKG: view

Variants for IKBKG Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IKBKG Gene

SNP ID Clinical significance and condition Chr 0X pos