IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] See more...

Aliases for IKBKE Gene

Aliases for IKBKE Gene

  • Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon 2 3 5
  • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Epsilon 2 3
  • Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Epsilon 3 4
  • Inducible I Kappa-B Kinase 3 4
  • I-Kappa-B Kinase Epsilon 3 4
  • IKK-Epsilon 3 4
  • IKK-E 3 4
  • IKK-I 3 4
  • IKKE 3 4
  • IKKI 3 4
  • IKK-Related Kinase Epsilon 3
  • Inducible IkappaB Kinase 3
  • EC 2.7.11.10 4
  • EC 2.7.11 52
  • KIAA0151 4
  • IkBKE 4

External Ids for IKBKE Gene

Previous GeneCards Identifiers for IKBKE Gene

  • GC01P202354
  • GC01P203287
  • GC01P203727
  • GC01P203032
  • GC01P204710
  • GC01P206643
  • GC01P177341

Summaries for IKBKE Gene

Entrez Gene Summary for IKBKE Gene

  • IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

GeneCards Summary for IKBKE Gene

IKBKE (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon) is a Protein Coding gene. Diseases associated with IKBKE include Rabies and Viral Infectious Disease. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and NGF Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TBK1.

UniProtKB/Swiss-Prot Summary for IKBKE Gene

  • Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.

Gene Wiki entry for IKBKE Gene

Additional gene information for IKBKE Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKBKE Gene

Genomics for IKBKE Gene

GeneHancer (GH) Regulatory Elements for IKBKE Gene

Promoters and enhancers for IKBKE Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J206469 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 515.6 +1.2 1232 4.2 CTCF SIN3A POLR2G PHF8 ZIC2 POLR2A TCF7 GABPA SAP30 RELA IKBKE NONHSAG004090.2 RASSF5 MAPKAPK2 MIR6769B RF00017-457
GH01J206480 Enhancer 0.9 Ensembl ENCODE 46.4 +11.1 11057 1 JUND FOS ZIC2 ZNF263 RELA MYC CTBP1 WT1 FOSL1 MAX NONHSAG004091.2 IKBKE ENSG00000261000 C1orf147
GH01J206510 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 25.1 +42.8 42824 4.6 JUND FOS ZIC2 REST POLR2A CTBP1 EP300 BRCA1 CEBPG CEBPB ENSG00000261000 IKBKE RASSF5 MAPKAPK2 RPL7AP20
GH01J206503 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 18.8 +33.8 33806 1.6 NRF1 USF1 GTF2E2 JUND FOS ZBTB5 EP300 POLR2A ZBTB11 AFF1 ENSG00000261000 IKBKE EIF2D ELK4 RASSF5
GH01J206554 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +92.7 92666 16.8 EP300 SIN3A NRF1 USF1 SP1 GTF2E2 SIX5 ZNF10 REST ZBTB11 RASSF5 EIF2D C1orf147 IKBKE MAPKAPK2 ENSG00000279946 piR-48611 lnc-EIF2D-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IKBKE on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKBKE

Top Transcription factor binding sites by QIAGEN in the IKBKE gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • Cart-1
  • CHOP-10
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • RORalpha1

Genomic Locations for IKBKE Gene

Genomic Locations for IKBKE Gene
chr1:206,470,243-206,496,890
(GRCh38/hg38)
Size:
26,648 bases
Orientation:
Plus strand
chr1:206,643,586-206,670,223
(GRCh37/hg19)
Size:
26,638 bases
Orientation:
Plus strand

Genomic View for IKBKE Gene

Genes around IKBKE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKBKE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKBKE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IKBKE Gene

Proteins for IKBKE Gene

  • Protein details for IKBKE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14164-IKKE_HUMAN
    Recommended name:
    Inhibitor of nuclear factor kappa-B kinase subunit epsilon
    Protein Accession:
    Q14164
    Secondary Accessions:
    • D3DT78
    • Q3B754
    • Q3KR43
    • Q5JTS6

    Protein attributes for IKBKE Gene

    Size:
    716 amino acids
    Molecular mass:
    80462 Da
    Quaternary structure:
    • Homodimer. Interacts with MAVS/IPS1 (PubMed:16177806, PubMed:28011935). Interacts (via protein kinase domain) with TTLL12 (via N-terminus); the interaction prevents MAVS binding to IKBKE (PubMed:28011935). Interacts with the adapter proteins AZI2/NAP1, TANK and TBKBP1/SINTBAD (PubMed:17568778). Interacts with SIKE1 (PubMed:16281057, PubMed:14560022). Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I; interactions are disrupted by the interaction between IKBKE and SIKE1 (PubMed:14739303, PubMed:16281057, PubMed:23478265). Interacts with TOPORS; induced by DNA damage (PubMed:20188669). Interacts with CYLD (PubMed:18636086). Interacts (when polyubiquitinated) with IKBKB, IKBKG and MYD88 (PubMed:23453969). Interacts with IFIH1 (PubMed:17600090). Interacts with DDX3X; the interaction is found to be induced upon virus infection (PubMed:18636090, PubMed:20657822, PubMed:23478265). Interacts with TRIM6 (via SPRY box) (PubMed:24882218). Interacts with unanchored K48-linked polyubiquitin chains; this leads to IKBKE activation (PubMed:24882218). Interacts with TBK1 (PubMed:29251827).
    • (Microbial infection) Interacts (via Protein kinase domain) with arenavirus protein N; the interaction inhibits IKBKE kinase function.
    • (Microbial infection) Interacts with Ebola virus protein VP35; the interaction leads to inhibition of cellular antiviral response by blocking necessary interactions between the IKBKE and MAVS/IPS as well as its substrates IRF3 and IRF7.
    • (Microbial infection) Interacts with human T-cell leukemia virus 1/HTLV-1 protein HBZ.
    SequenceCaution:
    • Sequence=BAA09772.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for IKBKE Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKBKE Gene

Selected DME Specific Peptides for IKBKE Gene

Q14164:
  • YGTEEYLHPDMYERAVLRK
  • YHAATGSLPF
  • YNEEQIHK
  • GPRRNKE
  • HRDIKPGN

Post-translational modifications for IKBKE Gene

  • Autophosphorylated and phosphorylated by IKBKB/IKKB. Phosphorylation at Ser-172 is enhanced by the interaction with DDX3X. Phosphorylated at Thr-501 upon IFN activation.
  • Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.
  • 'Lys-63'-linked polyubiquitinated at Lys-30 and Lys-401 by TRAF2:BIRC2 and TRAF2:BIRC3 complexes. Ubiquitination is induced by LPS, TNFA and interleukin-1 and required for full kinase activity and KF-kappa-B pathway activation.
  • Ubiquitination at Lys30, Lys401, and Lys549
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Boster Bio Antibodies for IKBKE

Domains & Families for IKBKE Gene

Gene Families for IKBKE Gene

Protein Domains for IKBKE Gene

Suggested Antigen Peptide Sequences for IKBKE Gene

GenScript: Design optimal peptide antigens:
  • Inducible I kappa-B kinase (IKKE_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14164

UniProtKB/Swiss-Prot:

IKKE_HUMAN :
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
genes like me logo Genes that share domains with IKBKE: view

Function for IKBKE Gene

Molecular function for IKBKE Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:19073, Rhea:RHEA-COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.10;.
UniProtKB/Swiss-Prot Induction:
Induced by lipopolysaccharide (LPS) and TNFA.

Enzyme Numbers (IUBMB) for IKBKE Gene

Phenotypes From GWAS Catalog for IKBKE Gene

Gene Ontology (GO) - Molecular Function for IKBKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS,IEA --
GO:0004674 protein serine/threonine kinase activity IBA 21873635
GO:0004704 NF-kappaB-inducing kinase activity IDA 10882136
GO:0005515 protein binding IPI 14743216
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with IKBKE: view
genes like me logo Genes that share phenotypes with IKBKE: view

Animal Models for IKBKE Gene

MGI Knock Outs for IKBKE:

Animal Model Products

  • Taconic Biosciences Mouse Models for IKBKE

CRISPR Products

miRNA for IKBKE Gene

miRTarBase miRNAs that target IKBKE

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKBKE

Clone Products

  • Addgene plasmids for IKBKE

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IKBKE Gene

Localization for IKBKE Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBKE Gene

Cytoplasm. Nucleus. Nucleus, PML body. Note=Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218). {ECO:0000269 PubMed:20188669, ECO:0000269 PubMed:24882218}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKBKE gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 4
endosome 4
plasma membrane 2
extracellular 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IKBKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 20188669
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA,IBA 20188669
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with IKBKE: view

Pathways & Interactions for IKBKE Gene

PathCards logo

SuperPathways for IKBKE Gene

genes like me logo Genes that share pathways with IKBKE: view

SIGNOR curated interactions for IKBKE Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for IKBKE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 10882136
GO:0006955 immune response NAS 10421793
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007252 I-kappaB phosphorylation IEA --
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP 20188669
genes like me logo Genes that share ontologies with IKBKE: view

Drugs & Compounds for IKBKE Gene

(10) Drugs for IKBKE Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0
BMS-345541 Pharma IKK inhibitor,highly selective 0
IKK-3 Inhibitor Pharma IKK-3 Inhibitor 0
IKKε-IN-1 Pharma 0

(6) Additional Compounds for IKBKE Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0

(4) ApexBio Compounds for IKBKE Gene

Compound Action Cas Number
BMS-345541 IKK inhibitor,highly selective 547757-23-3
IKK-3 Inhibitor IKK-3 Inhibitor 862812-98-4
IKKε-IN-1 1292310-49-6
MRT67307 SIK/TBK-1/IKKe inhibitor 1190378-57-4
genes like me logo Genes that share compounds with IKBKE: view

Drug Products

Transcripts for IKBKE Gene

mRNA/cDNA for IKBKE Gene

3 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKBKE

Clone Products

  • Addgene plasmids for IKBKE

Alternative Splicing Database (ASD) splice patterns (SP) for IKBKE Gene

No ASD Table

Relevant External Links for IKBKE Gene

GeneLoc Exon Structure for
IKBKE

Expression for IKBKE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IKBKE Gene

mRNA differential expression in normal tissues according to GTEx for IKBKE Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for IKBKE Gene

This gene is overexpressed in Lung (20.6), Peripheral blood mononuclear cells (13.0), and Lymph node (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IKBKE Gene



Protein tissue co-expression partners for IKBKE Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IKBKE

SOURCE GeneReport for Unigene cluster for IKBKE Gene:

Hs.321045

mRNA Expression by UniProt/SwissProt for IKBKE Gene:

Q14164-IKKE_HUMAN
Tissue specificity: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

Evidence on tissue expression from TISSUES for IKBKE Gene

  • Blood(4.4)
  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with IKBKE: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for IKBKE Gene

Orthologs for IKBKE Gene

This gene was present in the common ancestor of chordates.

Orthologs for IKBKE Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia IKBKE 30
  • 89.44 (n)
cow
(Bos Taurus)
Mammalia IKBKE 30
  • 87.76 (n)
rat
(Rattus norvegicus)
Mammalia Ikbke 30
  • 83.1 (n)
mouse
(Mus musculus)
Mammalia Ikbke 17 30
  • 83.01 (n)
chicken
(Gallus gallus)
Aves IKBKE 30
  • 69.47 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ikbke 30
  • 61.73 (n)
zebrafish
(Danio rerio)
Actinopterygii ikbke 30
  • 56.6 (n)
wufk70c05 30
Species where no ortholog for IKBKE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKBKE Gene

ENSEMBL:
Gene Tree for IKBKE (if available)
TreeFam:
Gene Tree for IKBKE (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IKBKE: view image

Paralogs for IKBKE Gene

Paralogs for IKBKE Gene

(1) SIMAP similar genes for IKBKE Gene using alignment to 1 proteins:

  • IKKE_HUMAN
genes like me logo Genes that share paralogs with IKBKE: view

Variants for IKBKE Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IKBKE Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs12059562 - p.Ala602Val
rs17021877 - p.Ala371Thr
rs3748022 - p.Pro713Leu
rs41296028 - p.Glu128Lys
rs41299015 - p.Glu515Asp

Additional dbSNP identifiers (rs#s) for IKBKE Gene

Structural Variations from Database of Genomic Variants (DGV) for IKBKE Gene

Variant ID Type Subtype PubMed ID
dgv564n100 CNV gain 25217958
nsv549068 CNV gain 21841781

Variation tolerance for IKBKE Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.88; 87.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IKBKE Gene

Human Gene Mutation Database (HGMD)
IKBKE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKBKE

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKBKE Gene

Disorders for IKBKE Gene

MalaCards: The human disease database

(4) MalaCards diseases for IKBKE Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rabies
  • lyssa
viral infectious disease
  • viral disease
t-cell leukemia
  • leukemia, t-cell, chronic
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search IKBKE in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IKBKE

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IKBKE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IKBKE Gene

Publications for IKBKE Gene

  1. SUMOylation-dependent localization of IKKepsilon in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. (PMID: 20188669) Renner F … Schmitz ML (Molecular cell 2010) 3 4 23 54
  2. SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. (PMID: 16281057) Huang J … Shu HB (The EMBO journal 2005) 3 4 23 54
  3. IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. (PMID: 10882136) Peters RT … Maniatis T (Molecular cell 2000) 2 3 4 54
  4. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. (PMID: 10421793) Shimada T … Akira S (International immunology 1999) 2 3 4 54
  5. Quantitative Proteomics Identified TTC4 as a TBK1 Interactor and a Positive Regulator of SeV-Induced Innate Immunity. (PMID: 29251827) Shang J … Guo L (Proteomics 2018) 3 4 54

Products for IKBKE Gene

Sources for IKBKE Gene