IKBKB Gene (Protein Coding)

Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta

GCID:: GC08P042271

GIFtS:: 54

Genes Participants

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011] See more...

Aliases for IKBKB Gene

Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta ² ³ ⁵
Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta ² ³
Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta ³ ⁴
Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta ³ ⁴
I-Kappa-B-Kinase Beta ³ ⁴
I-Kappa-B Kinase 2 ³ ⁴
EC 2.7.11.10 ⁴ ⁵²
IKK-Beta ³ ⁴

NFKBIKB ³ ⁴
IKK2 ³ ⁴
IKKB ³ ⁴
EC 2.7.11 ⁵²
IMD15A ³
IMD15B ³
IMD15 ³
IKK-B ⁴
IkBKB ⁴

External Ids for IKBKB Gene

HGNC: 5960
Entrez Gene: 3551
Ensembl: ENSG00000104365
OMIM: 603258
UniProtKB: O14920

Previous GeneCards Identifiers for IKBKB Gene

GC08M041757
GC08P042157
GC08P041869
GC08P042146
GC08P042247
GC08P040656

Search aliases for IKBKB gene in PubMed and other databases

Summaries for IKBKB Gene

Entrez Gene Summary for IKBKB Gene

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for IKBKB Gene

IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15A and Immunodeficiency 15B. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and NGF Pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CHUK.

UniProtKB/Swiss-Prot Summary for IKBKB Gene

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557, PubMed:15084260, PubMed:17213322, PubMed:19716809, PubMed:20410276, PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity).
- IKKB_HUMAN,O14920

Tocris Summary for IKBKB Gene

IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.

Gene Wiki entry for IKBKB Gene

Additional gene information for IKBKB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IKBKB Gene

Genomics for IKBKB Gene

GeneHancer (GH) Regulatory Elements for IKBKB Gene

Promoters and enhancers for IKBKB Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH08J042269	Promoter/Enhancer	2.3	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	515.6	-0.1	-95	3.2	HNRNPK CTCF NRF1 POLR2G USF1 SP1 PHF8 ZFX ZNF639 EP300	IKBKB ENSG00000253408 LOC101929897 POLB HGSNAT ENSG00000254165 KAT6A RF00017-7003
GH08J042050	Promoter/Enhancer	2.5	EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER	49	-220.0	-220001	3.8	FOXK2 HNRNPK ZBTB40 EP300 SIN3A TCF12 USF1 POLR2G SP1 NCOR1	KAT6A LOC105379393 lnc-AP3M2-3 IKBKB ENSG00000254165 AP3M2 PLAT GPAT4 POLB ENSG00000238966
GH08J042151	Promoter/Enhancer	2.3	EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER	22.4	-116.7	-116732	5.9	FOXK2 ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC POLR2G	AP3M2 ENSG00000261449 IKBKB ENSG00000253408 POLB KAT6A DKK4 ENSG00000254165 ENSG00000238966 piR-38189
GH08J043054	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE CraniofacialAtlas	19.4	+785.9	785877	5.2	HNRNPK ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 POLR2G USF1	FNTA HGSNAT ENSG00000254165 IKBKB HOOK3 ENSG00000254673 ENSG00000254198 RNF170 POMK THAP1
GH08J042841	Promoter/Enhancer	2.1	EPDnew Ensembl ENCODE CraniofacialAtlas	19.4	+571.6	571579	3.5	ZBTB40 ZNF217 EP300 SIN3A TCF12 USF1 POLR2G SP1 NCOR1 GTF2E2	ENSG00000286837 THAP1 lnc-RNF170-2 ENSG00000254165 IKBKB HOOK3 HGSNAT RNF170 FNTA RF00017-7012

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IKBKB on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IKBKB

Top Transcription factor binding sites by QIAGEN in the IKBKB gene promoter:

c-Myc
C/EBPalpha
C/EBPbeta
ER-alpha
HTF
Max1
p53
POU3F2
RREB-1
STAT1

Genomic Locations for IKBKB Gene

chr8:42,271,302-42,332,653: (GRCh38/hg38)

Size:: 61,352 bases
Orientation:: Plus strand

chr8:42,128,820-42,190,171: (GRCh37/hg19)

Size:: 61,352 bases
Orientation:: Plus strand

Genomic View for IKBKB Gene

Genes around IKBKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

8p11.21 by HGNC
8p11.21 by Entrez Gene
8p11.21 by Ensembl

IKBKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for IKBKB Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IKBKB Gene

NC_000008.11

Proteins for IKBKB Gene

Protein details for IKBKB Gene (UniProtKB/Swiss-Prot)
Protein Symbol:

O14920-IKKB_HUMAN

Recommended name:

Inhibitor of nuclear factor kappa-B kinase subunit beta

Protein Accession:

O14920

Secondary Accessions:
- B4DZ30
- B4E0U4
- O75327
Protein attributes for IKBKB Gene
Size:

756 amino acids

Molecular mass:

86564 Da
Quaternary structure:
Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985). Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14 (PubMed:9751059). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Interacts with SQSTM1 through PRKCZ or PRKCI (PubMed:10356400). Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). May interact with MAVS/IPS1 (PubMed:16177806). Interacts with NALP2 (PubMed:15456791). Interacts with TICAM1 (PubMed:14739303). Interacts with FAF1; the interaction disrupts the IKK complex formation (PubMed:17684021). Interacts with ATM (PubMed:16497931). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833). Interacts with NIBP; the interaction is direct (PubMed:15951441). Interacts with ARRB1 and ARRB2 (PubMed:15173580). Interacts with TRIM21 (PubMed:19675099). Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity (PubMed:20434986). Interacts with PDPK1 (PubMed:16207722). Interacts with EIF2AK2/PKR (PubMed:10848580). The phosphorylated form interacts with PPM1A and PPM1B (PubMed:18930133). Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055). Interacts with IKBKE (PubMed:23453969). Interacts with NAA10, leading to NAA10 degradation (PubMed:19716809). Interacts with FOXO3 (PubMed:15084260). Interacts with AKAP13 (PubMed:23090968). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375). Interacts with LRRC14; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation (PubMed:27426725). Interacts with SASH1 (PubMed:23776175). Interacts with ARFIP2 (PubMed:26296658).

(Microbial infection) Interacts with Yersinia yopJ.

(Microbial infection) Interacts with vaccinia virus protein B14.
Three dimensional structures from OCA and Proteopedia for IKBKB Gene
- 3BRT (3D)
- 3BRV (3D)
- 4E3C (3D)
- 4KIK (3D)
Alternative splice isoforms for IKBKB Gene
UniProtKB/Swiss-Prot:
O14920-1

O14920-2

O14920-3

O14920-4

neXtProt entry for IKBKB Gene

Protein Expression for IKBKB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for IKBKB Gene

O14920:

DQGSLCTSFVGTLQYLAPEL
HKIIDLGYAK
PLLAMEYC
QGQRAAM
RLGTGGFGNV
QLSKTVVCKQKALELLPKVEEVV
RDLKPEN
QQLKAKL
IIHRDLKPENIVLQ
MKERLGTGGFG
TVDYWSFGT

Post-translational modifications for IKBKB Gene

Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. Phosphorylated by the IKK-related kinases TBK1 and IKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent gene transcription. Dephosphorylated at Ser-177 and Ser-181 by PPM1A and PPM1B.
- O14920-IKKB_HUMAN
(Microbial infection) Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B pathway.
- O14920-IKKB_HUMAN
Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling. According to PubMed:19675099, 'Ser-163' does not serve as a monoubiquitination site. According to PubMed:16267042, ubiquitination on 'Ser-163' modulates phosphorylation on C-terminal serine residues.
- O14920-IKKB_HUMAN
(Microbial infection) Monoubiquitination by TRIM21 is disrupted by Yersinia yopJ.
- O14920-IKKB_HUMAN
Hydroxylated by PHD1/EGLN2, loss of hydroxylation under hypoxic conditions results in activation of NF-kappa-B.
- O14920-IKKB_HUMAN
Ubiquitination at Lys106, Lys163, and Lys555
- NX_O14920 (NX_O14920-1)
Modification sites at PhosphoSitePlus
- O14920

Other Protein References for IKBKB Gene

ENSEMBL proteins:

REFSEQ proteins:

Antibody Products

LifeSpan BioSciences IKBKB / IKK2 / IKK Beta Antibody (LS-B1362) and IKBKB / IKK2 / IKK Beta Antibody (LS-B715)

NSJ Bioreagents IKKb Antibody and IKK beta Antibody

Creative Diagnostics Anti-IKBKB monoclonal antibody, clone FQS7154

Creative Biolabs Recombinant Anti-Human IKBKB Antibody, Mouse Anti-IL2 Recombinant Antibody (627CT14.8.1), and Mouse Anti-IKBKB Recombinant Antibody (10A9B6)

BioLegend IKBKB (IKKbeta) Antibody

GeneTex Anti-IKK beta antibody (GTX105690) and Anti-IKK beta antibody (GTX107970)

OriGene Antibodies for IKBKB
- AM06154SU-N
- AM06155SU-N
- AM11078PU-N
- AP06396PU-N
- AP06526PU-N
- AP07309PU-N
- AP07860SU-N
- AP09040AF-N
- AP09508PU-N
- AP09508PU-S
- AP12624PU-N
- AP55884PU-N
- AP55884PU-S
- TA305996
- TA308825
- TA319266
- TA325556
- TA325557
- TA325558
- TA327264
- TA327836
- TA333219
- TA336374
- TA336378
- TA346977
- TA350752
- TA354395
- TA354898
- TA354899
- TA890128
- TA890128S
Custom Antibody Services

Novus Biologicals Antibodies for IKBKB

Abcam antibodies for IKBKB
- IKK beta

Invitrogen Antibodies for IKBKB (AFLGC-IKBKB)

Biorbyt antibodies for IKBKB
- orb135725
- orb14681
- orb157676
- orb214091
- orb214092
- orb329633
- orb329679
- orb343972
- orb390047
- orb393325
- orb393326
- orb400952
- orb5519
- orb556271

Boster Bio Antibodies for IKBKB
- PB9221
- PA2036
- PA2036-1
- M00118
- M00118-1
- A00118

ProSci Antibodies for IKBKB
- inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Custom Antibody Services

Santa Cruz Biotechnology (SCBT) Antibodies for IKBKB

Sino Biological Antibodies for IKBKB

Protein Products

OriGene Purified Proteins for IKBKB
Search Origene for MassSpec and Protein Over-expression Lysates for IKBKB
Origene Custom Protein Services for IKBKB

Novus Biologicals proteins and lysates for IKBKB

Browse ProSpec Recombinant Proteins

antibodies-online: Show 16 available IKBKB Proteins ranked by validation data
Compare Top IKBKB Proteins

Signalway Proteins for IKBKB
- AP84056

Search for IKBKB Proteins at ProSci

Abcam proteins for IKBKB
- IKK beta

Assay Products

Aviva Systems Biology IKBKB ELISA Kit (Human) (OKEH04742) and IKBKB ELISA Kit (Human) (OKCD09224)

antibodies-online: Show 27 available IKBKB Elisa Kits ranked by validation data
Compare Top IKBKB Elisa Kits
Quality Products:

Boster Bio ELISA Kits for IKBKB
- EKC1294
- EKC2044
- EKC2074

Signalway ELISA kits for IKBKB
- EK14726

Browse Sino Biological Assays

Domains & Families for IKBKB Gene

Gene Families for IKBKB Gene

HGNC:

IUPHAR :

IKK family

Human Protein Atlas (HPA):

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Protein Domains for IKBKB Gene

Blocks:

Ubiquitin domain

InterPro:

ProtoNet:

O14920

Suggested Antigen Peptide Sequences for IKBKB Gene

GenScript: Design optimal peptide antigens:

IKBKB protein (A1L159_HUMAN)
cDNA FLJ33978 fis, clone DFNES2004354, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (B3KRB7_HUMAN)
cDNA FLJ58217, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (B4E0U4_HUMAN)
Nuclear factor NF-kappa-B inhibitor kinase beta (IKKB_HUMAN)
IKBKB protein (Q32ND9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14920

UniProtKB/Swiss-Prot:

IKKB_HUMAN :

The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

Domain:

The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.

Family:

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

Function for IKBKB Gene

Molecular function for IKBKB Gene

UniProtKB/Swiss-Prot Function:

Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557, PubMed:15084260, PubMed:17213322, PubMed:19716809, PubMed:20410276, PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity).

IKKB_HUMAN,O14920

UniProtKB/Swiss-Prot CatalyticActivity:

Reaction=[I-kappa-B protein]-L-serine + ATP = [I-kappa-B protein]-O-phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:19073, Rhea:RHEA-COMP:13698, Rhea:RHEA-COMP:13699, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.10;.

IKKB_HUMAN,O14920

GENATLAS Biochemistry:

inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA

IKBKB

Enzyme Numbers (IUBMB) for IKBKB Gene

EC 2.7.11.10 ⁵² ⁴
EC 2.7.11 ⁵²

Phenotypes From GWAS Catalog for IKBKB Gene

Gene Ontology (GO) - Molecular Function for IKBKB Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004672	protein kinase activity	IEA,IDA	20434986
GO:0004674	protein serine/threonine kinase activity	TAS	--
GO:0005515	protein binding	IPI,IEA	9520446
GO:0005524	ATP binding	IEA	--
GO:0008384	IkappaB kinase activity	TAS	18626576

Phenotypes for IKBKB Gene

MGI mutant phenotypes for IKBKB:

inferred from 13 alleles

GenomeRNAi human phenotypes for IKBKB:

Human Phenotype Ontology for IKBKB Gene

HPO Id	HPO Name	Alternative Ids	Definition	Synonyms

Animal Models for IKBKB Gene

MGI Knock Outs for IKBKB:

Ikbkb ^{Ikbkb<tm1Ver>}
Ikbkb ^{Ikbkb<tm2.1Mka>}
Ikbkb ^{Ikbkb<tm1Mka>}
Ikbkb ^{Ikbkb<tm1a(EUCOMM)Wtsi>}
Ikbkb ^{Ikbkb<tm1Trk>}
Ikbkb ^{Ikbkb<tm1.1Cgn>}
Ikbkb ^{Ikbkb<tm2.1Cgn>}

Animal Model Products

Taconic Biosciences Mouse Models for IKBKB
- Ikbkb

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for IKBKB - Select products 50% OFF >
* IKBKB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for IKBKB
- GA102370
- GA202110
- KN419154
- KN508210

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IKBKB

genomics-online: gRNA clones - Search for available IKBKB gRNA products
Overview of 135 available IKBKB gene related products
Recommended

Santa Cruz Biotechnology (SCBT) CRISPR for IKBKB

miRNA for IKBKB Gene

miRTarBase miRNAs that target IKBKB

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for IKBKB

Browse OriGene miRNA Products For IKBKB

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for IKBKB
Browse OriGene Inhibitory RNA Products For IKBKB

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IKBKB

genomics-online: shRNA clones - Search for available IKBKB shRNA products
Overview of 135 available IKBKB gene related products
Recommended

Search Santa Cruz Biotechnology (SCBT) for IKBKB siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for IKBKB - Select products 50% OFF >
* IKBKB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for IKBKB
- SC214745
- MC220690
- MC221221
- RN206563
- SC125322
- SC323399
- SC330012
OriGene ORF clones in human,mouse,rat for IKBKB
- MG210500
- MG227004
- MR210500
- MR210500L3
- MR210500L4
- MR227004
- MR227004L3
- MR227004L4
- RC219154
- RC219154L1
- RC219154L2
- RC219154L3
- RC219154L4
- RC231402
- RC231402L3
- RC231402L4
- RC233092
- RG219154
- RG231402
- RG233092
- RR206563
- RR206563L3
- RR206563L4
- MR210500L3V
- MR210500L4V
- MR227004L3V
- MR227004L4V
- RC219154L1V
- RC219154L2V
- RC219154L3V
- RC219154L4V
- RC231402L3V
- RC231402L4V
- RR206563L3V
- RR206563L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for IKBKB

Addgene plasmids for IKBKB

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IKBKB

genomics-online: cdna clones - Search for available IKBKB CDNA products
Overview of 135 available IKBKB gene related products
Recommended
orf clones - Search for available IKBKB ORF products
Overview of 135 available IKBKB gene related products
Recommended

Human IKK beta (NP_001547) VersaClone cDNA (RDC2824)

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for IKBKB

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for IKBKB

Horizon Cell Lines for IKBKB

No data available for Transcription Factor Targets and HOMER Transcription for IKBKB Gene

Localization for IKBKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBKB Gene

Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:17287217}.

O14920-IKKB_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
cytosol	5
plasma membrane	4
nucleus	4
extracellular	2
cytoskeleton	2
mitochondrion	2
endoplasmic reticulum	2
peroxisome	1
endosome	1
lysosome	1
golgi apparatus	1

Subcellular locations from the

Human Protein Atlas (HPA)

Cytosol (2)

See all subcellular structures

Gene Ontology (GO) - Cellular Components for IKBKB Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IBA	21873635
GO:0005829	cytosol	TAS,IDA	--
GO:0008385	IkappaB kinase complex	TAS,IBA	18626576
GO:0009898	cytoplasmic side of plasma membrane	ISS	--

Pathways & Interactions for IKBKB Gene

SuperPathways for IKBKB Gene

	SuperPathway	Contained pathways
1	Activated TLR4 signalling	Toll Like Receptor 9 (TLR9) Cascade .94 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation .94 Activated TLR4 signalling .91 Toll Like Receptor 4 (TLR4) Cascade .91 MyD88 cascade initiated on plasma membrane .88 Toll Like Receptor 10 (TLR10) Cascade .88 Toll Like Receptor 5 (TLR5) Cascade .88 MyD88 dependent cascade initiated on endosome .86 Toll Like Receptor 7/8 (TLR7/8) Cascade .86	MyD88-independent TLR3/TLR4 cascade .86 Toll Like Receptor 3 (TLR3) Cascade .86 TRIF-mediated TLR3/TLR4 signaling .86 MyD88-Mal cascade initiated on plasma membrane .85 Toll Like Receptor 2 (TLR2) Cascade .85 Toll Like Receptor TLR1-TLR2 Cascade .85 Toll Like Receptor TLR6-TLR2 Cascade .85 Toll-Like Receptors Cascades .82 MAP kinase activation in TLR cascade .76
2	TNFR1 Pathway	DR3 Signaling .87 TWEAK Pathway .87 TNFR1 Pathway .56 TNF Signaling .55 Apoptosis and survival TNFR1 signaling pathway .52 GITR Pathway .46	Apoptotic Pathways Triggered By HIV1 .42 Apoptosis through Death Receptors .42 TRAIL Pathway .40 Fas Signaling .35 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway .34 TNF alpha Signaling Pathway .30
3	4-1BB Pathway	4-1BB Pathway .54 CD40 Signaling .54 CD27 Pathway .48 CMV and MAPK Pathways .46 NF-KappaB Activation by EBV .42	NF-kappaB Activation by Viruses .42 TNFR2 Pathway .37 PKR Pathway .36 SUMO Pathway .30
4	Toll-like Receptor Signaling Pathway	Toll-like receptor signaling pathway .92 Toll-like Receptor Signaling Pathway .92 Regulation of toll-like receptor signaling pathway .71 NOD-like Receptor Signaling Pathways .39	Hepatitis B .37 Hepatitis C .34 Chagas disease (American trypanosomiasis) .31
5	Cytosolic sensors of pathogen-associated DNA	RIP-mediated NFkB activation via ZBP1 .84 ZBP1(DAI) mediated induction of type I IFNs .84 TRAF6 mediated NF-kB activation .53 TAK1 activates NFkB by phosphorylation and activation of IKKs complex .47	Cytosolic sensors of pathogen-associated DNA .37 IkBA variant leads to EDA-ID .01 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) .01

Pathways by source for IKBKB Gene

5 Sino Biological pathways for IKBKB Gene

47 BioSystems pathways for IKBKB Gene

64 Reactome pathways for IKBKB Gene

53 KEGG pathways for IKBKB Gene

44 GeneGo (Thomson Reuters) pathways for IKBKB Gene

Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway
Apoptosis and survival APRIL and BAFF signaling
Apoptosis and survival Lymphotoxin-beta receptor signaling
Apoptosis and survival TNFR1 signaling pathway

9 R&D Systems pathways for IKBKB Gene

5 Tocris pathways for IKBKB Gene

63 Qiagen pathways for IKBKB Gene

14-3-3 Induced Apoptosis
4-1BB Pathway
Activation of NF-KappaB by PKR
Akt Signaling
Angiopoietin-TIE2 Signaling

2 Cell Signaling Technology pathways for IKBKB Gene

3 GeneTex pathways for IKBKB Gene

Interacting Proteins for IKBKB Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: O14920-IKKB_HUMAN ENSP00000430684 for IKBKB Gene via UniProtKB MINT STRING IID

Symbol	External ID(s)	Details
CHUK	O15111 ⁴ ²⁰ ¹²⁷ ENSP00000359424 ²¹	EBI-81266, EBI-81249 MINT-8205485 STRING: ENSP00000359424 IID: # exp=34 # pred=4
IKBKG	Q9Y6K9 ⁴ ²⁰ ¹²⁷ ENSP00000483825 ²¹	EBI-81266, EBI-81279 MINT-8209830 STRING: ENSP00000483825 IID: # exp=77 # pred=4
NFKBIA	P25963 ⁴ ²⁰ ¹²⁷ ENSP00000216797 ²¹	EBI-81266, EBI-307386 MINT-8209845 STRING: ENSP00000216797 IID: # exp=75 # pred=3
PPP2CA	P67775 ⁴ ²⁰ ¹²⁷ ENSP00000418447 ²¹	EBI-81266, EBI-712311 MINT-8209746 STRING: ENSP00000418447 IID: # exp=2
RELA	Q04206 ⁴ ²⁰ ¹²⁷ ENSP00000384273 ²¹	EBI-81266, EBI-73886 MINT-50167 STRING: ENSP00000384273 IID: # exp=7 # pred=4

GPS-Prot Interaction Network for IKBKB

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SIGNOR curated interactions for IKBKB Gene

Activates:

Inactivates:

Is activated by:

Is inactivated by:

Gene Ontology (GO) - Biological Process for IKBKB Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002223	stimulatory C-type lectin receptor signaling pathway	TAS	--
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS	--
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	--
GO:0006468	protein phosphorylation	IEA,NAS	9346484
GO:0006954	inflammatory response	TAS	18626576

Drugs & Compounds for IKBKB Gene

(66) Drugs for IKBKB Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
Arsenic trioxide	Approved, Investigational	MalaCards Medline Plus	Pharma	Target, inducer, inhibitor		130
Auranofin	Approved, Investigational	MalaCards Medline Plus	Pharma	Activation, Activator, Target, inhibitor	Thioredoxin reductase inhibitor; induces MPT	12
Sulfasalazine	Approved	MalaCards Medline Plus	Pharma	Inhibition, Inhibitor, Target, inhibitor	NF-κB activation inhibitor	81
Mesalazine	Approved	MalaCards Medline Plus	Pharma	Target, inhibitor		0
Aspirin	Approved, Vet_approved	MalaCards Medline Plus	Pharma	Channel blocker, Target		1440

(29) Additional Compounds for IKBKB Gene - From: Novoseek, HMDB, and Tocris

Name	Synonyms	Role	CAS Number	PubChem IDs	PubMed IDs
ADP	5'-Adenylphosphoric acid Adenosine 5'-diphosphate ADENOSINE-5'-diphosphATE H3ADP 5'-Adenylphosphate	Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor	MalaCards Medline Plus	58-64-0	6022	10551820
IKK 16			MalaCards Medline Plus	1186195-62-9

(3) Tocris Compounds for IKBKB Gene

Compound	Action	Cas Number
Amlexanox	Inhibitor of TBK1 and IKKepsilon; antiallergic agent	68302-57-8
IKK 16	Selective inhibitor of IKK	1186195-62-9
TPCA-1	Potent, selective inhibitor of IKKbeta	507475-17-4

(25) ApexBio Compounds for IKBKB Gene

Compound	Action	Cas Number
ACHP	IκB kinase inhibitor	406208-42-2
Andrographolide	NF-κB signaling Inhibitor	5508-58-7
Bardoxolone methyl	IKK inhibitor, potent antioxidant inflammation modulator	218600-53-4
Bay 11-7085	NK-κB activation inhibitor	196309-76-9
Bay 11-7821(BAY 11-7082)	IKK/NF-κB/TNFα inhibitor	19542-67-7
Bay 65-1942 free base	IKKβ kinase inhibitor,ATP-competitive	600734-02-9
Bay 65-1942 HCl salt		600734-06-3
Bay 65-1942 R form	IKKβ inhibitor, ATP-competitive and selective	758683-21-5
BMS-345541	IKK inhibitor,highly selective	547757-23-3
BMS-345541(free base)	IKK-1/IKK-2 inhibitor,potent and selective	445430-58-0
Choline Fenofibrate	Choline salt of fenofibric acid	856676-23-8
Honokiol	Antioxidant/antitumor/antiangiogenic agent	35354-74-6
IKK-16 (IKK Inhibitor VII)	Selective IκB kinase inhibitor	873225-46-8
IKK-2 inhibitor VIII	IKK-2 inhibitor,potent and selective	406209-26-5
IMD 0354		978-62-1
Luteolin	Antioxidant and free radical scavenger	491-70-3
LY2409881		946518-60-1
ML 120B dihydrochloride
MLN120B	IκB Kinase β Inhibitor	783348-36-7
PF 184		1187460-81-6
PS 1145 dihydrochloride		1049743-58-9
SC-514	ATP-competitive IKK-2 inhibitor, orally active	354812-17-2
Tanshinone IIA	Antioxidant and anti-inflammatory reagent	568-72-9
TPCA-1	IKK-2 inhibitor,potent and selective	507475-17-4
WS6		1421227-53-3

Drug Products

Tocris compounds for IKBKB

ApexBio compounds for IKBKB

Transcripts for IKBKB Gene