Aliases for IKBKB Gene
- Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta 2 3 5
- IKK-Beta 2 3 4
- NFKBIKB 2 3 4
- IKK2 2 3 4
- IKKB 2 3 4
- Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta 2 3
- Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta 3 4
- Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta 3 4
- Serine/Threonine Protein Kinase IKBKB 3 4
- I-Kappa-B-Kinase Beta 3 4
External Ids for IKBKB Gene
Previous GeneCards Identifiers for IKBKB Gene
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for IKBKB Gene
IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15A and Immunodeficiency 15B. Among its related pathways are Diseases associated with the TLR signaling cascade and TCR signaling in naive CD4+ T cells. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CHUK.
UniProtKB/Swiss-Prot Summary for IKBKB Gene
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE (PubMed:11297557, PubMed:20410276). IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor (PubMed:15084260). Also phosphorylates other substrates including NCOA3, BCL10 and IRS1 (PubMed:17213322). Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). Phosphorylates the C-terminus of IRF5, stimulating IRF5 homodimerization and translocation into the nucleus (PubMed:25326418).
IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.