Aliases for IKBKB Gene
Aliases for IKBKB Gene
External Ids for IKBKB Gene
- HGNC: 5960
- Entrez Gene: 3551
- Ensembl: ENSG00000104365
- OMIM: 603258
- UniProtKB: O14920
Previous GeneCards Identifiers for IKBKB Gene
- GC08M041757
- GC08P042157
- GC08P041869
- GC08P042146
- GC08P040656
Summaries for IKBKB Gene
-
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for IKBKB Gene
IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15 and Immunodeficiency 19. Among its related pathways are RANK Signaling in Osteoclasts and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CHUK.
UniProtKB/Swiss-Prot for IKBKB Gene
-
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
-
IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.
Additional gene information for IKBKB Gene
- Monarch Initiative
- Search for IKBKB at DataMed
- Search for IKBKB at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKBKB Gene
Genomics for IKBKB Gene
GeneHancer (GH) Regulatory Elements for IKBKB Gene
Promoters and enhancers for IKBKB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around IKBKB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for IKBKB Gene
Genomic Locations for IKBKB Gene
- chr8:42,271,302-42,332,653
- (GRCh38/hg38)
- Size:
- 61,352 bases
- Orientation:
- Plus strand
- chr8:42,128,820-42,190,171
- (GRCh37/hg19)
Genomic View for IKBKB Gene
Genes around IKBKB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p11.21 by Ensembl
- 8p11.21 by Entrez Gene
- 8p11.21 by HGNC
IKBKB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IKBKB Gene
Proteins for IKBKB Gene
-
Protein details for IKBKB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O14920-IKKB_HUMAN
- Recommended name:
- Inhibitor of nuclear factor kappa-B kinase subunit beta
- Protein Accession:
- O14920
- B4DZ30
- B4E0U4
- O75327
Protein attributes for IKBKB Gene
- Size:
- 756 amino acids
- Molecular mass:
- 86564 Da
- Quaternary structure:
-
- Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985). Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14 (PubMed:9751059). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Interacts with SQSTM1 through PRKCZ or PRKCI (PubMed:10356400). Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). May interact with MAVS/IPS1 (PubMed:16177806). Interacts with NALP2 (PubMed:15456791). Interacts with TICAM1 (PubMed:14739303). Interacts with FAF1; the interaction disrupts the IKK complex formation (PubMed:17684021). Interacts with ATM (PubMed:16497931). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833). Interacts with NIBP; the interaction is direct (PubMed:15951441). Interacts with ARRB1 and ARRB2 (PubMed:15173580). Interacts with TRIM21 (PubMed:19675099). Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity (PubMed:20434986). Interacts with PDPK1 (PubMed:16207722). Interacts with EIF2AK2/PKR (PubMed:10848580). The phosphorylated form interacts with PPM1A and PPM1B (PubMed:18930133). Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055). Interacts with IKBKE (PubMed:23453969). Interacts with NAA10, leading to NAA10 degradation (PubMed:19716809). Interacts with FOXO3 (PubMed:15084260). Interacts with AKAP13 (PubMed:23090968). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375). Interacts with LRRC14; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation (PubMed:27426725).
- (Microbial infection) Interacts with Yersinia yopJ.
Three dimensional structures from OCA and Proteopedia for IKBKB Gene
Protein Expression for IKBKB Gene
Selected DME Specific Peptides for IKBKB Gene
- O14920:
-
- DQGSLCTSFVGTLQYLAPEL
- HKIIDLGYAK
- PLLAMEYC
- QGQRAAM
- RLGTGGFGNV
- QLSKTVVCKQKALELLPKVEEVV
- RDLKPEN
- QQLKAKL
- IIHRDLKPENIVLQ
- MKERLGTGGFG
- TVDYWSFGT
Post-translational modifications for IKBKB Gene
- (Microbial infection) Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B pathway.
- (Microbial infection) Monoubiquitination by TRIM21 is disrupted by Yersinia yopJ.
- Hydroxylated by PHD1/EGLN2, loss of hydroxylation under hypoxic conditions results in activation of NF-kappa-B.
- Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling. According to PubMed:19675099, Ser-163 does not serve as a monoubiquitination site. According to PubMed:16267042, ubiquitination on Ser-163 modulates phosphorylation on C-terminal serine residues.
- Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. Phosphorylated by the IKK-related kinases TBK1 and IKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent gene transcription. Dephosphorylated at Ser-177 and Ser-181 by PPM1A and PPM1B.
- Ubiquitination at isoforms=2, 3, 4106, isoforms=2, 3, 4163, and isoforms=2, 4555
- Modification sites at PhosphoSitePlus
Other Protein References for IKBKB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for IKBKB (IKK beta)
-
Custom Antibody ServicesOriGene Antibodies for IKBKB
- Novus Biologicals Antibodies for IKBKB
-
Abcam antibodies for IKBKB
-
Cloud-Clone Corp. Antibodies for IKBKB
- Invitrogen Antibodies for IKBKB
- antibodies-online: Search results for 714 available IKBKB Antibodies ranked by validation data
- Compare Top IKBKB Antibodies
-
Recommended
- 302 WB Antibodies (anti-human)
- 60 IF (p) Antibodies (anti-human)
- 48 DB Antibodies (anti-human)
- 20 IF Antibodies (anti-human)
- 16 IHC Antibodies (anti-human)
- 6 FACS Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 5 DB Antibodies (anti-mouse)
- 6 FACS Antibodies (anti-mouse)
- 13 IF Antibodies (anti-mouse)
- 48 IF (p) Antibodies (anti-mouse)
- 125 WB Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-rat)
- 1 IF/ICC Antibody (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 12 IF Antibodies (anti-rat)
- 48 IF (p) Antibodies (anti-rat)
- 85 WB Antibodies (anti-rat)
- 2 IF/ICC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- GeneTex IKBKB antibody for IKBKB
-
Custom Antibody ServicesProSci Antibodies for IKBKB
-
Santa Cruz Biotechnology (SCBT) Antibodies for IKBKB
- Sino Biological Antibodies for IKBKB
Protein Products
-
OriGene Purified Proteins for IKBKB
- Search Origene for MassSpec and Protein Over-expression Lysates for IKBKB
- Origene Custom Protein Services for IKBKB
-
Cloud-Clone Corp. Proteins for IKBKB
- Search GeneTex for Proteins for IKBKB
-
Abcam proteins for IKBKB
Assay Products
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for IKBKB (IKK beta)
-
Cloud-Clone Corp. Assay Kits for IKBKB
Domains & Families for IKBKB Gene
Gene Families for IKBKB Gene
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- FDA approved drug targets
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for IKBKB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for IKBKB Gene
- GenScript: Design optimal peptide antigens:
-
- IKBKB protein (A1L159_HUMAN)
- cDNA FLJ33978 fis, clone DFNES2004354, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (B3KRB7_HUMAN)
- cDNA FLJ58217, highly similar to Inhibitor of nuclear factor kappa B kinase subunit beta (EC 2.7.11.10) (B4E0U4_HUMAN)
- Nuclear factor NF-kappa-B inhibitor kinase beta (IKKB_HUMAN)
- IKBKB protein (Q32ND9_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O14920UniProtKB/Swiss-Prot:
IKKB_HUMAN :- The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
- Domain:
-
- The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
- Family:
-
- Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Function for IKBKB Gene
Molecular function for IKBKB Gene
- GENATLAS Biochemistry:
- inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
- UniProtKB/Swiss-Prot Function:
- Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
Enzyme Numbers (IUBMB) for IKBKB Gene
Phenotypes From GWAS Catalog for IKBKB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA,IDA | 20434986 |
| GO:0004674 | protein serine/threonine kinase activity | TAS | -- |
| GO:0005515 | protein binding | IPI | 9520446 |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0008384 | IkappaB kinase activity | TAS | 18626576 |
Phenotypes for IKBKB Gene
- MGI mutant phenotypes for IKBKB:
-
inferred from 12 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- integument phenotype
- embryo phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for IKBKB:
-
- Mitotic spindle defects
- Synthetic lethal with Ras
- Decreased viability ratio
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased cell number in S
- Increased circadian period length
- Decreased viability
- Increased viability with TRAIL
- Decreased substrate adherent cell growth
- Decreased cell proliferation
- Decreased interferon-beta reporter expression
- Decreased cella89culturea89derived Hepatitis C virus (HCVcc
- Decreased Hepatitis C Virus pseudoparticles (HCVpp
- Decreased viability with paclitaxel
Animal Models for IKBKB Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for IKBKB
- Cyagen custom Knockout/knockin (KOKI) mouse models for IKBKB
-
-
ViGene Biosciences lentiviral particle packaged cDNA for IKBKB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IKBKB gene
- Search ViGene Biosciences for IKBKB
CRISPR Products
-
OriGene CRISPR knockouts for IKBKB
- genomics-online: gRNA clones - Search results for 115 available IKBKB gene related products
- Overview of 115 available IKBKB gene related products
- Applied Biological Materials CRISPR for IKBKB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKBKB
- GenScript: Design CRISPR guide RNA sequences for IKBKB
miRNA for IKBKB Gene
- miRTarBase miRNAs that target IKBKB
miRNA Products
- Search ViGene Biosciences for IKBKB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IKBKB
- Browse OriGene Inhibitory RNA Products For IKBKB
- genomics-online: shRNA clones - Search results for 115 available IKBKB gene related products
- Overview of 115 available IKBKB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IKBKB gene
Clone Products
- Sino Biological Human cDNA Clone for IKBKB
- VectorBuilder custom plasmid, inducible vectors for IKBKB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IKBKB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IKBKB
- Applied Biological Materials Clones for IKBKB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for IKBKB
-
ViGene Biosciences adenoviral particle packaged cDNA for IKBKB gene
-
ViGene Biosciences lentiviral particle packaged cDNA for IKBKB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for IKBKB gene
No data available for Transcription Factor Targets and HOMER Transcription for IKBKB Gene
Localization for IKBKB Gene
Subcellular locations from UniProtKB/Swiss-Prot for IKBKB Gene
- Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:17287217}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| nucleus | 4 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
- Cytosol (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS,IDA | -- |
| GO:0008385 | IkappaB kinase complex | TAS | 18626576 |
| GO:0009898 | cytoplasmic side of plasma membrane | ISS | -- |
Pathways & Interactions for IKBKB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | TNFR1 Pathway |
.87
.87
.56
.55
.46
|
.40
.35
|
| 3 | 4-1BB Pathway |
.54
.54
.48
|
.37
.36
.30
|
| 4 | Cytosolic sensors of pathogen-associated DNA | ||
| 5 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
Pathways by source for IKBKB Gene
5 Sino Biological pathways for IKBKB Gene
3 GeneTex pathways for IKBKB Gene
46 BioSystems pathways for IKBKB Gene
64 Reactome pathways for IKBKB Gene
46 KEGG pathways for IKBKB Gene
44 GeneGo (Thomson Reuters) pathways for IKBKB Gene
9 R&D Systems pathways for IKBKB Gene
5 Tocris pathways for IKBKB Gene
63 Qiagen pathways for IKBKB Gene
2 Cell Signaling Technology pathways for IKBKB Gene
Interacting Proteins for IKBKB Gene
Selected Interacting proteins:
ENSP00000430684
O14920-IKKB_HUMAN
for IKBKB Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for IKBKB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002223 | stimulatory C-type lectin receptor signaling pathway | TAS | -- |
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | TAS | -- |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | -- |
| GO:0006468 | protein phosphorylation | IEA,NAS | 9346484 |
| GO:0006954 | inflammatory response | TAS | 18626576 |
Drugs & Compounds for IKBKB Gene
(65) Drugs for IKBKB Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Arsenic trioxide | Approved, Investigational | Pharma | Target, inducer, inhibitor | 125 | ||
| Auranofin | Approved, Investigational | Pharma | Activation, Activator, Target, inhibitor | Thioredoxin reductase inhibitor; induces MPT | 11 | |
| Sulfasalazine | Approved | Pharma | Inhibition, Inhibitor, Target, inhibitor | NF-κB activation inhibitor | 63 | |
| Mesalazine | Approved | Pharma | Target, inhibitor | 0 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker, Target | 1232 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
(3) Tocris Compounds for IKBKB Gene
(25) ApexBio Compounds for IKBKB Gene
| Compound | Action | Cas Number |
|---|---|---|
| ACHP | IκB kinase inhibitor | 406208-42-2 |
| Andrographolide | NF-κB signaling Inhibitor | 5508-58-7 |
| Bardoxolone methyl | IKK inhibitor, potent antioxidant inflammation modulator | 218600-53-4 |
| Bay 11-7085 | NK-κB activation inhibitor | 196309-76-9 |
| Bay 11-7821(BAY 11-7082) | IKK/NF-κB/TNFα inhibitor | 19542-67-7 |
| Bay 65-1942 free base | IKKβ kinase inhibitor,ATP-competitive | 600734-02-9 |
| Bay 65-1942 HCl salt | 600734-06-3 | |
| Bay 65-1942 R form | IKKβ inhibitor, ATP-competitive and selective | 758683-21-5 |
| BMS-345541 | IKK inhibitor,highly selective | 547757-23-3 |
| BMS-345541(free base) | IKK-1/IKK-2 inhibitor,potent and selective | 445430-58-0 |
| Choline Fenofibrate | Choline salt of fenofibric acid | 856676-23-8 |
| Honokiol | Antioxidant/antitumor/antiangiogenic agent | 35354-74-6 |
| IKK-16 (IKK Inhibitor VII) | Selective IκB kinase inhibitor | 873225-46-8 |
| IKK-2 inhibitor VIII | IKK-2 inhibitor,potent and selective | 406209-26-5 |
| IMD 0354 | 978-62-1 | |
| Luteolin | Antioxidant and free radical scavenger | 491-70-3 |
| LY2409881 | 946518-60-1 | |
| ML 120B dihydrochloride | ||
| MLN120B | IκB Kinase β Inhibitor | 783348-36-7 |
| PF 184 | 1187460-81-6 | |
| PS 1145 dihydrochloride | 1049743-58-9 | |
| SC-514 | ATP-competitive IKK-2 inhibitor, orally active | 354812-17-2 |
| Tanshinone IIA | Antioxidant and anti-inflammatory reagent | 568-72-9 |
| TPCA-1 | IKK-2 inhibitor,potent and selective | 507475-17-4 |
| WS6 | 1421227-53-3 |
Transcripts for IKBKB Gene
mRNA/cDNA for IKBKB Gene
- (20) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (210) Selected AceView cDNA sequences:
- (30) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for IKBKB Gene
CRISPR Products
-
OriGene CRISPR knockouts for IKBKB
- genomics-online: gRNA clones - Search results for 115 available IKBKB gene related products
- Overview of 115 available IKBKB gene related products
- Applied Biological Materials CRISPR for IKBKB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for IKBKB
- GenScript: Design CRISPR guide RNA sequences for IKBKB
miRNA Products
- Search ViGene Biosciences for IKBKB
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for IKBKB
- Browse OriGene Inhibitory RNA Products For IKBKB
- genomics-online: shRNA clones - Search results for 115 available IKBKB gene related products
- Overview of 115 available IKBKB gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for IKBKB gene
Clone Products
- Sino Biological Human cDNA Clone for IKBKB
- VectorBuilder custom plasmid, inducible vectors for IKBKB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for IKBKB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for IKBKB
- Applied Biological Materials Clones for IKBKB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19 | ^ | 20a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | ||||||||||||
| SP3: | - | ||||||||||||
| SP4: | |||||||||||||
| SP5: | |||||||||||||
| SP6: | - | ||||||||||||
| SP7: | - | ||||||||||||
| SP8: |
Expression for IKBKB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Lymph node (21.0) and Peripheral blood mononuclear cells (15.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for IKBKB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of IKBKB Gene:
IKBKBSOURCE GeneReport for Unigene cluster for IKBKB Gene:
Hs.597664mRNA Expression by UniProt/SwissProt for IKBKB Gene:
O14920-IKKB_HUMAN
Tissue specificity:
Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Evidence on tissue expression from TISSUES for IKBKB Gene
- Heart(4.5)
- Lung(4.5)
- Liver(4.4)
- Nervous system(4.2)
- Skin(3)
- Blood(2.7)
- Intestine(2.6)
- Muscle(2.4)
- Spleen(2.4)
- Lymph node(2.3)
- Kidney(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IKBKB Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- immune
- lymphatic
- respiratory
Regions:
Thorax:
- bronchus
- lung
Abdomen:
- intestine
- large intestine
- small intestine
Pelvis:
- anus
- rectum
General:
- blood
- bone marrow
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for IKBKB
- genomics-online: primer clones - Search results for 115 available IKBKB gene related products
- Overview of 115 available IKBKB gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for IKBKB Gene
Orthologs for IKBKB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | IKBKB 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | IKBKB 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | IKBKB 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | IKBKB 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ikbkb 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ikbkb 33 |
|
||
| cow (Bos Taurus) |
Mammalia | IKBKB 33 34 |
|
||
| chicken (Gallus gallus) |
Aves | IKBKB 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | IKBKB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ikbkb 33 |
|
||
| Str.17591 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ikbkb 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | ird5 35 34 |
|
- Species where no ortholog for IKBKB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for IKBKB Gene
(17) SIMAP similar genes for IKBKB Gene using alignment to 12 proteins:
Variants for IKBKB Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs140666106 | benign, Immunodeficiency 15 | 42,316,898(+) | C/T | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs145086380 | likely-benign, Immunodeficiency 15 | 42,316,841(+) | G/T | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs151057347 | likely-benign, Immunodeficiency 15 | 42,321,909(+) | A/C | coding_sequence_variant, non_coding_transcript_variant, synonymous_variant | |
| rs200296680 | pathogenic, Immunodeficiency 15 | 42,316,223(+) | C/T | 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, stop_gained | |
| rs201052871 | uncertain-significance, Immunodeficiency 15 | 42,314,347(+) | G/A | 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv128n16 | CNV | deletion | 17901297 |
| dgv36e209 | CNV | deletion | 24192839 |
| dgv7185n100 | CNV | gain | 25217958 |
| esv1003654 | CNV | deletion | 20482838 |
| esv1761681 | CNV | deletion | 17803354 |
| esv2736935 | CNV | deletion | 23290073 |
| esv3543424 | CNV | deletion | 23714750 |
| esv3543425 | CNV | deletion | 23714750 |
| esv3617007 | CNV | loss | 21293372 |
| nsv1132145 | CNV | deletion | 24896259 |
| nsv1145767 | CNV | deletion | 26484159 |
| nsv398024 | CNV | deletion | 16902084 |
| nsv476099 | CNV | novel sequence insertion | 20440878 |
| nsv508508 | CNV | deletion | 20534489 |
| nsv611131 | CNV | gain | 21841781 |
| nsv6169 | CNV | deletion | 18451855 |
| nsv831301 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.39;
54.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IKBKB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKBKB Gene
Disorders for IKBKB Gene
(7) MalaCards diseases for IKBKB Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| immunodeficiency 15 |
|
|
| immunodeficiency 19 |
|
|
| neurodermatitis |
|
|
| hepatitis c virus |
|
|
| prostate cancer |
|
Search IKBKB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IKKB_HUMAN- Immunodeficiency 15 (IMD15) [MIM:615592]: An autosomal recessive primary immunodeficiency disorder characterized by onset in infancy of life-threatening bacterial, fungal, and viral infections and failure to thrive. Laboratory studies show hypo- or agammaglobulinemia with relatively normal numbers of B and T-cells, and impaired differentiation and activation of immune cells. {ECO:0000269 PubMed:24369075}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for IKBKB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for IKBKB Gene
Publications for IKBKB Gene
- Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. (PMID: 19716809) Kuo HP … Hung MC (Biochemical and biophysical research communications 2009) 3 4 22 58
- Ro52-mediated monoubiquitination of IKK{beta} down-regulates NF-{kappa}B signalling. (PMID: 19675099) Wada K … Kamitani T (Journal of biochemistry 2009) 3 4 22 58
- PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. (PMID: 18930133) Sun W … Yang J (Cellular signalling 2009) 3 4 22 58
- IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB. (PMID: 18308615) Schmid JA … Birbach A (Cytokine & growth factor reviews 2008) 2 3 22 58
- FAF1 suppresses IkappaB kinase (IKK) activation by disrupting the IKK complex assembly. (PMID: 17684021) Park MY … Kim E (The Journal of biological chemistry 2007) 3 4 22 58
Products for IKBKB Gene
- R&D Systems Antibodies for IKBKB (IKK beta)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Proteome Profiler Antibody Arrays and other biochemical assays for IKBKB (IKK beta)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes