Aliases for IKBKB Gene
- Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta 2 3 5
- IKK-Beta 2 3 4
- NFKBIKB 2 3 4
- IKK2 2 3 4
- IKKB 2 3 4
- Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta 2 3
- Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta 3 4
- Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta 3 4
- I-Kappa-B-Kinase Beta 3 4
External Ids for IKBKB Gene
Previous GeneCards Identifiers for IKBKB Gene
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
GeneCards Summary for IKBKB Gene
IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15A and Immunodeficiency 15B. Among its related pathways are GDNF-Family Ligands and Receptor Interactions and Antigen processing-Cross presentation. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CHUK.
UniProtKB/Swiss-Prot Summary for IKBKB Gene
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses (PubMed:30337470). Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation. Phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (PubMed:11297557, PubMed:15084260, PubMed:17213322, PubMed:19716809, PubMed:20410276, PubMed:20434986, PubMed:20797629, PubMed:21138416, PubMed:30337470). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity).
IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.