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IKBKB Gene(Protein Coding)

Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta

GCID:
GC08P042247
GIFtS:
60
Genes Participants
UDN Logo

Aliases for IKBKB Gene

Aliases for IKBKB Gene

  • Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta 2 3 5
  • Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B-Cells, Kinase Beta 2 3
  • Nuclear Factor NF-Kappa-B Inhibitor Kinase Beta 3 4
  • I-Kappa-B-Kinase Beta 3 4
  • I-Kappa-B Kinase 2 3 4
  • IKK-Beta 3 4
  • NFKBIKB 3 4
  • IKK-B 3 4
  • IKK2 3 4
  • IKKB 3 4
  • Inhibitor Of Nuclear Factor Kappa-B Kinase Subunit Beta 3
  • EC 2.7.11.10 4
  • IMD15 3
  • IkBKB 4

External Ids for IKBKB Gene

Previous GeneCards Identifiers for IKBKB Gene

  • GC08M041757
  • GC08P042157
  • GC08P041869
  • GC08P042146
  • GC08P040656

Summaries for IKBKB Gene

Entrez Gene Summary for IKBKB Gene

  • The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for IKBKB Gene

IKBKB (Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta) is a Protein Coding gene. Diseases associated with IKBKB include Immunodeficiency 15 and Immunodeficiency 19. Among its related pathways are Immune response Fc epsilon RI pathway and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is CHUK.

UniProtKB/Swiss-Prot for IKBKB Gene

  • Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

Tocris Summary for IKBKB Gene

  • IkappaB Kinase (IKK) is an enzyme complex that forms part of the NF-kappaB signaling pathway. The IKK complex is comprised of three subunits (IKKalpha (IKK1), IKKbeta (IKK2) and IKKgamma (NEMO)), the alpha- and beta-subunits are catalytically active whereas the gamma-subunit has a regulatory function.

Gene Wiki entry for IKBKB Gene

Additional gene information for IKBKB Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IKBKB Gene

Genomics for IKBKB Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IKBKB Gene

Promoters and enhancers for IKBKB Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J042269 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 693.8 -0.2 -237 2.9 PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 E2F8 ZNF143 KLF13 IKBKB LOC101929897 KAT6A POLB ENSG00000254165 HGSNAT PLAT
GH08J042049 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 56.9 -219.8 -219835 3.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC KAT6A LOC105379393 IKBKB ENSG00000254165 AP3M2 PLAT GPAT4 POLB GC08M041977
GH08J043054 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.3 +785.2 785234 4 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D ZNF610 GLIS1 FNTA IKBKB HGSNAT ENSG00000254165 HOOK3 ENSG00000254673 ENSG00000254198 RNF170 POMK THAP1
GH08J041791 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 43.4 -475.5 -475534 9.5 FEZF1 IRF4 YY1 ZNF213 SP3 GLIS1 RCOR2 NBN KDM1A WT1 ANK1 IKBKB ENSG00000254165 KAT6A RPL17P30 ENSG00000261449 NKX6-3 LOC105379392 GC08M041760 GC08P041762
GH08J041528 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 48.4 -741.9 -741873 1.9 HDGF ARID4B SIN3A DMAP1 IRF4 POLR2B ZNF213 E2F8 ZNF143 FOS GC08P041531 PIR57220 GINS4 IKBKB KAT6A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IKBKB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IKBKB gene promoter:
  • p53
  • ER-alpha
  • STAT1
  • C/EBPalpha
  • POU3F2
  • HTF
  • RREB-1
  • C/EBPbeta
  • c-Myc
  • Max1

Genomic Locations for IKBKB Gene

Genomic Locations for IKBKB Gene
chr8:42,271,302-42,332,653
(GRCh38/hg38)
Size:
61,352 bases
Orientation:
Plus strand
chr8:42,128,820-42,190,171
(GRCh37/hg19)
Size:
61,352 bases
Orientation:
Plus strand

Genomic View for IKBKB Gene

Genes around IKBKB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IKBKB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IKBKB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IKBKB Gene

Proteins for IKBKB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IKBKB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14920-IKKB_HUMAN
    Recommended name:
    Inhibitor of nuclear factor kappa-B kinase subunit beta
    Protein Accession:
    O14920
    Secondary Accessions:
    • B4DZ30
    • B4E0U4
    • O75327

    Protein attributes for IKBKB Gene

    Size:
    756 amino acids
    Molecular mass:
    86564 Da
    Quaternary structure:
    • Component of the I-kappa-B-kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex (PubMed:12612076). The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65 (By similarity). Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP (PubMed:11971985). Part of a 70-90 kDa complex at least consisting of CHUK/IKKA, IKBKB, NFKBIA, RELA, ELP1 and MAP3K14 (PubMed:9751059). Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB (PubMed:17287217). Interacts with SQSTM1 through PRKCZ or PRKCI (PubMed:10356400). Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). May interact with MAVS/IPS1 (PubMed:16177806). Interacts with NALP2 (PubMed:15456791). Interacts with TICAM1 (PubMed:14739303). Interacts with FAF1; the interaction disrupts the IKK complex formation (PubMed:17684021). Interacts with ATM (PubMed:16497931). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833). Interacts with NIBP; the interaction is direct (PubMed:15951441). Interacts with ARRB1 and ARRB2 (PubMed:15173580). Interacts with TRIM21 (PubMed:19675099). Interacts with NLRC5; prevents IKBKB phosphorylation and kinase activity (PubMed:20434986). Interacts with PDPK1 (PubMed:16207722). Interacts with EIF2AK2/PKR (PubMed:10848580). The phosphorylated form interacts with PPM1A and PPM1B (PubMed:18930133). Interacts with ZNF268 isoform 2; the interaction is further increased in a TNF-alpha-dependent manner (PubMed:23091055). Interacts with IKBKE (PubMed:23453969). Interacts with NAA10, leading to NAA10 degradation (PubMed:19716809). Interacts with FOXO3 (PubMed:15084260). Interacts with AKAP13 (PubMed:23090968). Interacts with IFIT5; the interaction synergizes the recruitment of IKK to MAP3K7 and enhances IKK phosphorylation (PubMed:26334375). Interacts with LRRC14; disrupts IKBKB-IKBKG interaction preventing I-kappa-B-kinase (IKK) core complex formation and leading to a decrease of IKBKB phosphorylation and NF-kappaB activation (PubMed:27426725).
    • (Microbial infection) Interacts with Yersinia yopJ.

    Three dimensional structures from OCA and Proteopedia for IKBKB Gene

    Alternative splice isoforms for IKBKB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IKBKB Gene

Protein Expression for IKBKB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for IKBKB Gene

  • Upon cytokine stimulation, phosphorylated on Ser-177 and Ser-181 by MEKK1 and/or MAP3K14/NIK as well as TBK1 and PRKCZ; which enhances activity. Once activated, autophosphorylates on the C-terminal serine cluster; which decreases activity and prevents prolonged activation of the inflammatory response. Phosphorylated by the IKK-related kinases TBK1 and IKBKE, which is associated with reduced CHUK/IKKA and IKBKB activity and NF-kappa-B-dependent gene transcription. Dephosphorylated at Ser-177 and Ser-181 by PPM1A and PPM1B.
  • (Microbial infection) Acetylation of Thr-180 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the I-kappa-B pathway.
  • Ubiquitinated. Monoubiquitination involves TRIM21 that leads to inhibition of Tax-induced NF-kappa-B signaling. According to PubMed:19675099, Ser-163 does not serve as a monoubiquitination site. According to PubMed:16267042, ubiquitination on Ser-163 modulates phosphorylation on C-terminal serine residues.
  • (Microbial infection) Monoubiquitination by TRIM21 is disrupted by Yersinia yopJ.
  • Hydroxylated by PHD1/EGLN2, loss of hydroxylation under hypoxic conditions results in activation of NF-kappa-B.
  • Ubiquitination at isoforms=2, 4555, isoforms=2, 3, 4163, and isoforms=2, 3, 4106
  • Modification sites at PhosphoSitePlus

Other Protein References for IKBKB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for IKBKB Gene

Domains & Families for IKBKB Gene

Gene Families for IKBKB Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IKBKB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for IKBKB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14920

UniProtKB/Swiss-Prot:

IKKB_HUMAN :
  • The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Domain:
  • The kinase domain is located in the N-terminal region. The leucine zipper is important to allow homo- and hetero-dimerization. At the C-terminal region is located the region responsible for the interaction with NEMO/IKBKG.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
genes like me logo Genes that share domains with IKBKB: view

Function for IKBKB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IKBKB Gene

UniProtKB/Swiss-Prot Function:
Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].
GENATLAS Biochemistry:
inhibitor of kappa light polypeptide enhancer in B cells,kinase beta,complexing with IKBKA

Enzyme Numbers (IUBMB) for IKBKB Gene

Phenotypes From GWAS Catalog for IKBKB Gene

Gene Ontology (GO) - Molecular Function for IKBKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IDA 20434986
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI,IEA 9520446
GO:0005524 ATP binding IEA --
GO:0008384 IkappaB kinase activity TAS 18626576
genes like me logo Genes that share ontologies with IKBKB: view
genes like me logo Genes that share phenotypes with IKBKB: view

Human Phenotype Ontology for IKBKB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IKBKB Gene

MGI Knock Outs for IKBKB:

Animal Model Products

  • Taconic Biosciences Mouse Models for IKBKB

Clone Products

  • Addgene plasmids for IKBKB

No data available for Transcription Factor Targets and HOMER Transcription for IKBKB Gene

Localization for IKBKB Gene

Subcellular locations from UniProtKB/Swiss-Prot for IKBKB Gene

Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269 PubMed:17287217}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IKBKB gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 4
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IKBKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol IDA,TAS --
GO:0008385 IkappaB kinase complex TAS 18626576
GO:0009898 cytoplasmic side of plasma membrane ISS --
genes like me logo Genes that share ontologies with IKBKB: view

Pathways & Interactions for IKBKB Gene

SuperPathways for IKBKB Gene

PathCards logo More details on SuperPathways for IKBKB
SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
2 TNFR1 Pathway
DR3 Signaling
.87
TWEAK Pathway
.87
TNFR1 Pathway
.56
TNF Signaling
.55
Apoptosis and survival TNFR1 signaling pathway
.52
GITR Pathway
.46
Apoptotic Pathways Triggered By HIV1
.42
Apoptosis through Death Receptors
.42
TRAIL Pathway
.40
Fas Signaling
.35
TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
.34
TNF alpha Signaling Pathway
.30
3 4-1BB Pathway
4-1BB Pathway
.54
CD40 Signaling
.54
CD27 Pathway
.48
CMV and MAPK Pathways
.46
NF-KappaB Activation by EBV
.42
NF-kappaB Activation by Viruses
.42
TNFR2 Pathway
.37
PKR Pathway
.36
SUMO Pathway
.30
4 Cytosolic sensors of pathogen-associated DNA
RIP-mediated NFkB activation via ZBP1
.84
ZBP1(DAI) mediated induction of type I IFNs
.84
TRAF6 mediated NF-kB activation
.53
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
.47
Cytosolic sensors of pathogen-associated DNA
.36
IkBA variant leads to EDA-ID
.01
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
.01
5 Toll-like Receptor Signaling Pathway
Toll-like receptor signaling pathway
.92
Toll-like Receptor Signaling Pathway
.92
Regulation of toll-like receptor signaling pathway
.71
NOD-like Receptor Signaling Pathways
.39
Chagas disease (American trypanosomiasis)
.31
NOD-like receptor signaling pathway
.31
genes like me logo Genes that share pathways with IKBKB: view

Pathways by source for IKBKB Gene

3 GeneTex pathways for IKBKB Gene
2 Cell Signaling Technology pathways for IKBKB Gene

SIGNOR curated interactions for IKBKB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for IKBKB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA,NAS 9346484
GO:0006954 inflammatory response TAS 18626576
genes like me logo Genes that share ontologies with IKBKB: view

Drugs & Compounds for IKBKB Gene

Products:

  1. Drug

(67) Drugs for IKBKB Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arsenic trioxide Approved, Investigational Pharma inhibitor, Target, inducer 125
Auranofin Approved, Investigational Pharma Activation, Activator, inhibitor, Target Thioredoxin reductase inhibitor; induces MPT 11
Sulfasalazine Approved Pharma Inhibition, Inhibitor, Target, inhibitor NF-κB activation inhibitor 63
Mesalazine Approved Pharma Target, inhibitor 0
Aspirin Approved, Vet_approved Pharma Channel blocker, Target, inhibitor 1232

(29) Additional Compounds for IKBKB Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
IKK 16
1186195-62-9

(3) Tocris Compounds for IKBKB Gene

Compound Action Cas Number
Amlexanox Inhibitor of TBK1 and IKKepsilon; antiallergic agent 68302-57-8
IKK 16 Selective inhibitor of IKK 1186195-62-9
TPCA-1 Potent, selective inhibitor of IKKbeta 507475-17-4

(25) ApexBio Compounds for IKBKB Gene

Compound Action Cas Number
ACHP IκB kinase inhibitor 406208-42-2
Andrographolide NF-κB signaling Inhibitor 5508-58-7
Bardoxolone methyl IKK inhibitor, potent antioxidant inflammation modulator 218600-53-4
Bay 11-7085 NK-κB activation inhibitor 196309-76-9
Bay 11-7821(BAY 11-7082) IKK/NF-κB/TNFα inhibitor 19542-67-7
Bay 65-1942 free base IKKβ kinase inhibitor,ATP-competitive 600734-02-9
Bay 65-1942 HCl salt 600734-06-3
Bay 65-1942 R form IKKβ inhibitor, ATP-competitive and selective 758683-21-5
BMS-345541 IKK inhibitor,highly selective 547757-23-3
BMS-345541(free base) IKK-1/IKK-2 inhibitor,potent and selective 445430-58-0
Choline Fenofibrate Choline salt of fenofibric acid 856676-23-8
Honokiol Antioxidant/antitumor/antiangiogenic agent 35354-74-6
IKK-16 (IKK Inhibitor VII) Selective IκB kinase inhibitor 873225-46-8
IKK-2 inhibitor VIII IKK-2 inhibitor,potent and selective 406209-26-5
IMD 0354 978-62-1
Luteolin Antioxidant and free radical scavenger 491-70-3
LY2409881 946518-60-1
ML 120B dihydrochloride
MLN120B IκB Kinase β Inhibitor 783348-36-7
PF 184 1187460-81-6
PS 1145 dihydrochloride 1049743-58-9
SC-514 ATP-competitive IKK-2 inhibitor, orally active 354812-17-2
Tanshinone IIA Antioxidant and anti-inflammatory reagent 568-72-9
TPCA-1 IKK-2 inhibitor,potent and selective 507475-17-4
WS6 1421227-53-3
genes like me logo Genes that share compounds with IKBKB: view

Drug Products

Transcripts for IKBKB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IKBKB Gene

(20) REFSEQ mRNAs :
(19) Additional mRNA sequences :
(210) Selected AceView cDNA sequences:
(30) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IKBKB Gene

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta:
Representative Sequences:

Clone Products

  • Addgene plasmids for IKBKB

Alternative Splicing Database (ASD) splice patterns (SP) for IKBKB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6:
SP7:
SP8:

ExUns: 20b ^ 21 ^ 22a · 22b ^ 23a · 23b · 23c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6: -
SP7: -
SP8:

Relevant External Links for IKBKB Gene

GeneLoc Exon Structure for
IKBKB
ECgene alternative splicing isoforms for
IKBKB

Expression for IKBKB Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IKBKB Gene

mRNA expression in normal human tissues for IKBKB Gene
mRNA expression by BioGPS for IKBKB GenemRNA expression by GTEx for IKBKB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IKBKB Gene

This gene is overexpressed in Lymph node (21.0) and Peripheral blood mononuclear cells (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IKBKB Gene



Protein tissue co-expression partners for IKBKB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IKBKB Gene:

IKBKB

SOURCE GeneReport for Unigene cluster for IKBKB Gene:

Hs.597664

mRNA Expression by UniProt/SwissProt for IKBKB Gene:

O14920-IKKB_HUMAN
Tissue specificity: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.

Evidence on tissue expression from TISSUES for IKBKB Gene

  • Heart(4.5)
  • Liver(4.5)
  • Lung(4.5)
  • Nervous system(4.3)
  • Skin(3)
  • Blood(2.7)
  • Intestine(2.6)
  • Muscle(2.4)
  • Spleen(2.4)
  • Lymph node(2.3)
  • Kidney(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IKBKB Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • lymphatic
  • respiratory
Regions:
Thorax:
  • bronchus
  • lung
Abdomen:
  • intestine
  • large intestine
  • small intestine
Pelvis:
  • anus
  • rectum
General:
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with IKBKB: view

No data available for mRNA differential expression in normal tissues for IKBKB Gene

Orthologs for IKBKB Gene

This gene was present in the common ancestor of animals.

Orthologs for IKBKB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IKBKB 34 33
  • 98.48 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia IKBKB 34 33
  • 90.11 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia IKBKB 34
  • 89 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia IKBKB 34
  • 89 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ikbkb 16 34 33
  • 87.15 (n)
rat
(Rattus norvegicus)
 Mammalia Ikbkb 33
  • 87.11 (n)
cow
(Bos Taurus)
 Mammalia IKBKB 34 33
  • 86.86 (n)
 OneToOne
chicken
(Gallus gallus)
 Aves IKBKB 34 33
  • 67.94 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia IKBKB 34
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ikbkb 33
  • 70.54 (n)
Str.17591 33
zebrafish
(Danio rerio)
 Actinopterygii ikbkb 34 33
  • 62.47 (n)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta ird5 34 35
  • 22 (a)
 OneToMany
Species where no ortholog for IKBKB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IKBKB Gene

ENSEMBL:
Gene Tree for IKBKB (if available)
TreeFam:
Gene Tree for IKBKB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IKBKB: view image

Paralogs for IKBKB Gene

Paralogs for IKBKB Gene

(17) SIMAP similar genes for IKBKB Gene using alignment to 12 proteins:

  • IKKB_HUMAN
  • A1L159_HUMAN
  • B3KRB7_HUMAN
  • E5RFG5_HUMAN
  • E5RFT3_HUMAN
  • E5RGA0_HUMAN
  • E5RGW5_HUMAN
  • E5RIW0_HUMAN
  • E5RJH2_HUMAN
  • G3V105_HUMAN
  • J3KNS5_HUMAN
  • Q32ND9_HUMAN
genes like me logo Genes that share paralogs with IKBKB: view

Variants for IKBKB Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for IKBKB Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs140666106 benign, Immunodeficiency 15 42,316,898(+) C/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs145086380 likely-benign, Immunodeficiency 15 42,316,841(+) G/T coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs151057347 likely-benign, Immunodeficiency 15 42,321,909(+) A/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs200296680 pathogenic, Immunodeficiency 15 42,316,223(+) C/T 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs201052871 uncertain-significance, Immunodeficiency 15 42,314,347(+) G/A 5_prime_UTR_variant, coding_sequence_variant, missense_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IKBKB Gene

Variant ID Type Subtype PubMed ID
dgv128n16 CNV deletion 17901297
dgv36e209 CNV deletion 24192839
dgv7185n100 CNV gain 25217958
esv1003654 CNV deletion 20482838
esv1761681 CNV deletion 17803354
esv2736935 CNV deletion 23290073
esv3543424 CNV deletion 23714750
esv3543425 CNV deletion 23714750
esv3617007 CNV loss 21293372
nsv1132145 CNV deletion 24896259
nsv1145767 CNV deletion 26484159
nsv398024 CNV deletion 16902084
nsv476099 CNV novel sequence insertion 20440878
nsv508508 CNV deletion 20534489
nsv611131 CNV gain 21841781
nsv6169 CNV deletion 18451855
nsv831301 CNV loss 17160897

Variation tolerance for IKBKB Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IKBKB Gene

Human Gene Mutation Database (HGMD)
IKBKB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IKBKB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IKBKB Gene

Disorders for IKBKB Gene

MalaCards: The human disease database

(8) MalaCards diseases for IKBKB Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency 15
  • imd15
immunodeficiency 19
  • imd19
neurodermatitis
t-cell leukemia
  • leukemia t-cell
hepatitis c virus
  • hepatitis c virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search IKBKB in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IKKB_HUMAN
  • Immunodeficiency 15 (IMD15) [MIM:615592]: An autosomal recessive primary immunodeficiency disorder characterized by onset in infancy of life-threatening bacterial, fungal, and viral infections and failure to thrive. Laboratory studies show hypo- or agammaglobulinemia with relatively normal numbers of B and T-cells, and impaired differentiation and activation of immune cells. {ECO:0000269 PubMed:24369075}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IKBKB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IKBKB: view

No data available for Genatlas for IKBKB Gene

Publications for IKBKB Gene