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The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016] See more...
Aliases for IGSF3 Gene
Aliases for IGSF3 Gene
External Ids for IGSF3 Gene
- HGNC: 5950
- NCBI Entrez Gene: 3321
- Ensembl: ENSG00000143061
- OMIM®: 603491
- UniProtKB/Swiss-Prot: O75054
Previous GeneCards Identifiers for IGSF3 Gene
- GC01M117619
- GC01M115999
- GC01M116264
- GC01M116466
- GC01M116829
- GC01M116918
- GC01M117117
- GC01M114976
Summaries for IGSF3 Gene
-
The protein encoded by this gene is an immunoglobulin-like membrane protein containing several V-type Ig-like domains. A mutation in this gene has been associated with bilateral nasolacrimal duct obstruction (LCDD). [provided by RefSeq, Jun 2016]
GeneCards Summary for IGSF3 Gene
IGSF3 (Immunoglobulin Superfamily Member 3) is a Protein Coding gene. Diseases associated with IGSF3 include Lacrimal Duct Defect and Gastrointestinal Tularemia. An important paralog of this gene is CD101.
Additional gene information for IGSF3 Gene
- HGNC (5950)
- NCBI Entrez Gene (3321)
- Ensembl (ENSG00000143061)
- OMIM® (603491)
- UniProtKB/Swiss-Prot (O75054)
- Open Targets Platform(ENSG00000143061)
- Monarch Initiative
- Search for IGSF3 at DataMed
- Search for IGSF3 at HumanCyc
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGSF3 Gene
Genomics for IGSF3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for IGSF3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around IGSF3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGSF3
- Top Transcription factor binding sites by QIAGEN in the IGSF3 gene promoter:
-
- AML1a
- Arnt
- HOXA9
- HOXA9B
- Ik-1
- Meis-1
- Meis-1b
- PPAR-gamma1
- PPAR-gamma2
Genomic Locations for IGSF3 Gene
Latest Assembly
- chr1:116,574,398-116,667,755
- (GRCh38/hg38)
- Size:
- 93,358 bases
- Orientation:
- Minus strand
Previous Assembly
- chr1:117,117,020-117,210,377
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 93,358 bases
- Orientation:
- Minus strand
- chr1:117,117,031-117,210,375
- (GRCh37/hg19 by Ensembl)
- Size:
- 93,345 bases
- Orientation:
- Minus strand
Genomic View for IGSF3 Gene
Genes around IGSF3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p13.1 by HGNC
- 1p13.1 by Entrez Gene
- 1p13.1 by Ensembl
IGSF3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for IGSF3 Gene
Proteins for IGSF3 Gene
-
Protein details for IGSF3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75054-IGSF3_HUMAN
- Recommended name:
- Immunoglobulin superfamily member 3
- Protein Accession:
- O75054
- A6NJZ6
- A6NMC7
Protein attributes for IGSF3 Gene
- Size:
- 1194 amino acids
- Molecular mass:
- 135196 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC72013.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA32311.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Likely interchromosomal Alu-mediated fusion between IGSF3 on 1p13.1 and GGT on 22q11.2. Breakpoints occurred inside Alu elements as well as in the 5' or 3' ends of them.
Protein Expression for IGSF3 Gene
Post-translational modifications for IGSF3 Gene
Other Protein References for IGSF3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for IGSF3
- Novus Biologicals Antibodies for IGSF3
-
Abcam antibodies for IGSF3
- Invitrogen Antibodies for IGSF3 (AFLGC-IGSF3)
- antibodies-online: Show 7 available IGSF3 Antibodies ranked by validation data
-
Biorbyt antibodies for IGSF3
-
Custom Antibody ServicesProSci Antibodies for IGSF3
- Sino Biological Antibodies for IGSF3
Protein products for research
-
OriGene Purified Proteins for IGSF3
- Search Origene for MassSpec and Protein Over-expression Lysates for IGSF3
- Origene Custom Protein Services for IGSF3
- Sino Biological Recombinant Proteins for IGSF3
- Sino Biological Cell Lysates for IGSF3
Assay products for research
- RayBiotech Custom Human IGSF3 ELISA
No data available for DME Specific Peptides for IGSF3 Gene
Domains & Families for IGSF3 Gene
Gene Families for IGSF3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for IGSF3 Gene
- InterPro:
- Blocks:
-
- Immunoglobulin V-set
- Immunoglobulin subtype
- ProtoNet:
Suggested Antigen Peptide Sequences for IGSF3 Gene
- GenScript: Design optimal peptide antigens:
-
- Glu-Trp-Ile EWI motif-containing protein 3 (IGSF3_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGSF3 Gene
Function for IGSF3 Gene
Molecular function for IGSF3 Gene
- GENATLAS Biochemistry:
- immunoglobulin superfamily member 3,highly expressed in placenta,kidney and lung
Phenotypes From GWAS Catalog for IGSF3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for IGSF3 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IGSF3 - Starting at $85 >
- * IGSF3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IGSF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGSF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGSF3
miRNA for IGSF3 Gene
- miRTarBase miRNAs that target IGSF3
-
- mmu-miR-17-5p (MIRT009935)
- mmu-miR-340-5p (MIRT010331)
- hsa-miR-7-5p (MIRT025690)
- hsa-miR-103a-3p (MIRT027022)
- hsa-miR-26b-5p (MIRT029114)
- hsa-let-7b-5p (MIRT032291)
- hsa-miR-1224-3p (MIRT036548)
- hsa-miR-769-5p (MIRT039143)
- hsa-miR-378a-5p (MIRT043984)
- hsa-miR-6807-5p (MIRT495081)
- hsa-miR-6823-3p (MIRT495082)
- hsa-miR-2114-3p (MIRT495083)
- hsa-miR-1972 (MIRT495084)
- hsa-miR-6510-5p (MIRT495085)
- hsa-miR-6165 (MIRT495086)
- hsa-miR-4690-5p (MIRT495087)
- hsa-miR-580-3p (MIRT502180)
- hsa-miR-7157-5p (MIRT502181)
- hsa-miR-4310 (MIRT502182)
- hsa-miR-3617-3p (MIRT502183)
- hsa-miR-6800-3p (MIRT502184)
- hsa-miR-8066 (MIRT502185)
- hsa-miR-34a-3p (MIRT502186)
- hsa-miR-1252-3p (MIRT502187)
- hsa-miR-3646 (MIRT502188)
- hsa-miR-107 (MIRT502189)
- hsa-miR-486-5p (MIRT567157)
- mmu-miR-467f (MIRT582954)
- mmu-miR-669m-3p (MIRT582955)
- mmu-miR-381-3p (MIRT582956)
- mmu-miR-539-3p (MIRT582957)
- mmu-miR-495-3p (MIRT582958)
- mmu-miR-1192 (MIRT582959)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGSF3
- Browse OriGene Inhibitory RNA Products For IGSF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGSF3
Clone products for research
- Applied Biological Materials (abm): Clones for IGSF3 - Starting at $45 >
- * IGSF3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IGSF3
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Cell Lines for research
-
Horizon Cell Lines for IGSF3
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for IGSF3 Gene
Localization for IGSF3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for IGSF3 Gene
- Membrane. Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| extracellular | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 0 |
| golgi apparatus | 0 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009986 | cell surface | HDA | 19581412 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IBA | 21873635 |
Pathways & Interactions for IGSF3 Gene
Interacting Proteins for IGSF3 Gene
GPS-Prot Interaction Network for IGSF3
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032808 | lacrimal gland development | IMP | 24372406 |
No data available for Pathways by source and SIGNOR curated interactions for IGSF3 Gene
Transcripts for IGSF3 Gene
mRNA/cDNA for IGSF3 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000318837 3842 nts (view in UCSC)
- ENST00000369483 7326 nts (view in UCSC)
- ENST00000369486 7235 nts (view in UCSC)
- ENST00000481589 268 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for IGSF3 - Starting at $85 >
- * IGSF3 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for IGSF3
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for IGSF3
-
Santa Cruz Biotechnology (SCBT) CRISPR for IGSF3
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for IGSF3
- Browse OriGene Inhibitory RNA Products For IGSF3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGSF3
Clone products for research
- Applied Biological Materials (abm): Clones for IGSF3 - Starting at $45 >
- * IGSF3 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for IGSF3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for IGSF3
Relevant External Links for IGSF3 Gene
- GeneLoc Exon Structure for
- IGSF3
Expression for IGSF3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Neural Crest (Gastrulation Derivatives)
- Paraxial Mesoderm (Gastrulation Derivatives)
-
Brain (Nervous System)
mRNA differential expression in normal tissues according to GTEx for IGSF3 Gene
This gene is overexpressed in Esophagus - Mucosa (x5.5).
This gene is overexpressed in Fetal Brain (55.3) and Placenta (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for IGSF3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGSF3
SOURCE GeneReport for Unigene cluster for IGSF3 Gene:
Hs.171057mRNA Expression by UniProt/SwissProt for IGSF3 Gene:
O75054-IGSF3_HUMAN
Tissue specificity:
Expressed in a wide range of tissues with High expression in Placenta, kidney and lung.
Evidence on tissue expression from TISSUES for IGSF3 Gene
- Nervous system(4.6)
- Skin(3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF3 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
Regions:
Head and neck:
- head
- lacrimal apparatus
Primer products for research
-
OriGene qPCR primer pairs for IGSF3
-
OriGene qPCR primer pairs and template standards for IGSF3
Gene Expression Assays for research
No data available for Protein tissue co-expression partners for IGSF3 Gene
Orthologs for IGSF3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | IGSF3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | IGSF3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | IGSF3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Igsf3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Igsf3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | IGSF3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | IGSF3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | IGSF3 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | IGSF3 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | igsf3 30 |
|
||
| Str.5486 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16592 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-247j6.1 30 |
|
||
| IGSF3 31 |
|
OneToOne |
- Species where no ortholog for IGSF3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for IGSF3 Gene
- ENSEMBL:
- Gene Tree for IGSF3 (if available)
- TreeFam:
- Gene Tree for IGSF3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for IGSF3: view image
Paralogs for IGSF3 Gene
(3) SIMAP similar genes for IGSF3 Gene using alignment to 1 proteins:
- IGSF3_HUMAN
Pseudogenes.org Pseudogenes for IGSF3 Gene
Variants for IGSF3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGSF3 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 915339 | Pathogenic: not provided | 116,600,246(-) |
C/T NM_001007237.3(IGSF3):c.1724G>A (p.Trp575Ter) |
NONSENSE | |
| rs1571118438 | Likely Benign: not provided | 116,584,943(-) |
G/T NM_001007237.3(IGSF3):c.2550C>A (p.Leu850=) |
SYNONYMOUS | |
| rs190300523 | Uncertain Significance: Pyloric stenosis; Esophageal atresia | 116,600,129(-) |
C/A NM_001007237.3(IGSF3):c.1841G>T (p.Arg614Leu) |
MISSENSE | |
| rs191438836 | Benign: not provided | 116,608,234(-) |
G/A NM_001007237.3(IGSF3):c.930C>T (p.Pro310=) |
SYNONYMOUS | |
| rs199596005 | Likely Benign: not provided | 116,600,213(-) |
G/A NM_001007237.3(IGSF3):c.1757C>T (p.Pro586Leu) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv85e212 | CNV | loss | 25503493 |
| esv2758963 | CNV | gain+loss | 17122850 |
| esv28283 | CNV | gain+loss | 19812545 |
| esv32882 | CNV | gain | 17666407 |
| esv33190 | CNV | gain+loss | 17666407 |
| esv3578131 | CNV | loss | 25503493 |
| nsv10661 | CNV | gain+loss | 18304495 |
| nsv1116609 | CNV | tandem duplication | 24896259 |
| nsv428190 | CNV | gain | 18775914 |
| nsv482103 | CNV | gain | 20164927 |
| nsv824309 | CNV | gain | 20364138 |
| nsv831148 | CNV | gain | 17160897 |
| nsv945587 | CNV | duplication | 23825009 |
| nsv945588 | CNV | duplication | 23825009 |
| nsv946165 | CNV | duplication | 23825009 |
| nsv946166 | CNV | duplication | 23825009 |
| nsv946167 | CNV | duplication | 23825009 |
| nsv946168 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
10.32;
90.70% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for IGSF3 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF3 Gene
Disorders for IGSF3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lacrimal duct defect |
|
|
| gastrointestinal tularemia |
|
|
| lacrimal duct obstruction |
|
|
| urethral calculus |
|
|
| bardet-biedl syndrome 1 |
|
|
Search IGSF3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
IGSF3_HUMAN- Lacrimal duct defect (LCDD) [MIM:149700]: A condition resulting in the imbalance between tear production and tear drainage. Infants typically manifest persistent epiphora and/or recurrent infections of the lacrimal pathway, such as conjunctivitis. LCDD is caused by failure of the nasolacrimal duct to open into the inferior meatus. {ECO:0000269 PubMed:24372406}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for IGSF3
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for IGSF3 Gene
Publications for IGSF3 Gene
- Identification of an IGSF3 mutation in a family with congenital nasolacrimal duct obstruction. (PMID: 24372406) Foster J … Tekin M (Clinical genetics 2014) 3 4 74
- Molecular cloning of a human cDNA IGSF3 encoding an immunoglobulin-like membrane protein: expression and mapping to chromosome band 1p13. (PMID: 9790749) Saupe S … De Sario A (Genomics 1998) 2 3 4
- EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily. (PMID: 11504738) Stipp CS … Hemler ME (The Journal of biological chemistry 2001) 4 23
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1997) 3 4
- The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3
ExternalLinks
Products for IGSF3 Gene
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- antibodies-online: Show 7 available IGSF3 Antibodies ranked by validation data
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- Biorbyt antibodies for IGSF3
Sources for IGSF3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
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- (111) MeSH
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- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB