This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011] See more...

Aliases for IGSF23 Gene

Aliases for IGSF23 Gene

  • Immunoglobulin Superfamily Member 23 2 3 4 5
  • Immunoglobulin Superfamily, Member 23 2
  • IGSF23 5

External Ids for IGSF23 Gene

Previous GeneCards Identifiers for IGSF23 Gene

  • GC19P045117

Summaries for IGSF23 Gene

Entrez Gene Summary for IGSF23 Gene

  • This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011]

GeneCards Summary for IGSF23 Gene

IGSF23 (Immunoglobulin Superfamily Member 23) is a Protein Coding gene.

Additional gene information for IGSF23 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGSF23 Gene

Genomics for IGSF23 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGSF23 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044610 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 600.7 +3.5 3536 11 GATAD2A CTCF ZNF629 REST TFE3 RCOR2 RBFOX2 RXRB IRF2 SP1 IGSF23 PVR CEACAM19 CEACAM22P NECTIN2
GH19J044923 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 8 +313.4 313367 4.1 SP1 HNRNPL CREB1 GATAD2A ATF7 REST TFE3 SOX13 IKZF1 NFKBIZ APOC1P1 ZNF180 ZNF45 CLASRP ZNF155 ZNF230 ZNF224 ZNF225 ZNF284 FBXO46
GH19J044723 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +112.5 112466 3.3 HNRNPL GATAD2A CTCF REST TFE3 RFX1 IKZF1 JUND LARP7 ZNF143 ENSG00000266903 ENSG00000252200 LOC107985305 APOC2 IGSF23 APOE APOC4 BCL3 RELB CEACAM16
GH19J044728 Enhancer 0.4 FANTOM5 2.8 +116.0 116038 0.3 IKZF1 MAFK RF00017-2998 IGSF23 CLASRP APOC2 ENSG00000252200 BCL3 CEACAM16
GH19J044633 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +27.0 26988 13.9 HNRNPL GATAD2A TEAD4 PRDM10 ZNF629 REST ZNF512 IKZF1 NFKBIZ ZNF692 PVR CEACAM19 ENSG00000267114 ZNF223 ENSG00000252200 ZNF227 ZNF235 ZNF226 CEACAM22P piR-35674-264
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGSF23 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGSF23

Genomic Locations for IGSF23 Gene

Genomic Locations for IGSF23 Gene
24,205 bases
Plus strand
23,142 bases
Plus strand

Genomic View for IGSF23 Gene

Genes around IGSF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF23 Gene

Proteins for IGSF23 Gene

  • Protein details for IGSF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 23
    Protein Accession:

    Protein attributes for IGSF23 Gene

    192 amino acids
    Molecular mass:
    20591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGSF23 Gene

Post-translational modifications for IGSF23 Gene

  • Glycosylation at Asn64

No data available for DME Specific Peptides for IGSF23 Gene

Domains & Families for IGSF23 Gene

Gene Families for IGSF23 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IGSF23 Gene

Suggested Antigen Peptide Sequences for IGSF23 Gene

GenScript: Design optimal peptide antigens:
  • Immunoglobulin superfamily member 23 (IGS23_HUMAN)
genes like me logo Genes that share domains with IGSF23: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGSF23 Gene

Function for IGSF23 Gene

Phenotypes From GWAS Catalog for IGSF23 Gene

Phenotypes for IGSF23 Gene

genes like me logo Genes that share phenotypes with IGSF23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGSF23

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGSF23 Gene

Localization for IGSF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF23 Gene

Membrane. Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF23 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
nucleus 2
extracellular 0
cytoskeleton 0
peroxisome 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGSF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGSF23: view

Pathways & Interactions for IGSF23 Gene

PathCards logo

SuperPathways for IGSF23 Gene

No Data Available

Interacting Proteins for IGSF23 Gene

Gene Ontology (GO) - Biological Process for IGSF23 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGSF23 Gene

Drugs & Compounds for IGSF23 Gene

No Compound Related Data Available

Transcripts for IGSF23 Gene

mRNA/cDNA for IGSF23 Gene

4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGSF23

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF23 Gene

No ASD Table

Relevant External Links for IGSF23 Gene

GeneLoc Exon Structure for

Expression for IGSF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGSF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF23 Gene

This gene is overexpressed in Liver (x31.9) and Small Intestine - Terminal Ileum (x5.9).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGSF23

SOURCE GeneReport for Unigene cluster for IGSF23 Gene:

genes like me logo Genes that share expression patterns with IGSF23: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF23 Gene

Orthologs for IGSF23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGSF23 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGSF23 30 31
  • 98.26 (n)
(Canis familiaris)
Mammalia IGSF23 30 31
  • 70.6 (n)
(Mus musculus)
Mammalia Igsf23 30 17 31
  • 67.63 (n)
(Bos Taurus)
Mammalia IGSF23 30 31
  • 67.16 (n)
(Rattus norvegicus)
Mammalia Igsf23 30
  • 66.91 (n)
Species where no ortholog for IGSF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGSF23 Gene

Gene Tree for IGSF23 (if available)
Gene Tree for IGSF23 (if available)
Evolutionary constrained regions (ECRs) for IGSF23: view image

Paralogs for IGSF23 Gene

No data available for Paralogs for IGSF23 Gene

Variants for IGSF23 Gene

Additional dbSNP identifiers (rs#s) for IGSF23 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGSF23 Gene

Variant ID Type Subtype PubMed ID
nsv1062812 CNV gain 25217958
nsv483005 CNV loss 15286789

Additional Variant Information for IGSF23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for IGSF23 Gene

Disorders for IGSF23 Gene

No disorders were found for IGSF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF23 Gene

Publications for IGSF23 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3

Products for IGSF23 Gene

Sources for IGSF23 Gene