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IGSF23 Gene(Protein Coding)

Immunoglobulin Superfamily Member 23

GCID:
GC19P044613
GIFtS:
31
Genes Participants
UDN Logo

Aliases for IGSF23 Gene

Aliases for IGSF23 Gene

  • Immunoglobulin Superfamily Member 23 2 3 5
  • Immunoglobulin Superfamily, Member 23 2

External Ids for IGSF23 Gene

Previous GeneCards Identifiers for IGSF23 Gene

  • GC19P045117

Summaries for IGSF23 Gene

Entrez Gene Summary for IGSF23 Gene

  • This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011]

GeneCards Summary for IGSF23 Gene

IGSF23 (Immunoglobulin Superfamily Member 23) is a Protein Coding gene.

Additional gene information for IGSF23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF23 Gene

Genomics for IGSF23 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for IGSF23 Gene

Promoters and enhancers for IGSF23 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I044610 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 550.8 0.0 -3 5.9 FOXA2 ARID4B DMAP1 ZNF48 YY1 RXRA SP5 REST PPARG KAT8 IGSF23 CEACAM22P PVR CEACAM19 ENSG00000224366
GH19I044923 Enhancer 1.4 FANTOM5 Ensembl ENCODE 8 +312.4 312421 4.3 HDGF FOXA2 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS APOC1P1 GC19P044927 APOC2 APOC4 IGSF23 BCAM APOE APOC1 GC19P044915
GH19I044721 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.3 +110.6 110642 4.9 ARID4B SIN3A DMAP1 IRF4 ZNF48 YY1 GATA2 ARID2 ZNF207 ZNF143 ENSG00000252200 GC19M044726 ENSG00000266903 APOE RELB APOC2 BCL3 CLASRP IGSF23 APOC4
GH19I044728 Enhancer 0.4 FANTOM5 2.8 +115.0 115025 0.3 IKZF1 IGSF23 CLASRP APOC2 ENSG00000252200 GC19M044726 BCL3
GH19I044633 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 0.3 +26.0 26023 11.6 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 MXD4 REST KAT8 PVR CEACAM19 ENSG00000267114 ZNF223 ENSG00000252200 ZNF227 ZNF235 ZNF226 CEACAM22P IGSF23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGSF23 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGSF23 Gene

Genomic Locations for IGSF23 Gene
chr19:44,613,590-44,636,781
(GRCh38/hg38)
Size:
23,192 bases
Orientation:
Plus strand
chr19:45,116,940-45,140,081
(GRCh37/hg19)

Genomic View for IGSF23 Gene

Genes around IGSF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF23 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGSF23 Gene

Proteins for IGSF23 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGSF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L1A6-IGS23_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 23
    Protein Accession:
    A1L1A6

    Protein attributes for IGSF23 Gene

    Size:
    192 amino acids
    Molecular mass:
    20591 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGSF23 Gene

Post-translational modifications for IGSF23 Gene

Other Protein References for IGSF23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGSF23 Gene

Domains & Families for IGSF23 Gene

Gene Families for IGSF23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for IGSF23 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGSF23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGSF23: view

No data available for UniProtKB/Swiss-Prot for IGSF23 Gene

Function for IGSF23 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for IGSF23 Gene

Phenotypes for IGSF23 Gene

GenomeRNAi human phenotypes for IGSF23:
genes like me logo Genes that share phenotypes with IGSF23: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGSF23 Gene

Localization for IGSF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF23 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF23 gene
Compartment Confidence
plasma membrane 3
mitochondrion 3
nucleus 2
extracellular 1
cytoskeleton 1
peroxisome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGSF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with IGSF23: view

Pathways & Interactions for IGSF23 Gene

SuperPathways for IGSF23 Gene

PathCards logo More details on SuperPathways for IGSF23
No Data Available

Interacting Proteins for IGSF23 Gene

Gene Ontology (GO) - Biological Process for IGSF23 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGSF23 Gene

Drugs & Compounds for IGSF23 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGSF23 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGSF23 Gene

(11) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGSF23 Gene

Immunoglobulin superfamily, member 23:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF23 Gene

No ASD Table

Relevant External Links for IGSF23 Gene

GeneLoc Exon Structure for
IGSF23
ECgene alternative splicing isoforms for
IGSF23

Expression for IGSF23 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF23 Gene

mRNA expression in normal human tissues for IGSF23 Gene
mRNA expression by GTEx for IGSF23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF23 Gene

This gene is overexpressed in Liver (x31.9) and Small Intestine - Terminal Ileum (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of IGSF23 Gene:

IGSF23

SOURCE GeneReport for Unigene cluster for IGSF23 Gene:

Hs.512509
genes like me logo Genes that share expression patterns with IGSF23: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF23 Gene

Orthologs for IGSF23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGSF23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia IGSF23 33 34
  • 98.26 (n)
dog
(Canis familiaris)
 Mammalia IGSF23 33 34
  • 70.6 (n)
mouse
(Mus musculus)
 Mammalia Igsf23 33 16 34
  • 67.63 (n)
cow
(Bos Taurus)
 Mammalia IGSF23 33 34
  • 67.16 (n)
rat
(Rattus norvegicus)
 Mammalia Igsf23 33
  • 66.91 (n)
Species where no ortholog for IGSF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF23 Gene

ENSEMBL:
Gene Tree for IGSF23 (if available)
TreeFam:
Gene Tree for IGSF23 (if available)

Paralogs for IGSF23 Gene

No data available for Paralogs for IGSF23 Gene

Variants for IGSF23 Gene

Sequence variations from dbSNP and Humsavar for IGSF23 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000030203 -- 44,627,976(+) G/C/T 3_prime_UTR_variant, intron_variant
rs1000040120 -- 44,627,654(+) C/T coding_sequence_variant, intron_variant, missense_variant
rs1000140092 -- 44,620,620(+) G/T intron_variant
rs1000245840 -- 44,615,055(+) C/G/T genic_upstream_transcript_variant, intron_variant
rs1000253227 -- 44,633,475(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF23 Gene

Variant ID Type Subtype PubMed ID
nsv483005 CNV loss 15286789
nsv1062812 CNV gain 25217958

Additional Variant Information for IGSF23 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGSF23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for IGSF23 Gene

Disorders for IGSF23 Gene

Additional Disease Information for IGSF23

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IGSF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF23 Gene

Publications for IGSF23 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  4. Creation of genome-wide protein expression libraries using random activation of gene expression. (PMID: 11329013) Harrington JJ … Ducar M (Nature biotechnology 2001) 3 58

Products for IGSF23 Gene

Sources for IGSF23 Gene

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