Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGSF22 Gene

Aliases for IGSF22 Gene

  • Immunoglobulin Superfamily Member 22 2 3 5
  • Immunoglobulin Superfamily, Member 22 2
  • IgSF22 4
  • IGFN2 3

External Ids for IGSF22 Gene

Previous GeneCards Identifiers for IGSF22 Gene

  • GC11M018410

Summaries for IGSF22 Gene

GeneCards Summary for IGSF22 Gene

IGSF22 (Immunoglobulin Superfamily Member 22) is a Protein Coding gene. An important paralog of this gene is IGFN1.

Additional gene information for IGSF22 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF22 Gene

Genomics for IGSF22 Gene

GeneHancer (GH) Regulatory Elements for IGSF22 Gene

Promoters and enhancers for IGSF22 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I018727 Enhancer 0.8 Ensembl ENCODE 550.8 -1.5 -1512 0.3 CTCF MAZ TRIM22 IRF4 RAD21 VEZF1 ZNF143 SMC3 EMSY ZBTB20 IGSF22 PIR60589 LOC105376579
GH11I018726 Promoter/Enhancer 0.7 EPDnew Ensembl 550.8 +0.1 111 0.2 IGSF22 LOC105376579
GH11I018578 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.1 +146.9 146902 1.3 HDAC1 PKNOX1 FOXA2 SIN3A BATF ZNF48 ZNF207 FOS RCOR1 SMARCA5 UEVLD LOC100129966 SPTY2D1 TMEM86A LOC105376579 IGSF22 TSG101 SERGEF SPTY2D1OS ENSG00000274589
GH11I018705 Promoter/Enhancer 1 Ensembl ENCODE 12.8 +19.5 19532 1.8 CTCF CTBP1 ATF1 ZNF316 POLR2A CREB1 ZBTB33 LOC105376579 IGSF22
GH11I018697 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.9 +27.0 26957 3.9 ATF1 SIN3A BRCA1 GLIS2 ZNF213 ATF7 SP3 RXRA SP5 NFYC TMEM86A PIR46171 GTF2H1 SPTY2D1 SAAL1 HPS5 IGSF22 LOC105376579 YWHABP2 UEVLD
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGSF22 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGSF22 gene promoter:

Genomic Locations for IGSF22 Gene

Genomic Locations for IGSF22 Gene
chr11:18,704,305-18,726,230
(GRCh38/hg38)
Size:
21,926 bases
Orientation:
Minus strand
chr11:18,725,852-18,747,777
(GRCh37/hg19)

Genomic View for IGSF22 Gene

Genes around IGSF22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF22 Gene

Proteins for IGSF22 Gene

  • Protein details for IGSF22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9C0-IGS22_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 22
    Protein Accession:
    Q8N9C0
    Secondary Accessions:
    • A6NNA0
    • D6RGV7

    Protein attributes for IGSF22 Gene

    Size:
    903 amino acids
    Molecular mass:
    100400 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for IGSF22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGSF22 Gene

Post-translational modifications for IGSF22 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGSF22 Gene

No data available for DME Specific Peptides for IGSF22 Gene

Domains & Families for IGSF22 Gene

Gene Families for IGSF22 Gene

Suggested Antigen Peptide Sequences for IGSF22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGSF22: view

No data available for UniProtKB/Swiss-Prot for IGSF22 Gene

Function for IGSF22 Gene

Phenotypes From GWAS Catalog for IGSF22 Gene

Gene Ontology (GO) - Molecular Function for IGSF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008307 structural constituent of muscle IBA --
GO:0051015 actin filament binding IBA --
GO:0051371 muscle alpha-actinin binding IBA --
GO:0097493 structural molecule activity conferring elasticity IBA --
genes like me logo Genes that share ontologies with IGSF22: view

Phenotypes for IGSF22 Gene

genes like me logo Genes that share phenotypes with IGSF22: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGSF22 Gene

Localization for IGSF22 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF22 gene
Compartment Confidence
cytoskeleton 3
nucleus 2
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGSF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005859 muscle myosin complex IBA --
GO:0030018 Z disc IBA --
GO:0031430 M band IBA --
genes like me logo Genes that share ontologies with IGSF22: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for IGSF22 Gene

Pathways & Interactions for IGSF22 Gene

SuperPathways for IGSF22 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGSF22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006941 striated muscle contraction IBA --
GO:0007015 actin filament organization IBA --
GO:0045214 sarcomere organization IBA --
GO:0071688 striated muscle myosin thick filament assembly IBA --
genes like me logo Genes that share ontologies with IGSF22: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF22 Gene

Drugs & Compounds for IGSF22 Gene

No Compound Related Data Available

Transcripts for IGSF22 Gene

mRNA/cDNA for IGSF22 Gene

Unigene Clusters for IGSF22 Gene

Immunoglobulin superfamily, member 22:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF22 Gene

No ASD Table

Relevant External Links for IGSF22 Gene

GeneLoc Exon Structure for
IGSF22
ECgene alternative splicing isoforms for
IGSF22

Expression for IGSF22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF22 Gene

Protein differential expression in normal tissues from HIPED for IGSF22 Gene

This gene is overexpressed in Serum (59.4) and Plasma (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF22 Gene



Protein tissue co-expression partners for IGSF22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGSF22 Gene:

IGSF22

SOURCE GeneReport for Unigene cluster for IGSF22 Gene:

Hs.434152

Evidence on tissue expression from TISSUES for IGSF22 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with IGSF22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF22 Gene

Orthologs for IGSF22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF22 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IGSF22 33 34
  • 90.16 (n)
oppossum
(Monodelphis domestica)
Mammalia IGSF22 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia IGSF22 34
  • 74 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 25 (a)
ManyToMany
Species where no ortholog for IGSF22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGSF22 Gene

ENSEMBL:
Gene Tree for IGSF22 (if available)
TreeFam:
Gene Tree for IGSF22 (if available)

Paralogs for IGSF22 Gene

Paralogs for IGSF22 Gene

(2) SIMAP similar genes for IGSF22 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IGSF22: view

Variants for IGSF22 Gene

Sequence variations from dbSNP and Humsavar for IGSF22 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000002455 -- 18,713,766(-) G/C intron_variant
rs1000029786 -- 18,717,364(-) A/C intron_variant
rs1000033826 -- 18,713,951(-) T/C coding_sequence_variant, missense_variant
rs1000161450 -- 18,719,513(-) C/T intron_variant
rs1000306632 -- 18,726,244(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF22 Gene

Variant ID Type Subtype PubMed ID
esv25440 CNV loss 19812545
nsv1047371 CNV gain 25217958
nsv525192 CNV loss 19592680
nsv525452 CNV gain 19592680
nsv553633 CNV gain 21841781
nsv825774 CNV loss 20364138

Variation tolerance for IGSF22 Gene

Residual Variation Intolerance Score: 98.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.86; 98.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGSF22 Gene

Human Gene Mutation Database (HGMD)
IGSF22
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGSF22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF22 Gene

Disorders for IGSF22 Gene

Additional Disease Information for IGSF22

No disorders were found for IGSF22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF22 Gene

Publications for IGSF22 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I … Futreal PA (Nature 2011) 4 58
  3. Serum disease-associated proteins of ankylosing spondylitis: results of a preliminary study by comparative proteomics. (PMID: 20483041) Li T … Gu J (Clinical and experimental rheumatology 2010) 22 58
  4. Screening disease-associated proteins from sera of patients with rheumatoid arthritis: a comparative proteomic study. (PMID: 20367977) Li TW … Gu JR (Chinese medical journal 2010) 22 58
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58

Products for IGSF22 Gene

Sources for IGSF22 Gene

Content
Loading form....