This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011] See more...

Aliases for IGSF21 Gene

Aliases for IGSF21 Gene

  • Immunoglobin Superfamily Member 21 2 3 5
  • Immunoglobulin Superfamily Member 21 3 4
  • Immunoglobin Superfamily, Member 21 2
  • IgSF21 4

External Ids for IGSF21 Gene

Previous GeneCards Identifiers for IGSF21 Gene

  • GC01P018180
  • GC01P018306
  • GC01P018434
  • GC01P016680

Summaries for IGSF21 Gene

Entrez Gene Summary for IGSF21 Gene

  • This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]

GeneCards Summary for IGSF21 Gene

IGSF21 (Immunoglobin Superfamily Member 21) is a Protein Coding gene. An important paralog of this gene is IGSF10.

UniProtKB/Swiss-Prot Summary for IGSF21 Gene

  • Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.

Additional gene information for IGSF21 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGSF21 Gene

Genomics for IGSF21 Gene

GeneHancer (GH) Regulatory Elements for IGSF21 Gene

Promoters and enhancers for IGSF21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J018108 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 500.7 +0.2 154 1 HNRNPK USF1 ZNF639 ZBTB10 ZBTB26 ZNF341 EZH2 WT1 SP2 ZBTB17 ENSG00000280222 IGSF21
GH01J017635 Enhancer 1 FANTOM5 ENCODE dbSUPER 11 -471.8 -471807 0.8 SPI1 ZFHX2 EBF1 IKZF1 TBX21 POLR2A BHLHE40 EGR2 IKZF2 DPF2 IGSF21 ARHGEF10L PADI4 RF00017-085 lnc-ACTL8-5
GH01J018128 Enhancer 0.8 Ensembl 12.2 +20.7 20655 0.4 NCOR1 KDM6A TGIF2 TEAD1 ZKSCAN8 FOXA2 ZSCAN9 NR2F2 CEBPB SAP130 IGSF21 IGSF21-AS1 piR-48209-025 ENSG00000280222
GH01J018256 Enhancer 0.9 ENCODE dbSUPER 10.3 +148.7 148736 0.2 ZIC2 REST AFF1 GABPA SAP30 RFX1 TGIF2 ZBTB26 ZSCAN9 MIER1 lnc-KLHDC7A-4 IGSF21 lnc-KLHDC7A-5
GH01J018262 Enhancer 0.6 Ensembl ENCODE 10.6 +154.9 154855 2.4 EP300 USF1 EZH2 POLR2A IGSF21 lnc-KLHDC7A-4 lnc-TAS1R2-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGSF21 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGSF21

Top Transcription factor binding sites by QIAGEN in the IGSF21 gene promoter:
  • AP-2gamma
  • E47
  • FOXO1
  • FOXO1a
  • IRF-1
  • MyoD
  • POU2F1
  • POU2F1a
  • Sp1
  • Tal-1beta

Genomic Locations for IGSF21 Gene

Genomic Locations for IGSF21 Gene
chr1:18,107,746-18,378,484
(GRCh38/hg38)
Size:
270,739 bases
Orientation:
Plus strand
chr1:18,434,240-18,704,977
(GRCh37/hg19)
Size:
270,738 bases
Orientation:
Plus strand

Genomic View for IGSF21 Gene

Genes around IGSF21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF21 Gene

Proteins for IGSF21 Gene

  • Protein details for IGSF21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ID5-IGS21_HUMAN
    Recommended name:
    Immunoglobulin superfamily member 21
    Protein Accession:
    Q96ID5
    Secondary Accessions:
    • Q8NBR8

    Protein attributes for IGSF21 Gene

    Size:
    467 amino acids
    Molecular mass:
    51835 Da
    Quaternary structure:
    • Interacts (Ig-like 1 domain) with NRXN2 (via Laminin G-like 1 domain) in a trans-interaction manner.

neXtProt entry for IGSF21 Gene

Post-translational modifications for IGSF21 Gene

  • Glycosylation at Asn82, Asn165, Asn407, and Asn444
  • Modification sites at PhosphoSitePlus

Other Protein References for IGSF21 Gene

No data available for DME Specific Peptides for IGSF21 Gene

Domains & Families for IGSF21 Gene

Gene Families for IGSF21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for IGSF21 Gene

Blocks:
  • Immunoglobulin subtype
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGSF21 Gene

GenScript: Design optimal peptide antigens:
  • Immunoglobulin superfamily member 21 (IGS21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96ID5

UniProtKB/Swiss-Prot:

IGS21_HUMAN :
  • Ig-like 1 domain is indispensable for synaptogenic activity whereas Ig-like 2 domain is secondarily responsible for the activity.
Domain:
  • Ig-like 1 domain is indispensable for synaptogenic activity whereas Ig-like 2 domain is secondarily responsible for the activity.
genes like me logo Genes that share domains with IGSF21: view

Function for IGSF21 Gene

Molecular function for IGSF21 Gene

UniProtKB/Swiss-Prot Function:
Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2.

Phenotypes From GWAS Catalog for IGSF21 Gene

Gene Ontology (GO) - Molecular Function for IGSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity IBA 21873635
GO:0042803 protein homodimerization activity IBA 21873635
GO:0050839 cell adhesion molecule binding IBA 21873635
genes like me logo Genes that share ontologies with IGSF21: view
genes like me logo Genes that share phenotypes with IGSF21: view

Animal Models for IGSF21 Gene

MGI Knock Outs for IGSF21:
  • Igsf21 Igsf21<tm2a(EUCOMM)Hmgu>

Animal Model Products

  • Taconic Biosciences Mouse Models for IGSF21

CRISPR Products

miRNA for IGSF21 Gene

miRTarBase miRNAs that target IGSF21

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGSF21 Gene

Localization for IGSF21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF21 Gene

Cell junction, synapse, postsynaptic cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF21 gene
Compartment Confidence
plasma membrane 4
extracellular 1
nucleus 1
lysosome 1
golgi apparatus 1
endoplasmic reticulum 0
cytosol 0

Gene Ontology (GO) - Cellular Components for IGSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005913 cell-cell adherens junction IBA 21873635
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0031225 anchored component of membrane IEA --
GO:0031362 anchored component of external side of plasma membrane ISS,IEA --
genes like me logo Genes that share ontologies with IGSF21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGSF21 Gene

Pathways & Interactions for IGSF21 Gene

PathCards logo

SuperPathways for IGSF21 Gene

No Data Available

Interacting Proteins for IGSF21 Gene

;

Gene Ontology (GO) - Biological Process for IGSF21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IBA 21873635
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA 21873635
GO:0060074 synapse maturation IEA,ISS --
genes like me logo Genes that share ontologies with IGSF21: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF21 Gene

Drugs & Compounds for IGSF21 Gene

No Compound Related Data Available

Transcripts for IGSF21 Gene

mRNA/cDNA for IGSF21 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF21 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12
SP1: - - - - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for IGSF21 Gene

GeneLoc Exon Structure for
IGSF21

Expression for IGSF21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGSF21 Gene

mRNA differential expression in normal tissues according to GTEx for IGSF21 Gene

This gene is overexpressed in Brain - Cerebellum (x8.2), Brain - Cerebellar Hemisphere (x7.4), Brain - Cortex (x6.2), Brain - Frontal Cortex (BA9) (x5.0), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for IGSF21 Gene

This gene is overexpressed in Frontal cortex (30.6) and Fetal Brain (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGSF21 Gene



Protein tissue co-expression partners for IGSF21 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGSF21

SOURCE GeneReport for Unigene cluster for IGSF21 Gene:

Hs.212511

Evidence on tissue expression from TISSUES for IGSF21 Gene

  • Eye(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with IGSF21: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF21 Gene

Orthologs for IGSF21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGSF21 31 30
  • 99.43 (n)
OneToOne
dog
(Canis familiaris)
Mammalia IGSF21 31 30
  • 91.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia IGSF21 31 30
  • 88.55 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Igsf21 30
  • 87.87 (n)
mouse
(Mus musculus)
Mammalia Igsf21 17 31 30
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia IGSF21 31
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IGSF21 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGSF21 31 30
  • 77.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGSF21 31
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf21 30
  • 74.28 (n)
zebrafish
(Danio rerio)
Actinopterygii igsf21a 31 30
  • 69.69 (n)
OneToMany
igsf21b 31
  • 64 (a)
OneToMany
Species where no ortholog for IGSF21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF21 Gene

ENSEMBL:
Gene Tree for IGSF21 (if available)
TreeFam:
Gene Tree for IGSF21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGSF21: view image

Paralogs for IGSF21 Gene

Pseudogenes.org Pseudogenes for IGSF21 Gene

genes like me logo Genes that share paralogs with IGSF21: view

Variants for IGSF21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGSF21 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs766575681 A colorectal cancer sample p.Thr467Met
rs12076815 - p.Thr379Met
rs2355877 - p.Arg245His

Additional dbSNP identifiers (rs#s) for IGSF21 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGSF21 Gene

Variant ID Type Subtype PubMed ID
dgv130n100 CNV loss 25217958
dgv177n54 CNV loss 21841781
dgv20e212 CNV loss 25503493
esv3585384 CNV loss 21293372
esv3585386 CNV loss 21293372
esv994039 CNV deletion 20482838
nsv1075264 CNV deletion 25765185
nsv1114938 CNV deletion 24896259
nsv1133820 CNV deletion 24896259
nsv1137738 CNV deletion 24896259
nsv1142750 CNV deletion 24896259
nsv1151366 CNV deletion 26484159
nsv1160182 CNV duplication 26073780
nsv4409 CNV insertion 18451855
nsv4520 CNV insertion 18451855
nsv460684 CNV loss 19166990
nsv4631 CNV insertion 18451855
nsv4743 CNV deletion 18451855
nsv475630 CNV novel sequence insertion 20440878
nsv478816 CNV novel sequence insertion 20440878
nsv528445 CNV loss 19592680
nsv545713 CNV loss 21841781
nsv545714 CNV loss 21841781
nsv545715 CNV loss 21841781
nsv834313 CNV loss 17160897
nsv834324 CNV gain 17160897
nsv834336 CNV loss 17160897
nsv954894 CNV deletion 24416366

Variation tolerance for IGSF21 Gene

Residual Variation Intolerance Score: 17.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGSF21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGSF21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF21 Gene

Disorders for IGSF21 Gene

Additional Disease Information for IGSF21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IGSF21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF21 Gene

Publications for IGSF21 Gene

  1. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α. (PMID: 28864826) Tanabe Y … Takahashi H (Nature communications 2017) 2 3 54
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 54
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 54

Products for IGSF21 Gene

  • Biorbyt antibodies for IGSF21

Sources for IGSF21 Gene