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Aliases for IGSF11 Gene

Aliases for IGSF11 Gene

  • Immunoglobulin Superfamily Member 11 2 3 5
  • Brain And Testis-Specific Immunoglobulin Superfamily Protein 3 4
  • V-Set And Immunoglobulin Domain-Containing Protein 3 3 4
  • Cancer/Testis Antigen 119 2 3
  • BT-IgSF 3 4
  • CXADRL1 3 4
  • VSIG3 3 4
  • Brain And Testis-Specific Immunoglobin Superfamily Protein 3
  • V-Set And Immunoglobulin Domain Containing 3 3
  • Immunoglobulin Superfamily, Member 11 2
  • CXADR Like 1 3
  • IgSF13 3
  • BTIGSF 4
  • IgSF11 4
  • CT119 3

External Ids for IGSF11 Gene

Previous GeneCards Identifiers for IGSF11 Gene

  • GC03M118248
  • GC03M119900
  • GC03M119941
  • GC03M119940
  • GC03M120102
  • GC03M118619
  • GC03M115994

Summaries for IGSF11 Gene

Entrez Gene Summary for IGSF11 Gene

  • IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]

GeneCards Summary for IGSF11 Gene

IGSF11 (Immunoglobulin Superfamily Member 11) is a Protein Coding gene. An important paralog of this gene is CXADR.

UniProtKB/Swiss-Prot for IGSF11 Gene

  • Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.

Additional gene information for IGSF11 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGSF11 Gene

Genomics for IGSF11 Gene

GeneHancer (GH) Regulatory Elements for IGSF11 Gene

Promoters and enhancers for IGSF11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I119034 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.1 +111.4 111357 1.1 RB1 SIN3A BMI1 GLIS2 EGR1 SCRT2 ZNF143 RUNX3 EGR2 SMARCA5 IGSF11 GC03M119012
GH03I119146 Promoter 0.6 EPDnew 550.8 +0.0 28 0.1 CTCF C3orf30 ENSG00000251012 IGSF11 UPK1B GC03M119012
GH03I119147 Promoter 0.5 EPDnew 555.3 -0.1 -83 0.1 IGSF11 C3orf30 ENSG00000251012
GH03I119292 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 7.6 -149.2 -149165 5.1 PKNOX1 SMAD1 SIN3A ZNF2 ZNF335 GLIS2 ZNF366 ATF7 RCOR1 ETV6 ARHGAP31 ARHGAP31-AS1 IGSF11 RPS26P21
GH03I119210 Enhancer 0.8 ENCODE 18.5 -65.3 -65308 2.4 HDAC1 MEIS2 PKNOX1 TAL1 SIN3A TCF12 NCOR1 CBFA2T2 FOSL2 SOX6 IGSF11 B4GALT4 UPK1B GC03M119181 B4GALT4-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGSF11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGSF11 gene promoter:

Genomic Locations for IGSF11 Gene

Genomic Locations for IGSF11 Gene
245,512 bases
Minus strand

Genomic View for IGSF11 Gene

Genes around IGSF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGSF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGSF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGSF11 Gene

Proteins for IGSF11 Gene

  • Protein details for IGSF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin superfamily member 11
    Protein Accession:
    Secondary Accessions:
    • C9JZN0
    • Q8N4F1
    • Q8N7T8
    • Q8NDD2

    Protein attributes for IGSF11 Gene

    431 amino acids
    Molecular mass:
    46120 Da
    Quaternary structure:
    No Data Available
    • The last 20 cytoplasmic amino acids are not required for the cell adhesion function.

    Alternative splice isoforms for IGSF11 Gene


neXtProt entry for IGSF11 Gene

Post-translational modifications for IGSF11 Gene

No data available for DME Specific Peptides for IGSF11 Gene

Domains & Families for IGSF11 Gene

Gene Families for IGSF11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for IGSF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGSF11: view

No data available for UniProtKB/Swiss-Prot for IGSF11 Gene

Function for IGSF11 Gene

Molecular function for IGSF11 Gene

UniProtKB/Swiss-Prot Function:
Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth.

Phenotypes From GWAS Catalog for IGSF11 Gene

genes like me logo Genes that share phenotypes with IGSF11: view

Animal Models for IGSF11 Gene

MGI Knock Outs for IGSF11:

Animal Model Products

CRISPR Products

miRNA for IGSF11 Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for IGSF11 Gene

Localization for IGSF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGSF11 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGSF11 gene
Compartment Confidence
extracellular 5
plasma membrane 4
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome HDA,IDA 23376485
genes like me logo Genes that share ontologies with IGSF11: view

Pathways & Interactions for IGSF11 Gene

SuperPathways for IGSF11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGSF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0040008 regulation of growth IEA --
genes like me logo Genes that share ontologies with IGSF11: view

No data available for Pathways by source and SIGNOR curated interactions for IGSF11 Gene

Drugs & Compounds for IGSF11 Gene

No Compound Related Data Available

Transcripts for IGSF11 Gene

Unigene Clusters for IGSF11 Gene

Immunoglobulin superfamily, member 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGSF11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for IGSF11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGSF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGSF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGSF11 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x5.0) and Testis (x4.5).

Protein differential expression in normal tissues from HIPED for IGSF11 Gene

This gene is overexpressed in Frontal cortex (39.1) and Adrenal (27.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGSF11 Gene

Protein tissue co-expression partners for IGSF11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGSF11 Gene:


SOURCE GeneReport for Unigene cluster for IGSF11 Gene:


mRNA Expression by UniProt/SwissProt for IGSF11 Gene:

Tissue specificity: Abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.

Evidence on tissue expression from TISSUES for IGSF11 Gene

  • Nervous system(4.8)
  • Kidney(4.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with IGSF11: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IGSF11 Gene

Orthologs for IGSF11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGSF11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGSF11 33 34
  • 99.46 (n)
(Canis familiaris)
Mammalia IGSF11 33 34
  • 91.87 (n)
(Bos Taurus)
Mammalia IGSF11 33 34
  • 90.02 (n)
(Mus musculus)
Mammalia Igsf11 33 16 34
  • 86.37 (n)
(Rattus norvegicus)
Mammalia Igsf11 33
  • 85.9 (n)
(Monodelphis domestica)
Mammalia IGSF11 34
  • 82 (a)
(Gallus gallus)
Aves IGSF11 33 34
  • 73.59 (n)
(Anolis carolinensis)
Reptilia IGSF11 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia igsf11 33
  • 63.16 (n)
(Danio rerio)
Actinopterygii igsf11 33 34
  • 64.69 (n)
Species where no ortholog for IGSF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGSF11 Gene

Gene Tree for IGSF11 (if available)
Gene Tree for IGSF11 (if available)

Paralogs for IGSF11 Gene

Paralogs for IGSF11 Gene

(6) SIMAP similar genes for IGSF11 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with IGSF11: view

Variants for IGSF11 Gene

Sequence variations from dbSNP and Humsavar for IGSF11 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000031433 -- 118,946,585(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000032365 -- 119,074,138(-) A/C genic_upstream_transcript_variant, intron_variant
rs1000034318 -- 119,086,273(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000034569 -- 119,022,563(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000039251 -- 118,928,814(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGSF11 Gene

Variant ID Type Subtype PubMed ID
nsv829692 CNV loss 17160897
nsv822226 CNV loss 20364138
nsv591350 CNV gain 21841781
nsv523926 CNV gain 19592680
nsv521267 CNV gain 19592680
nsv470860 CNV gain 18288195
nsv3961 CNV deletion 18451855
nsv3960 CNV insertion 18451855
nsv1152225 CNV duplication 26484159
nsv1141440 CNV duplication 24896259
nsv1139800 CNV duplication 24896259
nsv1011135 CNV gain 25217958
esv3597553 CNV loss 21293372
esv3597552 CNV loss 21293372
esv3597551 CNV gain 21293372
esv3597550 CNV gain 21293372
esv3597545 CNV gain 21293372
esv3597544 CNV gain 21293372
esv3392030 CNV duplication 20981092
esv3351388 CNV insertion 20981092
esv33349 CNV gain 17666407
esv2763752 CNV gain 21179565
esv2725820 CNV deletion 23290073
esv25249 CNV loss 19812545
dgv927e214 CNV loss 21293372
dgv8517n54 CNV gain 21841781
dgv8516n54 CNV gain 21841781
dgv618n27 CNV gain 19166990
dgv4846n100 CNV gain 25217958
dgv4845n100 CNV gain 25217958
dgv4844n100 CNV gain 25217958
dgv1403e212 CNV gain 25503493

Variation tolerance for IGSF11 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGSF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGSF11 Gene

Disorders for IGSF11 Gene

Additional Disease Information for IGSF11

No disorders were found for IGSF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGSF11 Gene

Publications for IGSF11 Gene

  1. Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas. (PMID: 16108831) Watanabe T … Nakamura Y (Cancer science 2005) 3 4 22 58
  2. BT-IgSF, a novel immunoglobulin superfamily protein, functions as a cell adhesion molecule. (PMID: 15795899) Harada H … Okada S (Journal of cellular physiology 2005) 3 4 22 58
  3. IGSF11 gene, frequently up-regulated in intestinal-type gastric cancer, encodes adhesion molecule homologous to CXADR, FLJ22415 and ESAM. (PMID: 12851705) Katoh M … Katoh M (International journal of oncology 2003) 3 4 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Molecular cloning of a novel immunoglobulin superfamily gene preferentially expressed by brain and testis. (PMID: 12207903) Suzu S … Motoyoshi K (Biochemical and biophysical research communications 2002) 2 3 58

Products for IGSF11 Gene

Sources for IGSF11 Gene

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