Aliases for IGLV7-46 Gene

Aliases for IGLV7-46 Gene

  • Immunoglobulin Lambda Variable 7-46 2 3 4
  • Immunoglobulin Lambda Variable 7-46 (Gene/Pseudogene) 2 5
  • IGLV7-46 5
  • IGLV746 3
  • V3-3 3

External Ids for IGLV7-46 Gene

Previous GeneCards Identifiers for IGLV7-46 Gene

  • GC22U990127
  • GC22P021048
  • GC22P021054
  • GC22P022723
  • GC22P022371
  • GC22P022373
  • GC22P023787

Summaries for IGLV7-46 Gene

GeneCards Summary for IGLV7-46 Gene

IGLV7-46 (Immunoglobulin Lambda Variable 7-46) is a Protein Coding gene. An important paralog of this gene is IGLV7-43.

UniProtKB/Swiss-Prot Summary for IGLV7-46 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLV7-46 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLV7-46 Gene

Genomics for IGLV7-46 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGLV7-46 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLV7-46 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGLV7-46 Gene

Genomic Locations for IGLV7-46 Gene
chr22:22,369,614-22,370,087
(GRCh38/hg38)
Size:
474 bases
Orientation:
Plus strand
chr22:22,723,982-22,724,455
(GRCh37/hg19)
Size:
474 bases
Orientation:
Plus strand

Genomic View for IGLV7-46 Gene

Genes around IGLV7-46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV7-46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV7-46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV7-46 Gene

Proteins for IGLV7-46 Gene

  • Protein details for IGLV7-46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6I9-LV746_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 7-46
    Protein Accession:
    A0A075B6I9

    Protein attributes for IGLV7-46 Gene

    Size:
    117 amino acids
    Molecular mass:
    12468 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV7-46 Gene

Post-translational modifications for IGLV7-46 Gene

No Post-translational modifications

Other Protein References for IGLV7-46 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV7-46 Gene

Domains & Families for IGLV7-46 Gene

Gene Families for IGLV7-46 Gene

Protein Domains for IGLV7-46 Gene

Suggested Antigen Peptide Sequences for IGLV7-46 Gene

GenScript: Design optimal peptide antigens:
  • V3-3 protein (Q5NV83_HUMAN)
genes like me logo Genes that share domains with IGLV7-46: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGLV7-46 Gene

Function for IGLV7-46 Gene

Molecular function for IGLV7-46 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV7-46 Gene

Localization for IGLV7-46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV7-46 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV7-46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0019814 immunoglobulin complex IEA --
genes like me logo Genes that share ontologies with IGLV7-46: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV7-46 Gene

Pathways & Interactions for IGLV7-46 Gene

PathCards logo

SuperPathways for IGLV7-46 Gene

No Data Available

Interacting Proteins for IGLV7-46 Gene

Gene Ontology (GO) - Biological Process for IGLV7-46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA 21873635
GO:0006955 immune response IBA 21873635
genes like me logo Genes that share ontologies with IGLV7-46: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV7-46 Gene

Drugs & Compounds for IGLV7-46 Gene

No Compound Related Data Available

Transcripts for IGLV7-46 Gene

mRNA/cDNA for IGLV7-46 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV7-46 Gene

No ASD Table

Relevant External Links for IGLV7-46 Gene

GeneLoc Exon Structure for
IGLV7-46

Expression for IGLV7-46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLV7-46 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV7-46 Gene

This gene is overexpressed in Spleen (x17.2), Colon - Transverse (x8.4), Small Intestine - Terminal Ileum (x7.5), and Minor Salivary Gland (x4.4).

Protein differential expression in normal tissues from HIPED for IGLV7-46 Gene

This gene is overexpressed in Skin (62.5) and Urine (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLV7-46 Gene



Protein tissue co-expression partners for IGLV7-46 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLV7-46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV7-46 Gene

Orthologs for IGLV7-46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV7-46 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 63 (a)
ManyToMany
-- 31
  • 63 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 63 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 51 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 39 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 38 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 37 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 27 (a)
ManyToMany
Species where no ortholog for IGLV7-46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGLV7-46 Gene

ENSEMBL:
Gene Tree for IGLV7-46 (if available)
TreeFam:
Gene Tree for IGLV7-46 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGLV7-46: view image

Paralogs for IGLV7-46 Gene

Pseudogenes.org Pseudogenes for IGLV7-46 Gene

genes like me logo Genes that share paralogs with IGLV7-46: view

Variants for IGLV7-46 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV7-46 Gene

LV746_HUMAN-A0A075B6I9
There are several alleles. The sequence shown is that of IMGT allele IGLV7-46*02.

Additional Variant Information for IGLV7-46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV7-46

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV7-46 Gene

Disorders for IGLV7-46 Gene

Additional Disease Information for IGLV7-46

No disorders were found for IGLV7-46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV7-46 Gene

Publications for IGLV7-46 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4

Products for IGLV7-46 Gene

Sources for IGLV7-46 Gene