IGLV5-45 Gene (Protein Coding)

Immunoglobulin Lambda Variable 5-45

GC22P022375
GIFtS:
10
See more...

Aliases for IGLV5-45 Gene

Aliases for IGLV5-45 Gene

  • Immunoglobulin Lambda Variable 5-45 2 3 4 5
  • IGLV5-45 5
  • IGLV545 3
  • V4-2 3

External Ids for IGLV5-45 Gene

Previous GeneCards Identifiers for IGLV5-45 Gene

  • GC22U990133
  • GC22P021055
  • GC22P021060
  • GC22P022730
  • GC22P005688

Summaries for IGLV5-45 Gene

GeneCards Summary for IGLV5-45 Gene

IGLV5-45 (Immunoglobulin Lambda Variable 5-45) is a Protein Coding gene. An important paralog of this gene is IGLV5-37.

UniProtKB/Swiss-Prot Summary for IGLV5-45 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLV5-45 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLV5-45 Gene

Genomics for IGLV5-45 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for IGLV5-45 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22J022375 Promoter/Enhancer 0.7 EPDnew Ensembl 600.7 -0.1 -86 0.2 MAFG PRDM10 IGLV5-45 IGLL5 IGLV1-44 ENSG00000232603 IGLV7-46 lnc-VPREB1-14 ENSG00000286129 IGL lnc-IGLL5-1 lnc-ZNF280B-6
GH22J022377 Enhancer 0.5 Ensembl 600.7 +1.2 1215 1.2 ZIC2 RAD21 CTCF ZBTB5 SPI1 IGLV5-45 IGLV1-44 IGLV1-41 ENSG00000286129 IGL lnc-IGLL5-1 lnc-ZNF280B-6
GH22J022376 Enhancer 0.3 Ensembl 600.7 -0.6 -585 0.4 MCM7 IGLV5-45 IGLV1-51 ENSG00000232603 lnc-VPREB1-14 IGLV7-46 ENSG00000286129 IGL lnc-IGLL5-1 lnc-ZNF280B-6
GH22J022368 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 0.4 -6.3 -6285 3.8 CTCF ZIC2 PKNOX1 REST FOXJ2 UBTF ZNF766 CTBP1 TSC22D4 KDM4B ENSG00000232603 IGLV7-46 lnc-VPREB1-14 IGLL5 TOP3B IGLV5-52 ENSG00000272779 PPIL2 ENSG00000234630 ENSG00000225544
GH22J022379 Enhancer 0.6 Ensembl 0.7 +3.5 3515 2.2 CTCF SCRT2 EGR1 SCRT1 ZFHX2 RAD21 MCM7 VEZF1 KLF1 BRF2 IGLV1-44 IGLV5-45 ENSG00000286129 IGL lnc-IGLL5-1 lnc-ZNF280B-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLV5-45 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGLV5-45 Gene

Genomic Locations for IGLV5-45 Gene
chr22:22,375,986-22,376,505
(GRCh38/hg38)
Size:
520 bases
Orientation:
Plus strand
chr22:22,730,355-22,730,874
(GRCh37/hg19)
Size:
520 bases
Orientation:
Plus strand

Genomic View for IGLV5-45 Gene

Genes around IGLV5-45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV5-45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV5-45 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for IGLV5-45 Gene

Proteins for IGLV5-45 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for IGLV5-45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A087WSX0-LV545_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 5-45
    Protein Accession:
    A0A087WSX0

    Protein attributes for IGLV5-45 Gene

    Size:
    123 amino acids
    Molecular mass:
    13162 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV5-45 Gene

Post-translational modifications for IGLV5-45 Gene

No Post-translational modifications

Other Protein References for IGLV5-45 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV5-45 Gene

Domains & Families for IGLV5-45 Gene

Gene Families for IGLV5-45 Gene

HGNC:

Protein Domains for IGLV5-45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGLV5-45 Gene

GenScript: Design optimal peptide antigens:
  • V4-2 protein (Q5NV82_HUMAN)
genes like me logo Genes that share domains with IGLV5-45: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGLV5-45 Gene

Function for IGLV5-45 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for IGLV5-45 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Phenotypes From GWAS Catalog for IGLV5-45 Gene

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV5-45 Gene

Localization for IGLV5-45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV5-45 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV5-45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0019814 immunoglobulin complex IEA --
genes like me logo Genes that share ontologies with IGLV5-45: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV5-45 Gene

Pathways & Interactions for IGLV5-45 Gene

PathCards logo

SuperPathways for IGLV5-45 Gene

No Data Available

Interacting Proteins for IGLV5-45 Gene

Gene Ontology (GO) - Biological Process for IGLV5-45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA 21873635
GO:0006955 immune response IBA 21873635
genes like me logo Genes that share ontologies with IGLV5-45: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV5-45 Gene

Drugs & Compounds for IGLV5-45 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for IGLV5-45 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for IGLV5-45 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV5-45 Gene

No ASD Table

Relevant External Links for IGLV5-45 Gene

GeneLoc Exon Structure for
IGLV5-45

Expression for IGLV5-45 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLV5-45 Gene

mRNA expression in normal human tissues for IGLV5-45 Gene
mRNA expression by GTEx for IGLV5-45 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV5-45 Gene

This gene is overexpressed in Minor Salivary Gland (x13.5), Spleen (x11.2), Small Intestine - Terminal Ileum (x8.0), Colon - Transverse (x6.6), and Whole Blood (x4.2).
genes like me logo Genes that share expression patterns with IGLV5-45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV5-45 Gene

Orthologs for IGLV5-45 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV5-45 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia -- 31
  • 63 (a)
 ManyToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 35 (a)
 OneToMany
Species where no ortholog for IGLV5-45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGLV5-45 Gene

ENSEMBL:
Gene Tree for IGLV5-45 (if available)
TreeFam:
Gene Tree for IGLV5-45 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGLV5-45: view image

Paralogs for IGLV5-45 Gene

Paralogs for IGLV5-45 Gene

(88) SIMAP similar genes for IGLV5-45 Gene using alignment to 1 proteins:

  • Q5NV82_HUMAN
genes like me logo Genes that share paralogs with IGLV5-45: view

Variants for IGLV5-45 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV5-45 Gene

LV545_HUMAN-A0A087WSX0
There are several alleles. The sequence shown is that of IMGT allele IGLV5-45*04.

Additional Variant Information for IGLV5-45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV5-45

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV5-45 Gene

Disorders for IGLV5-45 Gene

Additional Disease Information for IGLV5-45

Open Targets Platform

No disorders were found for IGLV5-45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLV5-45 Gene

Publications for IGLV5-45 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4

ExternalLinks

View latest publications for IGLV5-45 gene in Mastermind

Products for IGLV5-45 Gene

Sources for IGLV5-45 Gene