Free for academic non-profit institutions. Other users need a Commercial license

Aliases for IGLV10-54 Gene

Aliases for IGLV10-54 Gene

  • Immunoglobulin Lambda Variable 10-54 2 3 5
  • IGLV1054 3
  • V1-20 3

External Ids for IGLV10-54 Gene

Previous GeneCards Identifiers for IGLV10-54 Gene

  • GC22U990124
  • GC22P020893
  • GC22P020899
  • GC22P022569
  • GC22P022214

Summaries for IGLV10-54 Gene

GeneCards Summary for IGLV10-54 Gene

IGLV10-54 (Immunoglobulin Lambda Variable 10-54) is a Protein Coding gene. An important paralog of this gene is IGLV1-40.

UniProtKB/Swiss-Prot for IGLV10-54 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLV10-54 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLV10-54 Gene

Genomics for IGLV10-54 Gene

GeneHancer (GH) Regulatory Elements for IGLV10-54 Gene

Promoters and enhancers for IGLV10-54 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I022036 Enhancer 0.8 ENCODE 550.8 -0.8 -814 1.7 HDAC1 ARNT ZNF76 ZBTB40 TCF12 ZNF766 RBM34 ZNF143 FOS ATF7 ENSG00000278657 IGLV10-54 ENSG00000249333 HIC2 IGLVI-70 PRAMENP IGL
GH22I022214 Enhancer 0.6 ENCODE 19 +176.3 176308 1.2 HNRNPUL1 GATAD2A MCM3 TEAD1 MCM5 REST MCM2 TEAD3 SKI MCM7 TOP3B IGLV10-54 ENSG00000272779 IGLVIV-53 LOC100419915 IGL
GH22I022209 Enhancer 0.7 ENCODE 15.8 +171.8 171843 1.1 JUN MAX BATF FOSL1 FOS MAFK PHF21A RNF2 L3MBTL2 JUNB IGLV10-54 VPREB1 IGLV1-41 IGLVIV-53 LOC100419915 IGL
GH22I022215 Enhancer 0.4 ENCODE 15.6 +177.2 177187 0.3 ZFHX2 BATF IGLV10-54 IGLVIV-53 LOC100419915 IGL
GH22I022901 Enhancer 1 ENCODE dbSUPER 4.7 +864.2 864187 2.8 HNRNPUL1 RB1 BMI1 IRF4 EGR1 BCLAF1 IKZF2 MCM3 PHF21A SMAD5 IGLC2 TOP3B ZNF70 MIF-AS1 MMP11 IGLV2-5 IGLV3-4 SMARCB1 IGLC7 IGLV10-54
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGLV10-54 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGLV10-54 Gene

Genomic Locations for IGLV10-54 Gene
chr22:22,038,643-22,215,271
(GRCh38/hg38)
Size:
176,629 bases
Orientation:
Plus strand
chr22:22,569,184-22,569,661
(GRCh37/hg19)

Genomic View for IGLV10-54 Gene

Genes around IGLV10-54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLV10-54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLV10-54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLV10-54 Gene

Proteins for IGLV10-54 Gene

  • Protein details for IGLV10-54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A075B6I4-LVX54_HUMAN
    Recommended name:
    Immunoglobulin lambda variable 10-54
    Protein Accession:
    A0A075B6I4

    Protein attributes for IGLV10-54 Gene

    Size:
    117 amino acids
    Molecular mass:
    12395 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGLV10-54 Gene

Post-translational modifications for IGLV10-54 Gene

No Post-translational modifications

Other Protein References for IGLV10-54 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLV10-54 Gene

Domains & Families for IGLV10-54 Gene

Gene Families for IGLV10-54 Gene

Protein Domains for IGLV10-54 Gene

Suggested Antigen Peptide Sequences for IGLV10-54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLV10-54: view

No data available for UniProtKB/Swiss-Prot for IGLV10-54 Gene

Function for IGLV10-54 Gene

Molecular function for IGLV10-54 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Ontology (GO) - Molecular Function for IGLV10-54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGLV10-54: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLV10-54 Gene

Localization for IGLV10-54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLV10-54 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLV10-54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLV10-54: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLV10-54 Gene

Pathways & Interactions for IGLV10-54 Gene

SuperPathways for IGLV10-54 Gene

No Data Available

Interacting Proteins for IGLV10-54 Gene

Gene Ontology (GO) - Biological Process for IGLV10-54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002377 immunoglobulin production IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with IGLV10-54: view

No data available for Pathways by source and SIGNOR curated interactions for IGLV10-54 Gene

Drugs & Compounds for IGLV10-54 Gene

No Compound Related Data Available

Transcripts for IGLV10-54 Gene

mRNA/cDNA for IGLV10-54 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLV10-54 Gene

No ASD Table

Relevant External Links for IGLV10-54 Gene

GeneLoc Exon Structure for
IGLV10-54
ECgene alternative splicing isoforms for
IGLV10-54

Expression for IGLV10-54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLV10-54 Gene

mRNA differential expression in normal tissues according to GTEx for IGLV10-54 Gene

This gene is overexpressed in Spleen (x30.6), Colon - Transverse (x7.2), and Small Intestine - Terminal Ileum (x5.6).
genes like me logo Genes that share expression patterns with IGLV10-54: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLV10-54 Gene

Orthologs for IGLV10-54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLV10-54 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IGLV10-54 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 44 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 41 (a)
OneToMany
-- 34
  • 22 (a)
OneToMany
Species where no ortholog for IGLV10-54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGLV10-54 Gene

ENSEMBL:
Gene Tree for IGLV10-54 (if available)
TreeFam:
Gene Tree for IGLV10-54 (if available)

Paralogs for IGLV10-54 Gene

Pseudogenes.org Pseudogenes for IGLV10-54 Gene

genes like me logo Genes that share paralogs with IGLV10-54: view

Variants for IGLV10-54 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLV10-54 Gene

LVX54_HUMAN-A0A075B6I4
There are several alleles. The sequence shown is that of IMGT allele IGLV10-54*02.

Additional Variant Information for IGLV10-54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLV10-54

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLV10-54 Gene

Disorders for IGLV10-54 Gene

No disorders were found for IGLV10-54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLV10-54 Gene

Publications for IGLV10-54 Gene

  1. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  2. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
  3. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
  4. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58
  5. Recognition of immunoglobulins by Fcgamma receptors. (PMID: 11955599) Radaev S … Sun P (Molecular immunology 2002) 3 58

Products for IGLV10-54 Gene

Sources for IGLV10-54 Gene

Content
Loading form....