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Aliases for IGLON5 Gene

Aliases for IGLON5 Gene

  • IgLON Family Member 5 2 3 3 5
  • Ig-Like Domain-Containing Protein ENSP00000270642 3
  • HCG1651476 3

External Ids for IGLON5 Gene

Previous GeneCards Identifiers for IGLON5 Gene

  • GC19P056509
  • GC19P051815
  • GC19P048157

Summaries for IGLON5 Gene

GeneCards Summary for IGLON5 Gene

IGLON5 (IgLON Family Member 5) is a Protein Coding gene. Diseases associated with IGLON5 include Sleep Disorder. An important paralog of this gene is OPCML.

Additional gene information for IGLON5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLON5 Gene

Genomics for IGLON5 Gene

GeneHancer (GH) Regulatory Elements for IGLON5 Gene

Promoters and enhancers for IGLON5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051310 Enhancer 0.5 Ensembl 650.7 -0.2 -190 2.8 POLR2A ZNF740 VEZF1 NFYB ZSCAN29 IGLON5 ENSG00000268595 SIGLECL1 ENSG00000261341 LOC100420904
GH19J051687 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +378.6 378643 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 SPACA6 ZNF137P ZNF841 ZNF808 ZNF616 ZNF766 ZNF836 ZNF577 ENSG00000268970 ENSG00000269825
GH19J051349 Enhancer 1 ENCODE 9.5 +39.5 39549 3.9 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 YY1 ZNF766 FOS ZNF263 ZNF841 ZNF350 ZNF836 VSIG10L ZNF616 CTU1 CLEC11A ZNF613 ZNF175 SIGLEC8
GH19J051644 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 4.9 +334.0 334027 3.1 BCOR IKZF1 ZFP36 ZMYM3 KDM1A REST SPI1 SIGLEC14 SIGLEC5 ENSG00000268500 IGLON5
GH19J051319 Enhancer 0.5 FANTOM5 5.3 +7.4 7400 0.4 ZSCAN4 SIN3A EHMT2 REST IGLON5 GC19M051338
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLON5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGLON5 gene promoter:
  • Pax-4a
  • LHX3b
  • Lhx3a
  • MAZR
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • C/EBPalpha

Genomic Locations for IGLON5 Gene

Genomic Locations for IGLON5 Gene
19,001 bases
Plus strand
19,001 bases
Plus strand

Genomic View for IGLON5 Gene

Genes around IGLON5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLON5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLON5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLON5 Gene

Proteins for IGLON5 Gene

  • Protein details for IGLON5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IgLON family member 5
    Protein Accession:

    Protein attributes for IGLON5 Gene

    336 amino acids
    Molecular mass:
    36795 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGLON5 Gene

Post-translational modifications for IGLON5 Gene

  • Glycosylation at Asn288, Asn137, isoforms=67, isoforms=49, and Asn41
  • Modification sites at PhosphoSitePlus

Other Protein References for IGLON5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGLON5 Gene

Domains & Families for IGLON5 Gene

Protein Domains for IGLON5 Gene

Suggested Antigen Peptide Sequences for IGLON5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with IGLON5: view

Function for IGLON5 Gene

Phenotypes From GWAS Catalog for IGLON5 Gene

genes like me logo Genes that share phenotypes with IGLON5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLON5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLON5 Gene

Localization for IGLON5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLON5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGLON5 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGLON5: view

Pathways & Interactions for IGLON5 Gene

SuperPathways for IGLON5 Gene

No Data Available

Interacting Proteins for IGLON5 Gene

Gene Ontology (GO) - Biological Process for IGLON5 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGLON5 Gene

Drugs & Compounds for IGLON5 Gene

No Compound Related Data Available

Transcripts for IGLON5 Gene

mRNA/cDNA for IGLON5 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGLON5 Gene

IgLON family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLON5

Alternative Splicing Database (ASD) splice patterns (SP) for IGLON5 Gene

No ASD Table

Relevant External Links for IGLON5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGLON5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLON5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLON5 Gene

This gene is overexpressed in Brain - Cerebellum (x10.6), Brain - Cerebellar Hemisphere (x9.4), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for IGLON5 Gene

This gene is overexpressed in Fetal Brain (37.9), Cerebrospinal fluid (17.3), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLON5 Gene

Protein tissue co-expression partners for IGLON5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of IGLON5 Gene:


SOURCE GeneReport for Unigene cluster for IGLON5 Gene:

genes like me logo Genes that share expression patterns with IGLON5: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLON5 Gene

Orthologs for IGLON5 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGLON5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGLON5 34 33
  • 99.47 (n)
(Bos Taurus)
Mammalia IGLON5 34 33
  • 93.06 (n)
(Canis familiaris)
Mammalia IGLON5 34 33
  • 92.98 (n)
(Rattus norvegicus)
Mammalia Iglon5 33
  • 90.58 (n)
(Mus musculus)
Mammalia Iglon5 16 34 33
  • 90.48 (n)
(Monodelphis domestica)
Mammalia IGLON5 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia IGLON5 34
  • 66 (a)
(Anolis carolinensis)
Reptilia IGLON5 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488314 33
  • 66.67 (n)
(Danio rerio)
Actinopterygii zgc:110372 33
  • 63.13 (n)
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lac 34
  • 24 (a)
CG11320 34
  • 23 (a)
Ama 34
  • 21 (a)
CG14010 34
  • 20 (a)
CG40378 34
  • 20 (a)
CG14521 34
  • 20 (a)
CG42368 34
  • 18 (a)
CG34391 34
  • 18 (a)
CG31708 34
  • 17 (a)
CG42343 34
  • 16 (a)
CG34353 34
  • 16 (a)
CG32791 34
  • 16 (a)
klg 34
  • 16 (a)
wrapper 34
  • 16 (a)
CG31646 34
  • 15 (a)
CG7166 34
  • 15 (a)
CG31814 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea rig-5 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
Species where no ortholog for IGLON5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IGLON5 Gene

Gene Tree for IGLON5 (if available)
Gene Tree for IGLON5 (if available)
Evolutionary constrained regions (ECRs) for IGLON5: view image

Paralogs for IGLON5 Gene

Paralogs for IGLON5 Gene

(4) SIMAP similar genes for IGLON5 Gene using alignment to 1 proteins:

  • IGLO5_HUMAN Pseudogenes for IGLON5 Gene

genes like me logo Genes that share paralogs with IGLON5: view

Variants for IGLON5 Gene

Sequence variations from dbSNP and Humsavar for IGLON5 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000170095 -- 51,316,045(+) C/A intron_variant
rs1000191350 -- 51,328,158(+) T/C intron_variant
rs1000199803 -- 51,316,680(+) G/A intron_variant
rs1000934567 -- 51,317,805(+) C/T intron_variant
rs1001095556 -- 51,311,986(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGLON5 Gene

Variant ID Type Subtype PubMed ID
dgv1060e212 CNV loss 25503493
esv2718770 CNV deletion 23290073
nsv1071943 CNV deletion 25765185
nsv1118837 CNV deletion 24896259
nsv1132479 CNV duplication 24896259
nsv1138723 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv1151102 CNV duplication 26484159

Variation tolerance for IGLON5 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGLON5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLON5 Gene

Disorders for IGLON5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGLON5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
sleep disorder
  • non-organic sleep disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGLON5

genes like me logo Genes that share disorders with IGLON5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLON5 Gene

Publications for IGLON5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 58
  2. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. (PMID: 24703753) Sabater L … Graus F (The Lancet. Neurology 2014) 3 58

Products for IGLON5 Gene

Sources for IGLON5 Gene

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