Aliases for IGLON5 Gene

Aliases for IGLON5 Gene

  • IgLON Family Member 5 2 3 3 4 5
  • Ig-Like Domain-Containing Protein ENSP00000270642 3
  • HCG1651476 3
  • LOC402665 2
  • IGLON5 5

External Ids for IGLON5 Gene

Previous GeneCards Identifiers for IGLON5 Gene

  • GC19P056509
  • GC19P051815
  • GC19P048157

Summaries for IGLON5 Gene

GeneCards Summary for IGLON5 Gene

IGLON5 (IgLON Family Member 5) is a Protein Coding gene. Diseases associated with IGLON5 include Whipple Disease and Choreatic Disease. An important paralog of this gene is OPCML.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLON5 Gene

Genomics for IGLON5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGLON5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051310 Promoter 0.9 Ensembl CraniofacialAtlas 250.7 +0.5 457 2.2 ZSCAN29 CTBP1 POLR2A SCRT2 IGLON5 ENSG00000268595 SIGLECL1 LOC105372440 HSALNG0127201 VSIG10L
GH19J051309 Enhancer 0.2 Ensembl 250.7 -1.4 -1443 0.8 IGLON5 HSALNG0127200 SIGLECL1
GH19J051687 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +378.8 378847 6.9 NCOR1 IKZF1 ZNF580 ZSCAN16 NFIC ZIC2 ZBTB10 CTCF SMAD5 FEZF1 SPACA6 ZNF137P ZNF808 ZNF841 ZNF577 ZNF616 ZNF766 ZNF175 ZNF836 ENSG00000268970
GH19J051349 Enhancer 1.2 Ensembl ENCODE 9.6 +39.8 39753 3.9 NCOR1 IKZF1 SSRP1 ZNF592 CEBPA ATF3 NFIC CHD4 YY1 NONO HSALNG0127207 ZNF616 POLD1 ZNF841 VSIG10L LRRC4B ZNF480 ZNF836 ZNF766 ZNF577
GH19J051644 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 4.9 +334.2 334231 3.1 BHLHE40 SPI1 REST ZMYM3 IKZF1 KDM1A RAD51 BCOR SIGLEC14 ENSG00000268500 SIGLEC5 lnc-SIGLEC5-1 IGLON5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLON5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGLON5

Top Transcription factor binding sites by QIAGEN in the IGLON5 gene promoter:
  • C/EBPalpha
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • Lhx3a
  • LHX3b
  • MAZR
  • Pax-4a

Genomic Locations for IGLON5 Gene

Latest Assembly
19,248 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
19,248 bases
Plus strand

(GRCh37/hg19 by Ensembl)
18,507 bases
Plus strand

Genomic View for IGLON5 Gene

Genes around IGLON5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLON5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLON5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLON5 Gene

Proteins for IGLON5 Gene

  • Protein details for IGLON5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    IgLON family member 5
    Protein Accession:

    Protein attributes for IGLON5 Gene

    336 amino acids
    Molecular mass:
    36795 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for IGLON5 Gene

neXtProt entry for IGLON5 Gene

Post-translational modifications for IGLON5 Gene

  • Glycosylation at Asn41, Asn49, Asn67, Asn137, and Asn288
  • Modification sites at PhosphoSitePlus

Other Protein References for IGLON5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGLON5 Gene

Domains & Families for IGLON5 Gene

Gene Families for IGLON5 Gene

Protein Domains for IGLON5 Gene

Suggested Antigen Peptide Sequences for IGLON5 Gene

GenScript: Design optimal peptide antigens:
  • IgLON family member 5 (IGLO5_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with IGLON5: view

Function for IGLON5 Gene

Phenotypes From GWAS Catalog for IGLON5 Gene

genes like me logo Genes that share phenotypes with IGLON5: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLON5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLON5 Gene

Localization for IGLON5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLON5 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGLON5 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
cytoskeleton 1
lysosome 0

Gene Ontology (GO) - Cellular Components for IGLON5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGLON5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGLON5 Gene

Pathways & Interactions for IGLON5 Gene

PathCards logo

SuperPathways for IGLON5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGLON5 Gene


No data available for Pathways by source and SIGNOR curated interactions for IGLON5 Gene

Drugs & Compounds for IGLON5 Gene

No Compound Related Data Available

Transcripts for IGLON5 Gene

mRNA/cDNA for IGLON5 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLON5

Alternative Splicing Database (ASD) splice patterns (SP) for IGLON5 Gene

No ASD Table

Relevant External Links for IGLON5 Gene

GeneLoc Exon Structure for

Expression for IGLON5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLON5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLON5 Gene

This gene is overexpressed in Brain - Cerebellum (x10.6), Brain - Cerebellar Hemisphere (x9.4), and Brain - Hypothalamus (x4.2).

Protein differential expression in normal tissues from HIPED for IGLON5 Gene

This gene is overexpressed in Fetal Brain (37.9), Cerebrospinal fluid (17.3), and Retina (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLON5 Gene

Protein tissue co-expression partners for IGLON5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGLON5

SOURCE GeneReport for Unigene cluster for IGLON5 Gene:


Evidence on tissue expression from TISSUES for IGLON5 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with IGLON5: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLON5 Gene

Orthologs for IGLON5 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGLON5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IGLON5 29 30
  • 99.47 (n)
(Bos Taurus)
Mammalia IGLON5 29 30
  • 93.06 (n)
(Canis familiaris)
Mammalia IGLON5 29 30
  • 92.98 (n)
(Rattus norvegicus)
Mammalia Iglon5 29
  • 90.58 (n)
(Mus musculus)
Mammalia Iglon5 29 16 30
  • 90.48 (n)
(Monodelphis domestica)
Mammalia IGLON5 30
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia IGLON5 30
  • 66 (a)
(Anolis carolinensis)
Reptilia IGLON5 30
  • 67 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100488314 29
  • 66.67 (n)
(Danio rerio)
Actinopterygii zgc:110372 29
  • 63.13 (n)
  • 53 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta Lac 30
  • 24 (a)
CG11320 30
  • 23 (a)
Ama 30
  • 21 (a)
CG14010 30
  • 20 (a)
CG40378 30
  • 20 (a)
CG14521 30
  • 20 (a)
CG42368 30
  • 18 (a)
CG34391 30
  • 18 (a)
CG31708 30
  • 17 (a)
CG42343 30
  • 16 (a)
CG34353 30
  • 16 (a)
CG32791 30
  • 16 (a)
klg 30
  • 16 (a)
wrapper 30
  • 16 (a)
CG31646 30
  • 15 (a)
CG7166 30
  • 15 (a)
CG31814 30
  • 13 (a)
(Caenorhabditis elegans)
Secernentea rig-5 30
  • 17 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 28 (a)
Species where no ortholog for IGLON5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for IGLON5 Gene

Gene Tree for IGLON5 (if available)
Gene Tree for IGLON5 (if available)
Evolutionary constrained regions (ECRs) for IGLON5: view image
Alliance of Genome Resources:
Additional Orthologs for IGLON5

Paralogs for IGLON5 Gene

Paralogs for IGLON5 Gene

(4) SIMAP similar genes for IGLON5 Gene using alignment to 1 proteins:

  • IGLO5_HUMAN Pseudogenes for IGLON5 Gene

genes like me logo Genes that share paralogs with IGLON5: view

Variants for IGLON5 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for IGLON5 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for IGLON5 Gene

Variant ID Type Subtype PubMed ID
dgv1060e212 CNV loss 25503493
esv2718770 CNV deletion 23290073
nsv1071943 CNV deletion 25765185
nsv1118837 CNV deletion 24896259
nsv1132479 CNV duplication 24896259
nsv1138723 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv1151102 CNV duplication 26484159

Variation tolerance for IGLON5 Gene

Residual Variation Intolerance Score: 53.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGLON5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGLON5 Gene

Disorders for IGLON5 Gene

MalaCards: The human disease database

(15) MalaCards diseases for IGLON5 Gene - From: COP

Disorder Aliases PubMed IDs
whipple disease
  • intestinal lipodystrophy
choreatic disease
  • chorea
von economo's disease
  • encephalitis lethargica
rem sleep behavior disorder
  • rapid eye movement sleep behavior disorder
kleine-levin hibernation syndrome
  • kleine-levin syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGLON5

genes like me logo Genes that share disorders with IGLON5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLON5 Gene

Publications for IGLON5 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. A Proteomic Screen of Neuronal Cell-Surface Molecules Reveals IgLONs as Structurally Conserved Interaction Modules at the Synapse. (PMID: 30956130) Ranaivoson FM … Comoletti D (Structure (London, England : 1993) 2019) 3
  3. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. (PMID: 24703753) Sabater L … Graus F (The Lancet. Neurology 2014) 3

Products for IGLON5 Gene

Sources for IGLON5 Gene