This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segment... See more...

Aliases for IGLL5 Gene

Aliases for IGLL5 Gene

  • Immunoglobulin Lambda Like Polypeptide 5 2 3 5
  • Immunoglobulin Lambda-Like Polypeptide 5 2 3 4
  • Germline Immunoglobulin Lambda 1 3 4
  • G Lambda-1 3 4
  • Immunoglobulin Light Chain Variable Region EM1-PPS-4-L1-1 3
  • Immunoglobin Anti-GranzymeB Light Chain Variable Region 3
  • Immunoglobulin Lambda Light Chain Variable Region 3
  • Immunoglobulin Lambda-3 Surrogate Light Chain 3
  • Anti HBs Antibody Light-Chain Fab Fragment 3
  • Immunoglobulin Lambda 1 Light Chain 3
  • Immunoglobulin Lambda 2 Light Chain 3
  • Immunoglobulin Lambda 3 Light Chain 3
  • Omega Light Chain Protein 14.1 3
  • VL-MAR 3
  • IGLL5 5
  • IGLV 3
  • IGL 3

External Ids for IGLL5 Gene

Previous GeneCards Identifiers for IGLL5 Gene

  • GC22U900705
  • GC22P006197
  • GC22P023231
  • GC22P023233
  • GC22P023239
  • GC22P023299
  • GC22P023317
  • GC22P022807
  • GC22P022849
  • GC22P023518
  • GC22P023568
  • GC22P023636
  • GC22P023837
  • GC22P022897
  • GC22P022965
  • GC22P023072
  • GC22P023130
  • GC22P023188
  • GC22P023369
  • GC22P023426
  • GC22P023474

Summaries for IGLL5 Gene

Entrez Gene Summary for IGLL5 Gene

  • This gene encodes one of the immunoglobulin lambda-like polypeptides. It is located within the immunoglobulin lambda locus but it does not require somatic rearrangement for expression. The first exon of this gene is unrelated to immunoglobulin variable genes; the second and third exons are the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for IGLL5 Gene

IGLL5 (Immunoglobulin Lambda Like Polypeptide 5) is a Protein Coding gene. Diseases associated with IGLL5 include Schuurs-Hoeijmakers Syndrome and Retina Lymphoma. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLL1.

Additional gene information for IGLL5 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLL5 Gene

Genomics for IGLL5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGLL5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLL5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGLL5

Genomic Locations for IGLL5 Gene

Genomic Locations for IGLL5 Gene
chr22:22,887,780-22,896,111
(GRCh38/hg38)
Size:
8,332 bases
Orientation:
Plus strand
chr22:23,229,960-23,238,287
(GRCh37/hg19)
Size:
8,328 bases
Orientation:
Plus strand

Genomic View for IGLL5 Gene

Genes around IGLL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLL5 Gene

Proteins for IGLL5 Gene

  • Protein details for IGLL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B9A064-IGLL5_HUMAN
    Recommended name:
    Immunoglobulin lambda-like polypeptide 5
    Protein Accession:
    B9A064

    Protein attributes for IGLL5 Gene

    Size:
    214 amino acids
    Molecular mass:
    23063 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Located within the immunoglobulin lambda locus, but does not require somatic rearrangement for expression.

    Alternative splice isoforms for IGLL5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGLL5 Gene

Post-translational modifications for IGLL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGLL5 Gene

No data available for DME Specific Peptides for IGLL5 Gene

Domains & Families for IGLL5 Gene

Gene Families for IGLL5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for IGLL5 Gene

Suggested Antigen Peptide Sequences for IGLL5 Gene

GenScript: Design optimal peptide antigens:
  • Germline immunoglobulin lambda 1 (IGLL5_HUMAN)
genes like me logo Genes that share domains with IGLL5: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGLL5 Gene

Function for IGLL5 Gene

Phenotypes From GWAS Catalog for IGLL5 Gene

Gene Ontology (GO) - Molecular Function for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGLL5: view

Phenotypes for IGLL5 Gene

genes like me logo Genes that share phenotypes with IGLL5: view

Animal Models for IGLL5 Gene

MGI Knock Outs for IGLL5:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLL5

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IGLL5 Gene

Localization for IGLL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLL5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGLL5 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytoskeleton 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
mitochondrion 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0042571 immunoglobulin complex, circulating IBA 21873635
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with IGLL5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for IGLL5 Gene

Pathways & Interactions for IGLL5 Gene

PathCards logo

SuperPathways for IGLL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGLL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006958 complement activation, classical pathway IBA 21873635
GO:0042742 defense response to bacterium IBA 21873635
GO:0045087 innate immune response IBA 21873635
genes like me logo Genes that share ontologies with IGLL5: view

No data available for Pathways by source and SIGNOR curated interactions for IGLL5 Gene

Drugs & Compounds for IGLL5 Gene

No Compound Related Data Available

Transcripts for IGLL5 Gene

mRNA/cDNA for IGLL5 Gene

2 REFSEQ mRNAs :
194 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLL5

Alternative Splicing Database (ASD) splice patterns (SP) for IGLL5 Gene

No ASD Table

Relevant External Links for IGLL5 Gene

GeneLoc Exon Structure for
IGLL5

Expression for IGLL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLL5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Tonsil (Hematopoietic System)

mRNA differential expression in normal tissues according to GTEx for IGLL5 Gene

This gene is overexpressed in Spleen (x14.2), Colon - Transverse (x7.6), Small Intestine - Terminal Ileum (x6.9), and Minor Salivary Gland (x6.6).

Protein differential expression in normal tissues from HIPED for IGLL5 Gene

This gene is overexpressed in Pancreatic juice (16.2) and Plasma (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLL5 Gene



Protein tissue co-expression partners for IGLL5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGLL5

mRNA Expression by UniProt/SwissProt for IGLL5 Gene:

B9A064-IGLL5_HUMAN
Tissue specificity: Contrary to IGLL1, not expressed in pre-B-cells.

Evidence on tissue expression from TISSUES for IGLL5 Gene

  • Heart(3.1)
  • Blood(2.6)
  • Bone marrow(2.4)
  • Nervous system(2.3)
  • Lymph node(2.2)
  • Spleen(2.1)
  • Eye(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with IGLL5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLL5 Gene

Orthologs for IGLL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLL5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia LOC100614342 30
  • 92.19 (n)
-- 31
  • 83 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 87 (a)
ManyToMany
-- 31
  • 87 (a)
ManyToMany
LOC607582 30
  • 83.33 (n)
-- 31
  • 80 (a)
ManyToMany
-- 31
  • 79 (a)
ManyToMany
-- 31
  • 69 (a)
ManyToMany
-- 31
  • 56 (a)
ManyToMany
-- 31
  • 44 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia LOC100847119 30
  • 78.26 (n)
-- 31
  • 42 (a)
ManyToMany
IGLL1 31
  • 40 (a)
ManyToMany
VPREB 31
  • 36 (a)
ManyToMany
Rat
(Rattus norvegicus)
Mammalia Igll1 30
  • 72.67 (n)
Mouse
(Mus musculus)
Mammalia Igll1 30 17 31
  • 72.17 (n)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 50 (a)
ManyToMany
-- 31
  • 49 (a)
ManyToMany
-- 31
  • 48 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 12 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 35 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 31 (a)
ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101735033 30
  • 54.93 (n)
Zebrafish
(Danio rerio)
Actinopterygii FP016018.1 31
  • 12 (a)
ManyToMany
Species where no ortholog for IGLL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGLL5 Gene

ENSEMBL:
Gene Tree for IGLL5 (if available)
TreeFam:
Gene Tree for IGLL5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGLL5: view image

Paralogs for IGLL5 Gene

(15) SIMAP similar genes for IGLL5 Gene using alignment to 1 proteins:

  • IGLL5_HUMAN

Pseudogenes.org Pseudogenes for IGLL5 Gene

genes like me logo Genes that share paralogs with IGLL5: view

Variants for IGLL5 Gene

Additional dbSNP identifiers (rs#s) for IGLL5 Gene

Structural Variations from Database of Genomic Variants (DGV) for IGLL5 Gene

Variant ID Type Subtype PubMed ID
dgv4511n100 CNV gain 25217958
dgv4517n100 CNV gain 25217958
dgv4523n100 CNV gain 25217958
dgv551n27 CNV loss 19166990
dgv561n27 CNV gain 19166990
dgv562n27 CNV loss 19166990
dgv569n27 CNV loss 19166990
dgv570n27 CNV loss 19166990
dgv571n27 CNV loss 19166990
dgv572n27 CNV loss 19166990
dgv573n27 CNV loss 19166990
dgv574n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv733n67 CNV loss 20364138
dgv744n67 CNV loss 20364138
dgv745n67 CNV loss 20364138
dgv8005n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv8025n54 CNV loss 21841781
dgv8033n54 CNV loss 21841781
dgv8034n54 CNV loss 21841781
dgv8035n54 CNV loss 21841781
dgv8036n54 CNV loss 21841781
dgv822e199 CNV deletion 23128226
dgv826e214 CNV loss 21293372
esv2658780 CNV deletion 23128226
esv2662193 CNV deletion 23128226
esv33722 CNV gain 17666407
esv34158 CNV loss 18971310
esv3568289 CNV loss 25503493
esv3647375 CNV loss 21293372
esv3647377 CNV loss 21293372
esv3647379 CNV loss 21293372
esv3647381 CNV loss 21293372
esv3647383 CNV loss 21293372
esv3647384 CNV loss 21293372
esv3647385 CNV loss 21293372
esv3893457 CNV gain 25118596
esv990735 CNV gain 20482838
esv997030 CNV gain 20482838
nsv1057157 CNV gain 25217958
nsv1061433 CNV gain+loss 25217958
nsv1065323 CNV gain 25217958
nsv1066435 CNV loss 25217958
nsv1066891 CNV gain 25217958
nsv195 CNV deletion 15895083
nsv3572 CNV insertion 18451855
nsv433178 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459553 CNV loss 19166990
nsv459655 CNV loss 19166990
nsv459673 CNV loss 19166990
nsv469839 CNV gain+loss 16826518
nsv471597 CNV loss 15918152
nsv498982 CNV loss 21111241
nsv508728 CNV insertion 20534489
nsv514964 CNV loss 21397061
nsv517485 CNV gain+loss 19592680
nsv521695 CNV loss 19592680
nsv588512 CNV loss 21841781
nsv588516 CNV gain 21841781
nsv588582 CNV loss 21841781
nsv588587 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv819772 CNV gain 19587683
nsv820258 CNV gain 19587683
nsv820655 CNV deletion 20802225
nsv828979 CNV gain+loss 20364138
nsv829058 CNV loss 20364138
nsv829059 CNV loss 20364138
nsv829069 CNV loss 20364138
nsv829078 CNV loss 20364138
nsv829079 CNV loss 20364138
nsv829080 CNV gain 20364138
nsv834153 CNV loss 17160897

Variation tolerance for IGLL5 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.49; 43.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGLL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLL5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGLL5 Gene

Disorders for IGLL5 Gene

MalaCards: The human disease database

(12) MalaCards diseases for IGLL5 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search IGLL5 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with IGLL5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGLL5 Gene

Publications for IGLL5 Gene

  1. Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. (PMID: 1703205) Evans RJ … Hollis GF (The Journal of experimental medicine 1991) 3 4
  2. Expression of a novel type of immunoglobulin C lambda transcripts in human mature B lymphocytes producing kappa light chains. (PMID: 1900243) Guglielmi P … Davi F (European journal of immunology 1991) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer. (PMID: 30945288) Liu H … Yang C (The Journal of pathology 2019) 3
  5. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3

Products for IGLL5 Gene

  • Signalway Proteins for IGLL5

Sources for IGLL5 Gene