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Aliases for IGLL1 Gene

Aliases for IGLL1 Gene

  • Immunoglobulin Lambda Like Polypeptide 1 2 3 5
  • Immunoglobulin Lambda-Like Polypeptide 1 2 3 4
  • Immunoglobulin-Related Protein 14.1 3 4
  • CD179 Antigen-Like Family Member B 3 4
  • CD179b Antigen 3 4
  • Ig Lambda-5 3 4
  • IGL1 3 4
  • Immunoglobulin Omega Polypeptide Chain 3
  • Pre-B Lymphocyte-Specific Protein-2 3
  • Immunoglobulin-Related 14.1 Protein 3
  • Immunoglobulin Omega Polypeptide 4
  • IGLJ14.1 3
  • Lambda 5 2
  • Lambda5 3
  • CD179b 3
  • VPREB2 3
  • IGVPB 3
  • 14.1 3
  • AGM2 3
  • IGL5 3
  • IGLL 3
  • IGO 3

External Ids for IGLL1 Gene

Previous HGNC Symbols for IGLL1 Gene

  • IGLL

Previous GeneCards Identifiers for IGLL1 Gene

  • GC22M020611
  • GC22M022239
  • GC22M022245
  • GC22M023915
  • GC22M006905

Summaries for IGLL1 Gene

Entrez Gene Summary for IGLL1 Gene

  • The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGLL1 Gene

IGLL1 (Immunoglobulin Lambda Like Polypeptide 1) is a Protein Coding gene. Diseases associated with IGLL1 include Agammaglobulinemia 2, Autosomal Recessive and Agammaglobulinemia, Non-Bruton Type. Among its related pathways are Cell surface interactions at the vascular wall and Primary immunodeficiency. An important paralog of this gene is IGLL5.

UniProtKB/Swiss-Prot for IGLL1 Gene

Gene Wiki entry for IGLL1 Gene

Additional gene information for IGLL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGLL1 Gene

Genomics for IGLL1 Gene

GeneHancer (GH) Regulatory Elements for IGLL1 Gene

Promoters and enhancers for IGLL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J023580 Promoter/Enhancer 0.9 EPDnew dbSUPER 600.7 +0.2 162 0.1 GLIS2 POLR2A IGLL1 PIR35257 GC22M023576 GC22M023575
GH22J023579 Promoter/Enhancer 0.7 Ensembl dbSUPER 600.7 +1.5 1471 0.4 IGLL1 MMP11 SMARCB1 ENSG00000224277 PIR35257 GC22M023575 GC22M023576
GH22J023581 Enhancer 0.4 FANTOM5 dbSUPER 620 -1.0 -968 0.1 IGLL1 ENSG00000272733 DRICH1
GH22J023582 Enhancer 0.4 ENCODE dbSUPER 600.7 -0.3 -337 0.2 IGLL1 FAM230I ENSG00000272733 DRICH1
GH22J023565 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 22.4 +14.2 14171 1.4 SP5 KLF14 PRDM1 EGR1 GLIS2 ZIC2 PATZ1 IRF2 SOX13 KLF9 ENSG00000224277 LOC105372957 IGLL1 GGT5 GC22P023592
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGLL1 gene promoter:
  • AML1a

Genomic Locations for IGLL1 Gene

Genomic Locations for IGLL1 Gene
7,348 bases
Minus strand
7,184 bases
Minus strand

Genomic View for IGLL1 Gene

Genes around IGLL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLL1 Gene

Proteins for IGLL1 Gene

  • Protein details for IGLL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Immunoglobulin lambda-like polypeptide 1
    Protein Accession:
    Secondary Accessions:
    • Q0P681

    Protein attributes for IGLL1 Gene

    213 amino acids
    Molecular mass:
    22963 Da
    Quaternary structure:
    • Associates non-covalently with VPREB1.

    Three dimensional structures from OCA and Proteopedia for IGLL1 Gene

    Alternative splice isoforms for IGLL1 Gene


neXtProt entry for IGLL1 Gene

Post-translational modifications for IGLL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IGLL1 Gene

No data available for DME Specific Peptides for IGLL1 Gene

Domains & Families for IGLL1 Gene

Gene Families for IGLL1 Gene

Human Protein Atlas (HPA):
  • CD markers
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for IGLL1 Gene

Suggested Antigen Peptide Sequences for IGLL1 Gene

GenScript: Design optimal peptide antigens:
  • Immunoglobulin-related protein 14.1 (IGLL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGLL1: view

No data available for UniProtKB/Swiss-Prot for IGLL1 Gene

Function for IGLL1 Gene

Molecular function for IGLL1 Gene

UniProtKB/Swiss-Prot Function:
Critical for B-cell development.
GENATLAS Biochemistry:
immunoglobulin,lambda-like (14.1),encoding a gene associating with VpreB gene product,pre-B-cell specific

Phenotypes From GWAS Catalog for IGLL1 Gene

Gene Ontology (GO) - Molecular Function for IGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGLL1: view
genes like me logo Genes that share phenotypes with IGLL1: view

Human Phenotype Ontology for IGLL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLL1

Clone Products

  • Applied Biological Materials (abm): Clones for IGLL1 - Now 50% OFF >
  • * IGLL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IGLL1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLL1 Gene

Localization for IGLL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLL1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGLL1 gene
Compartment Confidence
plasma membrane 4
extracellular 4
nucleus 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane NAS 2501791
GO:0042571 immunoglobulin complex, circulating IBA 21873635
genes like me logo Genes that share ontologies with IGLL1: view

Pathways & Interactions for IGLL1 Gene

genes like me logo Genes that share pathways with IGLL1: view

Pathways by source for IGLL1 Gene

2 Reactome pathways for IGLL1 Gene
1 KEGG pathway for IGLL1 Gene

Gene Ontology (GO) - Biological Process for IGLL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006955 immune response NAS 2501791
GO:0006958 complement activation, classical pathway IBA 21873635
GO:0042742 defense response to bacterium IBA 21873635
genes like me logo Genes that share ontologies with IGLL1: view

No data available for SIGNOR curated interactions for IGLL1 Gene

Drugs & Compounds for IGLL1 Gene

(1) Drugs for IGLL1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 226
genes like me logo Genes that share compounds with IGLL1: view

Transcripts for IGLL1 Gene

mRNA/cDNA for IGLL1 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(106) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for IGLL1 Gene

Immunoglobulin lambda-like polypeptide 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IGLL1

Clone Products

  • Applied Biological Materials (abm): Clones for IGLL1 - Now 50% OFF >
  • * IGLL1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * IGLL1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for IGLL1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP3: -

Relevant External Links for IGLL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IGLL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGLL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGLL1 Gene

This gene is overexpressed in Testis (x44.0).

Protein differential expression in normal tissues from HIPED for IGLL1 Gene

This gene is overexpressed in Plasma (18.9), Urine (15.5), and Serum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGLL1 Gene:


SOURCE GeneReport for Unigene cluster for IGLL1 Gene:


mRNA Expression by UniProt/SwissProt for IGLL1 Gene:

Tissue specificity: Expressed only in pre-B-cells and a special B-cell line (which is surface Ig negative).

Evidence on tissue expression from TISSUES for IGLL1 Gene

  • Bone marrow(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLL1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • respiratory
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • eye
  • eyelid
  • face
  • head
  • jaw
  • mandible
  • maxilla
  • meninges
  • middle ear
  • mouth
  • neck
  • outer ear
  • sinus
  • skull
  • bronchus
  • chest wall
  • clavicle
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • biliary tract
  • gallbladder
  • intestine
  • kidney
  • large intestine
  • liver
  • pancreas
  • small intestine
  • pelvis
  • rectum
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with IGLL1: view

No data available for Protein tissue co-expression partners for IGLL1 Gene

Orthologs for IGLL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100614342 34
  • 83.85 (n)
(Canis familiaris)
Mammalia LOC608248 34
  • 83.76 (n)
-- 35
  • 79 (a)
-- 35
  • 79 (a)
-- 35
  • 75 (a)
-- 35
  • 72 (a)
-- 35
  • 64 (a)
-- 35
  • 48 (a)
-- 35
  • 42 (a)
(Bos Taurus)
Mammalia LOC100847119 34
  • 77.39 (n)
IGLL1 35
  • 41 (a)
-- 35
  • 39 (a)
  • 32 (a)
(Rattus norvegicus)
Mammalia Igll1 34
  • 72.97 (n)
(Mus musculus)
Mammalia Igll1 34
  • 71.53 (n)
Iglc2 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
-- 35
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
-- 35
  • 45 (a)
-- 35
  • 45 (a)
-- 35
  • 38 (a)
-- 35
  • 11 (a)
(Gallus gallus)
Aves -- 35
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 53 (a)
-- 35
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735033 34
  • 54.2 (n)
(Danio rerio)
Actinopterygii CU571382.2 35
  • 10 (a)
Species where no ortholog for IGLL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLL1 Gene

Gene Tree for IGLL1 (if available)
Gene Tree for IGLL1 (if available)
Evolutionary constrained regions (ECRs) for IGLL1: view image

Paralogs for IGLL1 Gene

(13) SIMAP similar genes for IGLL1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with IGLL1: view

Variants for IGLL1 Gene

Sequence variations from dbSNP and Humsavar for IGLL1 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1064422 pathogenic, Agammaglobulinemia 2, autosomal recessive, Agammaglobulinemia 2, autosomal recessive (AGM2) [MIM:613500] 23,573,483(-) G/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1064424 benign, Agammaglobulinemia 2, autosomal recessive 23,573,515(-) A/G 3_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs111903752 benign, not specified, Agammaglobulinemia 2, autosomal recessive 23,573,423(-) A/G/T 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs112775194 uncertain-significance, Agammaglobulinemia 2, autosomal recessive 23,573,471(-) G/A 3_prime_UTR_variant, coding_sequence_variant, missense_variant
rs114285337 benign, Agammaglobulinemia 2, autosomal recessive 23,574,980(-) C/T coding_sequence_variant, intron_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for IGLL1 Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv4529n100 CNV gain 25217958
dgv4530n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
dgv8043n54 CNV gain 21841781
dgv828e214 CNV loss 21293372
esv23191 CNV loss 19812545
esv2724041 CNV deletion 23290073
esv2724056 CNV deletion 23290073
esv2760716 CNV gain 21179565
esv2762117 CNV gain 21179565
esv3575443 CNV gain 25503493
esv3647408 CNV gain 21293372
esv3893457 CNV gain 25118596
esv3893461 CNV gain 25118596
nsv1059951 CNV gain 25217958
nsv1060587 CNV gain+loss 25217958
nsv1062411 CNV gain 25217958
nsv1066846 CNV loss 25217958
nsv1066891 CNV gain 25217958
nsv436353 CNV deletion 17901297
nsv459677 CNV loss 19166990
nsv459682 CNV gain 19166990
nsv471186 CNV loss 18288195
nsv471187 CNV gain 18288195
nsv511073 OTHER complex 20534489
nsv520582 CNV gain 19592680
nsv526567 CNV gain 19592680
nsv588601 CNV gain 21841781
nsv588606 CNV loss 21841781
nsv588619 CNV gain+loss 21841781
nsv7350 OTHER inversion 18451855
nsv953052 CNV deletion 24416366
nsv964604 CNV duplication 23825009
nsv9876 CNV gain+loss 18304495

Variation tolerance for IGLL1 Gene

Residual Variation Intolerance Score: 97.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.84; 67.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGLL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGLL1 Gene

Disorders for IGLL1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for IGLL1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
agammaglobulinemia 2, autosomal recessive
  • agm2
agammaglobulinemia, non-bruton type
  • autosomal agammaglobulinemia
  • hypogammaglobulinemia
b cell deficiency
  • b cell deficiencies
ventilation pneumonitis
  • air-conditioner and humidifier lung
- elite association - COSMIC cancer census association via MalaCards
Search IGLL1 in MalaCards View complete list of genes associated with diseases


  • Agammaglobulinemia 2, autosomal recessive (AGM2) [MIM:613500]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269 PubMed:9419212}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for IGLL1

genes like me logo Genes that share disorders with IGLL1: view

No data available for Genatlas for IGLL1 Gene

Publications for IGLL1 Gene

  1. Meta-analysis of genome-wide association for migraine in six population-based European cohorts. (PMID: 21448238) Ligthart L … Boomsma DI (European journal of human genetics : EJHG 2011) 3 45 58
  2. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 45 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. (PMID: 9419212) Minegishi Y … Conley ME (The Journal of experimental medicine 1998) 3 4 58
  5. Physical location of the human immunoglobulin lambda-like genes, 14.1, 16.1, and 16.2. (PMID: 8406611) Bauer TR … Blomberg BB (Immunogenetics 1993) 3 23 58

Products for IGLL1 Gene

Sources for IGLL1 Gene

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