Aliases for IGLC6 Gene

Aliases for IGLC6 Gene

  • Immunoglobulin Lambda Constant 6 2 3 4
  • Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant 6 (Gene/Pseudogene) 2 5
  • Ig Lambda-6 Chain C Region 3 4
  • Immunoglobulin Lambda Constant 6 (Kern+Oz- Marker, Gene/Pseudogene) 3
  • Immunoglobulin Lambda Constant Region 6 (Kern+ Oz- Marker) 3
  • IGLC6 5
  • IGLC 3

External Ids for IGLC6 Gene

Previous HGNC Symbols for IGLC6 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC6 Gene

  • GC22U990030
  • GC22P021586
  • GC22P021595
  • GC22P021605
  • GC22P021615
  • GC22P021625
  • GC22P021636
  • GC22P021646
  • GC22P021659
  • GC22P021672
  • GC22P023267
  • GC22P006229
  • GC22P023273
  • GC22P023279
  • GC22P023284
  • GC22P023289
  • GC22P023293
  • GC22P023308
  • GC22P023324

Summaries for IGLC6 Gene

GeneCards Summary for IGLC6 Gene

IGLC6 (Immunoglobulin Lambda Constant 6) is a Pseudogene. Among its related pathways are Cell surface interactions at the vascular wall and RET signaling. Gene Ontology (GO) annotations related to this gene include antigen binding.

UniProtKB/Swiss-Prot Summary for IGLC6 Gene

  • Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLC6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLC6 Gene

Genomics for IGLC6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGLC6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J022921 Enhancer 0.6 Ensembl 600.7 +1.8 1766 2.2 POLR2A MCM7 UBTF TCF7 MCM3 MCM5 ZKSCAN1 ZBTB5 MCM2 KLF1 IGLC7 IGLC6 IGLJ7 lnc-IGLL5-9 lnc-RSPH14-4 TOP3B MIF-AS1 ZNF70 IGLV5-52 ENSG00000272578
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLC6 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGLC6 Gene

Genomic Locations for IGLC6 Gene
chr22:22,919,535-22,919,858
(GRCh38/hg38)
Size:
324 bases
Orientation:
Plus strand
chr22:23,261,707-23,262,030
(GRCh37/hg19)
Size:
324 bases
Orientation:
Plus strand

Genomic View for IGLC6 Gene

Genes around IGLC6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC6 Gene

Proteins for IGLC6 Gene

  • Protein details for IGLC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CF74-IGLC6_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 6
    Protein Accession:
    P0CF74

    Protein attributes for IGLC6 Gene

    Size:
    106 amino acids
    Molecular mass:
    11277 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Displays the following serological isotype: Mgc-, Ke+, and Oz-. Mgc- has Ala-6, Ser-8 and Thr-57; Ke+ has Gly-46 and Oz- has Arg-83.

neXtProt entry for IGLC6 Gene

Post-translational modifications for IGLC6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGLC6 Gene

Domains & Families for IGLC6 Gene

Gene Families for IGLC6 Gene

Protein Domains for IGLC6 Gene

Suggested Antigen Peptide Sequences for IGLC6 Gene

GenScript: Design optimal peptide antigens:
  • Ig lambda-6 chain C region (LAC6_HUMAN)
genes like me logo Genes that share domains with IGLC6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGLC6 Gene

Function for IGLC6 Gene

Molecular function for IGLC6 Gene

UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 6 (Kern+Oz-marker)

Gene Ontology (GO) - Molecular Function for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGLC6: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGLC6 Gene

Localization for IGLC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC6 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 23580065
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0042571 immunoglobulin complex, circulating IBA 21873635
genes like me logo Genes that share ontologies with IGLC6: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLC6 Gene

Pathways & Interactions for IGLC6 Gene

genes like me logo Genes that share pathways with IGLC6: view

Gene Ontology (GO) - Biological Process for IGLC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006956 complement activation TAS --
GO:0006958 complement activation, classical pathway IBA, TAS --
genes like me logo Genes that share ontologies with IGLC6: view

No data available for Interacting Proteins and SIGNOR curated interactions for IGLC6 Gene

Drugs & Compounds for IGLC6 Gene

No Compound Related Data Available

Transcripts for IGLC6 Gene

mRNA/cDNA for IGLC6 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC6 Gene

No ASD Table

Relevant External Links for IGLC6 Gene

GeneLoc Exon Structure for
IGLC6

Expression for IGLC6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLC6 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC6 Gene

This gene is overexpressed in Spleen (x14.9), Small Intestine - Terminal Ileum (x8.4), Minor Salivary Gland (x6.7), and Colon - Transverse (x6.4).

Protein differential expression in normal tissues from HIPED for IGLC6 Gene

This gene is overexpressed in Testis (46.3) and Plasma (22.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC6 Gene



Protein tissue co-expression partners for IGLC6 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGLC6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC6 Gene

Orthologs for IGLC6 Gene

Evolution for IGLC6 Gene

ENSEMBL:
Gene Tree for IGLC6 (if available)
TreeFam:
Gene Tree for IGLC6 (if available)

No data available for Orthologs for IGLC6 Gene

Paralogs for IGLC6 Gene

No data available for Paralogs for IGLC6 Gene

Variants for IGLC6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC6 Gene

IGLC6_HUMAN-P0CF74
There are several alleles. The sequence shown is that of IMGT allele IGLC6*01 that is not represented on the reference genome assembly (GRCh38/hg38) and that is the only functional. The other existing alleles are pseudogenes. The sequence shown on the reference genome assembly (GRCh38/hg38) is that of IMGT allele IGLC6*05 that is a pseudogene due to a stop codon polymorphism at position 71.

Additional Variant Information for IGLC6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC6

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC6 Gene

Disorders for IGLC6 Gene

No disorders were found for IGLC6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC6 Gene

Publications for IGLC6 Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4
  2. Human immunoglobulin C lambda 6 gene encodes the Kern+Oz-lambda chain and C lambda 4 and C lambda 5 are pseudogenes. (PMID: 3122211) Dariavach P … Lefranc MP (Proceedings of the National Academy of Sciences of the United States of America 1987) 3 4
  3. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter PA … Leder P (Nature 1981) 3 4
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. (PMID: 23580065) Pieragostino D … Del Boccio P (Molecular bioSystems 2013) 3
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4

Products for IGLC6 Gene

Sources for IGLC6 Gene