Aliases for IGLC2 Gene

Aliases for IGLC2 Gene

  • Immunoglobulin Lambda Constant 2 2 3 4 5
  • Immunoglobulin Lambda Constant 2 (Kern-Oz- Marker) 2 3
  • Immunoglobulin Lambda Constant Region 2 (Kern- Oz- Marker) 3
  • Ig Light-Chain, Partial Ke-Oz- Polypeptide, C-Term 3
  • Ig Lambda Chain C Region NIG-64 4
  • Ig Lambda Chain C Region Kern 4
  • Ig Lambda Chain C Region SH 4
  • Ig Lambda Chain C Region X 4
  • Ig Lambda-2 Chain C Region 4
  • C2 Segment 3
  • IGLC 3

External Ids for IGLC2 Gene

Previous HGNC Symbols for IGLC2 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC2 Gene

  • GC22U990026
  • GC22P021090
  • GC22P021093
  • GC22P021096
  • GC22P021100
  • GC22P021102
  • GC22P021567
  • GC22P021296
  • GC22P021574
  • GC22P023243
  • GC22P006211

Summaries for IGLC2 Gene

GeneCards Summary for IGLC2 Gene

IGLC2 (Immunoglobulin Lambda Constant 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLC3.

UniProtKB/Swiss-Prot Summary for IGLC2 Gene

  • Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGLC2 Gene

Additional gene information for IGLC2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLC2 Gene

Genomics for IGLC2 Gene

GeneHancer (GH) Regulatory Elements for IGLC2 Gene

Promoters and enhancers for IGLC2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J022901 Enhancer 1 ENCODE dbSUPER 518.3 +1.9 1854 2.8 TARDBP MEF2C RCOR1 MCM3 POLR2A BCL11A CBFB ARNT MEF2B RBBP5 IGLC2 ZNF70 TOP3B MIF-AS1 IGLV2-5 IGLV3-4 MMP11 IGLV5-52 SMARCB1 FBXW4P1
GH22J022900 Promoter/Enhancer 0.8 Ensembl dbSUPER 500.7 -0.7 -675 1.4 MCM7 ZBTB5 POLR2A MLLT1 SMAD5 IGLJ2 IGLC2 IGLV2-5 IGLV3-4 lnc-ZNF280B-6 lnc-RSPH14-4 LOC105372948 IGL lnc-IGLL5-1
GH22J022902 Promoter/Enhancer 0.7 Ensembl dbSUPER 500.7 +0.3 324 0.2 POLR2A MLLT1 IGLC2 IGLJ2 IGLV2-5 IGLV3-4 IGLC7 IGLC5 IGLJ3 lnc-ZNF280B-6 lnc-RSPH14-4 LOC105372948
GH22J022913 Enhancer 0.8 Ensembl dbSUPER 19.2 +13.3 13325 1 ZIC2 SNRNP70 MCM3 RELA TCF12 EBF1 IKZF1 ZBTB7A YBX1 UBTF IGLC5 IGLJ5 lnc-IGLL5-8 TOP3B IGLC2 IGLV5-52 ENSG00000272578 MMP11 IGLV2-5 IGLV3-4
GH22J022904 Promoter/Enhancer 0.8 Ensembl dbSUPER 17.1 +4.5 4524 1 TSC22D4 MCM3 MCM7 MCM5 ZBTB5 MCM2 TAF7 SMAD5 IGLC3 IGLJ3 lnc-ZNF280B-6 TOP3B MIF-AS1 IGLC2 MMP11 ZNF70 lnc-RSPH14-4 LOC105372948
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLC2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGLC2 Gene

Genomic Locations for IGLC2 Gene
chr22:22,900,976-22,901,437
(GRCh38/hg38)
Size:
462 bases
Orientation:
Plus strand
chr22:23,243,156-23,243,617
(GRCh37/hg19)
Size:
462 bases
Orientation:
Plus strand

Genomic View for IGLC2 Gene

Genes around IGLC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC2 Gene

Proteins for IGLC2 Gene

  • Protein details for IGLC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DOY2-IGLC2_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 2
    Protein Accession:
    P0DOY2
    Secondary Accessions:
    • A0A075B6K9
    • A0M8Q4
    • P0CG05
    • P0CG06
    • P80423

    Protein attributes for IGLC2 Gene

    Size:
    106 amino acids
    Molecular mass:
    11294 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    Miscellaneous:
    • Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.
    SequenceCaution:
    • Sequence=AAA59107.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAA20026.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA36049.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAB38569.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW59547.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=EAW59549.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC2 Gene

neXtProt entry for IGLC2 Gene

Post-translational modifications for IGLC2 Gene

No Post-translational modifications

Other Protein References for IGLC2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC2 Gene

Domains & Families for IGLC2 Gene

Gene Families for IGLC2 Gene

Protein Domains for IGLC2 Gene

Suggested Antigen Peptide Sequences for IGLC2 Gene

GenScript: Design optimal peptide antigens:
  • Ig lambda-2 chain C regions (LAC2_HUMAN)
genes like me logo Genes that share domains with IGLC2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGLC2 Gene

Function for IGLC2 Gene

Molecular function for IGLC2 Gene

UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 2 (Kern-Oz-marker)

Gene Ontology (GO) - Molecular Function for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGLC2: view

Animal Model Products

CRISPR Products

miRNA for IGLC2 Gene

miRTarBase miRNAs that target IGLC2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC2 Gene

Localization for IGLC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 22664934
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLC2 Gene

Pathways & Interactions for IGLC2 Gene

PathCards logo

SuperPathways for IGLC2 Gene

No Data Available

Interacting Proteins for IGLC2 Gene

Selected Interacting proteins: P0DOY2-IGLC2_HUMAN for IGLC2 Gene via IID

;

Gene Ontology (GO) - Biological Process for IGLC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC2: view

No data available for Pathways by source and SIGNOR curated interactions for IGLC2 Gene

Drugs & Compounds for IGLC2 Gene

No Compound Related Data Available

Transcripts for IGLC2 Gene

mRNA/cDNA for IGLC2 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC2 Gene

No ASD Table

Relevant External Links for IGLC2 Gene

GeneLoc Exon Structure for
IGLC2

Expression for IGLC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLC2 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC2 Gene

This gene is overexpressed in Spleen (x14.6), Colon - Transverse (x7.3), Minor Salivary Gland (x6.9), and Small Intestine - Terminal Ileum (x5.3).

Protein differential expression in normal tissues from HIPED for IGLC2 Gene

This gene is overexpressed in Pancreatic juice (15.8), Plasma (12.3), and Cerebrospinal fluid (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC2 Gene



genes like me logo Genes that share expression patterns with IGLC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC2 Gene

Orthologs for IGLC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 31
  • 85 (a)
ManyToMany
-- 31
  • 85 (a)
ManyToMany
-- 31
  • 71 (a)
ManyToMany
-- 31
  • 70 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 35 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 63 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Iglc2 31
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 42 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 9 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia IGLL1 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
VPREB 31
  • 30 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 27 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
ManyToMany
-- 31
  • 25 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU571382.2 31
  • 11 (a)
ManyToMany
Species where no ortholog for IGLC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGLC2 Gene

ENSEMBL:
Gene Tree for IGLC2 (if available)
TreeFam:
Gene Tree for IGLC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGLC2: view image

Paralogs for IGLC2 Gene

Pseudogenes.org Pseudogenes for IGLC2 Gene

genes like me logo Genes that share paralogs with IGLC2: view

Variants for IGLC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC2 Gene

IGLC2_HUMAN-P0DOY2
There are several alleles. The sequence shown is that of IMGT allele IGLC2*02.

Additional Variant Information for IGLC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC2

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC2 Gene

Disorders for IGLC2 Gene

No disorders were found for IGLC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGLC2 Gene

Publications for IGLC2 Gene

  1. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 4 54
  2. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek TJ … Leder P (The Journal of experimental medicine 1990) 3 4 54
  3. Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup. (PMID: 6404900) Kametani F … Shimizu A (Journal of biochemistry 1983) 3 4 54
  4. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter PA … Leder P (Nature 1981) 3 4 54
  5. [Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation]. (PMID: 5549568) Ponstingl H … Hilschmann N (Hoppe-Seyler's Zeitschrift fur physiologische Chemie 1971) 3 4 54

Products for IGLC2 Gene

Sources for IGLC2 Gene