Aliases for IGLC1 Gene

Aliases for IGLC1 Gene

  • Immunoglobulin Lambda Constant 1 2 3 4 5
  • Immunoglobulin Lambda Constant 1 (Mcg Marker) 2 3
  • Immunoglobulin Lambda Constant Region 1 (Mcg Marker) 3
  • Ig Lambda Chain C Region MGC 4
  • Ig Lambda-1 Chain C Region 4
  • C1 Segment 3
  • IGLC1 5
  • IGLC 3

External Ids for IGLC1 Gene

Previous HGNC Symbols for IGLC1 Gene

  • IGLC

Previous GeneCards Identifiers for IGLC1 Gene

  • GC22P019928
  • GC22U900022
  • GC22P021089
  • GC22P021092
  • GC22P021095
  • GC22P021098
  • GC22P021562
  • GC22P021295
  • GC22P021568
  • GC22P023238
  • GC22P006205
  • GC22P023245
  • GC22P023251
  • GC22P023314

Summaries for IGLC1 Gene

GeneCards Summary for IGLC1 Gene

IGLC1 (Immunoglobulin Lambda Constant 1) is a Protein Coding gene. Among its related pathways are Cell surface interactions at the vascular wall and RET signaling. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.

UniProtKB/Swiss-Prot Summary for IGLC1 Gene

  • Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Additional gene information for IGLC1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGLC1 Gene

Genomics for IGLC1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGLC1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J022892 Promoter/Enhancer 0.9 Ensembl dbSUPER 600.7 -1.1 -1074 2.2 POLR2A ZIC2 TARDBP TSC22D4 MCM3 KDM4B RELA UBTF MCM7 KLF1 IGLC1 IGLJ1 IGLV2-5 IGLV3-4 MMP11 TOP3B SMARCB1 ZNF70 IGLC2 IGLC7
GH22J022897 Enhancer 0.6 ENCODE dbSUPER 600.7 +1.9 1881 0.2 POLR2A CTBP1 PBX2 ATF3 RBM39 IGLC1 TOP3B IGLV5-52 IGLV3-4 IGLV2-5 ENSG00000272578 ENSG00000234630 ZNF70 ASLP1 IGLJ2
GH22J022895 Enhancer 0.6 dbSUPER 600.7 +0.8 803 1.1 POLR2A ZNF239 TSC22D4 MCM3 GTF2F1 TBL1XR1 MCM7 KLF1 ATF1 ZFP37 IGLC1 IGLV2-5 IGLV3-4 MMP11 TOP3B ZNF70 IGLC2 IGLC7 IGLJ2 IGLL5
GH22J022899 Enhancer 0.6 Ensembl dbSUPER 0.7 +2.5 2526 0.2 CEBPB KLF1 IRF9 IGLJ2 IGLV2-5 IGLV3-4 IGLC7 IGLC1 lnc-ZNF280B-6 ENSG00000286129 IGL lnc-IGLL5-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGLC1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGLC1 Gene

Genomic Locations for IGLC1 Gene
chr22:22,895,375-22,895,834
(GRCh38/hg38)
Size:
460 bases
Orientation:
Plus strand
chr22:23,237,555-23,238,014
(GRCh37/hg19)
Size:
460 bases
Orientation:
Plus strand

Genomic View for IGLC1 Gene

Genes around IGLC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGLC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGLC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGLC1 Gene

Proteins for IGLC1 Gene

  • Protein details for IGLC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG04-IGLC1_HUMAN
    Recommended name:
    Immunoglobulin lambda constant 1
    Protein Accession:
    P0CG04
    Secondary Accessions:
    • A0A075B6K8
    • A0M8Q4
    • P01842
    • P80423

    Protein attributes for IGLC1 Gene

    Size:
    106 amino acids
    Molecular mass:
    11348 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=CAA36047.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGLC1 Gene

neXtProt entry for IGLC1 Gene

Post-translational modifications for IGLC1 Gene

No Post-translational modifications

Other Protein References for IGLC1 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGLC1 Gene

Domains & Families for IGLC1 Gene

Gene Families for IGLC1 Gene

Protein Domains for IGLC1 Gene

Suggested Antigen Peptide Sequences for IGLC1 Gene

GenScript: Design optimal peptide antigens:
  • Ig lambda-1 chain C regions (LAC1_HUMAN)
genes like me logo Genes that share domains with IGLC1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGLC1 Gene

Function for IGLC1 Gene

Molecular function for IGLC1 Gene

UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
GENATLAS Biochemistry:
immunoglobulin,lambda,constant segment 1 (Mcg marker)

Gene Ontology (GO) - Molecular Function for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA, NAS 4909564
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGLC1: view

Animal Model Products

CRISPR Products

miRNA for IGLC1 Gene

miRTarBase miRNAs that target IGLC1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGLC1 Gene

Localization for IGLC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGLC1 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 16502470
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0042571 immunoglobulin complex, circulating IBA 21873635
genes like me logo Genes that share ontologies with IGLC1: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGLC1 Gene

Pathways & Interactions for IGLC1 Gene

genes like me logo Genes that share pathways with IGLC1: view

Interacting Proteins for IGLC1 Gene

Gene Ontology (GO) - Biological Process for IGLC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006955 immune response NAS 4909564
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGLC1: view

No data available for SIGNOR curated interactions for IGLC1 Gene

Drugs & Compounds for IGLC1 Gene

(1) Drugs for IGLC1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pidolic acid Approved, Investigational Pharma Target 0
genes like me logo Genes that share compounds with IGLC1: view

Transcripts for IGLC1 Gene

mRNA/cDNA for IGLC1 Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGLC1 Gene

No ASD Table

Relevant External Links for IGLC1 Gene

GeneLoc Exon Structure for
IGLC1

Expression for IGLC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGLC1 Gene

mRNA differential expression in normal tissues according to GTEx for IGLC1 Gene

This gene is overexpressed in Spleen (x14.1), Colon - Transverse (x7.6), Small Intestine - Terminal Ileum (x6.9), and Minor Salivary Gland (x6.7).

Protein differential expression in normal tissues from HIPED for IGLC1 Gene

This gene is overexpressed in Skin (30.0), Plasma (16.0), Urine (9.9), and Serum (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGLC1 Gene



Protein tissue co-expression partners for IGLC1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGLC1

SOURCE GeneReport for Unigene cluster for IGLC1 Gene:

Hs.449585
genes like me logo Genes that share expression patterns with IGLC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGLC1 Gene

Orthologs for IGLC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGLC1 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia -- 31
  • 86 (a)
ManyToMany
-- 31
  • 86 (a)
ManyToMany
-- 31
  • 71 (a)
ManyToMany
-- 31
  • 71 (a)
ManyToMany
-- 31
  • 58 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 66 (a)
ManyToMany
-- 31
  • 26 (a)
ManyToMany
Mouse
(Mus musculus)
Mammalia Iglc2 31
  • 64 (a)
ManyToMany
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 48 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 43 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 42 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
-- 31
  • 9 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia IGLL1 31
  • 34 (a)
ManyToMany
-- 31
  • 34 (a)
ManyToMany
VPREB 31
  • 30 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves -- 31
  • 27 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
ManyToMany
-- 31
  • 24 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii CU571382.2 31
  • 10 (a)
ManyToMany
Species where no ortholog for IGLC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGLC1 Gene

ENSEMBL:
Gene Tree for IGLC1 (if available)
TreeFam:
Gene Tree for IGLC1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGLC1: view image

Paralogs for IGLC1 Gene

Pseudogenes.org Pseudogenes for IGLC1 Gene

genes like me logo Genes that share paralogs with IGLC1: view

Variants for IGLC1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGLC1 Gene

IGLC1_HUMAN-P0CG04
There are several alleles. The sequence shown is that of IMGT allele IGLC1*02.

Additional Variant Information for IGLC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGLC1

SNP Genotyping and Copy Number Assay Products

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGLC1 Gene

Disorders for IGLC1 Gene

No disorders were found for IGLC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGLC1 Gene

Publications for IGLC1 Gene

  1. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek TJ … Leder P (The Journal of experimental medicine 1990) 3 4
  2. Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms. (PMID: 2515285) Ely KR … Edmundson AB (Journal of molecular biology 1989) 3 4
  3. Clustered arrangement of immunoglobulin lambda constant region genes in man. (PMID: 6273747) Hieter PA … Leder P (Nature 1981) 3 4
  4. Primary structure of the Mcg lambda chain. (PMID: 4415202) Fett JW … Deutsch HF (Biochemistry 1974) 3 4
  5. Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification. (PMID: 25946035) Azkargorta M … Elortza F (Journal of proteome research 2015) 4

Products for IGLC1 Gene

Sources for IGLC1 Gene