Aliases for IGLC1 Gene
External Ids for IGLC1 Gene
Previous HGNC Symbols for IGLC1 Gene
Previous GeneCards Identifiers for IGLC1 Gene
GeneCards Summary for IGLC1 Gene
IGLC1 (Immunoglobulin Lambda Constant 1) is a Protein Coding gene. Among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and Creation of C4 and C2 activators. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGLL5.
UniProtKB/Swiss-Prot Summary for IGLC1 Gene
Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).