Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V... See more...

Aliases for IGL Gene

Aliases for IGL Gene

  • Immunoglobulin Lambda Locus 2 3
  • Immunoglobulin Lambda Gene Cluster 3
  • Ig Lambda-6 Chain C Region 3
  • IGLC6 3
  • IGL@ 3

External Ids for IGL Gene

Previous HGNC Symbols for IGL Gene

  • IGL@

Previous GeneCards Identifiers for IGL Gene

  • GC22P022407
  • GC22P022421

Summaries for IGL Gene

Entrez Gene Summary for IGL Gene

  • Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species. [provided by RefSeq, Jul 2008]

GeneCards Summary for IGL Gene

IGL (Immunoglobulin Lambda Locus) is a Protein Coding gene. Among its related pathways are Immune response Lectin induced complement pathway and Immune response NFAT in immune response.

Gene Wiki entry for IGL Gene

Additional gene information for IGL Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGL Gene

Genomics for IGL Gene

GeneHancer (GH) Regulatory Elements Pubs


GeneHancers around IGL on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGL Gene

Latest Assembly
chr22:22,026,076-22,922,913
(GRCh38/hg38)
Size:
896,838 bases
Orientation:
Plus strand

Previous Assembly
chr22:22,380,474-23,265,085
(GRCh37/hg19 by Entrez Gene)
Size:
884,612 bases
Orientation:
Plus strand

Genomic View for IGL Gene

Genes around IGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGL Gene

Proteins for IGL Gene

Post-translational modifications for IGL Gene

No Post-translational modifications

Antibodies for research

No data available for DME Specific Peptides for IGL Gene

Domains & Families for IGL Gene

Gene Families for IGL Gene

Suggested Antigen Peptide Sequences for IGL Gene

GenScript: Design optimal peptide antigens:
  • IGL@ protein (Q567P1_HUMAN)
  • IGL@ protein (Q5FWF9_HUMAN)
  • IGL@ protein (Q6GMW3_HUMAN)
  • IGL@ protein (Q6GMW4_HUMAN)
  • IGL@ protein (Q6GMX3_HUMAN)
genes like me logo Genes that share domains with IGL: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGL Gene

Function for IGL Gene

Phenotypes From GWAS Catalog for IGL Gene

Phenotypes for IGL Gene

genes like me logo Genes that share phenotypes with IGL: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGL Gene

Localization for IGL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGL Gene

Pathways & Interactions for IGL Gene

PathCards logo

SuperPathways for IGL Gene

SuperPathway Contained pathways
1 Immune response Fc epsilon RI pathway
.44
.44
2 Immune response Role of DAP12 receptors in NK cells
.32
3 Immune response Lectin induced complement pathway
.55
4 Development IGF-1 receptor signaling
.38
5 Immune response NFAT in immune response
.56
genes like me logo Genes that share pathways with IGL: view

Pathways by source for IGL Gene

7 GeneGo (Thomson Reuters) pathways for IGL Gene
  • Immune response BCR pathway
  • Immune response CD16 signaling in NK cells
  • Immune response Classical complement pathway
  • Immune response Fc epsilon RI pathway
  • Immune response IL-4 signaling pathway

Interacting Proteins for IGL Gene

Gene Ontology (GO) - Biological Process for IGL Gene

None

No data available for SIGNOR curated interactions for IGL Gene

Drugs & Compounds for IGL Gene

No Compound Related Data Available

Transcripts for IGL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for IGL Gene

No ASD Table

Relevant External Links for IGL Gene

GeneLoc Exon Structure for
IGL

No data available for mRNA/cDNA for IGL Gene

Expression for IGL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGL

genes like me logo Genes that share expression patterns with IGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGL Gene

Orthologs for IGL Gene

No data available for Orthologs and Evolution for IGL Gene

Paralogs for IGL Gene

No data available for Paralogs for IGL Gene

Variants for IGL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGL Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs2229695 Benign: not provided 22,549,913(+) G/A
NM_206956.3(PRAME):c.766C>T (p.Leu256=)
SYNONYMOUS
rs2229696 Benign: not provided 22,548,334(+) A/G
NM_206956.3(PRAME):c.1263T>C (p.Ser421=)
SYNONYMOUS
rs61730836 Benign: not provided 22,550,068(+) T/C
NM_206956.3(PRAME):c.611A>G (p.Asn204Ser)
MISSENSE

Additional Variant Information for IGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGL
Leiden Open Variation Database (LOVD)
IGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGL Gene

Disorders for IGL Gene

Additional Disease Information for IGL

No disorders were found for IGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGL Gene

Publications for IGL Gene

  1. The lambda gene immunoglobulin repertoire of human neonatal B cells. (PMID: 17675156) Richl P … Girschick HJ (Molecular immunology 2008) 3 22
  2. One-megabase sequence analysis of the human immunoglobulin lambda gene locus. (PMID: 9074928) Kawasaki K … Shimizu N (Genome research 1997) 3 22
  3. Structure and expression of the human immunoglobulin lambda genes. (PMID: 2115572) Vasicek TJ … Leder P (The Journal of experimental medicine 1990) 3 22
  4. Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11. (PMID: 3923432) Emanuel BS … Croce CM (Nucleic acids research 1985) 2 3
  5. Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. (PMID: 6795508) Erikson J … Croce CM (Nature 1981) 2 3

Products for IGL Gene

Sources for IGL Gene