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Aliases for IGKV1-13 Gene

Aliases for IGKV1-13 Gene

  • Immunoglobulin Kappa Variable 1-13 (Gene/Pseudogene) 2 3 5
  • Immunoglobulin Kappa Variable 1-13 2
  • IGKV113 3
  • L18 3

External Ids for IGKV1-13 Gene

Previous GeneCards Identifiers for IGKV1-13 Gene

  • GC02U990217
  • GC02M089230
  • GC02M089247
  • GC02M089185
  • GC02M089347
  • GC02M089388
  • GC02M089733
  • GC02M089941
  • GC02M090121

Summaries for IGKV1-13 Gene

GeneCards Summary for IGKV1-13 Gene

IGKV1-13 (Immunoglobulin Kappa Variable 1-13 (Gene/Pseudogene)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGKV1-13 Gene

  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGKV1-13 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGKV1-13 Gene

Genomics for IGKV1-13 Gene

GeneHancer (GH) Regulatory Elements for IGKV1-13 Gene

Promoters and enhancers for IGKV1-13 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I088855 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 5.9 +187.4 187359 7.8 CHD1 NR2F2 GABPA RELA NFIC POLR2A SPI1 NR2C2 GC02M088842 IGKC IGKJ4 IGKJ5 IGKV1-13 THNSL2 RPIA IGKV4-1 EIF2AK3 ENSG00000240040
GH02I088835 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 6.7 +203.9 203873 14.1 ZNF282 FOXA2 HLF CEBPB ATF2 RELA POLR2A IKZF1 NBN CREB1 EIF2AK3 ANKRD36BP2 IGKV1-13 RPIA LOC101928403 IGKDEL ENSG00000240040 GC02M088842 IGKC
GH02I088656 Enhancer 1.3 FANTOM5 Ensembl ENCODE 4 +387.7 387727 4.6 PKNOX1 FOXA2 SIN3A FEZF1 FOS SP5 REST KAT8 SREBF1 MAFF LOC101928371 ANKRD36BP2 IGKV1-13 GC02M088650 LOC102724805
GH02I088834 Enhancer 0.5 dbSUPER 5.7 +211.7 211688 0.9 ZNF316 POLR2A HLF MAFG MAFK EMSY IGKDEL ANKRD36BP2 IGKV1-13 IGKC ENSG00000240040
GH02I089184 Enhancer 0.2 Ensembl 7.8 -138.4 -138435 0.2 IGKV1-13 IGKV2-24 GC02M089583
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGKV1-13 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGKV1-13 Gene

Genomic Locations for IGKV1-13 Gene
chr2:89,045,990-89,046,466
(GRCh38/hg38)
Size:
477 bases
Orientation:
Minus strand
chr2:89,345,487-89,345,963
(GRCh37/hg19)

Genomic View for IGKV1-13 Gene

Genes around IGKV1-13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGKV1-13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGKV1-13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGKV1-13 Gene

Proteins for IGKV1-13 Gene

  • Protein details for IGKV1-13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DP09-KV113_HUMAN
    Recommended name:
    Immunoglobulin kappa variable 1-13
    Protein Accession:
    P0DP09

    Protein attributes for IGKV1-13 Gene

    Size:
    117 amino acids
    Molecular mass:
    12569 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGKV1-13 Gene

Post-translational modifications for IGKV1-13 Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGKV1-13 Gene

Domains & Families for IGKV1-13 Gene

Gene Families for IGKV1-13 Gene

Protein Domains for IGKV1-13 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGKV1-13: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGKV1-13 Gene

Function for IGKV1-13 Gene

Molecular function for IGKV1-13 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGKV1-13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGKV1-13: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGKV1-13 Gene

Localization for IGKV1-13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGKV1-13 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGKV1-13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with IGKV1-13: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGKV1-13 Gene

Pathways & Interactions for IGKV1-13 Gene

SuperPathways for IGKV1-13 Gene

No Data Available

Interacting Proteins for IGKV1-13 Gene

Gene Ontology (GO) - Biological Process for IGKV1-13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with IGKV1-13: view

No data available for Pathways by source and SIGNOR curated interactions for IGKV1-13 Gene

Drugs & Compounds for IGKV1-13 Gene

No Compound Related Data Available

Transcripts for IGKV1-13 Gene

mRNA/cDNA for IGKV1-13 Gene

(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGKV1-13 Gene

No ASD Table

Relevant External Links for IGKV1-13 Gene

GeneLoc Exon Structure for
IGKV1-13
ECgene alternative splicing isoforms for
IGKV1-13

Expression for IGKV1-13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGKV1-13 Gene

mRNA differential expression in normal tissues according to GTEx for IGKV1-13 Gene

This gene is overexpressed in Spleen (x13.6), Colon - Transverse (x7.3), Small Intestine - Terminal Ileum (x5.5), and Whole Blood (x4.8).
genes like me logo Genes that share expression patterns with IGKV1-13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGKV1-13 Gene

Orthologs for IGKV1-13 Gene

Evolution for IGKV1-13 Gene

ENSEMBL:
Gene Tree for IGKV1-13 (if available)
TreeFam:
Gene Tree for IGKV1-13 (if available)

No data available for Orthologs for IGKV1-13 Gene

Paralogs for IGKV1-13 Gene

No data available for Paralogs for IGKV1-13 Gene

Variants for IGKV1-13 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGKV1-13 Gene

KV113_HUMAN-P0DP09
There are several alleles. The sequence shown is that of the functional IMGT allele IGKV1-13*02 that is not represented on the reference genome assembly (GRCh38/hg38). The sequence of the reference genome assembly (GRCh38/hg38) is that of IMGT allele IGKV1-13*01 that is a pseudogene due to a stop codon polymorphism at position 57.

Additional Variant Information for IGKV1-13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGKV1-13

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGKV1-13 Gene

Disorders for IGKV1-13 Gene

No disorders were found for IGKV1-13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGKV1-13 Gene

Publications for IGKV1-13 Gene

  1. Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type. (PMID: 6086934) Pech M … Zachau HG (Journal of molecular biology 1984) 3 4 58
  2. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58

Products for IGKV1-13 Gene

Sources for IGKV1-13 Gene

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