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Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains (see MIM 147100) and 2 identical light chains, either kappa or lambda (see MIM 147220), joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. The kappa and lambda light chains have no apparent functional differences. Each Ig kappa light chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by a C region gene (IGKC; MIM 147200), that provides signaling functions. The kappa light chain V region is encoded by 2 types of genes: V genes (see MIM 146980) and joining (J) genes. Random selection of just 1 gene of each type to assemble a V region accounts for the great diversity of V regions among Ig molecules. The kappa light chain locus on chromosome 2 contains approximately 40 functional V genes, followed by approximately 5 functional J genes. Due to polymorphism, the numbers of functional V and J genes differ among individuals (Janeway et al., 2005).[supplied by OMIM, Apr 2008]
IGKJ (Immunoglobulin Kappa Joining Cluster) is a Genetic Locus. Among its related pathways are Immune response Fc epsilon RI pathway and Immune response Role of DAP12 receptors in NK cells.
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Immune response Fc epsilon RI pathway |
Immune response BCR pathway
.44
|
Immune response Fc epsilon RI pathway
.44
|
2 | Immune response Role of DAP12 receptors in NK cells |
Immune response CD16 signaling in NK cells
.32
|
|
3 | Immune response Lectin induced complement pathway |
Immune response Classical complement pathway
.55
|
|
4 | Development IGF-1 receptor signaling |
Immune response IL-4 signaling pathway
.38
|
|
5 | Immune response NFAT in immune response |
Immune response NFAT in immune response
.56
|
No disorders were found for IGKJ Gene.
No publications were found for IGKJ Gene.