Aliases for IGK Gene

Aliases for IGK Gene

  • Immunoglobulin Kappa Locus 2 3
  • IGK@ 3

External Ids for IGK Gene

Previous HGNC Symbols for IGK Gene

  • IGK@

Previous GeneCards Identifiers for IGK Gene

  • GC02P089931
  • GC02P090039
  • GC02P089854
  • GC02M088935
  • GC02M088976
  • GC02M088985
  • GC02M089083
  • GC02M088929

Summaries for IGK Gene

GeneCards Summary for IGK Gene

IGK (Immunoglobulin Kappa Locus) is a Protein Coding gene. Among its related pathways are Immune response Lectin induced complement pathway and Immune response NFAT in immune response.

Gene Wiki entry for IGK Gene

Additional gene information for IGK Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGK Gene

Genomics for IGK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J088853 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 250.7 +0.4 448 10.4 POLR2A NFIC TAF1 SPI1 NR2F6 NFIB EGR2 TFDP1 NR2F2 YY1 HSALNG0016724 IGK IGKC IGKV1-13 THNSL2 RPIA IGKV4-1 ANKRD36BP2 EIF2AK3 HSALNG0016725
GH02J088835 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -13.6 -13584 16.4 POLR2A CEBPB FOXA2 NBN TAF1 FOXP1 ATF2 CREB1 HLF SPI1 HSALNG0016723 EIF2AK3 ANKRD36BP2 IGKV1-13 RPIA EIF2AK3-DT IGK IGKDEL LOC105374854 ENSG00000240040
GH02J088831 Enhancer 1 Ensembl ENCODE dbSUPER 0.3 -25.0 -25002 2.3 ZNF654 POLR2A REST TRIM22 CTCF SIN3A MAFF SMC3 ZNF316 RAD21 IGKDEL ANKRD36BP2 HSALNG0016722 LOC105374854 IGK RPIA ENSG00000240040
GH02J088865 Enhancer 0.6 ENCODE dbSUPER 0.4 +8.9 8917 1.7 POLR2A TAF1 SPI1 RUNX3 CBFA2T3 IGKJ1 IGK IGKV4-1 ENSG00000240040 lnc-EIF2AK3-26
GH02J088879 Enhancer 0.8 ENCODE dbSUPER 0.4 +23.1 23099 1 ZNF654 CTCF RAD21 SMC3 ZNF24 ZNF143 TRIM28 HLF SPI1 ZBTB17 RPIA IGKV4-1 IGKJ1 IGK ENSG00000240040 lnc-EIF2AK3-26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGK on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGK Gene

Latest Assembly
chr2:88,857,361-90,235,368
(GRCh38/hg38)
Size:
1,378,008 bases
Orientation:
Plus strand

Previous Assembly
chr2:89,156,874-90,274,235
(GRCh37/hg19 by Entrez Gene)
Size:
1,117,362 bases
Orientation:
Plus strand

Alternative Locations (GRCh38/hg38)

  • chr2(PATCHES):1-439,675 (-)

Genomic View for IGK Gene

Genes around IGK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGK Gene

Proteins for IGK Gene

Post-translational modifications for IGK Gene

No Post-translational modifications

No data available for DME Specific Peptides for IGK Gene

Domains & Families for IGK Gene

Gene Families for IGK Gene

Suggested Antigen Peptide Sequences for IGK Gene

GenScript: Design optimal peptide antigens:
  • IGK@ protein (Q6P5S8_HUMAN)
  • IGK@ protein (Q6PIL8_HUMAN)
  • IGK@ protein (Q6PJF2_HUMAN)
genes like me logo Genes that share domains with IGK: view

No data available for Protein Domains , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGK Gene

Function for IGK Gene

Phenotypes From GWAS Catalog for IGK Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGK Gene

Localization for IGK Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for IGK Gene

Pathways & Interactions for IGK Gene

PathCards logo

SuperPathways for IGK Gene

SuperPathway Contained pathways
1 Immune response Fc epsilon RI pathway
.44
.44
2 Immune response Role of DAP12 receptors in NK cells
.32
3 Immune response Lectin induced complement pathway
.55
4 Development IGF-1 receptor signaling
.38
5 Immune response NFAT in immune response
.56
genes like me logo Genes that share pathways with IGK: view

Pathways by source for IGK Gene

7 GeneGo (Thomson Reuters) pathways for IGK Gene
  • Immune response BCR pathway
  • Immune response CD16 signaling in NK cells
  • Immune response Classical complement pathway
  • Immune response Fc epsilon RI pathway
  • Immune response IL-4 signaling pathway

Interacting Proteins for IGK Gene

Gene Ontology (GO) - Biological Process for IGK Gene

None

No data available for SIGNOR curated interactions for IGK Gene

Drugs & Compounds for IGK Gene

No Compound Related Data Available

Transcripts for IGK Gene

mRNA/cDNA for IGK Gene

7 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for IGK Gene

No ASD Table

Relevant External Links for IGK Gene

GeneLoc Exon Structure for
IGK

Expression for IGK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGK

SOURCE GeneReport for Unigene cluster for IGK Gene:

Hs.719895
genes like me logo Genes that share expression patterns with IGK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGK Gene

Orthologs for IGK Gene

No data available for Orthologs and Evolution for IGK Gene

Paralogs for IGK Gene

No data available for Paralogs for IGK Gene

Variants for IGK Gene

Additional Variant Information for IGK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGK
Leiden Open Variation Database (LOVD)
IGK

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGK Gene

Disorders for IGK Gene

Additional Disease Information for IGK

No disorders were found for IGK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGK Gene

Publications for IGK Gene

  1. Analysis of expressed and non-expressed IGK locus rearrangements in chronic lymphocytic leukemia. (PMID: 16622520) Belessi C … Laoutaris N (Molecular medicine (Cambridge, Mass.) 2005) 3 22
  2. IGK with conserved IGΚV/IGΚJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration. (PMID: 26429876) Wang C … Yin CC (Oncotarget 2015) 3
  3. Immunoglobulin kappa variable region gene selection during early human B cell development in health and systemic lupus erythematosus. (PMID: 25700344) Hehle V … Spencer J (Molecular immunology 2015) 3
  4. Role of κ→λ light-chain constant-domain switch in the structure and functionality of A17 reactibody. (PMID: 24598740) Ponomarenko N … Gabibov A (Acta crystallographica. Section D, Biological crystallography 2014) 3
  5. Cell membrane associated free kappa light chains are found on a subset of tonsil and in vitro-derived plasmablasts. (PMID: 25149546) Hutchinson AT … Raison RL (Human immunology 2014) 3

Products for IGK Gene

Sources for IGK Gene