Aliases for IGIP Gene

Aliases for IGIP Gene

  • IgA Inducing Protein 2 3 5
  • IgA-Inducing Protein Homolog (Bos Taurus) 2 3
  • IgA-Inducing Protein Homolog 3 4
  • C5orf53 3 4
  • Chromosome 5 Open Reading Frame 53 2

External Ids for IGIP Gene

Previous HGNC Symbols for IGIP Gene

  • C5orf53

Previous GeneCards Identifiers for IGIP Gene

  • GC05P139505

Summaries for IGIP Gene

GeneCards Summary for IGIP Gene

IGIP (IgA Inducing Protein) is a Protein Coding gene. Diseases associated with IGIP include Dieulafoy Lesion and Intracranial Abscess.

UniProtKB/Swiss-Prot Summary for IGIP Gene

Additional gene information for IGIP Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGIP Gene

Genomics for IGIP Gene

GeneHancer (GH) Regulatory Elements for IGIP Gene

Promoters and enhancers for IGIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J140126 Enhancer 0.4 Ensembl 500.7 +1.1 1065 0.8 GATA3 SCRT1 SCRT2 IGIP lnc-NRG2-5
GH05J139517 Promoter/Enhancer 1.7 FANTOM5 ENCODE CraniofacialAtlas 22.9 -607.8 -607761 1.9 ZBTB40 ZNF217 CTCF NRF1 TCF12 POLR2G SP1 NCOR1 RBAK GTF2E2 PURA ANKHD1 MALINC1 IGIP DNAJC18 MATR3 SLC23A1 ETF1 CTNNA1 PSD2
GH05J139270 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 14.1 -850.9 -850889 8.2 ZBTB40 ZNF217 EP300 ZSCAN5C SIN3A NRF1 TCF12 MYC POLR2G USF1 MATR3 HQ292149 ENSG00000280987 SNHG4 SNORA74D piR-48759-252 DNAJC18 REEP2 LRRTM2 IGIP
GH05J140710 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas 17.7 +585.1 585065 2 ZBTB40 ZSCAN5C SIN3A NRF1 TCF12 POLR2G SP1 RBAK JUND PHB2 LOC105378198 VTRNA1-1 lnc-HARS-1 PCDHB18P PURA PCDHGA6 PCDHA4 PCDHB19P HARS1 PCDHGA7
GH05J140663 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 14.1 +539.1 539145 3.4 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G SP1 PHF8 ZFX WDR55 TMCO6 ANKHD1 ENSG00000228737 HDAC3 SRA1 IGIP PCDHGC3 PCDHGB2 HARS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGIP on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for IGIP

Genomic Locations for IGIP Gene

Genomic Locations for IGIP Gene
chr5:140,125,936-140,129,392
(GRCh38/hg38)
Size:
3,457 bases
Orientation:
Plus strand
chr5:139,505,521-139,508,391
(GRCh37/hg19)
Size:
2,871 bases
Orientation:
Plus strand

Genomic View for IGIP Gene

Genes around IGIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGIP Gene

Proteins for IGIP Gene

  • Protein details for IGIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ69-IGIP_HUMAN
    Recommended name:
    IgA-inducing protein homolog
    Protein Accession:
    A6NJ69

    Protein attributes for IGIP Gene

    Size:
    53 amino acids
    Molecular mass:
    5937 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGIP Gene

Post-translational modifications for IGIP Gene

No Post-translational modifications

Other Protein References for IGIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGIP Gene

Domains & Families for IGIP Gene

Gene Families for IGIP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IGIP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for IGIP Gene

GenScript: Design optimal peptide antigens:
  • IgA-inducing protein homolog (IGIP_HUMAN)
genes like me logo Genes that share domains with IGIP: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGIP Gene

Function for IGIP Gene

Molecular function for IGIP Gene

UniProtKB/Swiss-Prot Function:
Enhances IgA secretion from B-cells stimulated via CD40.

Phenotypes From GWAS Catalog for IGIP Gene

genes like me logo Genes that share phenotypes with IGIP: view

Animal Model Products

miRNA for IGIP Gene

miRTarBase miRNAs that target IGIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGIP Gene

Localization for IGIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGIP gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGIP: view

Pathways & Interactions for IGIP Gene

PathCards logo

SuperPathways for IGIP Gene

No Data Available

Interacting Proteins for IGIP Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000327344 A6NJ69-IGIP_HUMAN for IGIP Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for IGIP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGIP Gene

Drugs & Compounds for IGIP Gene

No Compound Related Data Available

Transcripts for IGIP Gene

mRNA/cDNA for IGIP Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGIP Gene

No ASD Table

Relevant External Links for IGIP Gene

GeneLoc Exon Structure for
IGIP

Expression for IGIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGIP

SOURCE GeneReport for Unigene cluster for IGIP Gene:

Hs.696360

Evidence on tissue expression from TISSUES for IGIP Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with IGIP: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGIP Gene

Orthologs for IGIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGIP 31 30
  • 99.37 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Igip 17 30
  • 96.23 (n)
dog
(Canis familiaris)
Mammalia IGIP 30
  • 96.23 (n)
rat
(Rattus norvegicus)
Mammalia Igip 30
  • 94.34 (n)
cow
(Bos Taurus)
Mammalia IGIP 31
  • 94 (a)
OneToOne
Species where no ortholog for IGIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGIP Gene

ENSEMBL:
Gene Tree for IGIP (if available)
TreeFam:
Gene Tree for IGIP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGIP: view image

Paralogs for IGIP Gene

No data available for Paralogs for IGIP Gene

Variants for IGIP Gene

Additional dbSNP identifiers (rs#s) for IGIP Gene

Structural Variations from Database of Genomic Variants (DGV) for IGIP Gene

Variant ID Type Subtype PubMed ID
nsv819068 CNV loss 19587683

Variation tolerance for IGIP Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGIP Gene

Disorders for IGIP Gene

MalaCards: The human disease database

(2) MalaCards diseases for IGIP Gene - From: DISEASES

Disorder Aliases PubMed IDs
dieulafoy lesion
  • dieulafoy lesion of intestine
intracranial abscess
- elite association - COSMIC cancer census association via MalaCards
Search IGIP in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IGIP

genes like me logo Genes that share disorders with IGIP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGIP Gene

Publications for IGIP Gene

  1. Regulation of IgA responses in cattle, humans and mice. (PMID: 21074276) Estes DM (Veterinary immunology and immunopathology 2010) 2 3 54
  2. Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells. (PMID: 19201837) Endsley MA … Estes DM (Journal of immunology (Baltimore, Md. : 1950) 2009) 2 3 54
  3. Identification and characterization of a novel regulatory factor: IgA-inducing protein. (PMID: 12874223) Austin AS … Estes DM (Journal of immunology (Baltimore, Md. : 1950) 2003) 2 3 54
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 54
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 54

Products for IGIP Gene

  • Signalway ELISA kits for IGIP
  • Signalway Proteins for IGIP

Sources for IGIP Gene