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Aliases for IGIP Gene

Aliases for IGIP Gene

  • IgA Inducing Protein 2 3 5
  • IgA-Inducing Protein Homolog (Bos Taurus) 2 3
  • C5orf53 3 4
  • Chromosome 5 Open Reading Frame 53 2
  • IgA-Inducing Protein Homolog 3

External Ids for IGIP Gene

Previous HGNC Symbols for IGIP Gene

  • C5orf53

Previous GeneCards Identifiers for IGIP Gene

  • GC05P139505

Summaries for IGIP Gene

GeneCards Summary for IGIP Gene

IGIP (IgA Inducing Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGIP Gene

  • Enhances IgA secretion from B-cells stimulated via CD40.

Additional gene information for IGIP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGIP Gene

Genomics for IGIP Gene

GeneHancer (GH) Regulatory Elements for IGIP Gene

Promoters and enhancers for IGIP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I140125 Promoter 0.5 EPDnew 550.8 0.0 -17 0.1 GC05P140126 IGIP GC05P140117
GH05I139517 Enhancer 1.7 FANTOM5 Ensembl ENCODE 22.9 -607.8 -607760 1.9 ZFP64 FEZF1 DMAP1 ZNF213 ZNF416 ZNF143 ZNF263 SP3 ZC3H11A MEF2D PURA ANKHD1 MALINC1 IGIP MATR3 DNAJC18 SLC23A1 CTNNA1 PSD2 UBE2D2
GH05I139480 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 13 -643.9 -643887 3.3 HDGF PKNOX1 SMAD1 FEZF1 DMAP1 ZNF2 POLR2B ZNF766 ZNF213 KLF13 TMEM173 LOC101059986 ANKHD1 DNAJC18 PURA IGIP SMIM33 GC05M139466 GC05P138946
GH05I140710 Promoter/Enhancer 1.6 Ensembl ENCODE 17.7 +585.0 585049 1.9 CLOCK FEZF1 IRF4 YY1 ZNF213 ZNF143 SP3 SSRP1 ZNF610 GLIS1 GC05P142198 LOC105378198 VTRNA1-1 HARS2 PCDHB18P PURA WDR55 LOC102723915 HDAC3 PCDHGA6
GH05I140717 Promoter/Enhancer 1.6 Ensembl ENCODE 17.7 +593.2 593201 2.7 MLX IRF4 ZNF213 E2F8 ZNF416 ZNF143 SP3 PPARGC1A MEF2D GLIS1 GC05P142207 VTRNA1-2 PURA PCDHB18P PCDHB19P PCDHB15 PCDHB12 PCDHB3 PCDHB9 PCDHB13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGIP on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGIP Gene

Genomic Locations for IGIP Gene
chr5:140,125,935-140,129,392
(GRCh38/hg38)
Size:
3,458 bases
Orientation:
Plus strand
chr5:139,505,521-139,508,391
(GRCh37/hg19)

Genomic View for IGIP Gene

Genes around IGIP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGIP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGIP Gene

Proteins for IGIP Gene

  • Protein details for IGIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJ69-IGIP_HUMAN
    Recommended name:
    IgA-inducing protein homolog
    Protein Accession:
    A6NJ69

    Protein attributes for IGIP Gene

    Size:
    53 amino acids
    Molecular mass:
    5937 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IGIP Gene

Post-translational modifications for IGIP Gene

No Post-translational modifications

Other Protein References for IGIP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IGIP Gene

Domains & Families for IGIP Gene

Gene Families for IGIP Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for IGIP Gene

ProtoNet:

Suggested Antigen Peptide Sequences for IGIP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGIP: view

No data available for UniProtKB/Swiss-Prot for IGIP Gene

Function for IGIP Gene

Molecular function for IGIP Gene

UniProtKB/Swiss-Prot Function:
Enhances IgA secretion from B-cells stimulated via CD40.

Phenotypes From GWAS Catalog for IGIP Gene

Phenotypes for IGIP Gene

genes like me logo Genes that share phenotypes with IGIP: view

miRNA for IGIP Gene

miRTarBase miRNAs that target IGIP

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGIP Gene

Localization for IGIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGIP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGIP gene
Compartment Confidence
extracellular 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with IGIP: view

Pathways & Interactions for IGIP Gene

No Data Available

Interacting Proteins for IGIP Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327344%0d%0a9606.ENSP00000330572%0d%0a
Selected Interacting proteins: A6NJ69-IGIP_HUMAN ENSP00000327344 for IGIP Gene via IID STRING

Gene Ontology (GO) - Biological Process for IGIP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for IGIP Gene

Drugs & Compounds for IGIP Gene

No Compound Related Data Available

Transcripts for IGIP Gene

mRNA/cDNA for IGIP Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IGIP Gene

IgA-inducing protein homolog (Bos taurus):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGIP Gene

No ASD Table

Relevant External Links for IGIP Gene

GeneLoc Exon Structure for
IGIP
ECgene alternative splicing isoforms for
IGIP

Expression for IGIP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of IGIP Gene:

IGIP

SOURCE GeneReport for Unigene cluster for IGIP Gene:

Hs.696360

Evidence on tissue expression from TISSUES for IGIP Gene

  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with IGIP: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGIP Gene

Orthologs for IGIP Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGIP 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia IGIP 33
  • 96.23 (n)
mouse
(Mus musculus)
Mammalia Igip 33 16
  • 96.23 (n)
rat
(Rattus norvegicus)
Mammalia Igip 33
  • 94.34 (n)
cow
(Bos Taurus)
Mammalia IGIP 34
  • 94 (a)
OneToOne
Species where no ortholog for IGIP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGIP Gene

ENSEMBL:
Gene Tree for IGIP (if available)
TreeFam:
Gene Tree for IGIP (if available)

Paralogs for IGIP Gene

No data available for Paralogs for IGIP Gene

Variants for IGIP Gene

Sequence variations from dbSNP and Humsavar for IGIP Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001398135 -- 140,127,274(+) T/A 5_prime_UTR_variant
rs1001703725 -- 140,126,738(+) T/C 5_prime_UTR_variant
rs1002617515 -- 140,128,249(+) A/G 5_prime_UTR_variant
rs1004126275 -- 140,127,633(+) G/A 5_prime_UTR_variant
rs1004168819 -- 140,127,058(+) T/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for IGIP Gene

Variant ID Type Subtype PubMed ID
nsv819068 CNV loss 19587683

Variation tolerance for IGIP Gene

Residual Variation Intolerance Score: 73.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGIP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGIP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGIP Gene

Disorders for IGIP Gene

Additional Disease Information for IGIP

No disorders were found for IGIP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGIP Gene

Publications for IGIP Gene

  1. Regulation of IgA responses in cattle, humans and mice. (PMID: 21074276) Estes DM (Veterinary immunology and immunopathology 2010) 2 3 58
  2. Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells. (PMID: 19201837) Endsley MA … Estes DM (Journal of immunology (Baltimore, Md. : 1950) 2009) 2 3 58
  3. Identification and characterization of a novel regulatory factor: IgA-inducing protein. (PMID: 12874223) Austin AS … Estes DM (Journal of immunology (Baltimore, Md. : 1950) 2003) 2 3 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for IGIP Gene

Sources for IGIP Gene

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