Aliases for IGHV4-59 Gene

Aliases for IGHV4-59 Gene

  • Immunoglobulin Heavy Variable 4-59 2 3 4 5
  • Ig Heavy Chain V-II Region NEWM 3 4
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV4-59 5
  • IGHV459 3
  • VH 3

External Ids for IGHV4-59 Gene

Previous GeneCards Identifiers for IGHV4-59 Gene

  • GC14U990148
  • GC14M105054
  • GC14M105053
  • GC14M106154
  • GC14M107082
  • GC14M107084
  • GC14M107092
  • GC14M107186
  • GC14M107336
  • GC14M107488
  • GC14M107680
  • GC14M106650
  • GC14M107228
  • GC14M108831
  • GC14M108980
  • GC14M109128
  • GC14M109366
  • GC14M107785
  • GC14M107878
  • GC14M107977
  • GC14M108099
  • GC14M108240
  • GC14M108384
  • GC14M108533
  • GC14M108682

Summaries for IGHV4-59 Gene

GeneCards Summary for IGHV4-59 Gene

IGHV4-59 (Immunoglobulin Heavy Variable 4-59) is a Protein Coding gene. An important paralog of this gene is IGHV4-61.

UniProtKB/Swiss-Prot Summary for IGHV4-59 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGHV4-59 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGHV4-59 Gene

Genomics for IGHV4-59 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGHV4-59 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J106626 Enhancer 0.7 ENCODE dbSUPER 600.7 +0.7 654 0.2 ZNF143 TCF12 CTCF TRIM22 ZNF10 ZNF444 GABPB1 ZFP69B RAD21 ZNF654 IGHV4-59 IGHV3-66 IGHV1-58 COPDA1 lnc-BRF1-23 lnc-BRF1-42 IGH
GH14J106442 Enhancer 0.7 Ensembl ENCODE dbSUPER 4.5 +184.9 184872 1.7 CTCF SMC3 SPI1 IGHV3-41 IGHVII-40-1 lnc-BRF1-41 IGHV4-59 IGHV4-39 IGHV3-43 lnc-BRF1-79 COPDA1 lnc-BRF1-23 lnc-BRF1-42
GH14J106459 Enhancer 0.5 dbSUPER 5.2 +167.4 167381 1.4 CREB1 CTCF SMC3 ZNF662 ZBTB11 TRIM22 HOMER2P1 lnc-TMEM121-6 ENSG00000257270 IGHV4-59 IGHV3-43 piR-30350-027 lnc-BRF1-79 IGHV4-39 COPDA1 lnc-BRF1-23
GH14J106436 Enhancer 0.5 dbSUPER 4.8 +190.8 190761 2 CTCF RAD21 TRIM22 SMC3 YY1 ENSG00000228757 piR-54987-046 IGHV4-59 IGHV4-39 IGHV3-43 lnc-BRF1-79 COPDA1 lnc-BRF1-23 lnc-BRF1-42 IGH
GH14J105849 Enhancer 0.3 dbSUPER 5.1 +777.8 777799 1.3 POLR2A BMI1 IGHV4-59 CLBA1 IGHD lnc-BRF1-12 IGHM lnc-TMEM121-2 NONHSAG016150.2 COPDA1 lnc-BRF1-23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGHV4-59 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGHV4-59 Gene

Genomic Locations for IGHV4-59 Gene
chr14:106,627,249-106,627,825
(GRCh38/hg38)
Size:
577 bases
Orientation:
Minus strand
chr14:107,081,806-107,083,830
(GRCh37/hg19)
Size:
2,025 bases
Orientation:
Minus strand

Genomic View for IGHV4-59 Gene

Genes around IGHV4-59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV4-59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV4-59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV4-59 Gene

Proteins for IGHV4-59 Gene

  • Protein details for IGHV4-59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01825-HV459_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 4-59
    Protein Accession:
    P01825
    Secondary Accessions:
    • A0A0C4DH40
    • A0A0G2JPU1

    Protein attributes for IGHV4-59 Gene

    Size:
    116 amino acids
    Molecular mass:
    12936 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IGHV4-59 Gene

neXtProt entry for IGHV4-59 Gene

Post-translational modifications for IGHV4-59 Gene

No Post-translational modifications

Other Protein References for IGHV4-59 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV4-59 Gene

Domains & Families for IGHV4-59 Gene

Gene Families for IGHV4-59 Gene

Protein Domains for IGHV4-59 Gene

InterPro:
Blocks:
  • Immunoglobulin V-set
  • Immunoglobulin V-type
ProtoNet:
genes like me logo Genes that share domains with IGHV4-59: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGHV4-59 Gene

Function for IGHV4-59 Gene

Molecular function for IGHV4-59 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Phenotypes From GWAS Catalog for IGHV4-59 Gene

Gene Ontology (GO) - Molecular Function for IGHV4-59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding NAS 407927
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGHV4-59: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV4-59 Gene

Localization for IGHV4-59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV4-59 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV4-59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0019814 immunoglobulin complex IEA --
genes like me logo Genes that share ontologies with IGHV4-59: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV4-59 Gene

Pathways & Interactions for IGHV4-59 Gene

PathCards logo

SuperPathways for IGHV4-59 Gene

No Data Available

Interacting Proteins for IGHV4-59 Gene

Gene Ontology (GO) - Biological Process for IGHV4-59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
genes like me logo Genes that share ontologies with IGHV4-59: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV4-59 Gene

Drugs & Compounds for IGHV4-59 Gene

No Compound Related Data Available

Transcripts for IGHV4-59 Gene

mRNA/cDNA for IGHV4-59 Gene

1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV4-59 Gene

No ASD Table

Relevant External Links for IGHV4-59 Gene

GeneLoc Exon Structure for
IGHV4-59

Expression for IGHV4-59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHV4-59 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV4-59 Gene

This gene is overexpressed in Spleen (x14.9), Colon - Transverse (x8.1), and Small Intestine - Terminal Ileum (x4.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGHV4-59

genes like me logo Genes that share expression patterns with IGHV4-59: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV4-59 Gene

Orthologs for IGHV4-59 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV4-59 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 31
  • 56 (a)
ManyToMany
Species where no ortholog for IGHV4-59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for IGHV4-59 Gene

ENSEMBL:
Gene Tree for IGHV4-59 (if available)
TreeFam:
Gene Tree for IGHV4-59 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGHV4-59: view image

Paralogs for IGHV4-59 Gene

genes like me logo Genes that share paralogs with IGHV4-59: view

Variants for IGHV4-59 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV4-59 Gene

HV459_HUMAN-P01825
There are several alleles. The sequence shown is that of IMGT allele IGHV4-59*01.

Additional Variant Information for IGHV4-59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV4-59

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV4-59 Gene

Disorders for IGHV4-59 Gene

Additional Disease Information for IGHV4-59

No disorders were found for IGHV4-59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGHV4-59 Gene

Publications for IGHV4-59 Gene

  1. Amino acid sequence of the VH region of a human myeloma immunoglobulin (IgG New). (PMID: 407927) Poljak RJ … Konigsberg W (Biochemistry 1977) 3 4
  2. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3
  4. Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. (PMID: 22051533) Kostareli E … Stamatopoulos K (Leukemia 2012) 3
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4

Products for IGHV4-59 Gene

Sources for IGHV4-59 Gene