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Aliases for IGHV3-64D Gene

Aliases for IGHV3-64D Gene

  • Immunoglobulin Heavy Variable 3-64D 2 3

External Ids for IGHV3-64D Gene

Previous GeneCards Identifiers for IGHV3-64D Gene

  • GC14U901502
  • GC14M108065

Summaries for IGHV3-64D Gene

GeneCards Summary for IGHV3-64D Gene

IGHV3-64D (Immunoglobulin Heavy Variable 3-64D) is a Protein Coding gene.

UniProtKB/Swiss-Prot for IGHV3-64D Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGHV3-64D Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-64D Gene

Genomics for IGHV3-64D Gene

GeneHancer (GH) Regulatory Elements for IGHV3-64D Gene

Promoters and enhancers for IGHV3-64D Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I106066 Enhancer 0.4 dbSUPER 0.4 +19.7 19667 4 HLF NFE2 IGHV3-7 IGHV3-64D IGH
GH14I106062 Enhancer 0.5 ENCODE dbSUPER 0.3 +25.5 25506 0.2 POLR2A IGHV3-7 IGHV3-64D IGH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGHV3-64D on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGHV3-64D Gene

Genomic Locations for IGHV3-64D Gene
chr14:106,088,122-106,088,573
(GRCh38/hg38)
Size:
452 bases
Orientation:
Minus strand

Genomic View for IGHV3-64D Gene

Genes around IGHV3-64D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV3-64D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV3-64D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV3-64D Gene

Proteins for IGHV3-64D Gene

  • Protein details for IGHV3-64D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0J9YX35-HV64D_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 3-64D
    Protein Accession:
    A0A0J9YX35

    Protein attributes for IGHV3-64D Gene

    Size:
    117 amino acids
    Molecular mass:
    12823 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

neXtProt entry for IGHV3-64D Gene

Post-translational modifications for IGHV3-64D Gene

No Post-translational modifications

Other Protein References for IGHV3-64D Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV3-64D Gene

Domains & Families for IGHV3-64D Gene

Protein Domains for IGHV3-64D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV3-64D: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV3-64D Gene

Function for IGHV3-64D Gene

Molecular function for IGHV3-64D Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV3-64D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IEA --
genes like me logo Genes that share ontologies with IGHV3-64D: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-64D Gene

Localization for IGHV3-64D Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-64D Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV3-64D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHV3-64D: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV3-64D Gene

Pathways & Interactions for IGHV3-64D Gene

SuperPathways for IGHV3-64D Gene

No Data Available

Interacting Proteins for IGHV3-64D Gene

Gene Ontology (GO) - Biological Process for IGHV3-64D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with IGHV3-64D: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV3-64D Gene

Drugs & Compounds for IGHV3-64D Gene

No Compound Related Data Available

Transcripts for IGHV3-64D Gene

mRNA/cDNA for IGHV3-64D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-64D Gene

No ASD Table

Relevant External Links for IGHV3-64D Gene

GeneLoc Exon Structure for
IGHV3-64D
ECgene alternative splicing isoforms for
IGHV3-64D

Expression for IGHV3-64D Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV3-64D Gene

Orthologs for IGHV3-64D Gene

Evolution for IGHV3-64D Gene

ENSEMBL:
Gene Tree for IGHV3-64D (if available)
TreeFam:
Gene Tree for IGHV3-64D (if available)

No data available for Orthologs for IGHV3-64D Gene

Paralogs for IGHV3-64D Gene

No data available for Paralogs for IGHV3-64D Gene

Variants for IGHV3-64D Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-64D Gene

HV64D_HUMAN-A0A0J9YX35
There are several alleles. The sequence shown is that of IMGT allele IGHV3-64D*06.

Additional Variant Information for IGHV3-64D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV3-64D

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-64D Gene

Disorders for IGHV3-64D Gene

No disorders were found for IGHV3-64D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for IGHV3-64D Gene

Publications for IGHV3-64D Gene

  1. Complete haplotype sequence of the human immunoglobulin heavy-chain variable, diversity, and joining genes and characterization of allelic and copy-number variation. (PMID: 23541343) Watson CT … Breden F (American journal of human genetics 2013) 2 3 58
  2. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  3. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58
  4. Structure and function of immunoglobulins. (PMID: 20176268) Schroeder HW … Cavacini L (The Journal of allergy and clinical immunology 2010) 4 58
  5. Immunoglobulin somatic hypermutation. (PMID: 17576170) Teng G … Papavasiliou FN (Annual review of genetics 2007) 4 58

Products for IGHV3-64D Gene

Sources for IGHV3-64D Gene

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