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Aliases for IGHV3-21 Gene

Aliases for IGHV3-21 Gene

  • Immunoglobulin Heavy Variable 3-21 2 3 5
  • Immunogloblin Heavy Chain Variable Region 3
  • IGHV321 3
  • VH 3

External Ids for IGHV3-21 Gene

Previous GeneCards Identifiers for IGHV3-21 Gene

  • GC14U990200
  • GC14M104663
  • GC14M105762
  • GC14M106693
  • GC14M086832
  • GC14M106997
  • GC14M107429
  • GC14M107621
  • GC14M106236
  • GC14M106244
  • GC14M108066
  • GC14M108211
  • GC14M108357

Summaries for IGHV3-21 Gene

GeneCards Summary for IGHV3-21 Gene

IGHV3-21 (Immunoglobulin Heavy Variable 3-21) is a Protein Coding gene. Diseases associated with IGHV3-21 include Leukemia, Chronic Lymphocytic. An important paralog of this gene is IGHV3-48.

UniProtKB/Swiss-Prot for IGHV3-21 Gene

  • V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Additional gene information for IGHV3-21 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGHV3-21 Gene

Genomics for IGHV3-21 Gene

GeneHancer (GH) Regulatory Elements for IGHV3-21 Gene

Promoters and enhancers for IGHV3-21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J106234 Enhancer 0.6 ENCODE dbSUPER 650.7 +0.6 630 0.7 CTCF SMAD5 IGHV3-21 IGHV3-19 IGHV2-70D IGHVII-20-1 IGH
GH14J106227 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.4 +7.1 7050 1.9 CREB1 ATF7 ATF2 IGHV3-19 IGHV3-21 IGHVII-20-1 IGH
GH14J106229 Enhancer 0.6 Ensembl ENCODE dbSUPER 0.4 +5.5 5471 0.3 IGHV3-19 IGHV3-21 IGHVII-20-1 IGH
GH14J106223 Enhancer 0.4 ENCODE dbSUPER 0.4 +11.3 11305 1.4 IGHV3-19 IGHV3-21 IGHVII-20-1 IGH
GH14J106248 Enhancer 0.3 dbSUPER 0.4 -13.3 -13273 1.7 CREB1 IGHV3-22 IGHV3-21 IGH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGHV3-21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for IGHV3-21 Gene

Genomic Locations for IGHV3-21 Gene
chr14:106,235,062-106,235,594
(GRCh38/hg38)
Size:
533 bases
Orientation:
Minus strand
chr14:106,691,671-106,692,203
(GRCh37/hg19)
Size:
533 bases
Orientation:
Minus strand

Genomic View for IGHV3-21 Gene

Genes around IGHV3-21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHV3-21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHV3-21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHV3-21 Gene

Proteins for IGHV3-21 Gene

  • Protein details for IGHV3-21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A0B4J1V1-HV321_HUMAN
    Recommended name:
    Immunoglobulin heavy variable 3-21
    Protein Accession:
    A0A0B4J1V1

    Protein attributes for IGHV3-21 Gene

    Size:
    117 amino acids
    Molecular mass:
    12840 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

    Three dimensional structures from OCA and Proteopedia for IGHV3-21 Gene

neXtProt entry for IGHV3-21 Gene

Post-translational modifications for IGHV3-21 Gene

No Post-translational modifications

Other Protein References for IGHV3-21 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHV3-21 Gene

Domains & Families for IGHV3-21 Gene

Gene Families for IGHV3-21 Gene

Protein Domains for IGHV3-21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGHV3-21: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for IGHV3-21 Gene

Function for IGHV3-21 Gene

Molecular function for IGHV3-21 Gene

UniProtKB/Swiss-Prot Function:
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).

Gene Ontology (GO) - Molecular Function for IGHV3-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0034987 immunoglobulin receptor binding IBA --
genes like me logo Genes that share ontologies with IGHV3-21: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHV3-21 Gene

Localization for IGHV3-21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHV3-21 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHV3-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0042571 immunoglobulin complex, circulating IBA --
genes like me logo Genes that share ontologies with IGHV3-21: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHV3-21 Gene

Pathways & Interactions for IGHV3-21 Gene

SuperPathways for IGHV3-21 Gene

No Data Available

Interacting Proteins for IGHV3-21 Gene

Gene Ontology (GO) - Biological Process for IGHV3-21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006910 phagocytosis, recognition IBA --
GO:0006911 phagocytosis, engulfment IBA --
GO:0006958 complement activation, classical pathway IBA --
GO:0042742 defense response to bacterium IBA --
genes like me logo Genes that share ontologies with IGHV3-21: view

No data available for Pathways by source and SIGNOR curated interactions for IGHV3-21 Gene

Drugs & Compounds for IGHV3-21 Gene

No Compound Related Data Available

Transcripts for IGHV3-21 Gene

mRNA/cDNA for IGHV3-21 Gene

(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IGHV3-21 Gene

No ASD Table

Relevant External Links for IGHV3-21 Gene

GeneLoc Exon Structure for
IGHV3-21
ECgene alternative splicing isoforms for
IGHV3-21

Expression for IGHV3-21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGHV3-21 Gene

mRNA differential expression in normal tissues according to GTEx for IGHV3-21 Gene

This gene is overexpressed in Spleen (x12.6), Colon - Transverse (x7.6), and Whole Blood (x6.2).

Protein differential expression in normal tissues from HIPED for IGHV3-21 Gene

This gene is overexpressed in Saliva (27.3), Serum (24.0), and Urine (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHV3-21 Gene



Protein tissue co-expression partners for IGHV3-21 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHV3-21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHV3-21 Gene

Orthologs for IGHV3-21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for IGHV3-21 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 71 (a)
ManyToMany
Species where no ortholog for IGHV3-21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for IGHV3-21 Gene

ENSEMBL:
Gene Tree for IGHV3-21 (if available)
TreeFam:
Gene Tree for IGHV3-21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for IGHV3-21: view image

Paralogs for IGHV3-21 Gene

Variants for IGHV3-21 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHV3-21 Gene

HV321_HUMAN-A0A0B4J1V1
There are several alleles. The sequence shown is that of IMGT allele IGHV3-21*01.

Additional Variant Information for IGHV3-21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHV3-21

No data available for Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHV3-21 Gene

Disorders for IGHV3-21 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGHV3-21 Gene - From: Orphanet

Disorder Aliases PubMed IDs
leukemia, chronic lymphocytic
  • cll
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for IGHV3-21

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with IGHV3-21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IGHV3-21 Gene

Publications for IGHV3-21 Gene

  1. Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation. (PMID: 20511662) Oscier D … Chronic Lymphocytic Leukaemia Working Group, UK National Cancer Research Institute (Haematologica 2010) 3 44 58
  2. Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. (PMID: 25634617) Baliakas P … Stamatopoulos K (Blood 2015) 3 58
  3. Immunoglobulin and T Cell Receptor Genes: IMGT(®) and the Birth and Rise of Immunoinformatics. (PMID: 24600447) Lefranc MP (Frontiers in immunology 2014) 4 58
  4. IGHV3-21 gene frequency in a Swedish cohort of patients with newly diagnosed chronic lymphocytic leukemia. (PMID: 22464020) Cahill N … Rosenquist R (Clinical lymphoma, myeloma & leukemia 2012) 3 58
  5. Molecular programming of B cell memory. (PMID: 22158414) McHeyzer-Williams M … McHeyzer-Williams L (Nature reviews. Immunology 2011) 4 58

Products for IGHV3-21 Gene

Sources for IGHV3-21 Gene

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