Aliases for IGHG4 Gene
External Ids for IGHG4 Gene
Previous GeneCards Identifiers for IGHG4 Gene
GeneCards Summary for IGHG4 Gene
IGHG4 (Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.
UniProtKB/Swiss-Prot Summary for IGHG4 Gene
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).