Aliases for IGHG4 Gene

Aliases for IGHG4 Gene

  • Immunoglobulin Heavy Constant Gamma 4 (G4m Marker) 2 3 5
  • Immunoglobulin Heavy Chain Constant Region Gamma 4 3
  • Immunoglobulin Heavy Constant Gamma 4 4
  • Ig Gamma-4 Chain C Region 4
  • IGHG4 5

External Ids for IGHG4 Gene

Previous GeneCards Identifiers for IGHG4 Gene

  • GC14U990038
  • GC14M100081
  • GC14M104064
  • GC14M104066
  • GC14M105161
  • GC14M106090
  • GC14M105624
  • GC14M105757
  • GC14M105766
  • GC14M105779
  • GC14M105827
  • GC14M105690
  • GC14M105714
  • GC14M105722
  • GC14M105744
  • GC14M109516
  • GC14M109776

Summaries for IGHG4 Gene

GeneCards Summary for IGHG4 Gene

IGHG4 (Immunoglobulin Heavy Constant Gamma 4 (G4m Marker)) is a Protein Coding gene. Among its related pathways are Creation of C4 and C2 activators and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGHG2.

UniProtKB/Swiss-Prot Summary for IGHG4 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGHG4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGHG4 Gene

Genomics for IGHG4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGHG4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J104728 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.4 +892.7 892706 9.3 MYC ZNF600 ZNF580 ZNF592 ZMYM3 KLF9 CEBPA BRCA1 ZIC2 CHD4 AKT1 ADSS1 SIVA1 ENSG00000202275 CEP170B IGHG4 C14orf180 HSALNG0104126 LOC107984670
GH14J104752 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 4.2 +872.3 872269 4.4 SP1 ZNF207 MYC ZNF600 SIX5 SSRP1 JUND ZNF580 ATF2 POLR2A SIVA1 AKT1 ENSG00000202275 MTA1 ENSG00000257270 ENSG00000270591 CDCA4 PPP1R13B IGHG4 IGHE
GH14J104766 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 4.9 +858.1 858069 3.3 ZNF654 MYC SSRP1 POLR2A ZIC2 YY1 MXD4 CTCF REST BHLHE40 ENSG00000258430 LOC107987209 ADSS1 AKT1 MTA1 IGHG4 LOC102723342 lnc-AHNAK2-9 SIVA1
GH14J105329 Enhancer 0.6 ENCODE dbSUPER 6.2 +295.7 295706 1.2 EGR1 RFX1 EGR2 BMI1 NR2F2 ZFHX2 IGHG4 piR-48749-010 BRF1 lnc-TEX22-4 PACS2 TEX22
GH14J105587 Enhancer 0.6 Ensembl dbSUPER 5.2 +35.8 35765 3.8 REST NFIB ZBTB8A KLF16 IGHA2 IGHV2-26 IGHG4 lnc-TMEM121-2 lnc-BRF1-4 IGHE
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGHG4 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGHG4 Gene

Latest Assembly
chr14:105,620,506-105,626,066
(GRCh38/hg38)
Size:
5,561 bases
Orientation:
Minus strand

Previous Assembly
chr14:106,090,813-106,092,402
(GRCh37/hg19 by Entrez Gene)
Size:
1,590 bases
Orientation:
Minus strand

chr14:106,090,687-106,092,403
(GRCh37/hg19 by Ensembl)
Size:
1,717 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr14(ALT_REF_LOCI_1):92,245-93,834 (-)

Genomic View for IGHG4 Gene

Genes around IGHG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG4 Gene

Proteins for IGHG4 Gene

  • Protein details for IGHG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01861-IGHG4_HUMAN
    Recommended name:
    Immunoglobulin heavy constant gamma 4
    Protein Accession:
    P01861

    Protein attributes for IGHG4 Gene

    Size:
    327 amino acids
    Molecular mass:
    35941 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=AAB59394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG4 Gene

neXtProt entry for IGHG4 Gene

Post-translational modifications for IGHG4 Gene

  • Glycosylation at Asn177
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for IGHG4 Gene

Protein products for research

No data available for DME Specific Peptides for IGHG4 Gene

Domains & Families for IGHG4 Gene

Gene Families for IGHG4 Gene

Protein Domains for IGHG4 Gene

InterPro:
Blocks:
  • Immunoglobulin C-type

Suggested Antigen Peptide Sequences for IGHG4 Gene

GenScript: Design optimal peptide antigens:
  • Ig gamma-4 chain C region (IGHG4_HUMAN)
genes like me logo Genes that share domains with IGHG4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGHG4 Gene

Function for IGHG4 Gene

Molecular function for IGHG4 Gene

UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
GENATLAS Biochemistry:
immunoglobulin,gamma 4

Gene Ontology (GO) - Molecular Function for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGHG4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG4 Gene

Localization for IGHG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG4 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space HDA 22664934
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHG4: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHG4 Gene

Pathways & Interactions for IGHG4 Gene

genes like me logo Genes that share pathways with IGHG4: view

Pathways by source for IGHG4 Gene

1 GeneGo (Thomson Reuters) pathway for IGHG4 Gene
  • Immune response IL-4 signaling pathway

Interacting Proteins for IGHG4 Gene

Gene Ontology (GO) - Biological Process for IGHG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHG4: view

No data available for SIGNOR curated interactions for IGHG4 Gene

Drugs & Compounds for IGHG4 Gene

(2) Drugs for IGHG4 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 276
Imlifidase Approved, Investigational Pharma Target, cleavage 0
genes like me logo Genes that share compounds with IGHG4: view

Transcripts for IGHG4 Gene

mRNA/cDNA for IGHG4 Gene

4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG4 Gene

No ASD Table

Relevant External Links for IGHG4 Gene

GeneLoc Exon Structure for
IGHG4

Expression for IGHG4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHG4 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG4 Gene

This gene is overexpressed in Spleen (x29.3).

Protein differential expression in normal tissues from HIPED for IGHG4 Gene

This gene is overexpressed in Serum (14.5) and Vitreous humor (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG4 Gene



Protein tissue co-expression partners for IGHG4 Gene

- Elite partner
genes like me logo Genes that share expression patterns with IGHG4: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHG4 Gene

Orthologs for IGHG4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG4 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 30
  • 63 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Ighg1 30
  • 61 (a)
ManyToMany
Ighg3 30
  • 60 (a)
ManyToMany
Ighg2b 30
  • 57 (a)
ManyToMany
Ighg2c 30
  • 49 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 56 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 42 (a)
ManyToMany
-- 30
  • 37 (a)
ManyToMany
-- 30
  • 20 (a)
ManyToMany
-- 30
  • 16 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 36 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 25 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ighv1-4 30
  • 14 (a)
OneToMany
Species where no ortholog for IGHG4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGHG4 Gene

ENSEMBL:
Gene Tree for IGHG4 (if available)
TreeFam:
Gene Tree for IGHG4 (if available)
Alliance of Genome Resources:
Additional Orthologs for IGHG4

Paralogs for IGHG4 Gene

genes like me logo Genes that share paralogs with IGHG4: view

Variants for IGHG4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHG4 Gene

IGHG4_HUMAN-P01861
There are several alleles. The sequence shown is that of IMGT allele IGHG4*04.

Additional Variant Information for IGHG4 Gene

Human Gene Mutation Database (HGMD)
IGHG4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHG4
Leiden Open Variation Database (LOVD)
IGHG4

SNP Genotyping and Copy Number Assays for research

No data available for Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG4 Gene

Disorders for IGHG4 Gene

Genatlas disease for IGHG4 Gene

immunoglobulin,gamma 4 deficiency

Additional Disease Information for IGHG4

genes like me logo Genes that share disorders with IGHG4: view

No data available for MalaCards and UniProtKB/Swiss-Prot for IGHG4 Gene

Publications for IGHG4 Gene

  1. Nucleotide sequence of a human immunoglobulin C gamma 4 gene. (PMID: 6299662) Ellison J … Hood L (DNA (Mary Ann Liebert, Inc.) 1981) 3 4
  2. Human immunoglobulin subclasses. Partial amino acid sequence of the constant region of a gamma 4 chain. (PMID: 4192699) Pink JR … Milstein C (The Biochemical journal 1970) 3 4
  3. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. (PMID: 33060197) Gordon DE … Krogan NJ (Science (New York, N.Y.) 2020) 3
  4. Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability. (PMID: 31180492) Pladevall-Morera D … Lopez-Contreras AJ (Nucleic acids research 2019) 3
  5. Connecting the Dots in the Neuroglobin-Protein Interaction Network of an Unstressed and Ferroptotic Cell Death Neuroblastoma Model. (PMID: 31405213) Van Acker ZP … Dewilde S (Cells 2019) 3

Products for IGHG4 Gene

Sources for IGHG4 Gene