Aliases for IGHG2 Gene
- Immunoglobulin Heavy Constant Gamma 2 (G2m Marker) 2 3 5
- Immunoglobulin Heavy Constant Gamma 2 (Gm Marker) 3
- Constant Region Of Heavy Chain Of IgG2 3
- Immunoglobulin Gamma 2 (Gm Marker) 3
- Ig Gamma-2 Chain C Region DOT 4
- Ig Gamma-2 Chain C Region TIL 4
- Ig Gamma-2 Chain C Region ZIE 4
- Ig Gamma-2 Chain C Region 4
External Ids for IGHG2 Gene
Previous GeneCards Identifiers for IGHG2 Gene
GeneCards Summary for IGHG2 Gene
IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include Immunoglobulin Kappa Light Chain Deficiency. Among its related pathways are Creation of C4 and C2 activators and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGHG3.
UniProtKB/Swiss-Prot for IGHG2 Gene
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).