Aliases for IGHG2 Gene

Aliases for IGHG2 Gene

  • Immunoglobulin Heavy Constant Gamma 2 (G2m Marker) 2 3 5
  • Immunoglobulin Heavy Constant Gamma 2 (Gm Marker) 3
  • Constant Region Of Heavy Chain Of IgG2 3
  • Immunoglobulin Heavy Constant Gamma 2 4
  • Immunoglobulin Gamma 2 (Gm Marker) 3
  • Ig Gamma-2 Chain C Region DOT 4
  • Ig Gamma-2 Chain C Region TIL 4
  • Ig Gamma-2 Chain C Region ZIE 4
  • Ig Gamma-2 Chain C Region 4
  • IGHG2 5

External Ids for IGHG2 Gene

Previous GeneCards Identifiers for IGHG2 Gene

  • GC14U990036
  • GC14M100100
  • GC14M104146
  • GC14M104149
  • GC14M105180
  • GC14M106109
  • GC14M105643
  • GC14M105749
  • GC14M105767
  • GC14M105780
  • GC14M105829
  • GC14M105695
  • GC14M105715
  • GC14M105723
  • GC14M105734
  • GC14M109517
  • GC14M109777

Summaries for IGHG2 Gene

GeneCards Summary for IGHG2 Gene

IGHG2 (Immunoglobulin Heavy Constant Gamma 2 (G2m Marker)) is a Protein Coding gene. Diseases associated with IGHG2 include Immunoglobulin Kappa Light Chain Deficiency. Among its related pathways are Creation of C4 and C2 activators and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include antigen binding. An important paralog of this gene is IGHG4.

UniProtKB/Swiss-Prot Summary for IGHG2 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

Gene Wiki entry for IGHG2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGHG2 Gene

Genomics for IGHG2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGHG2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGHG2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGHG2 Gene

Latest Assembly
chr14:105,639,559-105,644,790
(GRCh38/hg38)
Size:
5,232 bases
Orientation:
Minus strand

Previous Assembly
chr14:106,109,540-106,111,126
(GRCh37/hg19 by Entrez Gene)
Size:
1,587 bases
Orientation:
Minus strand

chr14:106,109,389-106,111,127
(GRCh37/hg19 by Ensembl)
Size:
1,739 bases
Orientation:
Minus strand

Alternative Locations (GRCh38/hg38)

  • chr14(ALT_REF_LOCI_1):110,972-112,558 (-)

Genomic View for IGHG2 Gene

Genes around IGHG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHG2 Gene

Proteins for IGHG2 Gene

  • Protein details for IGHG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01859-IGHG2_HUMAN
    Recommended name:
    Immunoglobulin heavy constant gamma 2
    Protein Accession:
    P01859
    Secondary Accessions:
    • A6NE66

    Protein attributes for IGHG2 Gene

    Size:
    326 amino acids
    Molecular mass:
    35901 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
    SequenceCaution:
    • Sequence=AAB59393.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHG2 Gene

neXtProt entry for IGHG2 Gene

Post-translational modifications for IGHG2 Gene

  • Glycosylation at Asn176
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for IGHG2 Gene

Protein products for research

  • Abcam proteins for IGHG2

No data available for DME Specific Peptides for IGHG2 Gene

Domains & Families for IGHG2 Gene

Gene Families for IGHG2 Gene

Protein Domains for IGHG2 Gene

InterPro:
Blocks:
  • Immunoglobulin C-type

Suggested Antigen Peptide Sequences for IGHG2 Gene

GenScript: Design optimal peptide antigens:
  • Ig gamma-2 chain C region (IGHG2_HUMAN)
genes like me logo Genes that share domains with IGHG2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGHG2 Gene

Function for IGHG2 Gene

Molecular function for IGHG2 Gene

UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
GENATLAS Biochemistry:
immunoglobulin,gamma 2 (Gm marker)

Phenotypes From GWAS Catalog for IGHG2 Gene

Gene Ontology (GO) - Molecular Function for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA 21873635
GO:0005515 protein binding IPI 16457820
GO:0034987 immunoglobulin receptor binding IBA 21873635
genes like me logo Genes that share ontologies with IGHG2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHG2 Gene

Localization for IGHG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHG2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 25645918
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHG2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHG2 Gene

Pathways & Interactions for IGHG2 Gene

genes like me logo Genes that share pathways with IGHG2: view

Interacting Proteins for IGHG2 Gene

Gene Ontology (GO) - Biological Process for IGHG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006910 phagocytosis, recognition IBA 21873635
GO:0006911 phagocytosis, engulfment IBA 21873635
GO:0006956 complement activation TAS --
genes like me logo Genes that share ontologies with IGHG2: view

No data available for SIGNOR curated interactions for IGHG2 Gene

Drugs & Compounds for IGHG2 Gene

(10) Drugs for IGHG2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Imlifidase Approved, Investigational Pharma Target, cleavage 0
1-[N-4'-NITROBENZYL-N-4'-CARBOXYBUTYLAMINO]METHYLPHOSPHONIC ACID Experimental Pharma Target 0
3-(HYDROXY-PHENYL-PHOSPHINOYLOXY)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER Experimental Pharma Target 0
3-OXO-N-[(3S)-2-OXOPYRROLIDIN-3-YL]DODECANAMIDE Experimental Pharma Target 0
4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHG2: view

Transcripts for IGHG2 Gene

mRNA/cDNA for IGHG2 Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHG2 Gene

No ASD Table

Relevant External Links for IGHG2 Gene

GeneLoc Exon Structure for
IGHG2

Expression for IGHG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHG2 Gene

mRNA differential expression in normal tissues according to GTEx for IGHG2 Gene

This gene is overexpressed in Spleen (x33.9).

Protein differential expression in normal tissues from HIPED for IGHG2 Gene

This gene is overexpressed in Serum (7.9) and Cerebrospinal fluid (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHG2 Gene



Protein tissue co-expression partners for IGHG2 Gene

- Elite partner

Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHG2 Gene

Germ Layers:
  • mesoderm
Systems:
  • immune
Regions:
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with IGHG2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for IGHG2 Gene

Orthologs for IGHG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHG2 Gene

Organism Taxonomy Gene Similarity Type Details
Mouse
(Mus musculus)
Mammalia Ighg1 30
  • 64 (a)
ManyToMany
Ighg3 30
  • 62 (a)
ManyToMany
Ighg2b 30
  • 58 (a)
ManyToMany
Ighg2c 30
  • 49 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia -- 30
  • 63 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 56 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 43 (a)
ManyToMany
-- 30
  • 38 (a)
ManyToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 39 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 25 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii ighv1-4 30
  • 14 (a)
OneToMany
Species where no ortholog for IGHG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGHG2 Gene

ENSEMBL:
Gene Tree for IGHG2 (if available)
TreeFam:
Gene Tree for IGHG2 (if available)
Alliance of Genome Resources:
Additional Orthologs for IGHG2

Paralogs for IGHG2 Gene

genes like me logo Genes that share paralogs with IGHG2: view

Variants for IGHG2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHG2 Gene

IGHG2_HUMAN-P01859
There are several alleles. The sequence shown is that of IMGT allele IGHG2*06.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGHG2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
VAR_003889 -- p.Ser60Ala
VAR_077892 -- p.Ser257Ala

Additional Variant Information for IGHG2 Gene

Human Gene Mutation Database (HGMD)
IGHG2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHG2
Leiden Open Variation Database (LOVD)
IGHG2

SNP Genotyping and Copy Number Assays for research

No data available for dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHG2 Gene

Disorders for IGHG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IGHG2 Gene - From: ORP

Disorder Aliases PubMed IDs
immunoglobulin kappa light chain deficiency
  • igkcd
- elite association - COSMIC cancer census association via MalaCards
Search IGHG2 in MalaCards View complete list of genes associated with diseases

Genatlas disease for IGHG2 Gene

IGG2 deficiency caused by a mutated membrane-bound form of gamma 2 heavy chain,with recurrent sino-pulmonary infections

Additional Disease Information for IGHG2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with IGHG2: view

No data available for UniProtKB/Swiss-Prot for IGHG2 Gene

Publications for IGHG2 Gene

  1. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. (PMID: 18821675) O'Hanlon TP … Miller FW (Arthritis and rheumatism 2008) 3 40
  2. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen TZ … Pandey A (Molecular & cellular proteomics : MCP 2004) 3 4
  3. Characterization of the two unique human anti-flavin monoclonal immunoglobulins. (PMID: 7737190) Stoppini M … Ferri G (European journal of biochemistry 1995) 3 4
  4. Structure of human immunoglobulin gamma genes: implications for evolution of a gene family. (PMID: 6811139) Takahashi N … Honjo T (Cell 1982) 3 4
  5. Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes. (PMID: 6804948) Ellison J … Hood L (Proceedings of the National Academy of Sciences of the United States of America 1982) 3 4

Products for IGHG2 Gene

Sources for IGHG2 Gene