Aliases for IGHA2 Gene

Aliases for IGHA2 Gene

  • Immunoglobulin Heavy Constant Alpha 2 (A2m Marker) 2 3 5
  • Constant Region Of Heavy Chain Of IgA2 3
  • Immunoglobulin Heavy Constant Alpha 2 4
  • Immunoglobulin Alpha 2 (A2M Marker) 3
  • Ig Alpha-2 Chain C Region BUT 4
  • Ig Alpha-2 Chain C Region LAN 4
  • Ig Alpha-2 Chain C Region 4
  • IGHA2 5

External Ids for IGHA2 Gene

Previous GeneCards Identifiers for IGHA2 Gene

  • GC14U990031
  • GC14M100045
  • GC14M104024
  • GC14M105124
  • GC14M106050
  • GC14M105588
  • GC14M105614
  • GC14M105753
  • GC14M105763
  • GC14M105777
  • GC14M105825
  • GC14M105625
  • GC14M105635
  • GC14M105655
  • GC14M105671
  • GC14M105696
  • GC14M105710
  • GC14M105728
  • GC14M105742

Summaries for IGHA2 Gene

GeneCards Summary for IGHA2 Gene

IGHA2 (Immunoglobulin Heavy Constant Alpha 2 (A2m Marker)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include antigen binding and immunoglobulin receptor binding. An important paralog of this gene is IGHA1.

UniProtKB/Swiss-Prot Summary for IGHA2 Gene

  • Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).

Gene Wiki entry for IGHA2 Gene

Additional gene information for IGHA2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for IGHA2 Gene

Genomics for IGHA2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for IGHA2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J105587 Enhancer 0.6 Ensembl dbSUPER 600.7 -1.9 -1906 3.8 REST NFIB KLF16 ZBTB8A IGHA2 IGHV2-26 IGHG4 lnc-BRF1-4 lnc-TMEM121-2 IGHE
GH14J105586 Enhancer 0.3 Ensembl dbSUPER 600.7 +1.1 1094 1 IGHA2 IGHV3-41 ELK2BP lnc-TMEM121-2 TMEM121
GH14J105192 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 5.5 +392.0 392010 7.2 HNRNPL CREB1 PRDM10 ZNF692 JUND ZIC2 ZNF740 GABPA ZNF600 SOX6 BTBD6 NUDT14 IGHA2 CRIP2 TMEM121 JAG2 AB372644-003 piR-49637
GH14J105585 Enhancer 0.8 ENCODE dbSUPER 0.7 +2.4 2404 1 YBX1 TARDBP SCRT2 HES1 CTBP1 ZIK1 ZNF592 MLLT1 ZBTB17 ZNF512B TMEM121 PACS2 IGHA2 lnc-TMEM121-2
GH14J105566 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 0.4 +18.7 18665 6.2 YBX1 TARDBP ZNF300 LARP7 ZNF143 ZNF776 ZIC2 ZSCAN4 ZNF239 ZNF311 AB372778-010 MTA1 ENSG00000257270 CDCA4 RPS20P33 CEP170B GPR132 LINC00638 RPS8P1 IGHA2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IGHA2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for IGHA2 Gene

Genomic Locations for IGHA2 Gene
chr14:105,583,731-105,588,395
(GRCh38/hg38)
Size:
4,665 bases
Orientation:
Minus strand
chr14:106,053,226-106,054,732
(GRCh37/hg19)
Size:
1,507 bases
Orientation:
Minus strand

Genomic View for IGHA2 Gene

Genes around IGHA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGHA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGHA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGHA2 Gene

Proteins for IGHA2 Gene

  • Protein details for IGHA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01877-IGHA2_HUMAN
    Recommended name:
    Immunoglobulin heavy constant alpha 2
    Protein Accession:
    P01877
    Secondary Accessions:
    • A0A075B6N7

    Protein attributes for IGHA2 Gene

    Size:
    340 amino acids
    Molecular mass:
    36591 Da
    Quaternary structure:
    • Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked (PubMed:20176268). Monomeric or polymeric (PubMed:2241915).
    SequenceCaution:
    • Sequence=AAB59396.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IGHA2 Gene

neXtProt entry for IGHA2 Gene

Post-translational modifications for IGHA2 Gene

  • Glycosylation at Asn47, Asn92, Asn131, Asn205, and Asn327
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect

Other Protein References for IGHA2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for IGHA2 Gene

Domains & Families for IGHA2 Gene

Gene Families for IGHA2 Gene

Protein Domains for IGHA2 Gene

InterPro:
Blocks:
  • Immunoglobulin C-type
ProtoNet:

Suggested Antigen Peptide Sequences for IGHA2 Gene

GenScript: Design optimal peptide antigens:
  • Ig alpha-2 chain C region (IGHA2_HUMAN)
genes like me logo Genes that share domains with IGHA2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for IGHA2 Gene

Function for IGHA2 Gene

Molecular function for IGHA2 Gene

UniProtKB/Swiss-Prot Function:
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
GENATLAS Biochemistry:
immunoglobulin,alpha 2 (A2M marker)

Phenotypes From GWAS Catalog for IGHA2 Gene

Gene Ontology (GO) - Molecular Function for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding TAS 6421489
GO:0034987 contributes_to immunoglobulin receptor binding IDA 23250751
genes like me logo Genes that share ontologies with IGHA2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for IGHA2 Gene

Localization for IGHA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGHA2 Gene

Secreted. Cell membrane.

Gene Ontology (GO) - Cellular Components for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 23398317
GO:0005886 plasma membrane IEA --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with IGHA2: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for IGHA2 Gene

Pathways & Interactions for IGHA2 Gene

PathCards logo

SuperPathways for IGHA2 Gene

No Data Available

Interacting Proteins for IGHA2 Gene

Gene Ontology (GO) - Biological Process for IGHA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis HEP 23580065
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0003094 glomerular filtration IMP 23398317
GO:0006898 receptor-mediated endocytosis TAS --
genes like me logo Genes that share ontologies with IGHA2: view

No data available for Pathways by source and SIGNOR curated interactions for IGHA2 Gene

Drugs & Compounds for IGHA2 Gene

(1) Drugs for IGHA2 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dansyllysine Experimental Pharma Target 0
genes like me logo Genes that share compounds with IGHA2: view

Transcripts for IGHA2 Gene

mRNA/cDNA for IGHA2 Gene

5 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for IGHA2 Gene

No ASD Table

Relevant External Links for IGHA2 Gene

GeneLoc Exon Structure for
IGHA2

Expression for IGHA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for IGHA2 Gene

mRNA differential expression in normal tissues according to GTEx for IGHA2 Gene

This gene is overexpressed in Colon - Transverse (x18.0), Small Intestine - Terminal Ileum (x16.7), and Minor Salivary Gland (x7.9).

Protein differential expression in normal tissues from HIPED for IGHA2 Gene

This gene is overexpressed in Milk (21.1), Synovial fluid (10.2), and Serum (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for IGHA2 Gene



Protein tissue co-expression partners for IGHA2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for IGHA2

genes like me logo Genes that share expression patterns with IGHA2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for IGHA2 Gene

Orthologs for IGHA2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for IGHA2 Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia -- 31
  • 61 (a)
OneToMany
Mouse
(Mus musculus)
Mammalia Igha 31
  • 58 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 54 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 49 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 15 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii ighv1-4 31
  • 13 (a)
OneToMany
Species where no ortholog for IGHA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for IGHA2 Gene

ENSEMBL:
Gene Tree for IGHA2 (if available)
TreeFam:
Gene Tree for IGHA2 (if available)

Paralogs for IGHA2 Gene

genes like me logo Genes that share paralogs with IGHA2: view

Variants for IGHA2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for IGHA2 Gene

IGHA2_HUMAN-P01877
There are several alleles. The sequence shown is that of IMGT allele IGHA2*02.

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for IGHA2 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
VAR_003879 - p.Ser93Pro
VAR_003880 - p.Arg102Pro
VAR_003881 - p.Tyr279Phe
VAR_003882 - p.Glu296Asp
VAR_003883 - p.Ile326Val

Additional Variant Information for IGHA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGHA2

SNP Genotyping and Copy Number Assay Products

No data available for Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for IGHA2 Gene

Disorders for IGHA2 Gene

No disorders were found for IGHA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGHA2 Gene

Publications for IGHA2 Gene

  1. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P … Loo JA (Journal of proteome research 2006) 3 4
  2. Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. (PMID: 14760718) Bunkenborg J … Wiśniewski JR (Proteomics 2004) 3 4
  3. A proteomic analysis of human bile. (PMID: 15084671) Kristiansen TZ … Pandey A (Molecular & cellular proteomics : MCP 2004) 3 4
  4. The structure and function of human IgA. (PMID: 2241915) Kerr MA (The Biochemical journal 1990) 3 4
  5. Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences. (PMID: 6421489) Flanagan JG … Rabbitts TH (Cell 1984) 3 4

Products for IGHA2 Gene

Sources for IGHA2 Gene