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Aliases for IGFN1 Gene

Aliases for IGFN1 Gene

  • Immunoglobulin-Like And Fibronectin Type III Domain Containing 1 2 3 5
  • EEF1A2-Binding Protein 1 3 4
  • KY-Interacting Protein 1 3 4
  • EEF1A2BP1 3 4
  • Immunoglobulin-Like And Fibronectin Type III Domain-Containing Protein 1 3
  • EEF1A2 Binding Protein 3
  • KYIP1 4

External Ids for IGFN1 Gene

Previous GeneCards Identifiers for IGFN1 Gene

  • GC01P199448
  • GC01P172326

Summaries for IGFN1 Gene

GeneCards Summary for IGFN1 Gene

IGFN1 (Immunoglobulin-Like And Fibronectin Type III Domain Containing 1) is a Protein Coding gene. An important paralog of this gene is IGSF22.

Additional gene information for IGFN1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IGFN1 Gene

Genomics for IGFN1 Gene

GeneHancer (GH) Regulatory Elements for IGFN1 Gene

Promoters and enhancers for IGFN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I201191 Enhancer 0.9 FANTOM5 ENCODE 560.4 +1.4 1410 2 ZBTB21 JUN KLF17 CEBPG ZIC2 ZNF623 FOSL1 NFIC JUND GLIS1 IGFN1 ENSG00000229821 TMEM9
GH01I201190 Promoter 0.8 EPDnew 550.8 0.0 -1 0.1 E2F1 ZFHX2 PKNOX1 POLR2A GLIS1 EGR2 IGFN1 GC01M201173
GH01I201169 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 17 -19.5 -19461 4 MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D TMEM9 ENSG00000229821 IGFN1 IPO9-AS1 IPO9 ASCL5
GH01I201153 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.1 -36.4 -36413 1.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 TMEM9 DDX59 RNPEP ENSG00000273478 ELF3-AS1 IGFN1 ASCL5 CACNA1S ENSG00000229821
GH01I201394 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.5 +207.6 207580 7.7 HDGF FOXA2 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B ZNF48 YY1 SLC30A9 LAD1 LOC101929343 TNNI1 IGFN1 PKP1 CSRP1 TNNT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around IGFN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IGFN1 gene promoter:

Genomic Locations for IGFN1 Gene

Genomic Locations for IGFN1 Gene
chr1:201,190,806-201,228,952
(GRCh38/hg38)
Size:
38,147 bases
Orientation:
Plus strand
chr1:201,159,953-201,198,080
(GRCh37/hg19)

Genomic View for IGFN1 Gene

Genes around IGFN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IGFN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IGFN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IGFN1 Gene

Proteins for IGFN1 Gene

  • Protein details for IGFN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VF2-IGFN1_HUMAN
    Recommended name:
    Immunoglobulin-like and fibronectin type III domain-containing protein 1
    Protein Accession:
    Q86VF2
    Secondary Accessions:
    • F8WAI1
    • Q9NT72

    Protein attributes for IGFN1 Gene

    Size:
    1251 amino acids
    Molecular mass:
    137763 Da
    Quaternary structure:
    • Interacts with FLNC (By similarity). Interacts with KY.

    Alternative splice isoforms for IGFN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IGFN1 Gene

Post-translational modifications for IGFN1 Gene

  • Glycosylation at posLast=593593
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for IGFN1 Gene

Domains & Families for IGFN1 Gene

Gene Families for IGFN1 Gene

Suggested Antigen Peptide Sequences for IGFN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with IGFN1: view

No data available for UniProtKB/Swiss-Prot for IGFN1 Gene

Function for IGFN1 Gene

Gene Ontology (GO) - Molecular Function for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with IGFN1: view
genes like me logo Genes that share phenotypes with IGFN1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for IGFN1

miRNA for IGFN1 Gene

miRTarBase miRNAs that target IGFN1

Clone Products

  • Addgene plasmids for IGFN1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for IGFN1 Gene

Localization for IGFN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IGFN1 Gene

Nucleus. Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IGFN1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with IGFN1: view

Pathways & Interactions for IGFN1 Gene

SuperPathways for IGFN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IGFN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with IGFN1: view

No data available for Pathways by source and SIGNOR curated interactions for IGFN1 Gene

Drugs & Compounds for IGFN1 Gene

No Compound Related Data Available

Transcripts for IGFN1 Gene

Unigene Clusters for IGFN1 Gene

Immunoglobulin-like and fibronectin type III domain containing 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for IGFN1

Alternative Splicing Database (ASD) splice patterns (SP) for IGFN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for IGFN1 Gene

GeneLoc Exon Structure for
IGFN1
ECgene alternative splicing isoforms for
IGFN1

Expression for IGFN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IGFN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IGFN1 Gene

This gene is overexpressed in Muscle - Skeletal (x35.6) and Thyroid (x6.7).

Protein differential expression in normal tissues from HIPED for IGFN1 Gene

This gene is overexpressed in Urine (57.4) and Plasma (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for IGFN1 Gene



Protein tissue co-expression partners for IGFN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of IGFN1 Gene:

IGFN1

SOURCE GeneReport for Unigene cluster for IGFN1 Gene:

Hs.519024

mRNA Expression by UniProt/SwissProt for IGFN1 Gene:

Q86VF2-IGFN1_HUMAN
Tissue specificity: Expressed in skeletal muscle.

Evidence on tissue expression from TISSUES for IGFN1 Gene

  • Muscle(4.6)
genes like me logo Genes that share expression patterns with IGFN1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for IGFN1 Gene

Orthologs for IGFN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IGFN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IGFN1 33
  • 97.84 (n)
mouse
(Mus musculus)
Mammalia Igfn1 33 16 34
  • 69.77 (n)
rat
(Rattus norvegicus)
Mammalia Igfn1 33
  • 66.84 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 65 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia IGFN1 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IGFN1 34
  • 59 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IGFN1 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves IGFN1 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IGFN1 34
  • 49 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC100331959 33
  • 51.35 (n)
IGFN1 (4 of 4) 34
  • 38 (a)
OneToMany
IGFN1 (2 of 4) 34
  • 37 (a)
OneToMany
igfn1.1 34
  • 37 (a)
OneToMany
IGFN1 (3 of 4) 34
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14964 34
  • 9 (a)
ManyToMany
sls 34
  • 2 (a)
ManyToMany
Species where no ortholog for IGFN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IGFN1 Gene

ENSEMBL:
Gene Tree for IGFN1 (if available)
TreeFam:
Gene Tree for IGFN1 (if available)

Paralogs for IGFN1 Gene

Paralogs for IGFN1 Gene

(2) SIMAP similar genes for IGFN1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with IGFN1: view

Variants for IGFN1 Gene

Sequence variations from dbSNP and Humsavar for IGFN1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000053111 -- 201,221,273(+) G/T intron_variant
rs1000104375 -- 201,191,078(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000138379 -- 201,215,802(+) G/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000205792 -- 201,216,932(+) C/T intron_variant
rs1000313065 -- 201,199,720(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for IGFN1 Gene

Variant ID Type Subtype PubMed ID
esv1570400 CNV deletion 17803354
esv1754216 CNV insertion 17803354
esv25305 CNV gain 19812545
esv2721406 CNV deletion 23290073
esv2721417 CNV deletion 23290073
nsv1121446 CNV deletion 24896259
nsv1141747 CNV insertion 24896259
nsv428301 CNV gain 18775914
nsv518716 CNV loss 19592680
nsv548992 CNV loss 21841781

Variation tolerance for IGFN1 Gene

Gene Damage Index Score: 23.83; 99.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IGFN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
IGFN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IGFN1 Gene

Disorders for IGFN1 Gene

Additional Disease Information for IGFN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for IGFN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for IGFN1 Gene

Publications for IGFN1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PMID: 15385448) Beatham J … Blanco G (Human molecular genetics 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Translation elongation factor eEF1A binds to a novel myosin binding protein-C-like protein. (PMID: 18756455) Mansilla F … Knudsen CR (Journal of cellular biochemistry 2008) 3 58
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58

Products for IGFN1 Gene

  • Addgene plasmids for IGFN1

Sources for IGFN1 Gene

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